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| 1 | Epithelial-to-mesenchymal transition in cancer: complexity and opportunities显示文摘 | Yun Zhang Robert A. Weinberg | 2018 | Frontiers of Medicine2018，12，4： | 86 |
| 2 | Hallmarks of Cancer: The Next Generation显示文摘 | Douglas Hanahan Robert A. Weinberg | 2011 | Cell2011，，5： | 48 |
| 3 | The basics of epithelial-mesenchymal transition显示文摘 | Kalluri Raghu Weinberg Robert A | 2009 | Journal of Clinical Investigation2009，，6： | 17 |
| 4 | Pharmacokinetics and pharmacodynamics of lignocaine: A review显示文摘Lignocaine is an essential drug on World Health Organisation essential drug list, considered efficacious, safe and cost-effective for any health-care system. Despite its ubiquitous use in medicine and surgery, there are few detailed reviews of its pharmacokinetics and pharmacodynamics. Being an amide-type local anesthetic and Class 1b antiarrhythmic, lignocaine is most frequently used clinically for its anesthetic and antiarrhythmic benefits. However, lignocaine has important antinociceptive, immuno-modulating, and antiinflammatory properties. Information pertaining to the pharmacokinetics and pharmacodynamics of lignocaine was examined by performing a literature search of Pub Med, Embase and MEDLINE(via Ovid), pharmacology textbooks and online sources. We present a focused synopsis of lignocaine's pharmacological composition, indications for use and mechanisms of action, focusing on its anti-inflammatory, immuno-modulating and analgesia effects. In addition we review the dosing regimes and infusion kinetics of lignocaine in the clinical setting. Finally, we review the evidence for ligocaine's modulation of the inflammatory response during major surgery and its specific effects on cancer recurrence. These indirect effects of local anesthetics in tumor development may stem from the reduction of neuroendocrine responses to the stress response elicited by major surgery and tissue damage, enhanced preservation of immune-competence, in addition to opioid-sparing effects of modulating tumor growth. | Laurence Weinberg Benjamin Peake Chong Tan Mehrdad Nikfarjam | 2015 | World Journal of Anesthesiology2015，4，2： | 9 |
| 5 | The Hallmarks of Cancer显示文摘 | Douglas Hanahan Robert A Weinberg | 2000 | Cell2000，，1： | 7 |
| 6 | The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells显示文摘 | Sendurai A. Mani Wenjun Guo Mai-Jing Liao Elinor Ng. Eaton Ayyakkannu Ayyanan Alicia Y. Zhou Mary Brooks Ferenc Reinhard Cheng Cheng Zhang Michail Shipitsin Lauren L. Campbell Kornelia Polyak Cathrin Brisken Jing Yang Robert A. Weinberg | 2008 | Cell2008，，4： | 7 |
| 7 | Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis显示文摘 | Jing Yang Robert A. Weinberg | 2008 | Developmental Cell2008，，6： | 5 |
| 8 | Perioperative fluid management in major hepatic resection: an integrative review显示文摘BACKGROUND: Fluid intervention and vasoactive pharmacological support during hepatic resection depend on the preference of the attending clinician, institutional resources, and practice culture. Evidence-based recommendations to guide perioperative fluid management are currently limited. Therefore, we provide a contemporary clinical integrative overview of the fundamental principles underpinning fluid intervention and hemodynamic optimization for adult patients undergoing major hepatic resection. DATA SOURCES: A literature review was performed of MEDLINE, EMBASE and the Cochrane Central Registry of Controlled Trials using the terms 'surgery', 'anesthesia', 'starch', 'hydroxyethyl starch derivatives', 'albumin', 'gelatin', 'liver resection', 'hepatic resection', 'fluids', 'fluid therapy', 'crystalloid', 'colloid', 'saline', 'plasma-Lyte', 'plasmalyte', 'hartmann's', 'acetate', and 'lactate'. Search results for MEDLINE and EMBASE were additionally limited to studies on human populations that included adult age groups and publications in English. RESULTS: A total of 113 articles were included after appropriate inclusion criteria screening. Perioperative fluid management as it relates to various anesthetic and surgical techniques is discussed.CONCLUSIONS: Clinicians should have a fundamental understanding of the surgical phases of the resection, hemodynamic goals, and anesthesia challenges in attempts to individualize therapy to the patient's underlying pathophysiological condition. Therefore, an ideal approach for perioperative fluid therapy is always individualized. Planning and designing large-scale clinical trials are imperative to define the optimal type and amount of fluid for patients undergoing major hepatic resection. Further clinical trials evaluating different intraoperative goal-directed strategies are also eagerly awaited. | Osamu Yoshino Marcos Vinicius Perini Christopher Christophi Laurence Weinberg | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，5： | 5 |
| 9 | 下颌骨髁突骨折伴关节软组织损伤及其对口腔功能的影响显示文摘大多数关于下颌骨髁突骨折治疗优化的研究首先关注骨性方面,然而,下颌骨髁突骨折可能与颞下颌关节软组织损伤一起发生。本研究进行了关于该主题的文献检索,使用观察性队列和横断面研究的质量评估工具进行评估。回顾16篇文献显示,囊内骨折和脱位的髁突骨折导致更严重的损伤。 | Weinberg FM Speksnijder CM Forouzanfar T 赵泽亮 | 2019 | 中国口腔颌面外科杂志2019，17，2： | 5 |
| 10 | 四板沟水电站清洁发展机制额外性原理及CO2减排量的计算方法显示文摘清洁发展机制(CDM)是建立在《京都议定书》基础上的一种国际合作机制。水电是可再生能源,是符合要求的CDM项目,本文以四板沟水电站为例,按照联合国清洁发展机制的要求对其可行性进行了研究,探讨和分析了小水电额外性的论证原理、基准线的建立以及CO2减排量的计算方法。指出按照联合国清洁发展机制的标准,四板沟水电站具有明确的额外性,是符合清洁发展机制要求的项目,建立了四板沟水电站的基准线并计算了其每年CO2的减排量。 | 马智杰 Edward Weinberg | 2008 | 中国水利水电科学研究院学报2008，6，2： | 5 |
| 11 | Plasma-Lyte 148: A clinical review显示文摘AIM To outline the physiochemical properties and specific clinical uses of Plasma-Lyte 148 as choice of solution for fluid intervention in critical illness, surgery and perioperative medicine.METHODS We performed an electronic literature search from Medline and Pub Med(via Ovid), anesthesia and pharmacology textbooks, and online sources including studies that compared Plasma-Lyte 148 to other crystalloid solutions. The following keywords were used: 'surgery', 'anaesthesia', 'anesthesia', 'anesthesiology', 'anaesthesiology', 'fluids', 'fluid therapy', 'crystalloid', 'saline', 'plasma-Lyte', 'plasmalyte', 'hartmann's', 'ringers' 'acetate', 'gluconate', 'malate', 'lactate'. All relevant articles were accessed in full. We summarized the data and reported the data in tables and text. RESULTS We retrieved 104 articles relevant to the choice of Plasma-Lyte 148 for fluid intervention in critical illness, surgery and perioperative medicine. We analyzed the data and reported the results in tables and text.CONCLUSION Plasma-Lyte 148 is an isotonic, buffered intravenous crystalloid solution with a physiochemical composition that closely reflects human plasma. Emerging data supports the use of buffered crystalloid solutions in preference to saline in improving physicochemical outcomes. Further large randomized controlled trials assessing the comparative effectiveness of PlasmaLyte 148 and other crystalloid solutions in measuring clinically important outcomes such as morbidity and mortality are needed. | Laurence Weinberg Neil Collins Kiara Van Mourik Chong Tan Rinaldo Bellomo | 2016 | World Journal of Critical Care Medicine2016，5，4： | 5 |
| 12 | OX40 (CD134) engagement drives differentiation of CD4+T cells to effector cells显示文摘 | Huddleston CA Weinberg AD Parker DC | 2006 | Eur J Immunol2006，36，5： | 4 |
| 13 | Hallmarks of Cancer: The Next Generation显示文摘 | Douglas Hanahan Robert A. Weinberg | 2011 | Cell2011，，5： | 4 |
| 14 | Tumor Metastasis: Molecular Insights and Evolving Paradigms显示文摘 | Scott Valastyan Robert A. Weinberg | 2011 | Cell2011，，2： | 4 |
| 15 | 选择冲洗法在碳纳米管内部填充金属粒子显示文摘报道一种直接合成纳米碳管衍生材料的方法。利用纳米碳管的表面张力和毛细管作用,经过注入和选择冲洗法的两步法,制备填充铁、钴和镍的纳米碳管。通过选择合适的注入和洗脱溶液,金属粒子只会填充在纳米管内部。使用扫描电镜和扫描透射电镜研究证实金属粒子仅存在于纳米碳管内部。 | 傅强 Gisela Weinberg 苏党生 | 2008 | 新型炭材料2008，23，1： | 4 |
| 16 | Hallmarks of Cancer:The Next Generation显示文摘 | Hanahan D Weinberg RA | | 0，，05： | 3 |
| 17 | Raman Spectroscopic Study of Silicon Nanopowders显示文摘Vibrational properties of silicon nanopowders are discussed with reference to Raman spectroscopic measurements. The powders were produced in a low pressure rf plasma from the cluster induced agglomeration of positive ions formed during the dissociation of silane. Influence of thermal treatment and the crystallization phenomena of the powder were studied. Raman spectroscopic measurements reveal size quantization effects for the particles as well as the existence of partially ordered regions in the apparently amorphous primary particles. The crystalline and amorphous volume fraction in the material were calculated from the relative spectraI intensities. The results obtained in these experiments are consistent with the observations from recent high resolution transmission electron microscopy studies of these | S.M.Scholz J.Dutta and H.Hofmann(Lab. de Technologie des Poudres, Departement de Materiaux, Ecole Polytechnique Federale de Lausanne,1015 Lausanne, Switzerland)H.Hofmeister (Max-Planck-Institut fur Mikrostrukturphysik, Weinberg 2, D-06120 Halle, Germany) | 1997 | Journal of Materials Science & Technology1997，13，4： | 3 |
| 18 | Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion显示文摘 | Akira Orimo Piyush B. Gupta Dennis C. Sgroi Fernando Arenzana-Seisdedos Thierry Delaunay Rizwan Naeem Vincent J. Carey Andrea L. Richardson Robert A. Weinberg | 2005 | Cell2005，，3： | 3 |
| 19 | Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis显示文摘 | Jing Yang Sendurai A Mani Joana Liu Donaher Sridhar Ramaswamy Raphael A Itzykson Christophe Come Pierre Savagner Inna Gitelman Andrea Richardson Robert A Weinberg | 2004 | Cell2004，，7： | 3 |
| 20 | Mechanisms of cell death in hypoxia/reoxygenation injury显示文摘 | Saikumar P Dong Z Weinberg JM | | 0，，： | 2 |
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