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| 1 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 2 | Mechanisms of retention and flux decline for the nanofiltration of dye baths from the textile industry 显示文摘 | Bruggen B V Daems B Wilms D | 2001 | Separation and Purification Technology2001，2223，： | 1 |
| 3 | Influence of molecular size, polarity and charge on the retension of organic molecules by nanofiltration 显示文摘 | Van der Bruggen B Schaep J Wilms D | 1999 | J Membr Sci1999，156，： | 1 |
| 4 | Primary Gastric B-Cell Lymphoma: Results of a Prospective Multicenter Study显示文摘 | Wolfgang Fischbach* Brigitte Dragosics? Maria-Elisabeth Kolve-Goebeler§ Christian Ohmann∥ Axel Greiner? Qin Yang∥ Stephan B?hm? Patrick Verreet∥ Olaf Horstmann# Martin Busch** Eckhart Dühmke** Hans-Konrad Müller-Hermelink? Klaus Wilms§ | 2000 | Gastroenterology2000，，5： | 1 |
| 5 | Insertion angle impact on primary stability of orthodontic mini-implants显示文摘 | Wilmes B Su YY Drescher D | | 0，，06： | 1 |
| 6 | Insertion angle impact on primary stability of orthodontic mini-implants显示文摘 | Wilmes B Su YY Drescher D | | 0，，6： | 1 |
| 7 | Impact of bone quality, implant type, and implantation site preparation on insertion tor- ques of mini-implants used for orthodontic anchorage显示文摘 | Wilmes B Drescher D | 2011 | Int J Oral Maxillofac Surg2011，40，7： | 1 |
| 8 | Influence of molecular size,polarity and charge on the retention of organic molecules by nanofiltration显示文摘 | van der Bruggen B Schaep J Wilms D Vandecasteele C | | 0，，01： | 1 |
| 9 | Is glutamine a conditionally essential amino acid? 显示文摘 | LACEY J M WILM ORE D W | 1990 | Nutr Rev1990，48，8： | 1 |
| 10 | mRNA silencing in erythroid differentiation:hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3 'end显示文摘 | Ostareck D H Ostareck-Lederer A Wilm M | 1997 | Cell1997，89，： | 1 |
| 11 | Impact of insertion depth and predrilling diameter on primary stability of orthodontic mini-implants显示文摘 | Wilmes B Drescher D | | 0，，04： | 1 |
| 12 | Impact of bone quality, implant type, and im- plantation site preparation on insertion torques of mini - implants used for orthodontic anchorage 显示文摘 | Wilmes B Drescher D | 2001 | Int J Oral Maxillofac Surg2001，40，7： | 1 |
| 13 | Impact of bone quality,implant type ,and im- plantation sitte preparation on insertion torques of mini-implants used for orthodontic anchorage显示文摘 | Wilmes B Drescher D | | Int J Oral Maxilofac Surg0，40，7： | 1 |
| 14 | In vitro study of surface changes in fix orthodontic appliances following air polishing with Clin- pro Prophy and Air Flow 显示文摘 | Wilmes B Vali S Drescher D | 2009 | J Orofac Orthop2009，70，5： | 1 |
| 15 | Insertion angle impact on primary stability of orthodontic mini-implants显示文摘 | Wilmes B Su YY Drescher D | 2008 | An- gle Orthod2008，78，6： | 1 |
| 16 | mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' End 显示文摘 | Ostareck D H Ostareck-Lederer A Wilm M | 1997 | Cell1997，89，4： | 1 |
| 17 | High resolution in vivo characterization of apparent diffusion coefficient at the tumor-stromal boundary of breast carcinomas:a pilot study to assess treatment response using proximity- dependent diffusion-weighted imaging显示文摘 | Mclaughlin R L Newitt D C Wilmes L J | 2014 | J Magn Reson Imaging2014，39，5： | 1 |
| 18 | lmpact of insertion depth and predrilling diameter on primary stability of orthodontic mini-implants 显示文摘 | Wilmes B Drescher D | 2009 | Angle Orthod2009，79，： | 1 |
| 19 | Fast,scalable generation of high-quality protein multiple sequence alignments using Clustal O- mega显示文摘 | SIEVERS F WILM A DINEEN D | 2011 | Molecular Systems Biology2011，7，1： | 1 |
| 20 | Impact of insertion depth and predrilling diameter on primary stability of orthodontic mini- implants显示文摘 | Wilmes B Dreseher D | 2009 | Angle Orthod2009，79，4： | 1 |
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