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| 1 | Object-oriented protocol hierarchies for distributed workflow systems显示文摘 | Lockemann P C Walter H D | 1995 | Theory and Practice of Object Systems1995，1，4： | 2 |
| 2 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 3 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 4 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 5 | Microembolic signals and intraoperative stroke in carotid endarterectomy显示文摘 | Muller M Behnke S Walter P | 1998 | Acta Neurol Scand1998，97，2： | 2 |
| 6 | In situ fixation of metals in soils using bauxite residue: chemical assessment显示文摘 | Enzo Lombi Fang-Jie Zhao Gangya Zhang Bo Sun Walter Fitz Hao Zhang Steve P McGrath | 2002 | Environmental Pollution2002，，3： | 2 |
| 7 | IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality显示文摘 | Zhang Hong Neuh?fer Patrick Song Liang Rabe Bj?rn Lesina Marina Kurkowski Magdalena U Treiber Matthias Wartmann Thomas Regnér Sara Thorlacius Henrik Saur Dieter Weirich Gregor Yoshimura Akihiko Halangk Walter Mizgerd Joseph P Schmid Roland | 2013 | Journal of Clinical Investigation2013，，3： | 2 |
| 8 | Therapy for ankylosing spondylitis: new treatment modalities显示文摘 | Braun J Brehan Maxime Maksymowych P Walter | 2002 | Best Practice & Research Clinical Rheumatology2002，16，： | 2 |
| 9 | 老年高血压患者服用别嘌呤醇后血压的变化显示文摘尿酸可降低青少年血压,表明其在高血压发生发展的病理生理过程中可能起到直接的作用。但是其在老年人高血压中是否扮演同样的角色尚不清楚。该研究通过分析英国临床实践研究数据库的资料,以确定服用别嘌呤醇后血压的改变。方法:纳入〉65岁的使用别嘌呤醇治疗、且有治疗前和治疗时血压读数记录的高血压患者。同时纳入具有可比性的人群作为对照。 | 刘莉 叶鹏 Beattie CJ Fulton RL Higgins P Padmanabhan S McCallum L Walters MR Dominiczak AF Touyz RM Dawson J | 2014 | 中华高血压杂志2014，22，10： | 2 |
| 10 | Relation-ship of leaf dark respiration to leaf-nitrogen specific leaf area andleaf life span:a test across biomes and functional groups显示文摘 | REICH P B WALTERS M B ELLSWORTH D S | 1998 | Oecologia1998，114，： | 1 |
| 11 | Seismic behavior of composite RCS frame systems显示文摘 | Miehael N Bugeja Joseph M Bracci Walter P MooreJr | 2000 | Joumal of Structural Engineering2000，126，4： | 1 |
| 12 | The signal recognition particle in Saccharomyces cerevisiae显示文摘 | Hann BC Walter P | 1991 | Cell1991，67，： | 1 |
| 13 | ER-phagy: selective autophagy of the endoplasmic reticulum显示文摘 | Bemales S Sehuek S Walter P | 2007 | Autophagy2007，3，： | 1 |
| 14 | Unfolded proteins are Irel-aetivating ligands that directly induce the unfolded protein response 显示文摘 | Gardner BM Walter P | 2011 | Science2011，333，6051： | 1 |
| 15 | Structural and func- tional insights of RANKL-RANK interaction and signa- ling显示文摘 | Liu CZ Walter TS Huang P | 2010 | J Immunol2010，184，12： | 1 |
| 16 | Secretion of brain natriuretic peptide in patients with aneurysmal subarachnoid haemorrhage显示文摘 | Berendes E Walter M Cullen P | 1997 | Lancet1997，349，9047： | 1 |
| 17 | Workflow optimization through task redesign in business information processes显示文摘 | DEWAN R SEIDMANN A WALTER Z P | 1998 | Collaboration Systems and Technology Track1998，1，1： | 1 |
| 18 | Signal sequences specify the targeting routeto the endoplasmic reticulum membrane显示文摘 | Davis TW Brown JD Walter P | 1996 | J Cell Biol1996，134，： | 1 |
| 19 | Kinetics of oil saponification by lead salts in ancient preparations of pharmaceutical lead plasters and painting lead mediums 显示文摘 | Cotte M Checroun E Susini J Dumasc P Tchoreloffd P Besnardd M Walter Ph | 2006 | Talanta2006，70，5： | 1 |
| 20 | Metal nanowire arrays by electrodeposition显示文摘 | Erich C Walter Michael P Zach Benjamin J Murray | 2003 | Chemphychem2003，，4： | 1 |
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