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| 1 | 肺炎链球菌耐药性和血清型分布及隐匿性耐药克隆株的研究显示文摘目的 了解儿童肺炎链球菌携带者耐药菌株的流行情况 ,比较携带者菌株血清型与肺炎链球菌结合疫苗血清型的符合率 ,寻找单个患儿同时携带敏感和耐药菌株的可能性。方法 (1)对1997年 11月~ 12月在北京儿童医院普通门诊登记的 3个月~ 5岁儿童进行问卷调查 ;(2 )采集鼻咽拭子和尿标本 ,培养、分离和鉴定肺炎链球菌 ,并测定尿标本中的抗生素活性 ;(3)根据NCCLS方法使用微量稀释法测定肺炎链球菌对青霉素、头孢呋新、头孢噻肟、复方新诺明、红霉素和氯霉素的敏感性 ;(4 )从最初发现的青霉素、红霉素敏感株中寻找“隐匿性耐药克隆株”。结果 (1) 5 0 2例受试儿童中 ,分离出 190株肺炎链球菌 ,携带率为 37.8% (190 / 5 0 2 ) ,对青霉素的敏感率为 91.1% ;(2 )只有33 .9%的菌株血清型与建议使用的肺炎链球菌结合疫苗血清型相符 ;(3) 4 2例含青霉素和红霉素敏感菌株鼻咽拭子中发现 6株 (14% )“隐匿性耐药克隆株”。结论 在携带者中 ,肺炎链球菌对 β 内酰胺类耐药还不常见 ,但对红霉素和复方新诺明耐药却非常严重 ;建议使用的结合疫苗血清型不能覆盖大部分携带菌株 ;耐药菌株的小部分隐匿在敏感菌株中 。 | 俞桑洁 王槿芳 李洁 李艳 王雪莲 Whitney CG Levine OS Dowell SF 杨永弘 | 2000 | 中华儿科杂志2000，38，7： | 40 |
| 2 | Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma显示文摘瞄准:在整个 Barretts 食管的前进调查 cyclooxygenase-2 (COX-2 ) 和上皮的生长因素受体(EGFR ) 的表示() 。方法:COX-2 和 EGFR 蛋白质表情被使用免疫检测组织化学的方法。详细 cytomorphological 改变的 A 是坚定的。COX-2 和 EGFR 表示的区域被使用计算机成像系统确定。结果:COX-2 和 EGFR 的表情与前进一起增加了从到食管腺癌(EAC ) 。积极关联在 COX-2 表示和 EGFR 表示之间被发现。结论:COX-2 和 EGFR 可能在逐步的前进从是合作的到 EAC,从而导致致癌作用。 | Yan Li John M Wo Mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G Martin | 2006 | World Journal of Gastroenterology2006，12，6： | 14 |
| 3 | 新的铝锡硅发动机轴承合金显示文摘介绍一种用于发动机轴承的AlSn8Si2.5Pb2CuO.8Cr0.2新合金。专门开发的这种合金优化了抗咬合性,同时,又提供了极好的抗疲劳性和耐磨性。该合金的开发系利用高冷却率铸轧工艺的优点,并采用高温下把合金复于钢背上的粘结工艺。列出新合金的性能参数,包括抗疲劳、抗咬合特性及耐磨性,此数据包含与淬硬钢、球铁、软钢三种不同材料配对的抗咬合数据。 | Whitney W J 孙杰 张乐山 | 2000 | 国外内燃机2000，32，2： | 13 |
| 4 | Contemporary review of drug-induced pancreatitis: A different perspective显示文摘Although gallstone and alcohol use have been consid-ered the most common causes of acute pancreatitis, hundreds of frequently prescribed medications are as-sociated with this disease state. The true incidence is unknown since there are few population based studies available. The knowledge of drug induced acute pan-creatitis is limited by the availability and the quality of the evidence as the majority of data is extrapolated from case reports. Establishing a definitive causal rela-tionship between a drug and acute pancreatitis poses a challenge to clinicians. Several causative agent classifi-cation systems are often used to identify the suspected agents. They require regular updates since new drug induced acute pancreatitis cases are reported continu-ously. In addition, infrequently prescribed medications and herbal medications are often omitted. Furthermore, identification of drug induced acute pancreatitis with new medications often requires accumulation of post market case reports. The unrealistic expectation for a comprehensive list of medications and the multifacto-rial nature of acute pancreatitis call for a different ap-proach. In this article, we review the potential mecha-nisms of drug induced acute pancreatitis and providethe perspective of deductive reasoning in order to allow clinicians to identify potential drug induced acute pan-creatitis with limited data. | Whitney Y Hung Odaliz Abreu Lanfranco | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 10 |
| 5 | Operative complications and economic outcomes of cholecystectomy for acute cholecystitis显示文摘BACKGROUND Recent management of acute cholecystitis favors same admission(SA)or emergent cholecystectomy based on overall shorter hospital stay and therefore cost savings.We adopted the practice of SA cholecystectomy for the treatment of acute cholecystitis at our tertiary care center and wanted to evaluate the economic benefit of this practice.We hypothesized that the existence of complications,particularly among patients with a higher degree of disease severity,during SA cholecystectomy could negate the cost savings.AIM To compare complication rates and hospital costs between SA vs delayed cholecystectomy among patients admitted emergently for acute cholecystitis.METHODS Under an IRB-approved protocol,complications and charges for were obtained for SA,later after conservative management(Delayed),or elective cholecystectomies over an 8.5-year period.Patients were identified using the acute care surgery registry and billing database.Data was retrieved via EMR,operative logs,and Revenue Cycle Operations.The severity of acute cholecystitis was graded according to the Tokyo Guidelines.TG18 categorizes acute cholecystitis by Grades 1,2,and 3 representing mild,moderate,and severe,respectively.Comparisons were analyzed withχ2,Fisher’s exact test,ANOVA,ttests,and logistic regression;significance was set at P<0.05.RESULTS Four hundred eighty-six(87.7%)underwent a SA while 68 patients(12.3%)received Delayed cholecystectomy.Complication rates were increased after SA compared to Delayed cholecystectomy(18.5%vs 4.4%,P=0.004).The complication rates of patients undergoing delayed cholecystectomy was similar to the rate for elective cholecystectomy(7.4%,P=0.35).Mortality rates were 0.6%vs 0%for SA vs Delayed.Patients with moderate disease(Tokyo 2)suffered more complications among SA while none who were delayed experienced a complication(16.1%vs 0.0%,P<0.001).Total hospital charges for SA cholecystectomy were increased compared to a Delayed approach($44500±$59000 vs$35300±$16700,P=0.019).The relative risk of developing a complication was 4.2x[95%confidence interval(CI):1.4-12.9]in the SA vs Delayed groups.Among eight patients(95%CI:5.0-12.3)with acute cholecystitis undergoing SA cholecystectomy,one patient will suffer a complication.CONCLUSION Patients with Tokyo Grade 2 acute cholecystitis had more complications and increased hospital charges when undergoing SA cholecystectomy.This data supports a selective approach to SA cholecystectomy for acute cholecystitis. | Christopher P Rice Krishnamurthy B Vaishnavi Celia Chao Daniel Jupiter August B Schaeffer Whitney R Jenson Lance W Griffin William J Mileski | 2019 | World Journal of Gastroenterology2019，25，48： | 8 |
| 6 | Non-pharmacological therapies for inflammatory bowel disease: Recommendations for self-care and physician guidance显示文摘We performed a scoping review on sought-after complementary therapies for patients with inflammatory bowel disease(IBD), specifically diet, physical activity and exercise(PA/E), and psychotherapy. We aim to update patients with IBD on therapies for self-care and provide physicians with guidance on how to direct their patients for the management of IBD. A search of MEDLINE, EMBASE, and PUBMED was completed in Sept 2016. Studies on diet, PA/E, or psychotherapy in patients with IBD were included. Medical Subject Heading terms and Boolean operators were used. The search was limited to full-text English articles describing an adult population. This review included 67 studies: Diet(n = 19); PA/E(n = 19); and psychotherapy(n = 29). We have made the following recommendations:(1) Diet: Consumption of diets rich in vegetables, fruit and soluble fiber may be beneficial in IBD. A trial of a low FODMAP diet can be considered in those patients with functional gastrointestinal symptoms. Restrictive diets are lacking in evidence and should be avoided;(2) PA/E: Regular lowmoderate intensity activity, including cardiovascular and resistance exercise, has been shown to improve quality of life(QOL) and may improve inflammation; and(3) psychotherapy: Therapies such as cognitive-behavioural interventions, mindfulness, hypnosis, and stress management have been shown to improve QOL, but evidence is limited on their impact on anxiety, depression, and disease activity. Overall, these complementary therapies are promising and should be used to treat patients with IBD from a more holistic perspective. | Whitney Duff Natasha Haskey Gillian Potter Jane Alcorn Paulette Hunter Sharyle Fowler | 2018 | World Journal of Gastroenterology2018，24，28： | 6 |
| 7 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn’s and Colitis Epidemiology Study显示文摘 | Siew C. Ng Whitney Tang Jessica Y. Ching May Wong Chung Mo Chow A.J. Hui T.C. Wong Vincent K. Leung Steve W. Tsang Hon Ho Yu Mo Fong Li Ka Kei Ng Michael A. Kamm Corrie Studd Sally Bell Rupert Leong H. Janaka de Silva Anuradhani Kasturiratne M.N.F. Mufeen | 2013 | Gastroenterology2013，，1： | 6 |
| 8 | Exposure to air pollutants in Vietnam:Assessing potential risk for tourists显示文摘Tourism can form an important component of a nation's GDP,and Vietnam is among the most visited countries in Southeast Asia.Most studies on personal exposure focus on the general population,or occupational cohorts with exposure to specific pollutants.However,short-term exposure to air pollutants while visiting regions with high levels of air pollution can lead to acute health effects.A personal exposure study was conducted across three cities in Vietnam to estimate exposure to particulate matter(PM_(2.5)) and black carbon for tourists.Measurements were conducted during the wet season in 2014 in Ho Chi Minh City,Da Lat and Nha Trang using portable instrumentation.Average 24-hr PM_(2.5) and BC exposures were estimated as 18.9 ± 9.24 and 3.41 ± 1.33 μg/m^3 and among the three cities,Ho Chi Minh was found to have the highest PM_(2.5) concentrations.Environmental tobacco smoke,commuting and street food stands were found to contribute to highest levels of exposure to PM_(2.5) and BC across all cities. | Pallavi Pant Whitney Huynh Richard E.Peltier | 2018 | Journal of Environmental Sciences2018，30，11： | 4 |
| 9 | 美国航海院校海事类数字文献资源调研显示文摘对美国7家航海学院图书馆的数字文献资源进行调研,归纳其图书馆主页上列出的海事类数字文献资源情况,对其中的核心资源进行简要的分析,并对有关海事类数字文献资源建设与服务提出建议。 | 那春光 张世平 Brent Hall Rebecca Whitney Carl Phillips 董颖 | 2010 | 航海教育研究2010，27，3： | 4 |
| 10 | Ileal inflammatory fibroid polyp causing chronic ileocolic intussusception and mimicking cecal carcinoma显示文摘Inflammatory fibroid polyp(IFP) is a rare,idiopathic pseudotumorous lesion of the gastrointestinal tract.While mostly reported as solitary gastric lesions,multiple cases of small bowel IFPs are also reported.It is a documented cause of intussusception in adults.In the case reports of ileal inflammatory fibroid polyps with intussusception,an emergent presentation with small bowel obstruction has been most often described.Here we depict a case of ileal inflammatory fibroid polyp presenting with chronic intermittent ileocolic intussusception,anemia and weight loss with an endoscopic appearance mimicking necrotic cecal carcinoma. | Naveen Gara John S Falzarano Whitney ML Limm Thomas S Namiki Laurie KS Tom | 2009 | World Journal of Gastrointestinal Oncology2009，1，1： | 3 |
| 11 | Locomotor analysis identifies early compensatory changes during disease progression and subgroup classification in a mouse model of amyotrophic lateral sclerosis显示文摘Amyotrophic lateral sclerosis is a motoneuron degenerative disease that is challenging to diagnose and presents with considerable variability in survival.Early identification and enhanced understanding of symptomatic patterns could aid in diagnosis and provide an avenue for monitoring disease progression.Use of the m SOD1 G93 A mouse model provides control of the confounding environmental factors and genetic heterogeneity seen in amyotrophic lateral sclerosis patients,while investigating underlying disease-induced changes.In the present study,we performed a longitudinal behavioral assessment paradigm and identified an early hindlimb symptom,resembling the common gait abnormality foot drop,along with an accompanying forelimb compensatory mechanism in the m SOD1 G93 A mouse.Following these initial changes,m SOD1 mice displayed a temporary hindlimb compensatory mechanism resembling an exaggerated steppage gait.As the disease progressed,these compensatory mechanisms were not sufficient to sustain fundamental locomotor parameters and more severe deficits appeared.We next applied these initial findings to investigate the inherent variability in B6 SJL m SOD1 G93 A survival.We identified four behavioral variables that,when combined in a cluster analysis,identified two subpopulations with different disease progression rates:a fast progression group and a slow progression group.This behavioral assessment paradigm,with its analytical approaches,provides a method for monitoring disease progression and detecting m SOD1 subgroups with different disease severities.This affords researchers an opportunity to search for genetic modifiers or other factors that likely enhance or slow disease progression.Such factors are possible therapeutic targets with the potential to slow disease progression and provide insight into the underlying pathology and disease mechanisms. | Melissa M.Haulcomb Rena M.Meadows Whitney M.Miller Kathryn P.Mc Millan Me Kenzie J.Hilsmeyer Xuefu Wang Wesley T.Beaulieu Stephanie L.Dickinson Todd J.Brown Virginia M.Sanders Kathryn J.Jones | 2017 | Neural Regeneration Research2017，12，10： | 3 |
| 12 | Application of high-resolution DNA melting for genotyping and variant scanning of diploid and autotetraploid potato显示文摘 | David De Koeyer Katheryn Douglass Agnes Murphy Sean Whitney Lana Nolan Yong Song Walter De Jong | 2010 | Molecular Breeding2010，，1： | 2 |
| 13 | Fabrication and Magnetic-properties of arrays of metallic nanowires显示文摘 | Whitney T M Jiang J S Searson P C | 1993 | Science1993，261，： | 2 |
| 14 | Dry matter accumulation, mineral concentrations and nutrient distribution in winter wheat显示文摘 | Karlen D L Whitney D A | 1980 | Agronomy Journal1980，72，2： | 1 |
| 15 | (2008) It's time for a change in practice:reducing antibiotic use can alter antibiotic resistance 显示文摘 | Cindy R Friedman Cynthia C Whitney | 2008 | The Journal of Infectious Diseases2008，197，8： | 1 |
| 16 | K-shell line ratio and powers for diagnosing cylindrical plasmas of neon, aluminum, argon and titanium显示文摘 | Apruzese J P Whitney K G Davis J | 1997 | Journal of Quantitative Spectroscopy and Radiation Transfer1997，57，1： | 1 |
| 17 | Differentiable Manifolds显示文摘 | WHITNEY H | 1936 | Ann of Math1936，37，2： | 1 |
| 18 | Phase II acetate plus tamoxifen in advanced endometrial carcinoma: a Gynecolog- ic Oncology Group Study 显示文摘 | Whitney CW Brunetto VL Zaino RJ | 2004 | Gynecol 0ncol2004，92，： | 1 |
| 19 | Simplified generation of all mechanical assembly sequence显示文摘 | De Fazio T L Whitney D E | 1987 | IEEE Journal of Robotics and Automation1987，3，64： | 1 |
| 20 | Relation of sleepiness to respiratory disturbance index显示文摘 | Gottlieb DJ Whitney CW Bonekat WH | 1999 | Am J Respir Crit Care Med1999，159，： | 1 |
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