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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 3 | Hepatitis B virus subgenotype F3 reactivation with vaccine escape mutations:A case report and review of the literature显示文摘Hepatitis B represents a global health threat because its chronic course and sequelae contribute to a high morbidity and mortality. Hepatitis B virus(HBV) infection can be controlled by vaccines, antiviral treatment, and by interrupting transmission. Rare vaccine escape mutants are serious because they eliminate vaccine protection. Here, we present a 74-year-old vaccinated patient with HBV reactivation 11 years after kidney transplantation. The patient was HBV-positive but HBs Ag-negative prior to vaccination 6 years before transplantation. The reactivated virus was HBV genotype F3 with vaccine escape mutations G145 R, P120 Q, and Q129 P. The patient was successfully treated with entecavir. The epidemiological reasons for this subgenotype, which is extremely rare in Western Europe, were unclear. This case illustrates that second-generation vaccines are not always effective in a specific group of patients. | Stefan Schlabe Kathrin van Bremen Souhaib Aldabbagh Dieter Glebe Corinna M Bremer Tobias Marsen Walter Mellin Veronica Di Cristanziano Anna M Eis-Hübinger Ulrich Spengler | 2018 | World Journal of Hepatology2018，10，7： | 2 |
| 4 | Behavioural and neurochemical effects of post-weaning social isolation in rodents-Relevance to developmental neuropsychiatric disorders显示文摘 | Kevin C F F Veronica M P | 2008 | Neuroscience and Biobehavioral Reviews2008，，32： | 1 |
| 5 | Endophytic nitrogen fixation in sugarcane:present knowledge and future applications显示文摘 | Robert M B Segundo U Bruno J R Veronica R | 2003 | Plant & Soil2003，252，： | 1 |
| 6 | Current analytical methods for trichothecene my- cotoxins in cereals 显示文摘 | Veronica M T Lattanzio Michelangelo Pascale Angelo Visconti | 2009 | Trends in Analytical Chemistry2009，28，6： | 1 |
| 7 | Extracellular Ca2+stimulates the activation of mitogen-activated protein kinase and cell growth in human fibroblast显示文摘 | Shixia H Veronica M Justin M | | 0，，： | 1 |
| 8 | Excitotoxic damage,disrupted energy metabolism,and oxidative stress in the rat brain:antioxidant and neuroprotective effects of L-carnitine显示文摘 | DANIELA S A VERONICA P D C MARA N H M | 2008 | Jonrnal of Neurochemistry2008，105，： | 1 |
| 9 | Biolistic transformation of Chrysanthemum with the nucleocapsid gene of tomato spotted wilt virus显示文摘 | Yepes L M Veronica M Pang SZ | 1995 | Plant Cell Reports1995，14，： | 1 |
| 10 | Activation of human smooth muscle BK channels by hydrochlorothiazide requires cell integrity and the presence of BK β1 subunit显示文摘 | Pedro MARTIN Melisa MONCADA Guruprasad KUNTAMALLAPPANAVAR Alex M DOPICO Veronica MILESI | 2018 | Acta Pharmacologica Sinica2018，39，3： | 1 |
| 11 | Degradation of chlorophenols by means of advanced oxidation processes: a general review 显示文摘 | Marc P T Veronica G M Miguel A B | 2004 | Applied Catalysis B: Environmental2004，47，： | 1 |
| 12 | Transformational leadership, learning goal orientation, and expectations for ca-reer success in mentor-protege relationships: a multiple level of analysis perspective显示文摘 | John J Sosik and Veronica M Godshalk | 2004 | Eeadership Quarterly2004，15，： | 1 |
| 13 | Struc-tural evolution of the Neogene Gar Basin,western Tibet:Implications for releasing bend development and drainagepattems显示文摘 | Veronica I S Michael A M William R D | 2010 | GSA Bulletin2010，122，56： | 1 |
| 14 | Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells显示文摘 | Josep Domingo-Domenech Samuel J. Vidal Veronica Rodriguez-Bravo Mireia Castillo-Martin S. Aidan Quinn Ruth Rodriguez-Barrueco Dennis M. Bonal Elizabeth Charytonowicz Nataliya Gladoun Janis de la Iglesia-Vicente Daniel P. Petrylak Mitchell C. Benson Jose M | 2012 | Cancer Cell2012，，3： | 1 |
| 15 | Identification and characterization of nine polymorphic microsatellite loci in the North American pika,Ochotona princes显示文摘 | Veronica S Kirchoff and Susan J Merideth | 2002 | Molecukar Ecology Notes2002，11，2： | 1 |
| 16 | Efficiency and capacity of antioxidant rich foods in trapping peroxyl radicals:A full evaluation of radical scavenging activity显示文摘 | Paola V Monica R Veronica de M | 2011 | Food research International2011，44，1： | 1 |
| 17 | InkJet Printing of Electron Donor/Acceptor Blends:Towards Bulk Hetcrojunction Solar Cells显示文摘 | Veronica Marin Elisabeth Holder Martijn M Wienk | | 0，，： | 1 |
| 18 | Changes during early development in photosynthetic light acclimation capacity explain the shade to sun transition in Nothofagus nitida 显示文摘 | Coopman R E Reyes-Diaz M Veronica F B | 2008 | Tree Physiology2008，28，10： | 1 |
| 19 | Micromechanical adaptation as a treatment for spinal cord injury显示文摘Spinal cord injury: Thus far injury of the spinal cord is incurable and, in the majority of cases, a devastating and life-changing event. The worldwide incidence rate of spinal cord injury (SCI) ranges from 250,000 to 900,000 (www.who.int, 2013;Kumar et al., 2018) new cases per year. SCI outcome includes the damage of axons, demyelination of axons, loss of signal transduction, and consequential long-lasting motor and sensory deficits. Additionally, the non-use of muscles can lead to atrophy and joint contractures, thereby further reducing the possibility of recovery. Depending on the spinal level and the severity of the injury, the extent of the damage can vary and spontaneous recovery is possible to varying degrees. | Veronica estrada Hans werner Müller | 2019 | Neural Regeneration Research2019，14，11： | 1 |
| 20 | On the use of portfolio risk models and capital requirements in emerging markets:the case of Argentina显示文摘 | VERONICA B FALKENHEIM M POWELL A | 2002 | The World Bank Economic Review2002，，16： | 1 |
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