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| 1 | Surgical strategies in the therapy of non-small cell lung cancer显示文摘Lung cancer represents the leading cause of cancer mortality worldwide. Despite improvements in preoperative staging, surgical techniques, neoadjuvant/adjuvant options and postoperative care, there are still major difficulties in significantly improving survival, especially in locally advanced non-small cell lung cancer(NSCLC). To date, surgical resection is the primary mode of treatment for stage?Ⅰ?and Ⅱ NSCLC and has become an important component of the multimodality therapy of even more advanced disease with a curative intention. In fact, in NSCLC patients with solitary distant metastases, surgical interventions have been discussed in the last years. Accordingly, this review displays the recent surgical strategies implemented in the therapy of NSCLC patients. | Feras Al-Shahrabani Daniel Vallbhmer Sebastian Angenendt Wolfram T Knoefel | 2014 | World Journal of Clinical Oncology2014，5，4： | 10 |
| 2 | Intrahepatic endometriosis as differential diagnosis: Case report and literature review显示文摘Intrahepatic endometriosis is one of the rarest forms of atypical endometriosis; only eighteen cases have been reported in the English literature. We describe the case of a 32-year-old woman, who presented with persistent, non-cyclical upper right quadrant abdominal pain, a central liver cyst, and no history of endometriosis. Three years previous, she was diagnosed with an intrahepatic cyst. The lesion progressed and two laparoscopic deroofing-operations were performed, yet the diagnosis of intrahepatic endometriosis was never reached. She presented in our clinic with further progress of the cyst as well as obstruction of the intrahepatic biliary system. The magnetic resonance imaging showed a 9.5 cm × 12 cm, lobulated intrahepatic cyst. We performed an ultrasonic pericystectomy. Immunostaining confirmed intrahepatic endometriosis. Only one of the previously described eighteen patients with intrahepatic endometriosis presented with cyclical pain in the upper right abdominal quadrant accompanying menstruation. This lack of a 'typical' clinic makes it challenging to diagnose extragonadal endometriosis without histopathology. A previous history of endometriosis was described in only twelve cases, thus the diagnosis of this condition should not be limited to patients with a known history of endometriosis. Six of 18 patients were postmenopausal, demonstrating this condition is not limited to women of reproductive age. A preoperative diagnosis was only reached in seven of the previously described cases, highlighting the importance of preoperative biopsies. Yet due to the potential adverse effects, a transhepatic biopsy must be discussed individually. Although rare, intrahepatic endometriosis should always be considered as a differential diagnosis in women with recurrent hepatic cysts, regardless of age or previous medical history. In such cases, histology is essential and a pericystectomy should be performed as standard of care. | Georg Fluegen Frank Jankowiak Luisa Zacarias Foehrding Feride Kroepil Wolfram T Knoefel Stefan A Topp | 2013 | World Journal of Gastroenterology2013，19，29： | 9 |
| 3 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 4 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 5 | Robotic-assisted laparoscopic radical prostatectomy: the Frankfurt technique显示文摘 | Wolfram M Brautigam R Engl T | 2003 | World J Urol2003，21，3： | 1 |
| 6 | EGFR-TKI resistant non-small cell lung cancer ( NSCLC ) : new developments and implications for future treatment 显示文摘 | Brugger Wolfram Michael T | 2012 | Lung Cancer2012，77，1： | 1 |
| 7 | Roboticassisted laparoscopic radical cystectomy and intraabdominal formation of an orthotopic ileal neobladder显示文摘 | BEECKEN WD WOLFRAM M ENGL T | 2003 | Eur Urol2003，44，： | 1 |
| 8 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 9 | Infection with Helicobacter pylori Strains Lacking dupA is Associated with an Increased Risk of Gastric Ulcer and Gestric Cancer Development显示文摘 | Abadi AT Taghvaei T Wolfram L | | 0，，： | 1 |
| 10 | Aca- demic emotions in students'self-regulated learning and achievement: A program of qualitative and quantitative research 显示文摘 | PEKRUNP R THOMAS G WOLFRAM T | 2002 | Educational Psychologist2002，37，2： | 1 |
| 11 | 查看详情显示文摘 | Gruene P Wolfram T Pelzer K Schl(..o)gl R Trunschke A | | 0，，1： | 1 |
| 12 | Subunit vaccination of mice against new world cutaneous leishmaniasis: comparison of three proteins expressed in amastigotes and six adjuvants显示文摘 | Wolfram M Patzer SI | 2000 | Infect Immun2000，68，3： | 1 |
| 13 | Cloning of an Erwinia herbicola gene necessary for gluconie acid production and enhanced mineral phosphate solubilization in Escherichia coli IIB101: Nucleotide sequenee and propable involvement in biosynthesis of the coenzyme pyrroloquinoline quinine 显示文摘 | Liu S T Lee L Y Tai C Y Hung C H Chang Y S Wolfram J H Rogers R Goldstein A H | 1992 | Journal of Bacteriology1992，174，18： | 1 |
| 14 | Pathophyslology and pharmacologic treatment of acute spinal cord injury显示文摘 | Brian KK Wolfram T Graner JN | 2004 | Spine J2004，4，4： | 1 |
| 15 | Robticassisted laparoendoscopic radical cystectomy and intraabdominl formation of an orthotopic ileal neobladder显示文摘 | Beecken WD Wolfram M Engl T | 2003 | Eur Urol2003，44，3： | 1 |
| 16 | Robotic- assisted laparoscopic radical cystectomy and intra-abdominal formation of an orthotopic ileal neobladder显示文摘 | BEECKEN W D WOLFRAM M ENGL T | 2003 | Eur Urol2003，44，3： | 1 |
| 17 | Robotic-assisted laparoscopic radical cystectomy and intra-abdominal formation of an orthotopic ileal neobladder显示文摘 | Beecken WD Wolfram M Engl T | 2003 | Eur Urol2003，44，3： | 1 |
| 18 | Searching the Web : the public and their queries 显示文摘 | Wolfram Spink D Jansen B J Saracevic A T | 2001 | Journal of the American Society for Information Science2001，53，： | 1 |
| 19 | Robotic--assisted laparoscopic radical cystectomy and intra--abdominal formation of an orthotopic ileal neobladder显示文摘 | Beecken WD Wolfram M Engl T | 2003 | Eur Urol2003，44，： | 1 |
| 20 | Academic emotions in students' self-regulated learning and achievement: A program of qualitative and quantitative research 显示文摘 | Pekrun R Thomas G Wolfram T | 2002 | Educational Psychologist2002，37，2： | 1 |
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