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| 1 | 血压变异性与脑小血管病:人群队列的系统回顾和荟萃分析显示文摘脑小血管疾病(cerebral small vessel disease,CSVD)是一种常见的、具有破坏性的亚临床疾病,对卒中和痴呆都有重要影响。血压的变异性可能会增加卒中和痴呆的风险,但血压变异性是否与CSVD有关尚无定论。该研究针对前瞻性队列研究进行了系统回顾和荟萃分析,这些研究考察了血压变异性与CSVD标志物(包括磁共振成像上的白质高信号、腔隙和微出血)的存在或进展之间的关系。该研究搜索了Medline、Embase和Web of Science三大数据库。筛选出10项研究符合综合定性标准,并有7项研究可纳入荟萃分析。这些研究共包括2796例年龄为(74±4)岁的患者,平均随访时间为4.0年。经统计学分析,收缩期血压变异性与白质高信号存在或进展的概率增加相关,约增加1个标准差[优势比1.26(95%CI:1.06~1.50)]。而收缩压血压变异性与腔隙的存在[优势比0.93(95%CI:0.74~1.16)]和微出血的存在[优势比1.13(95%CI:0.89~1.44)]之间的相关性没有统计学意义。结果证明,大的血压变异性与更高的脑白质高信号(WMH)负担相关,这可能为探究卒中和痴呆的早期诱因提供重要的支持。二者的因果关系,则需要未来的纵向研究进行探究。如果观察到因果关系是成立的,则表明通过保持稳定的血压,可以很大程度上预防CSVD,从而预防卒中和痴呆。 | Ma Y Song A Viswanathan A 李铁梅(编译) | 2020 | 中华医学杂志2020，100，43： | 32 |
| 2 | Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ-induced hyperglycemic rats显示文摘Objective:To investigate the protective role of Cardiospermum halicacabum(C.halicacabum) leaf extract on glycoprotein metabolism in streptozotocin(STZ)-induced diabetic rats.Methods: Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ.The C.halicacabum leaf extract(CHE) was administered orally to normal and STZ-diabetic rats for 45 days.The effects of C.halicacabum leaf extract(CHE) on plasma and tissue glycoproteins (hexose,hexosamine,fucose and sialic acid) were determined.Results:The levels of plasma and tissues glycoproteins containing hexose,hexosamine and fucose were significantly increased in STZ-induced diabetic rats.In addition,the level of sialic acid significantly increased in plasma and liver while decreased in kidney of STZ-induced diabetic rats.After administration of CHE to diabetic rats,the metabolic alteration of glycoprotein reverted towards normal levels. Conclusions:The present study indicates that the CHE possesses a protective effect on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity. | Chinnadurai Veeramani Khalid S Al-Numair Mohammed A Alsaif Govindasamy Chandramohan Nouf S Al-Numair Kodukkur Viswanathan Pugalendi | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 2 |
| 3 | Distribution of octcnyl succinatc groups in octcnyl succinic anhydride modified waxy maize starch显示文摘 | SHOGRENR L VISWANATHAN A FELKER F | 2000 | Starch2000，52，4： | 1 |
| 4 | Path dependent options, the case of lookback options 显示文摘 | Conze A Viswanathan | 1991 | Journal of Finance1991，，46： | 1 |
| 5 | Small cell nueroendocrine carcinoma of cervix: outcome and patterns of recurrence显示文摘 | Viswanathan AN Deavers MT Jhingran A | 2004 | Gynecol Oncol2004，93，： | 1 |
| 6 | Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia显示文摘 | Saxena A Viswanathan S Moshynska O | 2004 | Am J Hematol2004，75，1： | 1 |
| 7 | Low silicon non-grain-orientedelectricalsteel:linkingmagneticpropertieswithmetallurgicalfactors显示文摘 | Chaudhury A KhatirkarR Viswanathan N N etal | 2007 | MagnMagnMater2007，，313： | 1 |
| 8 | A role for Lin28 in primordial germ-cell development and germ-cell malignancy显示文摘 | West JA Viswanathan SR Yabuuchi A | 2009 | Nature2009，460，7257： | 1 |
| 9 | Cerebral microhemorrhage显示文摘 | Viswanathan A Chabriat H | 2006 | Stroke2006，37，2： | 1 |
| 10 | MR imaging detection of cerebral microbleeds: effect of susceptibi- lity-weighted imaging, section thickness, and field strength 显示文摘 | Nandigam R N Viswanathan A Delgado P | 2009 | Am J Neuroradiol2009，30，2： | 1 |
| 11 | Plasma Abeta, homocys- teine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP)trial显示文摘 | Viswanathan A Raj S Greenberg SM | 2009 | Neurology2009，72，3： | 1 |
| 12 | Vascular risk factors and dementia: How to move forward显示文摘 | VISWANATHAN A ROCCA W TZOURIO C | 2009 | Neurology2009，72，4： | 1 |
| 13 | Optimal decition fusion in multiple sensor systems显示文摘 | Thomopoulos S C A Viswanathan R Bougoulias D C | 1987 | IEEE Trans on AES1987，23，5： | 1 |
| 14 | Distribution of octenyl succinate groups in octenyl succinic anhydride modified waxy maize starch显示文摘 | Shogren R L Viswanathan A Felker F | 2000 | Starch-Starke2000，52，6： | 1 |
| 15 | Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence显示文摘 | Viswanathan AN Deavers MT Jhingran A | 2004 | Gynecol Oncol2004，93，1： | 1 |
| 16 | Hyperfractionation in carcinoma of the cervix:tumor control and late bowel comlicarions显示文摘 | Viswanathan FR Varghese C Peedicayil A | 1999 | Int J Radiat Oncol Biol Phys1999，45，3： | 1 |
| 17 | Conze, Path Dependent Options: The Case of Look back Options显示文摘 | Viswanathan A | 1991 | Journal of finace1991，46，： | 1 |
| 18 | Structure pre-req- uisites for isoflavones as effective antibacterial agents 显示文摘 | MUKNE A P VISWANATHAN V PHADATARE A G | 2011 | Pharmacognolo- gy Review2011，5，9： | 1 |
| 19 | Specific role of polymorphs of supporting titania in catalytic CO oxidation on gold 显示文摘 | Beck A Magesh G Kuppan B Schay Z Gesztic O Benk6T Viswanath R P Selvam P Viswanathan B Guczi L | 2011 | Catalysis Today2011，164，1： | 1 |
| 20 | Evolution ofMultiprotocol LabelSwitching显示文摘 | VISWANATHAN A | 1998 | IEEE Computer Com1998，，5： | 1 |
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