|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 中国南海蜂海绵Haliclona cymae formis的化学成分研究显示文摘目的研究中国南海蜂海绵属Haliclona cymaeformis的化学成分。方法运用正相硅胶、反相硅胶(ODS)和凝胶(Sephadex LH-20)等多种柱色谱手段对化合物进行分离纯化;通过理化性质和波谱数据,结合文献对照,鉴定化合物的结构。结果从海绵H.cymaeformis的乙醇提取物中共分离鉴定了11个单体化合物:24-亚甲基胆甾醇(1),5α,8β-epidioxy-cholesta-6-en-3-ol(2),cholesta-7-en-3β,5α,6β,9α-tetraol(3),胆甾醇(4),3-吲哚甲酸(5),尿嘧啶(6),胸腺嘧啶(7),尿嘧啶核苷(8),胸腺嘧啶核苷(9),尿嘧啶脱氧核苷(10)和胸腺嘧啶脱氧核苷(11)。结论化合物1~11均为首次从该海绵中分离得到。细胞毒活性测试结果表明,化合物3对慢性髓原白血病细胞(K562)和人肝癌细胞(SMMC-7721)的增殖显示了较强的生长抑制活性。 | 吴旭东 梅文莉 邵长伦 Nicole J.de Voogd 王辉 王长云 戴好富 | 2011 | 中国海洋药物2011，30，5： | 17 |
| 2 | Four new polyhydroxylated steroids from the South Sea sponge Plakortis sp.显示文摘Four new polyhydroxylated steroids plaksterols A–D(1–4), together with two known related steroids ergost-7,9(11),22-trien-3β,5α,6α-triol(5) and ergosta-6β-methoxy-7,22-diene-3β,5α-diol(6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were identified by spectroscopic analysis, including NMR, MS, and IR. The cytotoxicity of the polyhydroxylated steroids were evaluated, and compound 6 showed moderate inhibitory activities against K562, HL-60 and BEL-7402 cells. | WANG Kun-Ya LI Ping-Lin SUN Jing-Fan de Voogd Nicole J TANG Xu-Li LI Guo-Qiang | 2020 | Chinese Journal of Natural Medicines2020，18，11： | 3 |
| 3 | 一种中国南海海绵Xestospongia testudinaria中化学成分的研究显示文摘综合运用正相和反相硅胶柱层析、Sephadex LH-20凝胶柱层析以及制备HPLC等分离方法,从1种中国南海海绵Xestospongia testudinaria中追踪分离抗肿瘤活性次级代谢产物。从95%乙醇提取物中分离获得8个单体化合物,通过NMR,MS等波谱技术鉴定其结构分别为:E-18,18-二溴-9,17-二烯-5,7-二炔硬脂酸甲酯(1),E-18,18-二溴-9,17-二烯-5,7-二炔硬脂酸乙酯(2),麦角甾-5,7,22-三烯-3-醇(3),麦角甾-4,6,8(14),22-四烯-3-酮(4),胆甾-4-烯-3-酮(5),3-吲哚醛(6),3-吲哚酸(7)和5-吲哚醛(8)。其中,化合物2-5和8为首次从该属海绵中分离得到。化合物1对肿瘤细胞株HCT116和A549显示较强的抑制活性。 | 孔雯雯 韩磊 李亮 邵长伦 章蓉 Nicole J.de Voogd 王长云 | 2011 | 中国海洋大学学报(自然科学版)2011，41，11： | 3 |
| 4 | Two new diterpene alkaloids from the South China Sea Sponge Agelas aff. nemoechinata显示文摘Two new N-methyladenine-containing diterpenes,nemoechines F(l)and G(2),were isolated from the South China Sea sponge Agelas aff.nemoechinata.The structures were assigned on the basis of spectroscopic date.Compound 2 showed weak activity against Jurkat cell lines with IC_(50) of 17.1 | Tao Li Bin Wang Nicole J.de Voogd Xu-Li Tang Qi Wang Mei-Jun Chu Ping-Lin Li Guo-Qiang Li | 2016 | Chinese Chemical Letters2016，27，7： | 2 |
| 5 | Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy:European organization for research and treatment of cancer 10801 trial显示文摘 | van Dougen JA Voogd AC Fentiman IS | 2000 | J Natl Cancer Inst2000，92，14： | 1 |
| 6 | The continent-ocean boundary at the rifted margin off eastern Canada:new results from deep seimic reflection studies显示文摘 | Keen C E De Voogd B | 1988 | Tectonics1988，7，1： | 1 |
| 7 | Long-term results of randomized trail comoaring breast-conserving thera- py with masteetomy: european organization for research and treatment of cancer 10801 trail显示文摘 | Van Dongen JA Voogd AC Fentiman I S | 2000 | Journal of the National Cancer Institute2000，92，： | 1 |
| 8 | Thin-layer response and spectral bandwidth显示文摘 | De Voogd N den Rooijen N | 1983 | Geophysics1983，48，1： | 1 |
| 9 | Low molecular weight iron and the oxygen paradox in isolated rat hearts 显示文摘 | Voogd A Sluiter W Eijk HG | 1992 | J Clin Invest1992，90，5： | 1 |
| 10 | Malpractice claims following screening mammography in The Netherlands显示文摘 | Vivian van Breest Smallenburg Wikke Setz‐Pels Johanna H. Groenewoud Adri C. Voogd Frits H. Jansen Marieke W.J. Louwman Alexander V. Tielbeek Lucien E.M. Duijm | 2012 | Int J Cancer2012，，6： | 1 |
| 11 | Syste mic antihypertensive medication and incident open-angle glau- eoma显示文摘 | MUSKENS R P DE VOOGD S WOLFS R C | 2007 | Ophthalmology2007，114，12： | 1 |
| 12 | Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy:European Organization for Research and Treatment of Cancer 10801 trial显示文摘 | Voogd AC Fentiman IS | 2000 | J Natl Cancer Inst2000，92，14： | 1 |
| 13 | Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy:European Organization for Research and Treatment of Cancer 10801 trial显示文摘 | Van Dongen JA Voogd AC Fentiman IS | 2000 | J Natl Cancer Inst2000，92，14： | 1 |
| 14 | Advanced methods for container stacking显示文摘 | Dekker R Voogd P Asperen E | 2006 | OR Spectrum2006，28，4： | 1 |
| 15 | Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy:European Organization for Research and Treatment of Cancer 10801 trial显示文摘 | Van Dongen JA Voogd AC Fentiman IS | | 0，，14： | 1 |
| 16 | Mutagenic activity of acrylamide in eukaryotic systems but not in bacteria 显示文摘 | KNAAP A P KRANIERS C VOOGD W | 1988 | Mutagenesis1988，，3： | 1 |
| 17 | Mammographic changes resulting from benign breast surgery impair breast cancer detection at screening mammography显示文摘 | van Breest Smallenburg V Duijm L E Voogd A C | 2012 | Eur J Cancer2012，，： | 1 |
| 18 | On the control of eye saccades in reading显示文摘 | Bouma H.de Voogd A H | | 0，，14： | 1 |
| 19 | Prognosis after treatment for loco- regional recurrence after mastectomy or breast conserving therapy in two randomized trials(EORTCl0801 and DBCG-82TM)显示文摘 | Van Tienhoven G Voogd AC Peterse JL | 1999 | Eur J Cancer1999，35，2： | 1 |
| 20 | Fibrin gel-immobilized primary osteoblasts in calcium phosphate bone cement: in vivo evaluation with regard to application as injectable biological bone substitute 显示文摘 | Kneser U Voogd A Ohnolz J | 2005 | Cells Tissues Organs2005，179，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员