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| 1 | Liver transplantation for patients with hepatolithiasis显示文摘Because of its complicated pathological features such as repeated cholangitis and multiple operations, hepatolithiasis is difficult to treat and often lead to portal hypertension, and liver failure. The aim of this study was to investigate the indications of orthotopic liver transplantation ( OLT) for patients with hepatolithiasis and the improvement of operative techniques and the treatment of postoperative complications. METHODS:The data of 4 patients with hepatolithiasis who had undergone OLT at our department in recent years were reviewed retrospectively. RESULTS:The 4 patients with hepatolithiasis complicated with secondary biliary cirrhosis in end-stage liver disease included 1 woman and 3 men. One patient underwent OLT using veno-venous bypass prior to the mobilization of the liver. Two patients were subjected to liver transplantation with improved piggyback technique without bypass. One patient received OLT without bypass. All patients were operated on successfully and recovered uneventfully. Patient 1 had bleeding from the digestive tract on the postoperative day 6. Patient 2 had hemorrhage from the digestive tract and a leakage of end-to-side intestinal anastomosis on the postoperative day 44. Patient 4 was reoperated on because of hemorrhage from the anastomotic stoma of the hepatic artery on the postoperative days 8 and 10. In the 4 patients the mean operative time was 7.9 hours and blood loss was 910 ml. Postoperative pathological analysis revealed biliary liver cirrhosis. Follow-up of all patients showed good conditions. CONCLUSIONS:Hepatolithiasis with secondary biliary liver cirrhosis in patients with end-stage liver disease is indicated for liver transplantation. Veno-venous bypass prior to the mobilization of the liver and improved piggyback tech- nique can lower the incidence of intraoperative bleeding, the duration of surgery and postoperative complications. | Guang-Dong Pan, Lu-Nan Yan, Bo Li, Shi-Chun Lu, Yong Zeng, Tian-Fu Wen, Ji-Chun Zhao, Nan-Sheng Cheng, Yu-Kui Ma, Wen-Tao Wang, Jia-Yin Yang and Zhi-Hui Li Center of Liver Transplantation, West China Hospital, Sichuan University, Chengdu 610041 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 13 |
| 2 | Magnetic characteristics of dustfall in urban area of north China and its environmental significance显示文摘Urban particulate pollutants not only affect urban air quality but also directly threaten public health. Lanzhou has been one of the most seriously polluted cities in the world due to its special geophysical location and weather conditions, which makes it an ideal place for urban particulate pollution study. In this study a set of environmental magnetic parameters (χlf, χfd%, χARM, SIRM, HIRM, SOFT and back field IRM) were measured and analyzed for the dustfall samples collected monthly during 1997.4―2000.5 and 2004.11―2005.10 at Lanzhou University campus (KLD and CCS) and at a clear site of Gaolanxian (GLX). Results demonstrate that the main magnetic minerals in the dustfall are magnetite, with some maghaemite and haematite. Cross plots of Mrs/Ms vs. Bcr/Bc and χfd% vs. χARM/SIRM indicate that the main magnetic grain sizes are pseudo-single-domain (PSD). The high concentration of magnetic min-erals in the dustfall indicates that Lanzhou is seriously polluted. The main pollution sources are an-thropogenic activities and nature dust, with the former posing a great threat during the whole year, which is different from the general view that the natural dust is the main contributor in summer. With great efforts of the government and local authority in the past decades, the air quality in Lanzhou has been improved in winter, but it is not so obvious in summer. This study also reveals that as a simple, rapid and accurate technology, environmental magnetism could be a valuable tool for urban pollution study. | XIA DunSheng1,2, YANG LiPing2, MA JianYing1, YU Ye1, WANG Guan2 & CHEN FaHu2 1 Key Laboratory of Desert and Desertification, Institute of Cold and Arid Regions Environmental and Engineering, Chinese Academy of Sciences, Lanzhou 730000, China 2 CAEP, Key Laboratory of West China’s Environmental System (Ministry of Education), Lanzhou University, Lanzhou 730000, China | 2007 | Science China Earth Sciences2007，50，11： | 8 |
| 3 | Modified techniques for adult-to-adult living donor liver transplantation显示文摘BACKGROUND: Because of critical organ shortage, transplant professionals have utilized living donor liver transplantation (LDLT) in recent years. We summarized our experience in adult-to-adult LDLT with grafts of right liver lobe by a modified technique. METHODS: From January 2002 to August 2005, 24 adult patients underwent living donor liver transplantation with grafts of the right liver lobe at West China Hospital, Sichuan University, China. Twenty-two patients underwent modi-Bed procedures designed to improve the reconstruction of the right hepatic vein and the tributaries of the middle hepatic vein by interposing a great saphenous vein ( GSV) graft and the anastomosis of the hepatic arteries and bile ducts. RESULTS: No severe complications and death occurred in all donors. In the first 2 patients, (patients 1 and 2), operative procedure was not modified. One patient suffered from 'small-for-size syndrome' and the other died of sepsis with progressive deterioration of graft function. In the rest 22 patients (patients 3 to 24), however, the procedure of venous reconstruction was modified, and better results were obtained. Complications occurred in 7 recipients including acute rejection (2 patients), hepatic artery thrombosis (1), bile leakage (1), intestinal bleeding (1), left sub-phrenic abscess (1), and pulmonary infection (1). One patient with pulmonary infection died of multiple organ failure (MOF). The 22 patients underwent direct anastomosis of the right hepatic vein to the inferior vena cava (IVC), 9 direct anastomosis plus the reconstruction of the right inferior hepatic vein, and 10 direct anastomosis plus the reconstruction of the tributaries of the middle hepatic vein by in-terpos-ing a GSV graft to provide sufficient venous outflow. Trifurcation of the portal vein was met in 3 patients. Venoplasty or separate anastomosis was performed. The ratio of graft to recipient body weight ranged from 0.72% to 1.17%. Among these patients, 19 had the ratio <1.0% and 4 <0.8%, and the ratio of graft weight to recipient standard liver volume was between 31.86% and 62.48%. Among these patients, 10 had the ratio <50% and 2 <40%. No 'small-for-size syndrome' occurred in the 22 recipients who were subjected to modified procedures. CONCLUSIONS: With the modified surgical techniques for the reconstruction of the hepatic vein to obtain an adequate outflow and provide a sufficient functioning liver mass, living donor liver graft in adults using the right lobe can be safe to prevent the 'small-for-size syndrome'. | Lu-Nan Yan, Bo Li, Yong Zeng, Tian-Fu Wen, Ji-Chun Zhao, Wen-Tao Wang, Jia-Yin Yang, Ming-Qing Xu,Yu-Kui Ma, Zhe-Yu Chen, Jiang-Wen Liu and Hong Wu Liver Transplantation Division, Department of Surgery, West China Hospital, Sichuan University, Chengdu 610041 , China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，2： | 6 |
| 4 | The Protection Policy of Eco-environment in Desertification Areas of Northern China:Contradictions and Countermeasures显示文摘中国北方沙漠化土地以其广泛的分布和迅速发展构成了区域环境和社会经济发展的丰题。截止2000年,中国北方沙漠化土地面积达3.857×10^5km^2,并且正以每年3595km^2的速度住扩展。为了遏制不断恶化的生态环境,中国政府曾诉诸丁生物技术措施和工程措施,但收效甚微。20世纪90年代末,中央政府在陕北看到了退耕还林(草)和封山绿化对保护生态环境的作用,于是节约用水、退耕还林(草)、禁牧以及移民搬迁等生态保护政策便成为中国沙漠化地区生态环境治理的主要内容。但由于生态保护政策与保护生态环境的现实产生了一系列的矛盾,并没有改变牛态环境局部治理、整体恶化的态势。 | Ma Yonghuan Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,260 Dong Gang West Road,Lanzhou 730000,People’s Republic of China.mayonghuan2OOO@sina.com.cnFan Shengyue Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,260 Dong Gang West Road,Lanzhou 730000,People’s Republic of China.syfan@ns.lzb.ac.cn | 2006 | AMBIO-人类环境杂志2006，35，3： | 4 |
| 5 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 6 | Ontology Dynamics in a Data Life Cycle: Challenges and Recommendations from a Geoscience Perspective显示文摘Ontologies are increasingly deployed as a computer-accessible representation of key semantics in various parts of a data life cycle and, thus, ontology dynamics may pose challenges to data management and re-use. By using examples in the field of geosciences, we analyze challenges raised by ontology dynamics, such as heavy reworking of data, semantic heterogeneity among data providers and users, and error propagation in cross-discipline data discovery and re-use. We also make recommendations to address these challenges:(1) communities of practice on ontologies to reduce inconsistency and duplicated efforts;(2) use ontologies in the procedure of data collection and make them accessible to data users; and(3) seek methods to speed up the reworking of data in a Semantic Web context. | Xiaogang Ma Peter Fox Eric Rozell Patrick West Stephan Zednik | 2014 | Journal of Earth Science2014，25，2： | 3 |
| 7 | Direct in vivo injection of ^(131)I-GMS and its distribution and excretion in rabbit显示文摘AIM: To explore the distribution and metabolism of 131 I-gelatin microspheres ( 131 I-GMSs) in rabbits after direct injection into rabbits’ livers.METHODS: Twenty-eight healthy New Zealand rabbits were divided into seven groups,with four rabbits per group.Each rabbit’s hepatic lobes were directly injected with 41.336 ± 5.106 MBq 131 I-GMSs.Each day after 131 I-GMSs administration,4 rabbits were randomly selected,and 250 μL of serum was collected for γ count.Hepatic and thyroid functions were tested on days 1,4,8,16,24,32,48 and 64 after 131 I-GMSs administration.Single-photon emission computed tomography (SPECT) was taken for each group on days 0,1,4,8,16,24,32,48,64 after 131 I-GMSs administration.A group of rabbits were sacrificed respectively on days 1,4,16,24,32,48,64 after 131 I-GMSs administration.Their livers were taken out for histological examination.RESULTS: After 131 I-GMSs administration,the nuclide was collected in the hepatic area with microspheres.The radiation could be detected on day 48 after 131 IGMSs administration,and radiography could be seen in thyroid areas in SPECT on days 4,8,16 and 24.One day after 131 I-GMSs administration,the liver function was damaged but recovered 4 d later.Eight days after 131 I-GMSs administration,the levels of free triiodothyronine and free thyroxin were reduced,which restored to normal levels on day 16.Histological examination showed that the microspheres were degraded to different degrees at 24,32 and 48 d after 131 I-GMSs administration.The surrounding parts of injection points were in fibrous sheathing.No microspheres were detected in histological examination on day 64 after 131 I-GMSs administration.CONCLUSION: Direct in vivo injection of 131 I-GMSs is safe in rabbits.It may be a promising method for treatment of malignant tumors. | Yu Ma,Yi Wan,Li-Geng Duan,Xiao-Li Chen,The Research Unit of Hepato-Bilio-Pancreatology and Department of Hepatic Surgery,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China Dong-Hui Luo,Chuan-Qin Xia,College of Chemistry,Sichuan University,Chengdu 610041,Sichuan Province,China Lin Li,Department of Nuclear Medicine and The National Key Discipline of Medical Imaging and Nuclear Medicine,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China | 2010 | World Journal of Gastroenterology2010，16，17： | 3 |
| 8 | Dynamic Programming for Multidimensional Stochastic Control Problems | Jin Ma Department of Mathematics,Purdue University,West Lafayette,IN 47907-1395,U S A E-mail:majin@math.purdue,eduJiongmin Yong Laboratory of Mathematics for Nonlinear Science,Department of Mathematics,and Institute of Mathematical Finance,Fudan University,Shanghai 200433,P.R.China E-mail:jyong@fudan,edu.cn | 1999 | Acta Mathematica Sinica,English Series1999，15，4： | 2 |
| 9 | Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension显示文摘 | Eric D. Austin Lijiang Ma Charles LeDuc Erika Berman Rosenzweig Alain Borczuk John A. Phillips Teresa Palomero Pavel Sumazin Hyunjae R. Kim Megha H. Talati James West James E. Loyd Wendy K. Chung | 2012 | Circulation: Cardiovascular Genetics2012，，3： | 2 |
| 10 | Cytokines and the pathogenesis of nosocomial pneumonia显示文摘 | Muehlstedt SG Richardson CJ West MA | 2001 | Surgery2001，130，4： | 1 |
| 11 | Defective lipopolysaccharide-dependent ERK 1/2 activation in endotoxin tolerant murine macrophages is reversed by direct protein kinase C stimulation 显示文摘 | West MA Clair L Bellingham J | 2000 | Shock2000，14，： | 1 |
| 12 | Endotoxin tolerance in sepsis:concentration-dependent augmentation or inhibition of LPS-stimulated macrophage TNF secretion by LPS protreatment显示文摘 | West MA Koons A | 2008 | J Trauma2008，65，4： | 1 |
| 13 | The Eigenfactor(TM) Metrics显示文摘 | Bergstrom Cr West JD Wiseman MA | 2008 | Journal of Neuroscience2008，28，11： | 1 |
| 14 | Intensive weight loss intervention in older individuals:results from the Action for Health in Diabetes Type 2 diabetes mellitus trial 显示文摘 | Espeland MA Rejeski WJ West DS | 2013 | J Am Geriatr Soc2013，61，6： | 1 |
| 15 | Enhanced dendritic cell antigen capture via Toll-like receptor-induced aetin remodeling显示文摘 | West MA Wallin RP Matthews SP | 2004 | Science2004，305，5687： | 1 |
| 16 | Measuring climate for work group innovation:development and validation of the team climate inventory显示文摘 | NR Anderson West MA | 1998 | Journal of Organisational Behavior1998，，： | 1 |
| 17 | Abdominal compartment syndrome:A concise clini- cal review显示文摘 | An G West MA | 2008 | Crit Care Med2008，36，4： | 1 |
| 18 | Mechanism of decreased in vitro murine macrophage cytokine release after exposure to carbon diox-ide:relevance to laparoscopic surgery显示文摘 | WEST MA HACKAM DJ BAKER J | | 0，，2： | 1 |
| 19 | Abdominal comparunent syndrome:Aconcise clinical review显示文摘 | An G West MA | 2008 | Crit Care ned2008，36，4： | 1 |
| 20 | Innovations at work:Psychological perspectives显示文摘 | West MA Farr JL | | 0，，： | 1 |
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