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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 4 | An evalution of low-temperature apatite U-Th/He themochronometry显示文摘 | Zeitler P K Wolf R A Bergman S C | 1997 | Geochimica et Cosmochimica Acta1997，61，： | 1 |
| 5 | Measuring the spatial frequency transfer function of phase-measuring interferometers for laser optics显示文摘 | Wolfe C R Downie J D Lawson J K | 1996 | SPIE1996，2870，： | 1 |
| 6 | Polo-like kinase:A novel marker of proliferation:Correlation with estrogen-receptor expression in human breast cancer 显示文摘 | Wolf G Hildenbrand R Schwar C | 2000 | Pathol Res Pract2000，196，11： | 1 |
| 7 | North American Forest Disturbance Mapped from a Decadal Landsat Record显示文摘 | Masek J G Huang C Wolfe R | 2008 | Remote Sensing of Environment2008，112，6： | 1 |
| 8 | Limited incision opentechniques for distal radius fracture management显示文摘 | SWIGART C R WOLFE S W | | 0，，02： | 1 |
| 9 | Determinants of care costs of patients with dementia or cognitive impairment显示文摘 | Handels R L Wolfs C A Aalten P | 2013 | Alzheimer Dis Assoc Disord2013，27，1： | 1 |
| 10 | Cardio- vascular mortality in children and young adults with end-stage kidney disease显示文摘 | PAREKH R S CARROLL C E WOLFE R A | 2002 | The Journal of Pediatrics2002，141，2： | 1 |
| 11 | Disintegration of the Scrophulariaceae 显示文摘 | OLMSTEAD R G DEPAMPHILIS C W WOLFE A D | 2001 | American Journal of Botany2001，88，2： | 1 |
| 12 | Using sampling theory to build a more universal forest vegetation database显示文摘 | Martin F C Baggett T Wolfe T and Mita R | 2000 | Computers and Electronics in Agriculture2000，，3： | 1 |
| 13 | Pre-operative chemoradiation for patients with locally advanced adenocarcinoma of the pancreas显示文摘 | White R Lee C Anscher M Gottfried M Wolf R Keogan M | | 0，，： | 1 |
| 14 | Large area laser conditioning of dielectric thin film mirrors显示文摘 | Kozlowski M R Wolfe C R Staggs M C | | 0，，： | 1 |
| 15 | Syste mic antihypertensive medication and incident open-angle glau- eoma显示文摘 | MUSKENS R P DE VOOGD S WOLFS R C | 2007 | Ophthalmology2007，114，12： | 1 |
| 16 | Uptime as a measure of recovery in children postappendectomy 显示文摘 | Eldridge B Kimber C Wolfe R | 2003 | J Pediatr Surg2003，38，12： | 1 |
| 17 | Achieving sub-pixel geolocation accuracy in support of MODIS land science显示文摘 | Wolfe R E Nishihama M Fleig A J Kuyper J A Roy D P Storey J C and Patt F S | | 0，，1： | 1 |
| 18 | Laser conditioning of optical thin films显示文摘 | Wolfe C R Kozlowski M R Campbell J H | | 0，，： | 1 |
| 19 | Relaxation kinetics of cytochrome P450 reductase:internal electron transfer is limited by conformational change and regulated by coenzyme binding 显示文摘 | GUTIERREZ A PAINE M WOLF C R | 2002 | Biochemistry2002，41，14： | 1 |
| 20 | Vascular remodeling and alteredprotein expression during growth of coronary collateral arteries显示文摘 | Wolf C Cai WJ Vosschulte R | 1998 | JMol Cell Cardiol1998，30，11： | 1 |
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