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| 1 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
| 2 | Effects of electroacupuncture and Chinese kidney-nourishing medicine on polycystic ovary syndrome in obese patients显示文摘OBJECTIVE: To explore the effect of electroacupuncture and Chinese kidney-nourishing medicine on insulin (INS), adiponectin (APN), leptin (LEP), and glucolipid metabolism of obese patients with polycystic ovary syndrome (PCOS). METHODS: Sixty-seven obese PCOS patients were randomly divided into two groups. Thirty-three patients in the acupuncture-medicine group were treated three times a week with electroacupuncture at the Tianshu (ST 25), Zhongwan (CV 12), Qihai (CV 6), Sanyinjiao (SP 6), Geshu (BL 17), and Cil-iao (BL 32) acupoints. They also took the Chinese drug, Tiankui capsule, for 3 months as a course of treatment. Point-taking and treatment in the electroacupuncture group of 34 patients was the same as those in the acupuncture-medicine group. We observed and compared the changes in the obesity-related indexes of body weight (BW), body mass index (BMI), and waist-hip ratio (WHR), as well as fasting plasma glucose (FPG), fasting insulin (FINS), APN, and LEP. RESULTS: BW, BMI, WHR, and FINS decreased and insulin sensitivity index (ISI) and APN were higher in the acupuncture-medicine group than in the electroacupuncture group (P<0.01). There was no obvious difference in LEP between the two groups (P>0.05). CONCLUSION: Acupuncture combined with medicine is better than just electroacupuncture for obese PCOS patients by improving obesity-related indexes, insulin sensitivity, and APN level. This indicates that acupuncture-medicine therapy is worth clinical popularization. | Liqing Yu Yanjun Liao Huangan Wu Jimeng Zhao Luyi Wu Yin Shi Jianqiao Fang | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 15 |
| 3 | Approximate Solution of Oil Film Load-carrying Capacity of Turbulent Journal Bearing with Couple Stress Flow显示文摘The instability of the rotor dynamic system supported by oil journal bearing is encountered frequently, such as the half-speed whirl of the rotor, which is caused by oil film lubricant with nonlinearity. Currently, more attention is paid to the physical characteristics of oil film due to an oil-lubricated journal bearing being the important supporting component of the bearing-rotor systems and its nonlinear nature. In order to analyze the lubrication characteristics of journal bearings efficiently and save computational efforts, an approximate solution of nonlinear oil film forces of a finite length turbulent journal bearing with couple stress flow is proposed based on Sommerfeld and Ocvirk numbers. Reynolds equation in lubrication of a finite length turbulent journal bearing is solved based on multi-parametric principle. Load-carrying capacity of nonlinear oil film is obtained, and the results obtained by different methods are compared. The validation of the proposed method is verified, meanwhile, the relationships of load-carrying capacity versus eccentricity ratio and width-to-diameter ratio under turbulent and couple stress working conditions are analyzed. The numerical results show that both couple stress flow and eccentricity ratio have obvious influence on oil film pressure distribution, and the proposed method approximates the load-carrying capacity of turbulent journal bearings efficiently with various width-to-diameter ratios. This research proposes an approximate solution of oil film load-carrying capacity of turbulent journal bearings with different width-to-diameter ratios, which are suitable for high eccentricity ratios and heavy loads. | ZHANG Yongfang WU Peng GUO Bo L Yanjun LIU Fuxi YU Yingtian | 2015 | Chinese Journal of Mechanical Engineering2015，28，1： | 10 |
| 4 | Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis显示文摘 | Yi Lu Shanshan Xie Wen Zhang Cheng Zhang Cheng Gao Qiang Sun Yuqi Cai Zhangqi Xu Min Xiao Yanjun Xu Xiao Huang Ximei Wu Wei Liu Fudi Wang Yibin Kang Tianhua Zhou | 2017 | Cell Research2017，27，12： | 9 |
| 5 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 6 | Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression显示文摘As an effective anticancer drug, the clinical limitation of doxorubicin(Dox) is the time-and dose-dependent cardiotoxicity. Yes-associated protein 1(YAP1) interacts with transcription factor TEA domain 1(TEAD1) and plays an important role in cell proliferation and survival. However, the role of YAP1 in Dox-induced cardiomyopathy has not been reported. In this study, the expression of YAP1 was reduced in clinical human failing hearts with dilated cardiomyopathy and Dox-induced in vivo and in vitro cardiotoxic model. Ectopic expression of Yap1 significantly blocked Dox-induced cardiomyocytes apoptosis in TEAD1 dependent manner. Isorhapontigenin(Isor) is a new derivative of stilbene and responsible for a wide range of biological processes. Here, we found that Isor effectively relieved Doxinduced cardiomyocytes apoptosis in a dose-dependent manner in vitro. Administration with Isor(30 mg/kg/day, intraperitoneally, 3 weeks) significantly protected against Dox-induced cardiotoxicity in mice. Interestingly, Isor increased Dox-caused repression in YAP1 and the expression of its target genes in vivo and in vitro. Knockout or inhibition of Yap1 blocked the protective effects of Isor on Dox-induced cardiotoxicity. In conclusion, YAP1 may be a novel target for Dox-induced cardiotoxicity and Isor might be a new compound to fight against Dox-induced cardiotoxicity by increasing YAP1 expression. | Panxia Wang Minghui Wang Yuehuai Hu Jianxing Chen Yanjun Cao Cui Liu Zhongkai Wu Juan Shen Jing Lu Peiqing Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 7 |
| 7 | Serum interleukin-10 levels and adverse events in patients with acute coronary syndrome: a systematic review and meta-analysis显示文摘 | Liu Jun Jia Yanjun Li Xiaolin Xu Ruixia Zhu Chenggang Guo Yuanlin Wu Naqiong Li Jianjun | 2014 | Chinese Medical Journal2014，，1： | 6 |
| 8 | Nonselective etching of GaN/AlGaN heterostructures by Cl2/Ar/BCl3 inductively coupled plasmas显示文摘A systematic study of the nonselective and smooth etching of GaN/AIGaN het-erostructures was performed using C12/Ar/BCI3 inductively coupled plasmas (ICR).Nonselective etching can be realized by adjusting the BCI3 ratio in the Cl2/Ar/BCI3 mixture (20%—60%), increasing the ICR power and dc bias, and decreasing the chamber pressure. Surface morphology of the etched heterostructures strongly depends on the gas chemistry and the chamber pressure. Specifically, with the addition of 20% BCI3 to Cl2/Ar (4:1) gas mixture, nonselective etching of GaN/Al0.28Ga0.72N heterostructures at high etch rate is maintained and the surface root-mean-square (rms) roughness is reduced from 10.622 to 0.495 nm, which is smoother than the as-grown sample. Auger electron spectroscopy (AES) analysis shows that the effective removal of residual oxygen from the surface of AIGaN during the etching process is crucial to the nonselective and smooth etching of GaN/AIGaN herterostructures at high etch rate. | HAN Yanjun XUE Song WU Tong WU Zhen GUO Wenping LUO Yi HAO Zhibiao SUN Changzheng | 2004 | Science China(Technological Sciences)2004，47，2： | 6 |
| 9 | Temperature dependent Raman and photoluminescence of vertical WS2/MoS2 monolayer heterostructures显示文摘Heterostructures from two-dimensional transition-metal dichalcogenides MX_2 have emerged as a hot topic in recent years due to their various fascinating properties. Here, we investigated the temperature dependent Raman and photoluminescence(PL) spectra in vertical stacked WS_2/MoS_2 monolayer heterostructures. Our result shows that both E_(2g)~1 and A_(1g) modes of WS_2 and MoS_2 vary linearly with temperature increasing from 300 to 642 K. The PL measurement also reveals strong temperature dependencies of the PL intensity and peak position. The activation energy of the thermal quenching of the PL emission has been found to be equal to 69.6 meV. The temperature dependence of the peak energy well follows the bandgap shrinkage of bulk semiconductor. | Zhijian Hu Yanjun Bao Ziwei Li Yongji Gong Rui Feng Yingdong Xiao Xiaochun Wu Zhaohui Zhang Xing Zhu Pulickel M. Ajayan Zheyu Fang | 2017 | Science Bulletin2017，62，1： | 5 |
| 10 | SET8 is involved in the regulation of hyperglycemic memory in human umbilical endothelial cells显示文摘 | Xiangyuan Chen Qichao Wu Hui Jiang Jiaqiang Wang Yanjun Zhao Yajun Xu Minmin Zhu1 | 2018 | Acta Biochimica et Biophysica Sinica2018，50，7： | 5 |
| 11 | Propofol attenuates high glucose-induced P66shc expression in human umbilical vein endothelial cells through Sirt1显示文摘Perioperative hyperglycemia is a common metabolic disorder in clinic settings.Hyperglycemia leads to endothelial inflammation,endothelial cell apoptosis,and dysfunction,thus resulting in endothelial injury.Propofol(2,6-diisopropylphenol)is a widely used intravenous anesthetic in clinic settings.Our previous study indicated that propofol inhibits mitochondrial reactive oxygen species(ROS)production via down-regulation of phosphatase A2(PP2A)expression,inhibition of Ser36-p66shc dephosphorylation and mitochondrial translocation,thus improving high glucose-induced endothelial injury.The expression of p66shc was inhibited by propofol in hyperglycemic human umbilical vein endothelial cells(HUVECs).However,the mechanism by which propofol inhibits p66shc expression in hyperglycemic HUVECs is still obscure.In the present study,we mainly examined how propofol inhibited high glucose-induced p66shc expression in HUVECs.Compared with 5 mM glucose treatment,high glucose increased p66shc expression and decreased sirt1 expression,which was inhibited by propofol treatment.Moreover,EX527(a sirt1 inhibitor)reversed the effect of propofol against high glucose-induced p66shc expression.However,EX527 did not reverse the effects of propofol against high glucose-induced ROS accumulation,endothelial inflammation,and apoptosis.Furthermore,when cells were incubated with propofol,EX527,and FTY720(a PP2A activator)simultaneously,the effects of propofol against high glucose-induced ROS accumulation,inflammation,and apoptosis were reversed.Our results suggested that propofol inhibited high glucose-induced p66shc expression via upregulation of sirt1 expression in hyperglycemic HUVECs.Moreover,propofol protects against high glucose-mediated ROS accumulation and endothelial injury via both inhibition of p66shc expression and dephosphorylation of Ser36-p66shc. | Jing Wang Jie Qi Qichao Wu Hui Jiang Yuehao Yin Yan Huanx Yanjun Zhao Minmin Zhu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，2： | 5 |
| 12 | Study of the Reservoir Damage during Cyclic Injection and Extraction Process in the Hutubi Gas Storage显示文摘During the injection and extraction process in gas storage,cyclic loading stress is applied to the reservoir pore structure,affecting the capacity and service life of gas storage. To study the influence of cyclic injection and extraction on reservoir physical property,a finite-element model of reservoir elastoplastic damage under the effect of pore pressure is established based on elastoplastic mechanics and fatigue-damage mechanics. Considering the mechanical property of the Hutubi reservoir and the injection-extraction mode of gas storage,the finite-element model is used to study the pore pressure and porosity change,fault safety,and ground surface deformation. The results show that the change in pore pressure and porosity,the deformation of the Hutubi fault,as well as the uplift and sink of the grounds surface are controlled by the fatigue damage of the reservoir pore structure during the injection-extraction process. After a 6-year service life, the cumulative deformation of the reservoir pore reaches its limit,causing pore structure collapse and porosity decrease. As a result,storage capacity declines and the ground surface starts to sink. Through this study,the safety of the Hutubi gas storage is evaluated,and some suggestions for field operations are offered. | Wang Jianbo Ge Hongkui Wang Xiaoqiong Liu Tongyuan Liu Dunqing Zhang Yanjun Wu Shan | 2018 | Earthquake Research in China2018，32，2： | 4 |
| 13 | Characterization of Catalytic Cracking Catalysts Regenerated by Gasifying Deposited Coke显示文摘部分或充分改革的催化裂开的催化剂被气化准备在一张固定的使流体化的床(FFB ) 上与氧和蒸气的气体的混合物在 coked 催化剂上扔的焦炭。结果的样品被象氮吸附解吸附作用分析那样的不同方法描绘,X光检查 diffractometry ,红外线的光谱学,氨规划温度的解吸附作用( NH3-TPD )方法,X光检查荧光( XRF )分析,传播电子显微镜学和精力散X光检查光谱学( TEM-EDX ), thermal-gravimetric 分析( TGA )和微分热分析( DTA )。结果显示了催化剂的那暴露在 800 不能引起焦炭等同到大约 0.27 m% 的催化剂,和数量的太多破坏的温度冒热气大约 10 分钟是足够的近似堵住所有酸地点在沸石催化剂微毛孔。科克没在能被附近的金属原子的催化行动加速的焦炭烧离开期间显示出相等的反应。然而,当催化剂上的碳内容到达了大约 2.44 m% 时,催化剂上的金属的催化行动不是明显的。严重热、热水的环境能在到在在大约为 30 分钟的 860-880 的范围的温度的蒸气的催化剂的暴露期间导致毛孔结构和水晶阶段的转变的倒塌并且因而在催化剂上表面区域和酸数量减少。 | Men Xiujie Zhan Shuhong Li Yanjun Wu Zhiguo Wang Zijun Wang Xieqing (Research Institute of Petroleum Processing,SINOPEC,Beijing 100083) | 2010 | China Petroleum Processing & Petrochemical Technology2010，12，1： | 4 |
| 14 | A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro显示文摘Highly virulent porcine epidemic diarrhea virus(PEDV)strains re-emerged and circulated in China at the end of 2010,causing significant economic losses in the pork industry worldwide.To understand the genetic dynamics of PEDV during its passage in vitro,the PEDV G2 strain FJzzl was serially propagated in Vero cells for up to 200 passages.The susceptibility and adaptability of the FJzzl strain increased gradually as it was serially passaged in vitro.Sequence analysis revealed that amino acid(aa)changes were mainly concentrated in the S glycoprotein,which accounted for 72.22%-85.71%of all aa changes.A continuous aa deletion(^(55)I^(56)G^(57)E→^(55)K^(56)Δ^(57)Δ)occurred in the N-terminal domain of S1(Sl-NTD).To examine how the aa changes affected its virulence,FJzzl-F20 and FJzzl-F200 were selected to simultaneously evaluate their pathogenicity in suckling piglets.All the piglets in the FJzzl-F20-infected group showed typical diarrhea at 24 h postinfection,and the piglets died successively by 48 h postinfection.However,the clinical signs of the piglets in the FJzzl-F200-infected group were significantly weaker,and no deaths occurred.The FJzzl-F200-infected group also showed a lower level of fecal viral shedding and lower viral loads in the intestinal tissues,and no obvious histopathological lesions.TypeⅠandⅢinterferon were induced in the FJzzl-F200 infection group,together with pro-inflammatory cytokines,such as TNF-α,IL-1βand IL-8.These results indicate that the identified genetic changes may contribute to the attenuation of FJzzl strain,and the attenuated FJzzl-F200 may have the potential for developing PEDV live-attenuated vaccines. | Pengfei Chen Xiongwei Zhao Shuting Zhou Tianxing Zhou Xiangmei Tan Xia Wu Wu Tong Fei Gao Lingxue Yu Yifeng Jiang Hai Yu Zhibiao Yang Guangzhi Tong Yanjun Zhou | 2021 | Virologica Sinica2021，36，5： | 4 |
| 15 | Fabrication of Crack-Free Flattened Bamboo and Its Macro-/MicroMorphological and Mechanical Properties显示文摘This work aimed to help the bamboo industry develop methodology for producing imperfection-free bamboo boards that can serve either decorative or structural benefit to consumers seeking to engage with the bioeconomy.Specifically,softened and slotted bamboo tubes were handled by a roller device with nails to render crack-free flattened bamboo board.Softening temperature and time were optimized herein according to findings regarding chemical composition and board mechanical properties.The optimal softening parameters for saturated steam heat treatment is proved to be 160°C for 8 min.The flattened bamboo board possesses an increased bending strength of 101.5 MPa and a decreased bending modulus of 7.7 GPa,being compared with only-softened bamboo.The corresponding changing mechanism is determined in-depth by the micro-morphological and mechanical results based on in-situ SEM and AFM technologies.Under the action of nails and rolling processes,the bamboo texture becomes compact with crushed and fragmented conduit walls.The resulting cell cavity then becomes stretched and compressed,taking on a morphology which allows for the mechanical penalties associated with flattening to be avoided.According to the micro-mechanical results obtained by AFM,compared with unflatten bamboo,the Young’s modulus of the cell membrane in transverse direction(YT)decreases to 1.00 GPa while the corresponding Young’s modulus in radial direction(YR)increases to 7.29 GPa. | Zhichao Lou Tiancheng Yuan Qiuyi Wang Xinwu Wu Shouheng Hu Xiaomeng Hao Xianmiao Liu Yanjun Li | 2021 | Journal of Renewable Materials2021，9，5： | 4 |
| 16 | Development characteristics of the fault system and its control on basin structure, Bodong Sag, East China显示文摘The Bodong Sag,located in the Bohai Sea,offshore China,is one of the most petroliferous basins in China.Based on three dimensional seismic reflection data and time slice data,we analyze the fault system of the Bodong area in detail,establish the fault structure pattern of different types and summarize the distribution of the fault system.It is concluded that the development characteristics of the Cenozoic fault system are in accordance with the dextral stress field of the Tanlu Fault,which displayed a brush structure with NNE strike-slip faults as its principal faults,NE-trending extensional faults as secondary faults and EW-trending faults as minor faults.Faults can be divided into (1) strike-slip type,(2) extensional type,(3) strike-slip extensional type and (4) extensional strike-slip type.The spatial structures of different faults have obvious differences because of the fault properties and activity intensity.The fault system at different stages shows tremendous differences because of the transition of the Tanlu Fault from sinistral strike-slip to dextral strike-slip,the transition between extension and strike-slip,and the transition from mantle upwelling to thermal subsidence.According to the controlling effect of faults on basin structure,the Cenozoic basin experienced four evolutionary stages,(a) transition stage from sinistral strike-slip to dextral strike-slip,(b) strike-slip extensional faulted stage,(c) extensional strike-slip faulted stage and (d) strike-slip depression stage.The identification of temporal and spatial differences of faults could be used as a significant guideline for oil and gas exploration in the Bodong area. | Wu Zhiping Cheng Yanjun Yan Shiyong Su Wen Wang Xin Xu Changgui Zhou Xinhuai | 2013 | Petroleum Science2013，10，4： | 4 |
| 17 | Characterization of mechanical properties of aluminum cast alloy at elevated temperature显示文摘The tensile response, the low cycle fatigue(LCF) resistance, and the creep behavior of an aluminum(Al) cast alloy are studied at ambient and elevated temperatures.A non-contact real-time optical extensometer based on the digital image correlation(DIC)is developed to achieve strain measurements without damage to the specimen. The optical extensometer is validated and used to monitor dynamic strains during the mechanical experiments. Results show that Young's modulus of the cast alloy decreases with the increasing temperature, and the percentage elongation to fracture at 100℃ is the lowest over the temperature range evaluated from 25℃ to 300℃. In the LCF test, the fatigue strength coefficient decreases, whereas the fatigue strength exponent increases with the rising temperature. The fatigue ductility coefficient and exponent reach maximum values at 100℃. As expected, the resistance to creep decreases with the increasing temperature and changes from 200℃ to 300℃. | Shuiqiang ZHANG Yichi ZHANG Ming CHEN Yanjun WANG Quan CUI Rong WU D.AROLA Dongsheng ZHANG | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，7： | 4 |
| 18 | Thymosin Alpha-1 Inhibits Complete Freund’s Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord显示文摘Activation of inflammatory responses regulates the transmission of pain pathways through an integrated network in the peripheral and central nervous systems.The immunopotentiator thymosin alpha-1(Tal)has recently been reported to have anti-inflammatory and neuroprotective functions in rodents.However,how Tα1 affects inflammatory pain remains unclear.In the present study,intraperitoneal injection of Tal attenuated complete Freund's adjuvant(CFA)-induced pain hypersensitivity,and decreased the up-regulation of pro-inflammatory cytokines(TNF-α,IL-1β,and IL-6)in inflamed skin and the spinal cord.We found that CFA-induced peripheral inflammation evoked strong microglial activation,but the effect was reversed by Tα1.Notably,Tα1 reversed the CFA-induced up-regulation of vesicular glutamate transporter(VGLUT)and down-regulated the vesicular γ-aminobutyric acid transporter(VGAT)in the spinal cord.Taken together,these results suggest that Tα1 plays a therapeutic role in inflammatory pain and in the modulation of microgliainduced pro-inflammatory cytokine production in addition to mediation of VGLUT and VGAT expression in the spinal cord. | Yunlong Xu Yanjun Jiang Lin Wang Jiahua Huang Junmao Wen Hang Lv Xiaoli Wu Chaofan Wan Chuanxin Yu Wenjie Zhang Jiaying Zhao Yinqi Zhou Yongjun Chen | 2019 | Neuroscience Bulletin2019，35，4： | 4 |
| 19 | Numerical simulation of seepage flow field in groundwater source heat pump system and its influence on temperature field显示文摘Energy utilization in the aquifers is a new technology closely related to development of heat pump technique. It is significant for the flow distribution to be predicted in the aquifer surrounding the Groundwater Source Heat Pump System (GSHPS). The authors presented a new concept of 'flow transfixion' by analyzing general features of aquifers, and then discussed interaction of the flow transfixion with the heat transfixion, which has practical significance to projects. A numerical model of groundwater flow was established based on the basic tenets of water-heat transferring in the aquifer. On this basis the flow field and the temperature field of GSHPS for a site in Shenyang City were numerically simulated. The basis of the flow transfixion was obtained; it was discussed for the influence of the flow transfixion on the heat transfixion. To a certain extent, the study offers some reference for the projects' design of GSHP in the studied area. | Jihua HU Yanjun ZHANG Danyan DU Gang WU Ziwang YU Chen WANG Fuquan NI | 2008 | Global Geology2008，11，3： | 4 |
| 20 | Searching for the Nano-Hertz Stochastic Gravitational Wave Background with the Chinese Pulsar Timing Array Data ReleaseⅠ显示文摘Observing and timing a group of millisecond pulsars with high rotational stability enables the direct detection of gravitational waves(GWs).The GW signals can be identified from the spatial correlations encoded in the times-of-arrival of widely spaced pulsar-pairs.The Chinese Pulsar Timing Array(CPTA)is a collaboration aiming at the direct GW detection with observations carried out using Chinese radio telescopes.This short article serves as a“table of contents”for a forthcoming series of papers related to the CPTA Data Release 1(CPTA DR1)which uses observations from the Five-hundred-meter Aperture Spherical radio Telescope.Here,after summarizing the time span and accuracy of CPTA DR1,we report the key results of our statistical inference finding a correlated signal with amplitude logA_(c)=-14.4_(-2.8)^(+1.0)for spectral index in the range ofα∈[-1.8,1.5]assuming a GW background(GWB)induced quadrupolar correlation.The search for the Hellings–Downs(HD)correlation curve is also presented,where some evidence for the HD correlation has been found that a 4.6σstatistical significance is achieved using the discrete frequency method around the frequency of 14 n Hz.We expect that the future International Pulsar Timing Array data analysis and the next CPTA data release will be more sensitive to the n Hz GWB,which could verify the current results. | Heng Xu Siyuan Chen Yanjun Guo Jinchen Jiang Bojun Wang Jiangwei Xu Zihan Xue RNicolas Caballero Jianping Yuan Yonghua Xu Jingbo Wang Longfei Hao Jingtao Luo Kejia Lee Jinlin Han Peng Jiang Zhiqiang Shen Min Wang Na Wang Renxin Xu Xiangping Wu Richard Manchester Lei Qian Xin Guan Menglin Huang Chun Sun Yan Zhu | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 3 |
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