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| 1 | Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis显示文摘AIM: To determine the eff icacy of tacrolimus on clinical status, histopathological status and biochemical markers in patients with steroid refractory autoimmune hepatitis (AIH). METHODS: Retrospectively, clinical parameters, biochemistry and histology were obtained from patient records. RESULTS: Nine patients [8 females/1 male, median age 32 (range 16-64) years] were identified to have received tacrolimus for a median duration of 18 (12-37) mo. Before initiation of tacrolimus treatment the patients were maintained on a prednisolone dose of 20 mg daily (range 20-80 mg/d), which was tapered to 7.5 (5-12.5) mg/d (P = 0.004). Alanine aminotransferase and immunoglobulin-G concentrations decreased from 154 (100-475) to 47(22-61) U/L (P = 0.007), and from 16 (10-30.2) to 14.5 (8.4-20) g/L (P = 0.032), respectively. All patients showed improvement of the liver inflammatory activity, as determined by the Ishak score (P = 0.016), while the degree of f ibrosis tended to decrease (P = 0.049). CONCLUSION: The use of low dose tacrolimus can lead to biochemical and histologic improvement of inflammation with no progression of the stage of f ibrosis in patients with steroid refractory AIH. Low dose tacrolimus therapy also allows substantial reduction of prednisone dose. | Fin Stolze Larsen Ben Vainer Martin Eefsen Peter Nissen Bjerring Bent Adel Hansen | 2007 | World Journal of Gastroenterology2007，13，23： | 15 |
| 2 | Interactions between arsenic-induced toxicity and nutrition in early life 显示文摘 | Vainer ME | 2007 | J Nutr2007，137，： | 1 |
| 3 | Colonic e: epression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease显示文摘 | VAINER B NIELSEN O HENDEL J | 2000 | Cytokine2000，12，： | 1 |
| 4 | Brain expression of the water channels Aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema显示文摘 | Martin Eefsen Peter Jelnes Lars E. Schmidt Ben Vainer Hanne Cathrine Bisgaard Fin S. Larsen | 2010 | Metabolic Brain Disease2010，，3： | 1 |
| 5 | Effect of a magnetic field on the rate of decomposition of H O by catalase and by the EDTA complex with Fe 显示文摘 | L M Vainer A V Podoplelov T V Leshina | 1978 | Biophysics ( Biofizika)1978，，23： | 1 |
| 6 | Acute lymphoblastic leukemia with philadelphia chromosome in a 39-year-old woman with down syndrome presenting as meningitis and fulminant liver failure显示文摘 | Hjorth SV Vainer B Petersen BL | 2010 | Leuk Res2010，34，： | 1 |
| 7 | Young people' s health: the need for action 显示文摘 | Russell M Vainer and Maggie Barker | | BMJ2(D50，，： | 1 |
| 8 | Correlation between circulating soluble ICAM-1 and prednisolone-induced amelioration of ulcerative colitis显示文摘 | VAINER B NIELSEN O H | 2003 | Scand J Gastroenterol2003，38，3： | 1 |
| 9 | 查看详情显示文摘 | O H Nielsen B Vainer M J Rask | | 0，，： | 1 |
| 10 | Colortie expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease 显示文摘 | Vainer B Nielsen O Hendel J | 2000 | Cytokine2000，12，10： | 1 |
| 11 | A phase 1/2 of a combination of Cetuximab and Taxane for “triple negative” breast cancer patients显示文摘 | Hovav Nechushtan Gilad Vainer Hana Stainberg Asher Y. Salmon Tamar Hamburger Tamar Peretz | 2014 | The Breast2014，，： | 1 |
| 12 | Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease显示文摘 | Vainer B Nielsen OH Hendel J | 2000 | Cytokine2000，12，10： | 1 |
| 13 | Chemotactic properties of ICAM -1 and PECAM - 1 on neutrophil granulocytes in nephrotic syndrome: effects of prednisolone and mesalazine显示文摘 | Vainer B Nielsen OH | 2000 | Aliment Pharmacol Ther2000，14，8： | 1 |
| 14 | Juvenile nasopharyngeal angiofibromas in Denmark 1981-2003:diagnosis,incidence,and treatment显示文摘 | GLAD H VAINER B BUCHWALD C | 2007 | Acta Otolaryngol2007，27，： | 1 |
| 15 | Intercellular adhesion molecule-1 (ICAM-1) in ulcerative colitis: Presence, visualization, and significance显示文摘 | B. Vainer | 2005 | Inflammation Research2005，，： | 1 |
| 16 | Established and emerging biological activity markers of inflammatory bowel disease 显示文摘 | Nielson OH Vainer B Madsen SM | 2000 | Am J Gastroenterol2000，95，2： | 1 |
| 17 | Review article:the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine显示文摘 | NIELSEN OH VAINER B RASK-MADSEN J | 2001 | Aliment Pharmacol Ther2001，15，： | 1 |
| 18 | Value of the electrocardiogram in localizing the occlusion site in the left anterior descending coronary artery in acute anterior myocardial infarction显示文摘 | Domien J Engelen Anton P Gorgels Emile C Cheriex Ebo D De Muinck Anton J Oude Ophuis Willem R Dassen Jindra Vainer Vincent G van Ommen Hein J Wellens | 1999 | Journal of the American College of Cardiology1999，，2： | 1 |
| 19 | Contradictory functions of NF-κB in liver physiology and cancer显示文摘 | Gilad W. Vainer Eli Pikarsky Yinon Ben-Neriah | 2008 | Cancer Letters2008，，2： | 1 |
| 20 | Expression of matrix metallo-pro-teinase 9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) by colorectal cancer cells and adjacent stroma cells-associations withhistopathology and patients outcome 显示文摘 | Jensen SA Vainer B Bartels A | 2010 | Eur J Cancer2010，46，18： | 1 |
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