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| 1 | Entecavir vs lamivudine therapy for na?ve patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure显示文摘AIM:To investigate the short-term and long-term efficacy of entecavir versus lamivudine in patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure(ACLF).METHODS:This was a single center,prospective cohort study.Eligible,consecutive hospitalized patients received either entecavir 0.5 mg/d or lamivudine 100mg/d.All patients were given standard comprehensive internal medicine.The primary endpoint was survival rate at day 60,and secondary endpoints were reduction in hepatitis B virus(HBV)DNA and alanine aminotransferase(ALT)levels,and improvement in Child-Turcotte-Pugh(CTP)and model for end-stage liver disease(MELD)scores at day 60 and survival rate at week 52.RESULTS:One hundred and nineteen eligible subjects were recruited from 176 patients with severe acute exacerbation of chronic hepatitis B:65 were included in the entecavir group and 54 in the lamivudine group(full analysis set).No significant differences were found in patient baseline clinical parameters.At day 60,entecavir did not improve the probability of survival(P=0.066),despite resulting in faster virological suppression(P<0.001),higher rates of virological response(P<0.05)and greater reductions in the CTP and MELD scores(all P<0.05)than lamivudine.Intriguingly,at week 52,the probability of survival was higher in the entecavir group than in the lamivudine group[42/65(64.6%)vs 26/54(48.1%),respectively;P=0.038].The pretreatment MELD score(B,1.357;95%Cl:2.138-7.062;P=0.000)and virological response at day30(B,1.556;95%Cl:1.811-12.411;P=0.002),were found to be good predictors for 52-wk survival.CONCLUSION:Entecavir significantly reduced HBV DNA levels,decreased the CTP and MELD scores,and thereby improved the long-term survival rate in patients with spontaneous reactivation of hepatitis B presenting as ACLF. | Yang Zhang Xiao-Yu Hu Sen Zhong Fang Yang Tao-You Zhou Guo Chen Yan-Yan Wang Jian-Xing Luo | 2014 | World Journal of Gastroenterology2014，20，16： | 42 |
| 2 | Electroacupuncture improves gut barrier dysfunction in prolonged hemorrhagic shock rats through vagus anti-inflammatory mechanism显示文摘AIM:To investigate whether electroacupuncture(EA)at Zusanli(ST36)prevents intestinal barrier and remote organ dysfunction following prolonged hemorrhagic shock through a vagus anti-inflammatory mechanism.METHODS:Sprague-Dawley rats were subjected to about 45%of total blood volume loss followed by delayed fluid replacement(DFR)with Ringer lactate 3h after hemorrhage.In a first study,rats were randomly divided into six groups:(1)EAN:EA at non-channel acupoints followed by DFR;(2)EA:EA at ST36 after hemorrhage followed by DFR;(3)VGX/EA:vagotomy(VGX)before EA at ST36 and DFR;(4)VGX/EAN:VGX before EAN and DFR;(5)α-bungarotoxin(α-BGT)/EA:intraperitoneal injection ofα-BGT before hemorrhage,followed by EA at ST36 and DFR;and(6)α-BGT/EAN group:α-BGT injection before hemorrhage followed by EAN and DFR.Survival and mean arterial pressure(MAP)were monitored over the next 12 h.In a second study,with the same grouping and treatment,cytokine levels in plasma and intestine,organ parameters,gut injury score,gut permeability to 4 kDa FITC-dextran,and expression and distribution of tight junction protein ZO-1 were evaluated.RESULTS:MAP was significantly lowered after blood loss;EA at ST36 improved the blood pressure at corresponding time points 3 and 12 h after hemorrhage.EA at ST36 reduced tumor necrosis factor-αand interleukin(IL)-6 levels in both plasma and intestine homogenates after blood loss and DFR,while vagotomy or intraperitoneal injection ofα-BGT before EA at ST36reversed its anti-inflammatory effects,and EA at ST36did not influence IL-10 levels in plasma and intestine.EA at ST36 alleviated the injury of intestinal villus,the gut injury score being significantly lower than that of EAN group(1.85±0.33 vs 3.78±0.59,P<0.05).EA at ST36 decreased intestinal permeability to FITCdextran compared with EAN group(856.95 ng/mL±90.65 ng/mL vs 2305.62 ng/mL±278.32 ng/mL,P<0.05).EA at ST36 significantly preserved ZO-1 protein expression and localization at 12 h after hemorrhage.However,EA at non-channel acupoints had no such effect,and abdominal vagotomy andα-BGT treatment could weaken or eliminate the effects of EA at ST36.Besides,EA at ST36 decreased blood aminotransferase,MB isoenzyme of creatine kinase and creatinine vs EAN group at corresponding time points.At the end of 12-h experiment,the survival rate of the EA group was significantly higher than that of the other groups.CONCLUSION:EA at ST36 attenuates the systemic inflammatory response,protects intestinal barrier integrity,improves organ function and survival rate after hemorrhagic shock via activating the cholinergic antiinflammatory mechanism. | Ming-Hua Du Hong-Min Luo Sen Hu Yi Lv Zhi-Long Lin Li Ma | 2013 | World Journal of Gastroenterology2013，19，36： | 21 |
| 3 | Incidence of infectious complications is associated with a high mortality in patients with hepatitis B virus-related acute-on-chronic liver failure显示文摘BACKGROUND In China,hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is the most common liver failure characterized by serious clinical syndromes of liver decompensation with a very high mortality.Bacterial and/or fungal infections are the most common complications that are associated with high short-term mortality.Bacterial translocation from the intestine,impaired hepatic clearance,and immune paralysis of circulating immune cells are thought to contribute to infectious complications in liver failure.The control of bacterial and fungal infections is the key to improving HBV-ACLF outcomes.Active prevention,early diagnosis,and timely treatment of bacterial and fungal infections are essential for treating HBV-ACLF.AIM To investigate the frequency and role of bacterial and fungal infections in patients with HBV-ACLF.METHODS Patients with HBV-ACLF hospitalized at Taihe Hospital,Hubei University of Medicine from January 2014 to December 2017 were retrospectively enrolled.Patient-related information was retrieved from the hospital case database,including general information,blood biochemistry,complications,etc.According to the occurrence of secondary infection or not,the patients were divided into an infection group and a non-infection group.The sites,types,and incidences of bacterial and fungal infections and the influence of infections on the prognosis of HBV-ACLF were statistically analyzed.The risk factors for infections were assessed by unconditional logistic regression.RESULTS There were 174 cases of HBV-ACLF that met the enrollment criteria,of which 114 (65.52%) were diagnosed with infectious complications.Infections occurred in the abdominal cavity (87 cases),respiratory tract (51 cases),urinary tract (18 cases),and biliary tract (10 cases).Patients with infectious complications had a significantly higher 28-d mortality (70.18%,80/114) than those without (40.00%,24/60)(70.18% vs 40.00%,P < 0.05).And patients with infectious complications had a much higher incidence of non-infectious complications (54.39%,62/114)(54.39% vs 15.00%,P < 0.05),leading to an extremely high 28-d mortality of 88.71%(55/62)(P < 0.05).The grade of liver failure,period of hospital stay ≥ 30 d,age ≥ 45 years,and percentage of neutrophils > 70% were identified as risk factors for infectious complications.CONCLUSION The high incidence of infectious complications in patients with HBV-ACLF is associated with severity and deterioration of the disease and may contribute to the extremely high mortality of these patients. | Chen Wang De-Qiang Ma Sen Luo Chuan-Min Wang De-Ping Ding You-You Tian Kang-Jian Ao Yin-Hua Zhang Yue Chen Zhong-Ji Meng | 2019 | World Journal of Clinical Cases2019，7，16： | 18 |
| 4 | Electroacupuncture activates enteric glial cells and protects the gut barrier in hemorrhaged rats显示文摘AIM:To investigate whether electroacupuncture ST36 activates enteric glial cells,and alleviates gut inflammation and barrier dysfunction following hemorrhagic shock.METHODS:Sprague-Dawley rats were subjected to approximately 45% total blood loss and randomly divided into seven groups:(1) sham:cannulation,but no hemorrhage;(2) subjected to hemorrhagic shock(HS);(3) electroacupuncture(EA) ST36 after hemorrhage;(4) vagotomy(VGX)/EA:VGX before hemorrhage,then EA ST36;(5) VGX:VGX before hemorrhage;(6) a-bungarotoxin(BGT)/EA:intraperitoneal injection of a-BGT before hemorrhage,then EA ST36; and(7) a-BGT group:a-BGT injection before hemorrhage.Morphological changes in enteric glial cells(EGCs) were observed by immunofluorescence,and glial fibrillary acidic protein(GFAP; a protein marker of enteric glial activation) was evaluated using reverse transcriptase polymerase chain reaction and western blot analysis.Intestinal cytokine levels,gut permeability to 4-k Da fluorescein isothiocyanate(FITC)-dextran,and the expression and distribution of tight junction protein zona occludens(ZO)-1 were also determined.RESULTS:EGCs were distorted following hemorrhage and showed morphological abnormalities.EA ST36 attenuated the morphological changes in EGCs at 6 h,as compared with the VGX,a-BGT and HS groups.EA ST36 increased GFAP expression to a greater degree than in the other groups.EA ST36 decreased intestinal permeability to FITC-dextran(760.5 ± 96.43 ng/m L vs 2466.7 ± 131.60 ng/m L,P < 0.05) and preserved ZO-1 protein expression and localization at 6 h afterhemorrhage compared with the HS group.However,abdominal VGX and a-BGT treatment weakened or eliminated the effects of EA ST36.EA ST36 reduced tumor necrosis factor-a levels in intestinal homogenates after blood loss,while vagotomy or intraperitoneal injection of a-BGT before EA ST36 abolished its antiinflammatory effects.CONCLUSION:EA ST36 attenuates hemorrhageinduced intestinal inflammatory insult,and protects the intestinal barrier integrity,partly via activation of EGCs. | Sen Hu Zeng-Kai Zhao Rui Liu Hai-Bin Wang Chun-Yu Gu Hong-Min Luo Huan Wang Ming-Hua Du Yi Lv Xian Shi | 2015 | World Journal of Gastroenterology2015，21，5： | 15 |
| 5 | The apricot(Prunus armeniaca L.)genome elucidates Rosaceae evolution and beta-carotenoid synthesis显示文摘Apricots,scientifically known as Prunus armeniaca L,are drupes that resemble and are closely related to peaches or plums.As one of the top consumed fruits,apricots are widely grown worldwide except in Antarctica.A high-quality reference genome for apricot is still unavailable,which has become a handicap that has dramatically limited the elucidation of the associations of phenotypes with the genetic background,evolutionary diversity,and population diversity in apricot.DNA from P.armeniaca was used to generate a standard,size-selected library with an average DNA fragment size of~20 kb.The library was run on Sequel SMRT Cells,generating a total of 16.54 Gb of PacBio subreads(N50=13.55 kb).The high-quality P.armeniaca reference genome presented here was assembled using long-read single-molecule sequencing at approximately 70×coverage and 171×Illumina reads(40.46 Gb),combined with a genetic map for chromosome scaffolding.The assembled genome size was 221.9 Mb,with a contig NG50 size of 1.02 Mb.Scaffolds covering 92.88%of the assembled genome were anchored on eight chromosomes.Benchmarking Universal Single-Copy Orthologs analysis showed 98.0%complete genes.We predicted 30,436 protein-coding genes,and 38.28%of the genome was predicted to be repetitive.We found 981 contracted gene families,1324 expanded gene families and 2300 apricot-specific genes.The differentially expressed gene(DEG)analysis indicated that a change in the expression of the 9-cis-epoxycarotenoid dioxygenase(NCED)gene but not lycopene beta-cyclase(LcyB)gene results in a lowβ-carotenoid content in the white cultivar“Dabaixing”.This complete and highly contiguous P.armeniaca reference genome will be of help for future studies of resistance to plum pox virus(PPV)and the identification and characterization of important agronomic genes and breeding strategies in apricot. | Fengchao Jiang Junhuan Zhang Sen Wang Li Yang Yingfeng Luo Shenghan Gao Meiling Zhang Shuangyang Wu Songnian Hu Haoyuan Sun Yuzhu Wang | 2019 | Horticulture Research2019，6，1： | 9 |
| 6 | Sedimentary and geochemical characteristics of the Triassic Chang 7 Member shale in the Southeastern Ordos Basin,Central China显示文摘The Ordos Basin is the largest petroliferous basin in China, where the Chang 7 Member shale serves as the major source rock in the basin, with an area of more than 100,000 km^2 So far, sedimentary and geochemical characterizations have rarely been conducted on the shale in shallow(< 1000 m) areas in the southeastern part of the basin, but such characterizations can help identify the genesis of organic-rich shale and promote the prediction and recovery of shale oil. In this paper,several outcrop sections of the Chang 7 Member in the Tongchuan area were observed and sampled, and sedimentary and geochemical characterizations were conducted for the well-outcropped YSC section. The study results show that the Chang7 Member shale is widely distributed laterally with variable thickness. The organic-rich shale is 7-25 m thick in total and exhibits obvious horizontal variation in mineral composition. In the eastern sections, the shale contains organic matter of TypeⅡ_2-Ⅲ and is low in thermal maturity, with high clay mineral content, low K-feldspar content, and no pyrite. In the western sections, the shale contains Type Ⅱ_1 organic matter and is low in thermal maturity, with high clay mineral, K-feldspar, and pyrite contents. The YSC section reveals three obvious intervals in vertical mineral composition and organic abundance.The Chang 7 Member organic-rich shale(TOC > 10%) contains mainly sapropelite and liptinite, with Type Ⅱ kerogen. It is generally characterized by a hydrocarbon potential of more than 70 mg/g, low maturity, and shallow-semideep lacustrine facies. In the western sections, the shale, still in a low maturity stage, has a higher hydrocarbon potential and is optional for shale oil recovery. However, the Chang 7 Member shale in the study area is highly heterogeneous and its shale oil recovery is practical only in the organic-rich intervals. | Jing-Wei Cui Ru-Kai Zhu Zhong Luo Sen Li | 2019 | Petroleum Science2019，16，2： | 7 |
| 7 | Heat Transfer and Central Segregation of Continuously Cast High Carbon Steel Billet显示文摘A numerical model of heat transfer was developed to investigate the heat transfer of continuously cast billet with the aid of surface temperature tests by ThermaCAMTMresearcher and nail shooting experiments.The effects of secondary cooling practice and casting speed on the solidification process and central segregation of carbon were investigated as well with the actual central segregation tests.The results show that the surface center and billet center temperatures exhibit a different pattern during solidification,and the solidified shell thickness is presented as an'S'type.With the increase of secondary cooling intensity and the decrease of casting speed,the end points of the solidus line and the liquidus line move forward,and the central segregation level of carbon decreases.The optimal casting condition is suggested for continuously cast high carbon billet with F-EMS(final electromagnetic stirring). | Wang SU Wei-ling WANG Sen LUO Dong-bin JIANG Miao-yong ZHU | 2014 | Journal of Iron and Steel Research(International)2014，21，6： | 6 |
| 8 | Simultaneous determination of brominated phenols in soils显示文摘Brominated phenols(BPs),a widely used group of emerging flame retardants,are important environmental contaminants and exhibit endocrine disrupting potential.Method for simultaneous determination of tetrabromobisphenol A(TBBPA),tribromophenol(TBP),dibromophenols(DBPs)and monobromophenols(MBPs)in soils using gas chromatography-mass spectrometry analysis(GC/MS)was successfully developed.Cleanup methods for soil extracts including several solid-phase extraction cartridges and diferent elution solvents were compared and optimized.Florisil cartridge with dichloromethane as the elution reagent was selected for sample cleanup owing to its high and reproducible recoveries of the target analytes in soils.Derivatization conditions were tested and the optimal conditions were obtained with 20μL silylation reagent at room temperature.The chromatographic separation was optimized with diferent columns and DB-XLB column was selected for its excellent separation of the analytes.The limits of detection for the target compounds were from 0.04 to 0.19 ng/g.Mean recoveries of the compounds from spiked soils exceeded 84%with a good reproducibility,excepting that the recovery of 2-bromophenol was relatively poor(lower than 55%)due to its instability.The developed method was applied to the determination of the BPs in the soils collected from e-waste sites.The contents of BPs in the soils were at ng/g levels with TBBPA and TBP the most frequently detected.To our knowledge,this is the first report for the simultaneous determination of TBBPA,TBP,DBPs and MBPs in soils. | Wei Han Sen Wang Honglin Huang Lei Luo Shuzhen Zhang | 2013 | Journal of Environmental Sciences2013，25，11： | 5 |
| 9 | Influence of aging modes on microstructure and mechanical properties of AZ80 magnesium alloy显示文摘The microstructure and mechanical properties of AZ80 magnesium alloy after solid solution and aging treatments were studied by using optical microscope(OM),X-ray diffraction(XRD),scanning electron microscopy(SEM)as well as tensile testing.The results indicated that β-Mg17Al12 phase was getting to distribute discontinuously along the grain boundary after treated at 395℃ ageing for 12 h followed by water-cooling,but it did not dissolve into α-Mg completely.The residual β-Mg17Al12 phase distributed along the grain boundary and had block-like or island shapes.The size of α-Mg was getting to be coarsening but not significantly.The β-Mg17Al12 precipitates appeared in discontinuous and continuous patterns from supersaturated α-Mg solid solution after aged at 200℃.The precipitation patterns were associated with the aging time essentially.The tensile strength and elongation of the alloy increased significantly but the hardness and yield strength decreased after solid solution treatment.However,with the prolonging of aging time,the hardness and strength of alloy increased while the ductility decreased. | ZHANG Ju-mei JIANG Bai-ling WANG Zhi-hu YUAN Sen NAN Hong-qiang LUO Hong-bin | 2007 | China Foundry2007，4，4： | 4 |
| 10 | Numerical Simulation and Experimental Study of F-EMS for Continuously Cast Billet of High Carbon Steel显示文摘A final electromagnetic stirring model was developed for billet continuous casting of high carbon steel using the commercial software ANSYS and CFX, and the numerical model was validated by the magnetic flux density measured under a Teslameter CT-3. The magnetic flux density and fluid flow in the liquid pool at the location of final electromagnetic stirring(F-EMS) were calculated by the present numerical model. Meanwhile, the plant trials were carried out to determine the optimum current intensity and frequency of F-EMS for the continuously cast billet of high carbon steel. The numerical results show that, through increasing the current intensity by 100 A, the corresponding increases of magnetic induction intensity, tangential electromagnetic force and flow velocity at the solid/liquid interface in the strand are 0.025 T, 1933 N/m3 and 6.9 cm/s, respectively. Moreover, the industrial trial results showed that for the continuously cast billet of 60 steel, the optimum current intensity and frequency of F-EMS, which is 8.2 m from the meniscus, are respectively 380 A and 6 Hz. With the optimum F-EMS parameters, the significant improvement of center segregation of billet is achieved, and the center carbon segregation index in billet reaches 1.04. | Sen LUO Feng-yun PIAO Dong-bin JIANG Wei-ling WANG Miao-yong ZHU | 2014 | Journal of Iron and Steel Research(International)2014，21，S1： | 4 |
| 11 | Relationships among KRAS mutation status, expression of RAS pathway signaling molecules, and clinicopathological features and prognosis of patients with colorectal cancer显示文摘BACKGROUND The RAS/RAF/MEK/ERK and PI3 K/AKT/mTOR signaling pathways all belong to mitogen-activated protein kinase(MAPK) signaling pathways, Mutations in any one of the upstream genes(such as the RAS gene or the BRAF gene) may be transmitted to the protein through transcription or translation, resulting in abnormal activation of the signaling pathway. This study investigated the relationship between the KRAS gene mutation and the clinicopathological features and prognosis of colorectal cancer(CRC), and the effect of KRAS mutations on its associated proteins in CRC, with an aim to clarify the cause of tumor progression and drug resistance caused by mutation of the KRAS gene.AIM To investigate the KRAS gene and RAS pathway signaling molecules in CRC and to analyze their relationship with clinicopathological features and prognosis METHODS Colorectal cancer tissue specimens from 196 patients were analyzed for KRAS mutations using quantitative polymerase chain reaction and for KRAS, BRAF,MEK, and ERK protein expression levels using immunohistochemistry of tumor microarrays. To analyze differences of RAS pathway signaling molecule expression levels in different KRAS gene status, the relationships between these parameters and clinicopathological features, 4-year progression-free survival, and overall survival were analyzed by independent sample t test, Kaplan-Meier plots,and the log-rank test. Predictors of overall and disease-free survival were assessed using a Cox proportional hazards model.RESULTS Of the 196 patients, 62(32%) carried mutations in codon 12(53/62) or codon 13(9/62) in exon 2 of the KRAS gene. KRAS, BRAF, ERK, and MEK protein expression was detected in 71.4%, 78.8%, 64.3%, and 50.8% of CRC tissues,respectively. There were no significant differences between KRAS mutation status and KRAS, BRAF, MEK, or ERK protein levels. Positive expression of KRAS and ERK was associated with poor tumor differentiation, and KRAS expression was also associated with age < 56 years. MEK expression was significantly associated with distant metastasis(P < 0.05). The 4-year progression-free survival rate, but not overall survival rate, was significantly higher in patients with KRAS-negative tumors than in those with KRAS-positive tumors(P < 0.05), whereas BRAF, MEK,and ERK expression was unrelated to survival. Multivariate analysis showed that only the expression of KRAS protein was a risk factor for tumor recurrence(P <0.05). No other clinicopathological factors correlated with KRAS, BRAF, MEK, or ERK expression.CONCLUSION KRAS gene mutations do not affect downstream protein expression in CRC.KRAS protein is associated with poor tumor differentiation, older age, and a risk of tumor recurrence. | Xiang-Bin Wan Ai-Qin Wang Jian Cao Zhi-Chuang Dong Ning Li Sen Yang Miao-Miao Sun Zhi Li Su-Xia Luo | 2019 | World Journal of Gastroenterology2019，25，7： | 3 |
| 12 | NLRP3 Deficiency Attenuates Secondary Degeneration of Visual Cortical Neurons Following Optic Nerve Injury显示文摘In the visual pathway, optic nerve(ON) injury may cause secondary degeneration of neurons in distal regions, such as the visual cortex. However, the role of the neuroinflammatory response in regulating secondary impairment in the visual cortex after ON injury remains unclear. The NOD-like receptor family pyrin domain containing 3(NLRP3) is an important regulator of neuroinflammation. In this study, we established a mouse model of unilateral ON crush(ONC) and showed that the expression of NLRP3 was significantly increased in the primary visual cortex(V1) as a response to ONC and that the NLRP3 inflammasome was activated in the contralateral V1 1 days–14 days after ONC. Ablation of the NLRP3 gene significantly decreased the trans-neuronal degeneration within 14 days. Visual electrophysiological function was improved in NLRP3-/- mice. Taken together, these findings suggest that NLRP3 is a potential therapeutic target for protecting visual cortical neurons against degeneration after ON injury. | Zhou Zhang Wenyi Liu Yubin Huang Linlin Luo Xiaofeng Cai Yunjia Liu Liqianyu Ai Jun Yan Sen Lin Jian Ye | 2020 | Neuroscience Bulletin2020，36，3： | 3 |
| 13 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 14 | Efficiency against multidrug resistance by co-delivery of doxorubicin and curcumin with a legumain-sensitive nanocarrier显示文摘Multidrug 抵抗蛋白质(MDRP ) 在肿瘤在 multidrug 抵抗的调停被含有,代表主要障碍到成功的化疗。当 curcumin (杂种狗) 在 MDRP 的表示和功能上施加禁止的效果,为杂种狗和 doxorubicin (纪录影片) 的合作交货的 nanocarrier 被准备通过他们的 synergistic 效果克服 MDR 肿瘤。由于在肿瘤的 legumain 的 overexpression,从这 nanocarrier 的纪录影片的版本侧面被设计是调制的 legumain,它被与 legumain 敏感的肽衔接纪录影片到基本材料(chitosan ) 完成。与 nanoparticles 相比仅仅包含纪录影片,纪录影片和杂种狗的 coadministration 显著地禁止了 multidrug 抵抗(P < 0.05 ) 在一个 multidrug 抵抗的癌症房间模型(MCF-7/ADR 房间线) ,与到正常房间(L929 房间线) 的 cytotoxicity。如此的抑制能在 MCF-7/ADR 原子核被归功于到增加的纪录影片累积。合作交货系统整个延长发行量时间,改进指向肿瘤的效率,肿瘤抑制活动的举起,和 MDRP 表示的抑制展出了好 anticancer 效果。这些数据为癌症治疗揭示了这个合作交货系统的庞大的潜力,特别在 multidrug 抵抗可以发展的以后的阶段。 | Sen Lin Peiling Xie Mengmeng Luo Qing Li Ling Li Jinzhao Zhang Qinxiang Zheng Hao Chen Kaihui Nan | 2018 | Nano Research2018，11，7： | 2 |
| 15 | Conversion of Catalytically Inert 2D Bismuth Oxide Nanosheets for Effective Electrochemical Hydrogen Evolution Reaction Catalysis via Oxygen Vacancy Concentration Modulation显示文摘Oxygen vacancies(Vo)in electrocatalysts are closely correlated with the hydrogen evo-lution reaction(HER)activity.The role of vacancy defects and the effect of their concentration,how-ever,yet remains unclear.Herein,Bi2O3,an unfavorable electrocata-lyst for the HER due to a less than ideal hydrogen adsorption Gibbs free energy(ΔGH*),is utilized as a perfect model to explore the func-tion of Vo on HER performance.Through a facile plasma irradia-tion strategy,Bi2O3 nanosheets with different Vo concentrations are fabricated to evaluate the influence of defects on the HER process.Unexpectedly,while the generated oxygen vacancies contribute to the enhanced HER performance,higher Vo concentrations beyond a saturation value result in a significant drop in HER activity.By tunning the Vo concentration in the Bi_(2)O_(3)nanosheets via adjusting the treatment time,the Bi2O3 catalyst with an optimized oxygen vacancy concentration and detectable charge carrier concentration of 1.52×10^(24)cm^(−3)demonstrates enhanced HER performance with an overpotential of 174.2 mV to reach 10 mA cm^(−2),a Tafel slope of 80 mV dec−1,and an exchange current density of 316 mA cm−2 in an alkaline solution,which approaches the top-tier activity among Bi-based HER electrocatalysts.Density-functional theory calculations confirm the preferred adsorption of H*onto Bi2O3 as a function of oxygen chemical potential(ΔμO)and oxygen partial potential(PO2)and reveal that high Vo concentrations result in excessive stability of adsorbed hydrogen and hence the inferior HER activity.This study reveals the oxygen vacancy concentration-HER catalytic activity relationship and provides insights into activating catalytically inert materials into highly efficient electrocatalysts. | Ziyang Wu Ting Liao Sen Wang Janith Adikaram Mudiyanselage Aaron SMicallef Wei Li Anthony PO’Mullane Jianping Yang Wei Luo Kostya Ostrikov Yuantong Gu Ziqi Sun | 2022 | Nano-Micro Letters2022，14，6： | 2 |
| 16 | Kinetic and Thermodynamic Studies on Raney Ni/Al2O3 Adsorption for Deep Desulfurization of Benzene Stream显示文摘How to remove trace amount of sulfur in benzene is of significance,and deep desulfurization by Ni-containing absorbents is an efficient and promising method.In this paper,The Raney Ni/Al2 O3 adsorbent was prepared and its kinetic and thermodynamic characteristics on adsorptive desulfurization of benzene were studied.The results showed that Raney Ni/Al2 O3 adsorbent exhibited good adsorption performance.The equilibrium isotherms indicated that the adsorption of thiophene over the Raney Ni/Al2 O3 adsorbent complied with the Freundlich model.The results of adsorption kinetics studies showed that the pseudo-second-order kinetics equation was more advantageous than the pseudo-first-order kinetics equation in describing the adsorption kinetics of thiophene on Raney Ni/Al2 O3.The rate constant value(kp)was positively correlated with the temperature whereas the adsorption mass transfer process was mainly determined by the intraparticle and film diffusion.The adsorption thermodynamic analysis proved that△G^0<0,△H^0>0,and△S^0>0,implying that the adsorption was a spontaneous,entropy-increasing and endothermic process. | Cao Yongzheng Luo Guohua Zhang Lanxi Xu Xin Jin Haibo Dong Sen Guo Xuehua | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，2： | 2 |
| 17 | An Investigation on the Molecular Characteristics and Intracellular Growth Ability among Environmental and Clinical Isolates of Legionella pneumophila in Sichuan Province, China显示文摘Objective To investigate the molecular characteristics and intracellular growth ability of Legionella pneumophila(L. pneumophila) strains from 1989 to 2016 in Sichuan Province, China. Methods Seventy-nine isolates of L. pneumophila were collected from environmental and clinical sources, including cooling towers, hot springs, bath water, fountains, and patients, and identified with 16 S rRNA gene analysis and serum agglutination assay. The isolates were then typed by Sequence-Based Typing(SBT), and Genotyping of forty-two LP1 strains were analyzed by means of multiple-locus VNTR analysis with 8 loci(MLVA-8). All strains were further analyzed for two virulence genes: Legionella vir homologue(lvh) and repeats in structural toxin(rtx A). The intracellular growth ability of 33 selected isolates was determined by examining their interaction with J774 cells. Results All isolates were identified to L. pneumophila including 11 serogroups, among which the main serogroup were LP1, accounting for 54.43%. Thirty-three different sequence types(STs) from five main clonal groups and five singletons were identified, along with 8 different MLVA patterns. Both the lvh and rtx A loci were found in all 79 strains. Thirty isolates showed high intracellular growth ability in J774 cells. Conclusion L. pneumophila is a potential threat to public health, and effective control and prevention strategies are urgently needed. | ZENG Lin Zi LIAO Hong Yu LUO Long Ze HE Shu Sen QIN Tian ZHOU Hai Jian LI Hong Xia CHEN Da Li CHEN Jian Ping | 2019 | Biomedical and Environmental Sciences2019，32，7： | 1 |
| 18 | New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Decompensation of Cirrhosis显示文摘Background and Aims:Approximately 10%of patients with acute decompensated(AD)cirrhosis develop acute-on-chronic liver failure(ACLF)within 28 days.Such cases have high mortality and are difficult to predict.Therefore,we aimed to establish and validate an algorithm to identify these patients on hospitalization.Methods:Hospitalized patients with AD who developed ACLF within 28 days were considered pre-ACLF.Organ dysfunction was defined accord-ing to the chronic liver failure-sequential organ failure as-sessment(CLIF-SOFA)criteria,and proven bacterial infec-tion was taken to indicate immune system dysfunction.A retrospective multicenter cohort and prospective one were used to derive and to validate the potential algorithm,re-spectively.A miss rate of<5%was acceptable for the calcu-lating algorithm to rule out pre-ACLF.Results:In the deri-vation cohort(n=673),46 patients developed ACLF within 28 days.Serum total bilirubin,creatinine,international normalized ratio,and present proven bacterial infection at admission were associated with the development of ACLF.AD patients with≥2 organ dysfunctions had a higher risk for pre-ACLF patients[odds ratio=16.58195%confidence interval:(4.271-64.363),p<0.001].In the derivation co-hort,67.5%of patients(454/673)had≤1 organ dysfunction and two patients(0.4%)were pre-ACLF,with a miss rate of 4.3%(missed/total,2/46).In the validation cohort,65.9%of patients(914/1388)had≤1 organ dysfunction,and four(0.3%)of them were pre-ACLF,with a miss rate of 3.4%(missed/total,4/117).Conclusions:AD patients with≤1 organ dysfunction had a significantly lower risk of developing ACLF within 28 days of admission and could be safely ruled out with a pre-ACLF miss rate of<5%. | Xiaoting Tang Hai Li Guohong Deng Xin Zheng Xianbo Wang Yan Huang Yanhang Gao Zhongji Meng Zhiping Qian Feng Liu Xiaobo Lu Yu Shi Beiling Li Wenyi Gu Xiaomei Xiang Yan Xiong Yixin Hou Jun Chen Na Gao Sen Luo Liujuan Ji Jing Li Rongjiong Zheng Haotang Ren Jinjun Chen | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 19 | A two-dimensional model for the quantitative simulation of the dendritic growth with cellular automaton method显示文摘 | Sen Luo Miao Yong Zhu | 2013 | Computational Materials Science2013，，： | 1 |
| 20 | State feedback sliding-mode control of a class of uncertain time-delay systems显示文摘 | Luo N de la Sen M | 1993 | IEE Proc:Control Theory and Applications1993，140，： | 1 |
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