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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 3 | Peroral Endoscopic Myotomy for the Treatment of Achalasia: An International Prospective Multicenter Study显示文摘 | Daniel Von Renteln Karl–Hermann Fuchs Paul Fockens Peter Bauerfeind Melina C. Vassiliou Yuki B. Werner Gerald Fried Wolfram Breithaupt Henriette Heinrich Albert J. Bredenoord Jan F. Kersten Tessa Verlaan Michael Trevisonno Thomas R?sch | 2013 | Gastroenterology2013，，2： | 2 |
| 4 | Robotic-assisted laparoscopic radical prostatectomy: the Frankfurt technique显示文摘 | Wolfram M Brautigam R Engl T | 2003 | World J Urol2003，21，3： | 1 |
| 5 | Molecular cloningand relationship to freezing tolerance of cold-acclimation-specific genes of Alfalfa显示文摘 | Mohapatra S S Wolfram L Poole R J | 1989 | Plant Physiol1989，89，： | 1 |
| 6 | Prevalence of refractive errors in the European adult population: the Gutenberg Health Study (GHS)显示文摘 | Wolfram C Htihn R Kottler U | 2014 | Br J Ophthalmol2014，98，7： | 1 |
| 7 | Effect of prickly pear( O- puntia robusta) on glucose 2 and lipid 2 metabolism in nondiabetics with hyperlipidemia-a pilot study 显示文摘 | Wolfram R M Kritz H Efthimiou Y | 2002 | Wien Klin Wochenschr2002，114，： | 1 |
| 8 | Immunohistochemical analysis of nm23 protein expression in malignant bone tumors显示文摘 | Yoshinao Oda Hajo Walter Kathrin Radig Ingeborg R?se Wolfram Neumann Albert Roessner M.D | 1995 | Journal of Cancer Research and Clinical Oncology1995，，11： | 1 |
| 9 | Aca- demic emotions in students'self-regulated learning and achievement: A program of qualitative and quantitative research 显示文摘 | PEKRUNP R THOMAS G WOLFRAM T | 2002 | Educational Psychologist2002，37，2： | 1 |
| 10 | Principles and phenomena of bioengineering with glass-ceramics for dental restoration 显示文摘 | Wolfram H Volker R Elke A | 2007 | Journal of the European Ceramics Society2007，27，： | 1 |
| 11 | Deficiences in phenotype expression and fimction of dentritic cells from patients with early breast cancer显示文摘 | Kichler-Lakomy C Budinsky AC Wolfram R | 2006 | Eur J Med Res2006，11，1： | 1 |
| 12 | 查看详情显示文摘 | Gruene P Wolfram T Pelzer K Schl(..o)gl R Trunschke A | | 0，，1： | 1 |
| 13 | Effect of prickly pear(Opuntia robusta) on glucose and lipid metabolism in nondiabetics with hyperlipidemia --a pilot study显示文摘 | WOLFRAM R M KRITZ H EFTHIMIOU Y | 2002 | Wien Klin Wochenschr2002，114，： | 1 |
| 14 | Deficiences in phenotype expression and function of dentritic cells from patients with early breast cancer显示文摘 | KICHLER-LAKOMY C BUDINSKY A C WOLFRAM R | | 0，，01： | 1 |
| 15 | Cloning of an Erwinia herbicola gene necessary for gluconie acid production and enhanced mineral phosphate solubilization in Escherichia coli IIB101: Nucleotide sequenee and propable involvement in biosynthesis of the coenzyme pyrroloquinoline quinine 显示文摘 | Liu S T Lee L Y Tai C Y Hung C H Chang Y S Wolfram J H Rogers R Goldstein A H | 1992 | Journal of Bacteriology1992，174，18： | 1 |
| 16 | Academic emotions in studengs' self--regulated learning and achievement: A program of qualitative and quantitative re- search 显示文摘 | Pekrun R Thomas Gortz Wolfram Titz | 2002 | Educational Psychologist2002，，2： | 1 |
| 17 | Rubber nanocom- posites: morphology and mechanical properties of BR and SBR vulcanizates显示文摘 | MARKUS G WOLFRAM G PETER R | 2001 | Rubber chemistry and technology2001，74，2： | 1 |
| 18 | Principles and phenomena of bioengineering with glass ceramics for dental restoration显示文摘 | Wolfram H Volker R Christian V H | 2007 | Journal of the European Ceramic Society2007，27，： | 1 |
| 19 | Deficiences in phenotype expression and function of dentritic cells from patients with early breast cancer显示文摘 | Kichler-Lakomy C Budinsky AC Wolfram R | 2006 | Eur J Med Res2006，11，1： | 1 |
| 20 | Liquid drops on a tilting plate,contact angle hysteresis and the Young contact angle显示文摘 | Wolfram E Faust R | 1978 | New York Academic1978，65，11： | 1 |
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