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| 1 | Efficacy and safety of Xinglouchengqi decoction for acute ischemic stroke with constipation:study protocol for a randomized con-trolled trial显示文摘OBJECTIVE: To investigate the efficacy and safety of Xinglouchengqi(XLCQ) decoction in treatment of acute ischemic stroke with constipation.METHODS: In this prospective, multicenter, assessor-blinded, randomized controlled trial, 360 eligible participants will be randomized to the XLCQ group or the control group. Participants in the XLCQ group will receive XLCQ decoction, while those in the control group will undergo clysis therapy using glycerin enemas or oral administration of lactulose solution. Both groups will undergo a treatment period of(5 ± 2) d and a 1-month follow-up.The primary outcome measure will be the Constipation Scale score. The secondary outcome measures will include scores on the National Institutes of Health Stroke Scale, the Traditional Chinese Medicine(TCM) Stroke Scale, the Diagnostic Scale for TCM Syndromes of Ischemic Stroke and TCM Scale for Syndrome of Phlegm-heat and Fu-organ Excess.Therapeutic mechanism outcomes and safety outcomes will also be assessed. Assessments will be conducted at baseline, at the end of the treatment period, and at the follow-up. Moreover, daily visits will be scheduled to grade the status of constipation during the treatment period.DISCUSSION: The results of this study will provide scientific and objective data with which to assess the efficacy and safety of XLCQ decoction for patients with acute ischemic stroke and constipation. | Chen Pei Zhang Yong Ling Lili Chen Xing Ren Yi Jiang Lan Wu Shuang Wang Wenting Wang Yuguang Zou Yihuai | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 7 |
| 2 | Therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion injury显示文摘The time window in which a drug is effective varies between drugs. The present study investigated the therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion in mice. Animals underwent middle cerebral artery occlusion and were injected with Qingkailing (1.5, 3, 6 mL/kg). Infarct volume and neurological function were assessed after 24 hours of ischemia. In addition, to establish the therapeutic time window, mice were injected with 3 mL/kg Qingkailing at 0, 1, 3, 4, 6, 9 and 12 hours after occlusion. Results revealed that Qingkailing injection significantly reduced infarct volume and improved neurological function in model mice after cerebral infarction for up to 9 hours, demonstrating that the therapeutic window of Qingkailing injection can extend to 9 hours for cerebral ischemia/reperfusion in mice. | Fafeng Cheng Wenting Song Xianggen Zhong Yi Lu Shaoying Guo Dong Wang Weipeng Zhao Qingguo Wang | 2011 | Neural Regeneration Research2011，6，21： | 3 |
| 3 | Identification of Key Genes for the Ultrahigh Yield of Rice Using Dynamic Cross-tissue Network Analysis显示文摘Significantly increasing crop yield is a major and worldwide challenge for food supply and security.It is well-known that rice cultivated at Taoyuan in Yunnan of China can produce the highest yield worldwide.Yet,the gene regulatory mechanism underpinning this ultrahigh yield has been a mystery.Here,we systematically collected the transcriptome data for seven key tissues at different developmental stages using rice cultivated both at Taoyuan as the case group and at another regular rice planting place Jinghong as the control group.We identified the top 24 candidate high-yield genes with their network modules from these well-designed datasets by developing a novel computational systems biology method,i.e.,dynamic cross-tissue(DCT)network analysis.We used one of the candidate genes,Os SPL4,whose function was previously unknown,for gene editing experimental validation of the high yield,and confirmed that Os SPL4 significantly affects panicle branching and increases the rice yield.This study,which included extensive field phenotyping,cross-tissue systems biology analyses,and functional validation,uncovered the key genes and gene regulatory networks underpinning the ultrahigh yield of rice.The DCT method could be applied to other plant or animal systems if different phenotypes under various environments with the common genome sequences of the examined sample.DCT can be downloaded from http://gffzz188fe103f8f1460askwwnqfvx59ok6cfu.ffgz.tsg.suse.edu.cn/ztpub/DCT. | Jihong Hu Tao Zeng Qiongmei Xia Liyu Huang Yesheng Zhang Chuanchao Zhang Yan Zeng Hui Liu Shilai Zhang Guangfu Huang Wenting Wan Yi Ding Fengyi Hu Congdang Yang Luonan Chen Wen Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，3： | 2 |
| 4 | Estimation of transpiration coefficient and aboveground biomass in maize using time-series UAV multispectral imagery显示文摘Estimating spatial variation in crop transpiration coefficients(CTc) and aboveground biomass(AGB)rapidly and accurately by remote sensing can facilitate precision irrigation management in semiarid regions. This study developed and assessed a novel machine learning(ML) method for estimating CTc and AGB using time-series unmanned aerial vehicle(UAV)-based multispectral vegetation indices(VIs)of maize under several irrigation treatments at the field scale. Four ML regression methods: multiple linear regression(MLR), support vector regression(SVR), random forest regression(RFR), and adaptive boosting regression(ABR), were used to address the complex relationship between CTcand VIs. AGB was then estimated using exponential, logistic, sigmoid, and linear equations because of their clear mathematical formulations based on the optimal CTcestimation model. The UAV VIs-derived CTcusing the RFR estimation model yielded the highest accuracy(R^(2)= 0.91, RMSE = 0.0526, and n RMSE = 9.07%). The normalized difference red-edge index, transformed chlorophyll absorption in reflectance index, and simple ratio contributed significantly to the RFR-based CTcmodel. The accuracy of AGB estimation using nonlinear methods was higher than that using the linear method. The exponential method yielded the highest accuracy(R^(2)= 0.76, RMSE = 282.8 g m, and n RMSE = 39.24%) in both the 2018 and 2019 growing seasons. The study confirms that AGB estimation models based on cumulative CTcperformed well under several irrigation treatments using high-resolution time-series UAV multispectral VIs and can support irrigation management with high spatial precision at a field scale. | Guomin Shao Wenting Han Huihui Zhang Yi Wang Liyuan Zhang Yaxiao Niu Yu Zhang Pei Cao | 2022 | The Crop Journal2022，10，5： | 2 |
| 5 | Morphology and property investigation of primary particulate matter particles from different sources显示文摘 | Rufan Zhang Chong Liu Guangmin Zhou Jie Sun Nian Liu Po-Chun Hsu Haotian Wang Yongcai Qiu Jie Zhao Tong Wu Wenting Zhao Yi Cui | 2018 | Nano Research2018，11，6： | 2 |
| 6 | Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking显示文摘Injectable hydrogels are ideal biomaterials tor delivering cells,growth tactors and dmgs specifically to localized lesions and subsequent controlled release.Many factors can a fleet the efficacy of injectable hydrogels.To avoid potential damage to encapsulated cells or dmgs,injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly refonn after injection.However,dynamic hydrogels are often mechanically weak,leading to the leakage of encapsulated cells or drugs.Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds.We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not atlected by the fonnation of multivalent binding.Yet,the mechanical stability of the hydrogels was significantly improved due to the increased themiodynamic stability of the crosslinkers.We turthcr showed that the drug release rates were slowed down by the formation of multivalent crosslinkers.Our results highlight the importance of ligand valency to themechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels. | YU Wenting XUE Bin ZHU Zhenshu SHEN Ziqin QIN Meng WANG Wei CAO Yi | 2020 | Chemical Research in Chinese Universities2020，36，5： | 1 |
| 7 | Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity显示文摘 | Wen Wang Fangling Sun Yi An Houxi Ai Li Zhang Wenting Huang Lin Li | 2009 | European Journal of Pharmacology2009，，1： | 1 |
| 8 | Morroniside Prevents Peroxide-induced Apoptosis by Induction of Endogenous Glutathione in Human Neuroblastoma Cells显示文摘 | Wen Wang Wenting Huang Lin Li Houxi Ai Fangling Sun Ci Liu Yi An | 2008 | Cellular and Molecular Neurobiology2008，，2： | 1 |
| 9 | Effect of soybean oil on the production of myceliai biomass and pleuromutilin in the shake-flask culture of Pleurotus mutilis 显示文摘 | Hu Changhua Zou Yi Zhao Wenting | 2009 | World J Microbiol Biotechnol2009，25，10： | 1 |
| 10 | Changes in modes of hepatitis C infection acquisition and genotypes in southwest China显示文摘 | YouQian Zhou XiaoHong Wang Qing Mao Yi Fan Yan Zhu XuQing Zhang Lin Lan Li Jiang WenTing Tan | 2009 | Journal of Clinical Virology2009，，3： | 1 |
| 11 | Formal concept analysis for ontologies and their annotation files显示文摘 | Cross V Yi Wenting | 2008 | Fuzzy Systems2008，，3： | 1 |
| 12 | Study on barriers and countermeasures of technological innovation of ecological service function assessment of ur- ban greenbelt显示文摘 | WU WENTING ZHAO HENGYU REN YI SHEN DAN etal | 2012 | Energy Procedia2012，，16： | 1 |
| 13 | A microexplosive shockwave-based drug delivery microsystem for treating hard-to-reach areas in the human body显示文摘Implantable drug-delivery microsystems have the capacity to locally meet therapeutic requirements by maximizing local drug efficacy and minimizing potential side effects.The internal organs of the human body including the esophagus,gastrointestinal tract,and respiratory tract,with anfractuos contours,all manifest with endoluminal lesions often located in a curved or zigzag area.The ability of localized drug delivery for these organs using existing therapeutic modalities is limited.Spraying a drug onto these areas and using the adhesion and water absorption properties of the drug powder to attach to lesion areas can provide effective treatment.This study aimed to report the development and application of microsystems based on microshockwave delivery of drugs.The devices comprised a warhead-like shell with a powder placed at the head of the device and a flexible rod that could be inserted at the tail.These devices had the capacity to deposit drugs on mucous membranes in curved or zigzag areas of organs in the body.The explosive impact characteristics of the device during drug delivery were analyzed by numerical simulation.In the experiment of drug delivery in pig intestines,we described the biosafety and drug delivery capacity of the system.We anticipate that such microsystems could be applied to a range of endoluminal diseases in curved or zigzag regions of the human body while maximizing the on-target effects of drugs. | Yi Sun Wenzhong Lou Hengzhen Feng Wenting Su Sining Lv | 2022 | Microsystems & Nanoengineering2022，8，5： | 0 |
| 14 | Radioanalytical chemistry for nuclear forensics in China:Progress and future perspective显示文摘A relatively new branch of science-nuclear forensics,aiming at providing the nature,origin,history and possible trafficking route of seized nuclear materials/devices,has been established and rapidly developed over decades to screen illicit nuclear activities.This highly interdisciplinary science is built upon a foundation of analytical chemistry,radiochemistry,nuclear physics,material sciences,geology,and other scientific disciplines,within which radiochemical methodologies and radioanalytical techniques play a key role.The present review provides a brief overview about the crucial aspects of nuclear forensics,including basic content,procedure,concerned elements,common separation,analytical method,and so on.The state of the art and recent progresses of nuclear forensics by research communities in China are reviewed,while selected examples and practical applications are emphasized.The challenges associated with this new area and on-going developments are highlighted and discussed. | Yi Liu Xuepeng Shao Wenting Bu Zhen Qin Youyi Ni Fengcheng Wu Chuting Yang Xiaolin Wang | 2022 | Chinese Chemical Letters2022，33，7： | 0 |
| 15 | Investigation on the short-term outcome and prognostic impact of predisposition,and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE(CATCH-LIFE)cohorts显示文摘Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.Methods:The study included 3970 hospitalized patients with CLDs from two prospective longitudinal multicenter studies(NCT02457637 and NCT03641872)conducted in highly endemic hepatitis B virus(HBV)areas.Competing risk analysis was used to evaluate the effect of predispositions,including the etiology and severity of CLDs and precipitants;on sequential 28,90,and 365-day liver transplantation(LT)-free mortality.Results:Among all enrolled patients,76.8%of adverse outcomes(including death and LT)within one year occurred within 90 days.Compared with alcoholic etiology,the association of HBV etiology with poorer outcomes was remarkably on the 28th day(hazard ratio[HR],1.81;95%confidence interval[CI],1.07-3.06;p=0.026);however,and dimin-ished or became insignificant at 90 days and 365 days.Cirrhosis increased the adjusted risk for 365-day(HR,1.50;CI,1.13-1.99;p=0.004)LT-free mortality when compared with noncirrhosis.In patients with cirrhosis,prior decompensation(PD)independently increased the adjusted risk of 365-day LT-free mortality by 1.25-fold(p=0.021);however,it did not increase the risk for 90-day mortality.Neither the category nor the number of precipitants influenced the adjusted risk of 28 or 90-day LT-free mortality.Conclusions:The 90-day outcome should be considered a significant endpoint for evaluating the short-term prognosis of hospitalized patients with CLD.Predisposing factors,other than etiology,mainly affected the delayed(365-day)outcome.Timely effective therapy for CLD etiology,especially antiviral treatments for HBV,and post-discharge long-term surveillance monitoring in cirrhotic patients undergoing PD are suggested to enhance disease management and reduce mortality. | Yan Zhang Wenting Tan Xiaobo Wang Xin Zheng Yan Huang Beiling Li Zhongji Meng Yanhang Gao Zhiping Qian Feng Liu Xiaobo Lu Jia Shang Yubao Zheng Weituo Zhang Shan Yin Wenyi Gu Tongyu Wang Jianyi Wei Zixuan Shen Guohong Deng Yi Zhou Yixin Hou Qun Zhang Shue Xiong Jing Liu Liyuan Long Ruochan Chen Jinjun Chen Xiuhua Jiang Sen Luo Yuanyuan Chen Chang Jiang Jinming Zhao Liujuan Ji Xue Mei Jing Li Tao Li Rongjiong Zheng Xinyi Zhou Haotang Ren Yu Shi Hai Li for the CATCH‐LIFE Study Investigators of Chinese(Acute‐on)Chronic Liver Failure(CLIF)Consortium(Ch‐CLIFC) | 2023 | Portal Hypertension & Cirrhosis2023，2，3： | 0 |
| 16 | Therapeutic potential of an anti-HER2 single chain antibody-DM1 conjugates for the treatment of HER2-positive cancer显示文摘Antibody–drug conjugates(ADCs)take the advantage of monoclonal antibodies to selectively deliver highly potent cytotoxic drugs to tumor cells,which have become a powerful measure for cancer treatment in recent years.To develop a more effective therapy for human epidermal growth factor receptor 2(HER2)-positive cancer,we explored a novel ADCs composed of anti-HER2 scFv–HSA fusion antibodies conjugates with a potent cytotoxic drug DM1.The resulting ADCs,T-SA1–DM1 and T-SA2–DM1(drug-to-antibody ratio in the range of 3.2–3.5)displayed efficient inhibition in the growth of HER2-positive tumor cell lines and the half-maximal inhibitory concentration on SKBR-3 and SKOV3 cells were both at the nanomolar levels in vitro.In HER2-positive human ovarian cancer xenograft models,T-SA1–DM1 and T-SA2–DM1 also showed remarkable antitumor activity.Importantly,three out of six mice exhibited complete remission without regrowth in the high-dose group of T-SA1–DM1.On the basis of the analysis of luminescence imaging,anti-HER2 scFv–HSA fusion antibodies,especially T-SA1,showed strong and rapid tumor tissue penetrability and distribution compared with trastuzumab.Collectively,the novel type of ADCs is effective and selective targeting to HER2-positive cancer,and may be a promising antitumor drug candidate for further studies. | Hang Zhang Yuxi Wang Yangping Wu Xiaohua Jiang Yiran Tao Yuqin Yao Yujia Peng Xiangzheng Chen Yuyin Fu Lin Yu Ruixue Wang Qinhuai Lai Weirong Lai Wenting Li Yuhuan Kang Shuli Yi Ying Lu Lantu Gou Min Wu Jinliang Yang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 17 | The Role of Special Economic Zones in Enhancing Enterprise’s Export Structures:The Perspective of Industry Complexity显示文摘Special economic zones(SEZs)help provide the momentum for China’s economic growth.This paper studies the influence of SEZs on enterprise’s export structures from the perspective of production complexity using data from the China Industry Business Performance Database(CIBPD)collected between 2000 and 2007.We found that enterprises in SEZs have a higher export propensity and volume due to more complexity.Also,enterprises with more complexity outside SEZs show a higher export propensity and volume depending on the number of SEZs near them and the radiation effect of the SEZs.Similarly,high and new-tech industrial development zones perform more prominently in this regard. | Chang Zihao Lan Wenting Wen Yi | 2019 | Contemporary Social Sciences2019，4，6： | 0 |
| 18 | Surface Coordination Decouples Hydrogenation Catalysis on Supported Metal Catalysts显示文摘Supported metal catalysts integrating advantages of catalytic hydrogenation and stoichiometric reduction are highly desirable for the green production of fine chemicals.Decoupling catalytic hydrogenation into H_(2)activation and selective reduction taking place at different locations is expected to provide an effective strategy to fabricate such catalyst systems.Herein,we report a decoupled hydrogenation system by modifying Pt catalysts supported on reducible In2O3 with ethylenediamine(EDA).The system exhibits good catalytic performance in oximes production from nitroalkanes,an industrially important reaction,by employing H_(2).Systematic studies demonstrate that the surface coordination of EDA on Pt is crucial to passivate the Pt surface from nitro hydrogenation without inhibiting H_(2)activation.The activated H_(2)species can then transfer and reduce the In_(2)O_(3)support in situ to generate sustainable stoichiometric reducing agents for the chemoselective reduction of nitroalkanes.Based upon the mechanistic understanding,a sustainable strategy for the production of oximes has been successfully fabricated. | Qingyuan Wu Wenting Zhou Hui Shen Ruixuan Qin Qiming Hong Xiaodong Yi Nanfeng Zheng | 2023 | CCS Chemistry2023，5，5： | 0 |
| 19 | miR-335-5p regulates the proliferation,migration and phenotypic switching of vascular smooth muscle cells in aortic dissection by directly regulating SP1显示文摘Uncontrolled proliferation,migration and phenotypic switching of vascular smooth muscle cells(VSMCs)are important steps in the development and progression of aortic dissection(AD).The function and potential mechanism of miR-335-5p in the pathogenesis of AD are explored in this study.Specifically,the biological function of miR-335-5p is explored in vitro through CCK-8,Transwell,immunofluorescence,EdU,wound-healing,RT-qPCR and western blotting assays.In addition,an AD model induced by angiotensin II is used to investigate the function of miR-335-5p in vivo.A dual-luciferase assay is performed to verify the targeting relationship between miR-335-5p and specificity protein 1(SP1).Experiments involving the loss of SP1 function are performed to demonstrate the function of SP1 in the miR-335-5p-mediated regulation of human aortic-VSMCs(HA-VSMCs).AD tissues and platelet-derived growth factor BB(PDGF-BB)-stimulated HA-VSMCs show significant downregulation of miR-335-5p expression and upregulated SP1 expression.Overexpression of miR-335-5p effectively suppresses cell proliferation,migration and synthetic phenotype markers and enhances contractile phenotype markers induced by PDGF-BB treatment.Additionally,SP1 is identified as a target gene downstream of miR-335-5p,and its expression is negatively correlated with miR-335-5p in AD.Upregulation of SP1 partially reverses the inhibitory effect of miR-335-5p on HA-VSMCs,whereas the downregulation of SP1 has the opposite effect.Furthermore,Ad-miR-335-5p clearly suppresses aorta dilatation and vascular media degeneration in the AD model.Our results suggest that miR-335-5p inhibits HA-VSMC proliferation,migration and phenotypic switching by negatively regulating SP1,and indicate that miR-335-5p may be a potential therapeutic target in AD. | Runwei Ma Dayong Zhang Yi Song Jichang Kong Chunjie Mu Pin Shen Wenting Gui | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 0 |
| 20 | Effects of nitrogen and phosphorus additions on soil microbial community structure and ecological processes in the farmland of Chinese Loess Plateau显示文摘Microorganisms regulate the responses of terrestrial ecosystems to anthropogenic nutrient inputs.The escalation of anthropogenic activities has resulted in a rise in the primary terrestrial constraining elements,namely nitrogen(N)and phosphorus(P).Nevertheless,the specific mechanisms governing the influence of soil microbial community structure and ecological processes in ecologically vulnerable and delicate semi-arid loess agroecosystems remain inadequately understood.Therefore,we explored the effects of different N and P additions on soil microbial community structure and its associated ecological processes in the farmland of Chinese Loess Plateau based on a 36-a long-term experiment.Nine fertilization treatments with complete interactions of high,medium,and low N and P gradients were set up.Soil physical and chemical properties,along with the microbial community structure were measured in this study.Additionally,relevant ecological processes such as microbial biomass,respiration,N mineralization,and enzyme activity were quantified.To elucidate the relationships between these variables,we examined correlation-mediated processes using statistical techniques,including redundancy analysis(RDA)and structural equation modeling(SEM).The results showed that the addition of N alone had a detrimental effect on soil microbial biomass,mineralized N accumulation,andβ-1,4-glucosidase activity.Conversely,the addition of P exhibited an opposing effect,leading to positive influences on these soil parameters.The interactive addition of N and P significantly changed the microbial community structure,increasing microbial activity(microbial biomass and soil respiration),but decreasing the accumulation of mineralized N.Among them,N24P12 treatment showed the greatest increase in the soil nutrient content and respiration.N12P12 treatment increased the overall enzyme activity and total phospholipid fatty acid(PLFA)content by 70.93%.N and P nutrient contents of the soil dominate the microbial community structure and the corresponding changes in hydrolytic enzymes.Soil microbial biomass,respiration,and overall enzyme activity are driven by mineralized N.Our study provides a theoretical basis for exploring energy conversion processes of soil microbial community and environmental sustainability under long-term N and P additions in semi-arid loess areas. | KOU Zhaoyang LI Chunyue CHANG Shun MIAO Yu ZHANG Wenting LI Qianxue DANG Tinghui WANG Yi | 2023 | Journal of Arid Land2023，15，8： | 0 |
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