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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli , but S. aureus fails to both activate NF-κB in mammary epithelial cells and to quickly induce TNFα and interleukin-8 (CXCL8) expression in the udder显示文摘 | Wei Yang Holm Zerbe Wolfram Petzl Ronald Marco Brunner Juliane Günther Christian Draing Sonja von Aulock Hans-Joachim Schuberth Hans-Martin Seyfert | 2007 | Molecular Immunology2007，，5： | 2 |
| 3 | Continuum percolation of wireless ad hoc communication networks 显示文摘 | Ingmar G Wolfram K Rudolf S | 2003 | Statistical Mechanics and its Applications2003，325，34： | 1 |
| 4 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 5 | Existence range,structural and dielectric properties of ZrxTiySnz O4 ceramics (x+y+z=2)显示文摘 | WOLFRAM G GOBEL H E | 1981 | Mater Res Bull1981，16，： | 1 |
| 6 | Postpancreatectomyhemotrhage : diagnosisand treatment- an analysis in 1669 consecutive pancreatic resections 显示文摘 | Yekebas EF Wolfram L Cataldegirmen G | 2007 | Ann Surg2007，26，2： | 1 |
| 7 | Postpancreatectomy hemorrhage:diagnosis and treatment:an analysis in 1669consecutive pancreatic resections显示文摘 | Yekebas EF Wolfram L Cataldeginnen G | 2007 | 2007，，02： | 1 |
| 8 | The sale of development rights and zoning in the preservation of open space:Lindahl equilibrium and a case study显示文摘 | WOLFRAM G | 1981 | Land Economics1981，57，3： | 1 |
| 9 | Aca- demic emotions in students'self-regulated learning and achievement: A program of qualitative and quantitative research 显示文摘 | PEKRUNP R THOMAS G WOLFRAM T | 2002 | Educational Psychologist2002，37，2： | 1 |
| 10 | Postpancreatectomy hemorrhage:diagnosis and treatment:an analysis in 1669 consecutive pancreatic resections显示文摘 | Yekebas EF Wolfram L Cataldegirmen G | | 0，，02： | 1 |
| 11 | Expression of Lymphangiogenic Factors and Evidence of Intratumoral Lymphangiogenesis in Pancreatic Endocrine Tumors显示文摘 | Bence Sipos Wolfram Klapper Marie-Luise Kruse Holger Kalthoff Dontscho Kerjaschki Günter Kl?ppel | 2004 | The American Journal of Pathology2004，，4： | 1 |
| 12 | Advances in amino acid analysis显示文摘 | Hannelore K Katja D Wolfram G | 2009 | Anal Biochem2009，393，2： | 1 |
| 13 | Flavonoid intake of adults in a Bavarian subgroup of the national food consumption survey 显示文摘 | Radtke J Wolfram G | 1997 | Z Ernahrung Swiss1997，36，4： | 1 |
| 14 | Rubber nanocom- posites: morphology and mechanical properties of BR and SBR vulcanizates显示文摘 | MARKUS G WOLFRAM G PETER R | 2001 | Rubber chemistry and technology2001，74，2： | 1 |
| 15 | Postpancreatectomy hemorrhage:diagnosis and treatment:an analysis in 1669 consecutive pancreatic resections显示文摘 | Yekebas E F Wolfram L Cataldegirmen G | | 0，，02： | 1 |
| 16 | Effect of diet on cecal pH and feeding behavior of horses显示文摘 | Willard J G Willard J C Wolfram S A | | 0，，01： | 1 |
| 17 | Measurementsof static and dynamic mooing line damping and their importancefor floating WEC devices 显示文摘 | JOHANNING L SIMTH G H WOLFRAM J | 2007 | Ocean engineering2007，34，1415： | 1 |
| 18 | Conversion of sodium cyanide to carbon dioxide and ammonia by immobilized cells of Pseudornonas putida 显示文摘 | Babu G R V Wolfram J H Chapatwala K D | 1992 | Journal of Industrial Microbiology and Bioteehnology1992，9，34： | 1 |
| 19 | Prognostic value of E-cadherin expression in 413 gastric carcinomas显示文摘 | Helmut E G Wolfram M Ank S | 1996 | Int J Cancer1996，69，： | 1 |
| 20 | Postpancrea- tectomy hemorrhage: diagnosis and treatment: an analysis in 1 669 consecutive pancreatic resections 显示文摘 | Yekebas EF Wolfram L Cataldegirmen G | 2007 | Ann Surg2007，246，2： | 1 |
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