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| 1 | 未经治疗脑动静脉畸形患者出血的预测因素显示文摘Background: Intracranial hemorrhage is a serious possible complication in patients with brain arteriovenous malformation (AVM). Several morphologic factors associated with hemorrhagic AVM presentation have been established, but their relevance for the risk of subsequent AVM hemorrhage remains unclear. Methods: The authors analyzed follow-up data on 622 consecutive patients from the prospective Columbia AVM database, limited to the period between initial AVM diagnosis and the start of treatment (i.e., any endovascular, surgical, or radiation therapy). Univariate and multivariate logistic regression and Cox proportional hazard models were applied to analyze the effect of patient age, gender, AVM size, anatomic location, venous drainage pattern, and associated arterial aneurysms on the risk of intracranial hemorrhage at initial presentation and during follow-up. Results: The mean pretreatment follow-up was 829 days (median: 102 days), during which 39 (6%) patients experienced AVM hemorrhage. Increasing age (hazard ratio [HR] 1.05, 95%CI 1.03 to 1.08), initial hemorrhagic AVM presentation (HR 5.38, 95%CI 2.64 to 10.96), deep brain location (HR 3.25, 95%CI 1.30 to 8.16), and exclusive deep venous drainage (HR 3.25, 95%CI 1.01 to 5.67) were independent predictors of subsequent hemorrhage. Annual hemorrhage rates on follow-up ranged from 0.9%for patients without hemorrhagic AVM presentation, deep AVM location, or deep venous drainage to as high as 34.4%for those harboring all three risk factors. Conclusions: Hemorrhagic arteriovenous malformation (AVM) presentation, increasing age, deep brain location, and exclusive deep venous drainage appear to be independent predictors for AVM hemorrhage during natural history follow-up. The risk of spontaneous hemorrhage may be low in AVMs without these risk factors. | Stapf C. Mast H. Sciacca R. R. 邱伟庆(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 8 |
| 2 | Improvement of pristinamycin I(PI)production in Streptomyces pristinaespiralis by metabolic engineering approaches显示文摘Pristinamycin,produced by Streptomyces pristinaespiralis,which is a streptogramin-like antibiotic consisting of two chemically unrelated components:pristinamycin I(PI)and pristinamycin II(PII),shows potent activity against many antibiotic-resistant pathogens.However,so far pristinamycin production titers are still quite low,particularly those of PI.In this study,we constructed a PI single component producing strain by deleting the PII biosynthetic genes(snaE1 and snaE2).Then,two metabolic engineering approaches,including deletion of the repressor gene papR3 and chromosomal integration of an extra copy of the PI biosynthetic gene cluster(BGC),were employed to improve PI production.The final engineered strain DPIIDpapR3/PI produced a maximum PI level of 132 mg/L,with an approximately 2.4-fold higher than that of the parental strain S.pristinaespiralis HCCB10218.Considering that the PI biosynthetic genes are clustered in two main regions in the 210 kb“supercluster”containing the PI and PII biosynthetic genes as well as a cryptic polyketide BGC,these two regions were cloned separately and then were successfully assembled into the PI BGC by the transformation-associated recombination(TAR)system.Collectively,the metabolic engineering approaches employed is very efficient for strain improvement in order to enhance PI titer. | Jiali Meng Rongrong Feng Guosong Zheng Mei Ge Yvonne Mast Wolfgang Wohlleben Jufang Gao Weihong Jiang Yinhua Lu | 2017 | Synthetic and Systems Biotechnology2017，2，2： | 7 |
| 3 | Nelson segmented mirror control system hardware for CELT显示文摘 | MAST T S | 2000 | SPIE2000，4003，： | 2 |
| 4 | Donor-specific T-cell reactivity identifies kindey transplant patients in whom immunosuppressive therapy can be safely reduced 显示文摘 | van Besouw NM van der Mast BJ de Kuiper P | 2000 | Transplantation2000，70，1： | 1 |
| 5 | Metabolism,disposition and excretion of melamine in male Fischer 344 rats 显示文摘 | Mast R W Jeffcoat A R Sadler B M | 1983 | Food Chem Toxicol1983，21，6： | 1 |
| 6 | Risk of spontaneous hemorrhage after diagnosis of cerebral arteriovenous malformation显示文摘 | Mast H Young WL Koennecke HC | 1997 | Lancet1997，350，9084： | 1 |
| 7 | Hepatitis C virus infection as an opportunistic disease in persons infected with human immunodeficiency显示文摘 | Sulkowski MS Mast EE Seeff LB | 2000 | Virus Clin Infect Dis2000，30，： | 1 |
| 8 | Flexural strength design of concrete beams reinforced with high-strength steel bars 显示文摘 | Mast R F Dawood M Rizkalla S H | 2008 | ACI Structural Journal2008，105，5： | 1 |
| 9 | Metabolism, dis position and excretion of melamine in male Fischer 344 rats显示文摘 | Mast R W Jeffcoat A R Sadler B M etal | 1983 | FoodChemToxicol1983，21，6： | 1 |
| 10 | Development of immunocompetence of broiler chickens显示文摘 | Mast J Goddeeris B M | 1999 | Veterinary Immunology and Immunopa-thology1999，70，3： | 1 |
| 11 | Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments显示文摘 | ZHENG W MAST N SAADANE A | 2015 | J Lipid Res2015，56，1： | 1 |
| 12 | Carbon gas exchange at a southern Rocky Mountain wetland, 1996-1998显示文摘 | WICKLAND K P STRIEGL R G MAST A | 2001 | Global Biogeochemical Cycles2001，15，2： | 1 |
| 13 | Characterization of strain-induced damage in composites based on the dissipated energy density part I:Basic scheme and formulation显示文摘 | Mast P W Nash G E Michopoulos J G | 1995 | Theoretical and Applied Fracture Mechanics1995，22，： | 1 |
| 14 | The nasolabial flap revisited as an adjunct to floor of mouth reconstruction显示文摘 | Napolitano M Mast B A | 2001 | Ann Plast Surg2001，46，3： | 1 |
| 15 | Metabolism, disposition and excretion of melamine in male Fischer 344 rats显示文摘 | Mast RW Jeffcoat AR Sadler BM | 1983 | Food Chem Toxieol1983，21，6： | 1 |
| 16 | Delayed reconstruction of acetabular fractures 21-120 days following injury 显示文摘 | Johnson EE Matta JM Mast JW | 1994 | Clin Orthop1994，305，1： | 1 |
| 17 | Gender related association between β2 fibrinogen genotype and plasma fibrinogen levels and linkage disequilibrium at the fibrinogen locus in greenland inuit显示文摘 | de Mast MPM de Knijff P Green FR | 1995 | Arterioscler Thromb Vase Biol1995，15，： | 1 |
| 18 | Metabolism, disposition and excretion of melamine in male Fischer 344 rats显示文摘 | Mast R W Jeffcoat A R Sadler B M | 1983 | Food Chem Toxicol1983，21，6： | 1 |
| 19 | Evidence for a selective migration of fetus-specific CD4 + CD25 bright regulatory T cells from the peripheral blood to the decidua in human pregnancy显示文摘 | Tilburgs T Roelen DL van der Mast BJ | | 0，，08： | 1 |
| 20 | Development of a polyclonal antibody-based sandwich enzyme-linked immunosorbent assay for the detection of spores of Alicyclobacillus acidoterrestris in various fruit juices 显示文摘 | MAST S DIETRICH R DIDIER A | 2016 | Journal of Agricultural and Food Chemistry2016，64，2： | 1 |
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