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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 3 | An α‐E‐catenin ( CTNNA1 ) mutation in hereditary diffuse gastric cancer显示文摘 | Ian J Majewski Irma Kluijt Annemieke Cats Thomas S Scerri Daphne Jong Roelof JC Kluin Samantha Hansford Frans BL Hogervorst Astrid J Bosma Ingrid Hofland Marcel Winter David Huntsman Jos Jonkers Melanie Bahlo René Bernards | 2013 | J. Pathol2013，，4： | 2 |
| 4 | Phenotypic instability and rapid gene silencing in newly formed Arabidopsis alloteraploids显示文摘 | Comai L Tyagi A P Winter K Holmes-Davis R Reynolds S H Stevens Y Byers B | 2000 | Plant Cell2000，12，9： | 2 |
| 5 | Early prediction of endocrine therapy effect in advanced breast cancer patients using ^99mTc-depreotide scintigraphy 显示文摘 | VAN DEN BOSSCHE B VAN BELLE S DE WINTER F | 2006 | J Nucl Med2006，47，11： | 1 |
| 6 | A Baseline Model of Industry Evolution显示文摘 | KANIOVSKI Y M DOSI G | 2003 | J Evol Econ2003，13，12： | 1 |
| 7 | Defective endothelially mediated pulmonary vasodilation in systemic sclerosis显示文摘 | Cailes J Winter S du Bois RM | | 0，，： | 1 |
| 8 | Clinical and immunologic results of a phase II trial of sequential imiquimod and photodynamic therapy for vulval intraepithelial neoplasia显示文摘 | Winters U Daayana S LearJT | 2008 | Clin Cancer Res2008，14，16： | 1 |
| 9 | Influenza but not pneumococcal vaccination protects against all-cause mortality in patients with COPD显示文摘 | Schembri S Morant S Winter JH | | 0，，07： | 1 |
| 10 | Integration of go annotations in correspondence analysis:facilitating the interpretation of micro-array data显示文摘 | Winter S Hauser N | 2005 | Bioinformatics2005，21，10： | 1 |
| 11 | Clinical and immunologic results of a phase Ⅱ trial of sequential imiquimod and photodynamic therapy for vulval intraepithelial neoplasia 显示文摘 | Winters U Daayana S Lear JT | 2008 | Clin Cancer Res2008，14，16： | 1 |
| 12 | Enhancement of ionic conductivity by the addition of plasticizers in cationic monoconducting polymer electrolytes显示文摘 | Chung S H Heitjans P Winter R | 1998 | Solid State Ionics1998，112，： | 1 |
| 13 | The Satisficing Principle in Capability Learning 显示文摘 | Winter S G | 2000 | Strategic Management Journal2000，，21： | 1 |
| 14 | Molecular identification of a volume regulated chloride channel显示文摘 | Duan D Winter C Cowley S | 1997 | Nature1997，390，： | 1 |
| 15 | Gonadotropin therapy in men with isolated hypogonadotropic hypogonadism: the response to human chorionic Gonadotropin is predicted by initial testicular size显示文摘 | Burris AS Rodbard HW Winters S J | 1988 | Clin Endocrinol Metab1988，66，6： | 1 |
| 16 | Replieation as strategy显示文摘 | WINTER S G SZULANSKI G | 2001 | Organization Science2001，12，6： | 1 |
| 17 | Molecular imaging of angiogenic therapy in peripheral vascular disease with alphanubeta3-integrin-targeted nanoparticles 显示文摘 | Winter PM Caruthers SD Allen J S | 2010 | Magn Reson Med2010，64，： | 1 |
| 18 | Assessing Forest Naturalness显示文摘 | Mcroberts R E Winter S Chirici G | 2012 | Forest Science2012，58，3： | 1 |
| 19 | Effect of Ammonia on the Anaerobic Degradation of Protein by a Mesophilic and Thermophilic Biowaste Population显示文摘 | GALLERT C BAUER S WINTER J | 1998 | Applied Microbiology Biotechnology1998，50，4： | 1 |
| 20 | Maternal MTHFR genotype contributes to the risk of non-syndromic cleft lip and palate 显示文摘 | Winter RM Malcolm S | 2002 | J Med Genet2002，39，5： | 1 |
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