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474篇 您的检索式:作者名="WINTER S G"
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1Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis.Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels 2010World Journal of Gastroenterology2010,16,6:11
2A Baseline Model of Industry Evolution显示文摘 KANIOVSKI Y M DOSI G 2003J Evol Econ2003,13,12:1
3The Satisficing Principle in Capability Learning 显示文摘Winter S G 2000Strategic Management Journal2000,,21:1
4Replieation as strategy显示文摘WINTER S G SZULANSKI G 2001Organization Science2001,12,6:1
5Assessing Forest Naturalness显示文摘Mcroberts R E Winter S Chirici G 2012Forest Science2012,58,3:1
6The satisficing principle in capability learning显示文摘Winter S G 2000Strategic Management Journal2000,21,10:1
7Deliberate Learning and Evolution of Dynamic Capabilities显示文摘Zollo M Winter S G 2002Organization Science2002,13,3:1
8Deliberate learning and the evo- lution of dynamic capabilities显示文摘ZOLLO M WINTER S G 2002Organization Science2002,13,3:1
9Comparative analysis of the sialic acid binding activity and the tropism for the respiratory epithelium of four different strains of avian infectious bronchitis virus显示文摘Abd E1 Rahman S E1-Kenawy AA Neumann U Herrler G Winter C 2009Avian Pathol2009,38,1:1
10Deliberate learning and the evolu- tion of the dynamics capabilities显示文摘Zollo M and Winter S G 2002Organization Science2002,13,3:1
11Deliberate Learning and the Evolution of Dynamic Capabilities显示文摘Zollo M Winter S G 2002Organization Science2002,13,3:1
12Aortic replace- ment in aorto-occlusive disease: an observational study 显示文摘Morris-Stiff G Ogunbiyi S Winter R K 2008BMC Surg2008,31,8:1
13Endotension as a result of pressure transmission through the graft follow-ing endovascular aneurysm repair--an in vitro study 显示文摘Gawenda M Jaschke G Winter S 2003Eur J Vasc Endovasc Surg2003,26,5:1
14Deliberate learning and the evolution of dynamic capabilities显示文摘Zollo M S G Winter 2002Organization Science2002,,13:1
15From organizational routines to dynamic capabilities显示文摘ZOLLO M WINTER S G A working paper of the Reginald H Jones Center0,,:1
16Deliberate learning and the evolution of dynamic capabilities显示文摘Zollo M and Winter S G 2002Organization Science2002,13,3:1
17The Schumpeterian tradeoff re- visited显示文摘Nelson R R Winter S G 1982American Economic Review1982,72,1:1
18Deliberate learning and the evo- lution of dynamic capabilities 显示文摘ZOLLO M WINTER S G 2002Organization Science2002,13,3:1
19Aortic replacement in aorto-ocelusive disease: an observational study 显示文摘Morris-Stiff G Ogunbiyi S Winter RK 2008BMC Surg2008,31,8:1
20Deliberate learning and the evolution of dynamic capabilities 显示文摘Zollo M Winter S G 2002Organization Science2002,13,:1
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