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| 1 | AJCN:过敏症来袭怎么办?新型益生菌组合疗法显神效显示文摘当进入过敏季节我们可能并不太会拿出手帕或者打喷嚏来预防过敏。日前,一项刊登在国际杂志The American Journal of Clinical Nutrition上的研究报告中。来自佛罗里达大学的研究人员通过研究发现。一种益生菌组合或许能够帮助减轻花粉症的症状。 | Jennifer C Dennis-Wall Tyler Culpepper Carmelo Nieves Jr. Cassie C Rowe Alyssa M Burns Carley T Rusch Ashton Federico Maria Ukhanova Sheldon Waugh Volker Mai Mary C Christman Bobbi Langkamp-Henken | 2017 | 现代生物医学进展2017，17，18： | 3 |
| 2 | Use of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophages显示文摘Tuberculosis is one of the leading infectious diseases plaguing mankind and is mediated by the facultative pathogen, Mycobacterium tuberculosis(MTB). Once the pathogen enters the body, it subverts the host immune defenses and thrives for extended periods of time within the host macrophages in the lung granulomas, a condition called latent tuberculosis(LTB). Persons with LTB are prone to reactivation of the disease when the body's immunity is compromised. Currently there are no reliable and effective diagnosis and treatment options for LTB, which necessitates new research in this area. The mycobacterial proteins and genes mediating the adaptive responses inside the macrophage is largely yet to be determined. Recently, it has been shown that the mce operon genes are critical for host cell invasion by the mycobacterium and for establishing a persistent infection in both in vitro and in mouse models of tuberculosis. The Yrb E and Mce proteins which are encoded by the MTB mce operons display high degrees of homology to the permeases and the surface binding protein of the ABC transports, respectively. Similarities in structure and cell surface location impute a role in cell invasion at cholesterol rich regions and immunomodulation. The mce4 operon is also thought to encode a cholesterol transport system that enables the mycobacterium to derive both energy and carbon from the host membrane lipids and possibly generating virulence mediating metabolites, thus enabling the bacteria in its long term survival within the granuloma. Various deletion mutation studies involving individual or whole mce operon genes have shown to be conferring varying degrees of attenuation of infectivity or at times hypervirulence to the host MTB, with the deletion of mce4 A operon gene conferring the greatest degree of attenuation of virulence. Antisense technology using synthetic si RNAs has been used in knocking down genes in bacteria and over the years this has evolvedinto a powerful tool for elucidating the roles of various genes mediating infectivity and survival in mycobacteria. Molecular beacons are a newer class of antisense RNA tagged with a fluorophore/quencher pair and their use for in vivo detection and knockdown of mR NA is rapidly gaining popularity. | Remo George Renata Cavalcante Celso Carvalho Jr Elyana Marques Jonathan B Waugh M Tino Unlap | 2015 | World Journal of Experimental Medicine2015，5，3： | 2 |
| 3 | Computational and experimental character- ization of physically clustered simple sequence repeats in plants显示文摘 | CARDLE L RAMSAY L MILBOURNE D MACAULAY M MARSHALL D WAUGH R | 2000 | Genetics2000，156，： | 1 |
| 4 | Differentialeffects of short affinity tags on the crystallization of Pyro-coccus furiosus maltodextrin-binding protein显示文摘 | Bucher M H Evdokimov A G Waugh D S | 2002 | ActaCrystallogr Biol Crystallogr2002，58，3： | 1 |
| 5 | Calibration Precision of Capacitance and Neutron Soil Water Content Gauges in Arid Soils显示文摘 | WAUGH W J BAKER D A KASTENS M K | 1996 | Arid Soil Research and Rehabilitation1996，10，： | 1 |
| 6 | Incidental gallblad- der cancer:Analysis of surgical findings and survivor显示文摘 | Butte JM Waugh E Meneses M | 2010 | J Surg 0ncol2010，102，6： | 1 |
| 7 | Incidental gallbladder cancer: Analysis of surgical findings and survivor 显示文摘 | Butte JM Waugh E Meneses M | 2010 | J Surg Oncol2010，102，6： | 1 |
| 8 | Approach to high-resolution NMR in solids显示文摘 | Waugh J S Huber L M Haeberlen U | 1968 | Phys Rev Lett1968，20，： | 1 |
| 9 | Computational and experimental characterization of physically clustered simple sequence repeats in plants显示文摘 | CARDLE L RAMSAY L MILBOURME D MACAULAY M MARSHALL D WAUGH R | 2000 | Genetics2000，156，2： | 1 |
| 10 | Plant cover and water balance in gravel admixtures at an arid waste burial site 显示文摘 | Waugh W J Thiede M E Bates D J | 1994 | Journal of Environmental Quality1994，23，4： | 1 |
| 11 | Vascular endothelial growth factor enhances atherosclerotic plaque P-rogression显示文摘 | Celletti FL Waugh J M Amabile PG | 2001 | Nat Med2001，7，4： | 1 |
| 12 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 13 | On the role of Cs, Cl and subsurface O in promoting selectivity in Ag/a- Al2O3 catalysed oxidation of ethene to ethene epoxide显示文摘 | Atkins M Couves J Waugh K C | 2005 | J Catal2005，235，1： | 1 |
| 14 | Gene therapy to promote thromboresistance:local overexpression of tissue plasminogen activator to prevent arteriaal thrombosis in an in vivo rabbit model显示文摘 | Waugh JM Kattash M Li J | | 0，，： | 1 |
| 15 | Distribution and molecular forms of urotensin Ⅱ and its role in cardiovascular regulation in vertebrates显示文摘 | Conlon J M Yano K Waugh D | 1996 | J Exp Zool1996，275，23： | 1 |
| 16 | What good are pos-itive emotions in crises? A prospective study of resilience and emotions following the terrorist attacks on the United States on September 11 th, 2001 显示文摘 | Fredrickson B L Tugade M M Waugh C E | 2003 | J Pers Soc Psychol2003，84，2： | 1 |
| 17 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 18 | Functional outcomes of intramuscular Botulinum toxin type A and occupational thera- py in the upper limbs of children with cerebral palsy: a random- ized controlled trial 显示文摘 | Wallen M O'flaherty S J Waugh MC | 2007 | Arch Phys Med Rehabil2007，88，1： | 1 |
| 19 | Chloro-plast DNA diversisty in the genusRubus(Rosaceae)re-vealed by southern hybridization显示文摘 | Waugh R Van de Ven W T G Phillips M S | 1990 | Plant System Evol1990，172，： | 1 |
| 20 | Resection of the duodenum and head of the pancreas for carcinoma:an analysis of thirty cases显示文摘 | Waugh J M Clagett O T | | 0，，： | 1 |
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