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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features显示文摘 | Walter F Stewart Joshua N Liberman Robert S Sandler Michael S Woods Annette Stemhagen Elsbeth Chee Richard B Lipton Christina E Farup | 1999 | The American Journal of Gastroenterology1999，，12： | 2 |
| 3 | Acute surgical emergencies in inflammatory bowel disease显示文摘 | Dale F Berg Anil M Bahadursingh Donald L Kaminski Walter E Longo | 2002 | The American Journal of Surgery2002，，： | 2 |
| 4 | Electron microscope study of the structure of cold rolled and annealed (100) crystals of high-purity silicon-iron显示文摘 | Walter J L Koch E F | 1962 | Acta Metallurgica1962，10，11： | 1 |
| 5 | Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels显示文摘 | Walter E | 2001 | Radiology2001，219，1： | 1 |
| 6 | Estimating Basin-wide Hydraulic Parameters of a Semi-arid Mountainous Watershed by Recessionflow Analysis显示文摘 | Mendoza G F Steenhuis T S Walter M T | 2003 | Journal of Hydrology2003，279，： | 1 |
| 7 | The cellulolytic system of Streptomyces reticuli显示文摘 | Schremp f H Walter S | 1995 | Biol Macromol1995，17，： | 1 |
| 8 | (18)F-FDG PET/CT for mon- itoring treatment responses to the epidermal growth factor receptor in- hibitor erlotinib 显示文摘 | Benz MR Herrmann K Walter F | 2011 | Nucl Med2011，52，11： | 1 |
| 9 | Pareto ant colonyoptimization:A metaheuristic approach to multiobjectiveportfolio selection 显示文摘 | Karl D Walter J Richard F | 2004 | Annals of Operations Research2004，131，1234： | 1 |
| 10 | Crea- tive performance under pressure an integrative concep- tual framework显示文摘 | Gutnick D Walter F De Dreu C K W | 2012 | Organizational Psychology Review2012，2，3： | 1 |
| 11 | Making Euler deconvolution applicable to small ground magnetic surveys显示文摘 | Valéria C F Barbosa Joao B C Silva Walter E Medeiros | 2000 | Journal of Applied Geophysics2000，43，1： | 1 |
| 12 | Numerical study of detonation stabilization by finite length wedges显示文摘 | WALTER M A T FIGUEIRA L F | 2006 | A1AA Journal2006，44，2： | 1 |
| 13 | A model of a trust-based recommendation system on a social network 显示文摘 | WALTER F E BA33'ISTION S SCHWEITZER F | 2006 | Autonomous Agents and Multi-agents Systems2006，16，1： | 1 |
| 14 | Value of arteriography scanning in lower limb artery evaluation:a preliminary study显示文摘 | Walter F Leyder B Fays J | 2001 | J Radiol2001，82，4： | 1 |
| 15 | Combination of bacterial vaginosis and leukorrhea as a predictor of cervical chlamydial or gonococcal infection 显示文摘 | Lauren S Jeffrey F P Walter H | 2002 | Obstet Gynecol2002，99，4： | 1 |
| 16 | Familial segregation of hemangiomas and vascular malformations as an autosomal dominant trait显示文摘 | Blei F Walter J Orlow SJ | | 0，，06： | 1 |
| 17 | Incidence of and preoperative predictors for delirium after cardiac surgery显示文摘 | Rose C van der Mast Walter W van den Broek Durk Fekkes Lolke Pepplinkhuizen J.Dik F Habbema | 1999 | Journal of Psychosomatic Research1999，，5： | 1 |
| 18 | Analysis of an Orthotropic Deck Stiffened with a Cement-based Overlay 显示文摘 | WALTER R OLESEN J F STANG H | 2007 | Journal of Bridge Engineering2007，12，3： | 1 |
| 19 | Perspectives on fuel ethanol consumption and trade 显示文摘 | Walter A Rosillo Calle F Dolzan P | 2008 | Biomass and Bioenergy2008，32，8： | 1 |
| 20 | Hydrolofically sensitive areas:variable source area hydrology implications for water quality risk assessment显示文摘 | Walter M T Walter M F Brooks E S | 2000 | J Soil and Water Conservation2000，55，3： | 1 |
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