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| 1 | Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study显示文摘Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations. | Yihui Du Yingru Zhao Grigory Sidorenkov Geertruida H.de Bock Xiaonan Cui Yubei Huang Monique D.Dorrius Mieneke Rook Harry J.M.Groen Marjolein A.Heuvelmans Rozemarijn Vliegenthart Kexin Chen Xueqian Xie Shiyuan Liu Matthijs Oudkerk Zhaoxiang Ye | 2019 | Cancer Biology & Medicine2019，16，1： | 7 |
| 2 | 法国烟雾血管病临床实践指南显示文摘1序言
1.1制定机构
本指南在法国卫生部的组织下由法国脑部和眼部罕见血管疾病中心(reference center for rare vascular diseases of the brain and eye,CERVCO)与法国儿童卒中中心联合起草。 | D. Herve(著) M. Kossorotoff(著) D. Bresson(著) T. Blauwblomme(著) M. Carneiro(著) E. Touze(著) F. Proust(著) I. Desguerre(著) S. Alamowitch(著) J.-P. Bleton(著) A. Borsali(著) E. Brissaud F.Brunelle(著) L. Calviere(著) M. Chevignard(著) G. Geffroy-Greco(著) S. Faesch(著) M.-O. Habert(著) H.De Larocque(著) P. Meyer(著) S. Reyes L. Thines(著) E. Tournier-Lasserve(著) H.Chabriat 郝方斌(译) 张勇(译) 韩聪(译) 段炼(译) | 2018 | 国际脑血管病杂志2018，26，5： | 5 |
| 3 | Region-Specific Expression of Immunoregulatory Proteins on Microglia in the Healthy CNS显示文摘与中枢神经系统的空间结构高度一致,大部分的中枢神经系统疾病表现为区域性分布。虽然小胶质细胞已被公认在各种中枢神经系统疾病中发挥重要的作用,但是小胶质细胞是否表现为区域特异性目前还不清楚。因此,本研究目的是评估在健康成年小鼠的中枢神经系统的不同区域中小胶质细胞的不同表型。运用体外流式细胞仪分析CD11b,CD40,CD45,CD80,CD86,F4/80,TREM-2b,MHCII,CXCR3,CCR9以及CCR7的表面表达。这些免疫调节标记物大部分均存在于小胶质细胞上并且在表达水平上有明显的区域特异性差异。这些发现在很大程度上证实了在健康成年小鼠中枢神经系统的小胶质细胞中存在着免疫多样性。 | ALEXANDER H.DE HAAS HENDRIKUS W.G.M.BODDEKE KNUT BIBER | 2008 | 神经损伤与功能重建2008，3，3： | 4 |
| 4 | The Teodorescu Operator in Clifford Analysis显示文摘Euclidean Clifford analysis is a higher dimensional function theory centred around monogenic functions, i.e., null solutions to a first order vector valued rotation in-variant differential operator called the Dirac operator. More recently, Hermitian Clifford analysis has emerged as a new branch, offering yet a refinement of the Euclidean case; it focuses on the simultaneous null solutions, called Hermitian monogenic functions, to two Hermitian Dirac operators _z and _(zt) which are invariant under the action of the unitary group. In Euclidean Clifford analysis, the Teodorescu operator is the right inverse of the Dirac operator . In this paper, Teodorescu operators for the Hermitian Dirac operators _z and _(zt) are constructed. Moreover, the structure of the Euclidean and Hermitian Teodor-escu operators is revealed by analyzing the more subtle behaviour of their components. Finally, the obtained inversion relations are still refined for the differential operators is-suing from the Euclidean and Hermitian Dirac operators by splitting the Clifford algebra product into its dot and wedge parts. Their relationship with several complex variables theory is discussed. | F.BRACKX H.De SCHEPPER M.E. LUNA-ELIZARRARS M.SHAPIRO | 2012 | Chinese Annals of Mathematics,Series B2012，33，4： | 3 |
| 5 | The role of forensic anthropology in disaster victim identification(DVI):recent developments and future prospects显示文摘Forensic anthropological knowledge has been used in disaster victim identification(DVI)for over a century,but over the past decades,there have been a number of disaster events which have seen an increasing role for the forensic anthropologist.The experiences gained from some of the latest DVI operations have provided valuable lessons that have had an effect on the role and perceived value of the forensic anthropologist as part of the team managing the DVI process.This paper provides an overview of the ways in which forensic anthropologists may contribute to DVI with emphasis on how recent experiences and developments in forensic anthropology have augmented these contributions.Consequently,this paper reviews the value of forensic anthropological expertise at the disaster scene and in the mortuary,and discusses the way in which forensic anthropologists may use imaging in DVI efforts.Tissue-sampling strategies for DNA analysis,especially in the case of disasters with a large amount of fragmented remains,are also discussed.Additionally,consideration is given to the identification of survivors;the statistical basis of identification;the challenges related to some specific disaster scenarios;and education and training.Although forensic anthropologists can play a valuable role in different phases of a DVI operation,they never practice in isolation.The DVI process requires a multidisciplinary approach and,therefore,has a close collaboration with a range of forensic specialists. | Hans H.de Boer Soren Blau Tania Delabarde Lucina Hackman | 2019 | Forensic Sciences Research2019，4，4： | 3 |
| 6 | Disaster victim identification operations with fragmented,burnt,or commingled remains:experience-based recommendations显示文摘Human-made and natural disasters can result in severely fragmented,compromised,and commingled human remains.The related disaster victim identification(DVI)operations are invariably challenging,with the state of the remains potentially precluding some identifications.Practitioners involved in these DVI operations will routinely face logistical,practical,and ethical challenges.This review provides information and guidance derived from firsthand experiences to individuals tasked with managing DVI operations with fragmented human remains.We outline several key issues that should be addressed during disaster preparedness planning and at the outset of an operation,when incident-specific strategies are developed.Specific challenges during recovery and examination of fragmented remains are addressed,highlighting the importance of experienced specialists at the scene and in the mortuary.DNA sample selection and sampling techniques are reviewed,as well as downstream effects of commingling and contamination,which can complicate reconciliation and emphasise the need for rigorous quality control.We also touch on issues that may arise during communication with families.While recommendations are provided,they are not intended as proscriptive policy but rather as an addition to the general recommendations given in the International Criminal Police Organization(INTERPOL)DVI Guide,to inform preparative discussions between government officials,judiciary,police,and forensic specialists. | Hans H.de Boer Julie Roberts Tania Delabarde Amy Z.Mundorff Soren Blau | 2020 | Forensic Sciences Research2020，5，3： | 3 |
| 7 | 草甘膦制剂中非离子和阳离子型表面活性剂的影响显示文摘草甘膦制剂中表面活性剂的浓度偏高(0.1%W/V)时可能会增加植物毒性。由于还不完全认识表面活性剂对草甘膦毒性的影响,本研究试图通过两种表面活性剂对冬小麦的影响,以及用萤光法测定表面活性剂与叶面沉积物的关系,用电子显微镜观察不同浓度的表面活性剂对叶片膜质渗透与^(14)C-草甘膦的吸收关系,来解释表面活性剂的作用机理,从而能更合理地指导表面活性剂的使用。 | H.de Ruiter M.A.M.Verbeek 黄群 程隆新 | 1991 | 农药译丛1991，13，6： | 2 |
| 8 | On the control of eye saccades in reading显示文摘 | Bouma H.de Voogd A H | | 0，，14： | 1 |
| 9 | Nutritional quality of Drosophila melanogaster as factitious prey for rearing the predatory bug Orius majusculus显示文摘The predatory bug,Orius majusculus(Reuter),is an important predator of thrips commercially produced for augmentative releases using the eggs of the Mediterranea n flour moth Ephestia kuehniella(Zeller).In this study,we assessed the potential for using frozen adults of fruit flies,Drosophila melanogaster(Meigen),either as nymphal rearing diet or as diet throughout the entire life-cycle.We compared life-hi story traits and reproduction of predators when fed D.melanogaster with high lipid body content(lipid-rich)and with high protein body content(protein-rich),using a diet of 100%E.kuehniella eggs as control.We also analyzed the biochemical composition of both prey and predator in order to assess the nutritional quality of each diet,which partially explained the adequacy of the different diets for O.majusculus.There were significant differences between predators fed the two types of D.melanogaster,with the protein-rich flies as diet providing the best results in terms of mortality and fecundity.Furthermore,we show that while feeding O.majusculus throughout their development with D.melanogaster increases mortality and reduces reproduction,protein-rich D.melanogaster can be used as nymphal diet with minimal reduction in reproductivity and minimal increase in mortality. | Marta Montoro Henrik H.De Fine Licht Lene Sigsgaard | 2021 | Insect Science2021，28，1： | 1 |
| 10 | 激素诱导大鼠离体肝细胞糖原分解的调节显示文摘利用大鼠肝细胞激素诱导磷酸化酶α激活,来研究不同激素对cAMP和Ca^(2+)依赖的糖原分解途径的调节。血管加压素和血管紧张素Ⅱ降低胰高血糖素诱导cAMP水平增加,呈明显的剂量效应关系。血管加压素、血管紧张素Ⅱ和苯肾上腺素诱导肝细胞^(45)Ca掺入及其激活磷酸化酶α的时间反应动力学近似。激素诱导离体肝细胞糖原分解具有不同的下调特点,这可能在体内有一定的生理意义。 | 陈望秋 S.Keppens H.De Wulf | 1993 | 中国医学科学院学报1993，15，2： | 1 |
| 11 | Frequency determination and step-length control for exponentially-fitted Runge–Kutta methods显示文摘 | G.Vanden Berghe L.Gr. Ixaru H.De Meyer | 2001 | Journal of Computational and Applied Mathematics2001，，1： | 1 |
| 12 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 13 | Digestion of peanut allergens Ara h 1, Ara h 2, Ara h 3, and Ara h 6: A comparative in vitro study and partial characterization of digestion‐resistant peptides显示文摘 | Stef J.Koppelman Sue L.Hefle Steve L.Taylor Govardus A. H.de Jong | 2010 | Mol Nutr Food Res2010，，12： | 1 |
| 14 | Cytot oxicity study of some Ti alloys used as biomaterial显示文摘 | Tatiani A G.Donato Luciano H.de Almeida Renata A.Nogueira Terlize C.Niemeyer Carlos R.Grandini | | 0，，： | 1 |
| 15 | The clinical picture of rheumatoid arthritis according to the 2010 American College of Rheumatology/European League Against Rheumatism criteria: Is this still the same disease?显示文摘 | M. J. H.de Hair K. A.Lehmann M. G. H.van de Sande K. I.Maijer D. M.Gerlag P. P.Tak | 2012 | Arthritis & Rheumatism2012，，2： | 1 |
| 16 | Exponentially fitted explicit Runge-Kutta methods显示文摘 | G.Vanden Berghe H.De Meyer M.Van Daele T.Van Hecke | | 0，，1： | 1 |
| 17 | Exponentially fitted Runge-Kutta methods显示文摘 | G.Vanden Berghe H.De Meyer M.Van Daele T.Van Hecke | | 0，，1： | 1 |
| 18 | First Diagnosis of Encephalitozoon intestinalis and E. Hellem in a European Brown Hare (Lepus europaeus) with Kidney Lesions显示文摘 | H.De Bosschere Z.Wang P. A.Orlandi | 2007 | Zoonoses and Public Health . 2007 (3‐4)2007，，： | 1 |
| 19 | Curing behavior of a novolac‐type phenolic resin analyzed by differential scanning calorimetry显示文摘 | Eliton S.De Medeiros José A. M.Agnelli KuruvillaJoseph Laura H.De Carvalho Luiz H. C.Mattoso | 2003 | J Appl Polym Sci2003，，6： | 1 |
| 20 | HILBERT-DIRAC OPERATORS IN CLIFFORD ANALYSIS显示文摘Around the central theme of 'square root' of the Laplace operator it is shown that the classical Riesz potentials of the first and of the second kind allow for an explicit expression of so-called Hilbert-Dirac convolution operators involving natural and complex powers of the Dirac operator. | F.BRACKX H.DE SCHEPPER | 2005 | Chinese Annals of Mathematics,Series B2005，26，1： | 1 |
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