|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis显示文摘AIM: To determine the eff icacy of tacrolimus on clinical status, histopathological status and biochemical markers in patients with steroid refractory autoimmune hepatitis (AIH). METHODS: Retrospectively, clinical parameters, biochemistry and histology were obtained from patient records. RESULTS: Nine patients [8 females/1 male, median age 32 (range 16-64) years] were identified to have received tacrolimus for a median duration of 18 (12-37) mo. Before initiation of tacrolimus treatment the patients were maintained on a prednisolone dose of 20 mg daily (range 20-80 mg/d), which was tapered to 7.5 (5-12.5) mg/d (P = 0.004). Alanine aminotransferase and immunoglobulin-G concentrations decreased from 154 (100-475) to 47(22-61) U/L (P = 0.007), and from 16 (10-30.2) to 14.5 (8.4-20) g/L (P = 0.032), respectively. All patients showed improvement of the liver inflammatory activity, as determined by the Ishak score (P = 0.016), while the degree of f ibrosis tended to decrease (P = 0.049). CONCLUSION: The use of low dose tacrolimus can lead to biochemical and histologic improvement of inflammation with no progression of the stage of f ibrosis in patients with steroid refractory AIH. Low dose tacrolimus therapy also allows substantial reduction of prednisone dose. | Fin Stolze Larsen Ben Vainer Martin Eefsen Peter Nissen Bjerring Bent Adel Hansen | 2007 | World Journal of Gastroenterology2007，13，23： | 15 |
| 2 | Brain expression of the water channels Aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema显示文摘 | Martin Eefsen Peter Jelnes Lars E. Schmidt Ben Vainer Hanne Cathrine Bisgaard Fin S. Larsen | 2010 | Metabolic Brain Disease2010，，3： | 1 |
| 3 | The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema显示文摘 | Peter Nissen Bjerring Martin Eefsen Bent Adel Hansen Fin Stolze Larsen | 2009 | Metabolic Brain Disease2009，，1： | 1 |
| 4 | Brain expression of the water chan- nels aquapofin-1 and -4 in mice with acute liver injury, hyperammone- mia and brain ederaa显示文摘 | Eefsen M Jelnes P Schmidt L E | 2010 | Metab Brain Dis2010，25，3： | 1 |
| 5 | Brain expression of the water channels aquaporin-1 and -4 in mice with acute liver injury,hyperammonemia and brain edema 显示文摘 | Eefsen M Jelnes P Schmidt LE | 2010 | Metab Brain Dis2010，25，3： | 1 |
| 6 | Ciclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia显示文摘AIM:To investigate the neuroprotective potential of ciclosporin during acute liver failure. We evaluated the effect of intrathecally administered ciclosporin on intracranial pressure, brain water content and aquaporin-4 expression in a rat model with acute hyperammonaemia.METHODS:Twenty-four male Wistar rats with portacaval anastomosis were randomised into four groups receiving ciclosporin or vehicle and ammonia or saline infusion. Ciclosporin or vehicle was given intrathecally prior to the ammonia or saline infusion. The ammonia or saline infusion was given intravenously for 4 h,while intracranial pressure and arterial pressure was recorded. At the end of the experiment, cerebral cortex and cerebellar brain tissue was analysed for water and aquaporin-4 content.RESULTS:The following intracranial pressures were found at the end of the experiment:ammonia + ciclosporin:10.0±1.7 mmHg, ammonia + vehicle:6.8±1.0mmHg, saline + ciclosporin:3.1±0.5 mmHg, saline +vehicle:3.3 ± 0.6 mmHg. Ammonia infusion had a significant effect on intracranial pressure and brain water content, which both were higher in the groups receiving ammonia(P<0.001, two-way analysis of variance). Treatment with ciclosporin resulted in relevant tissue concentrations of ciclosporin(>0.2 micromolar)but did not reduce intracranial pressure after 4 h. Furthermore, ciclosporin did not attenuate the increase in cerebral water content, and did not affect aquaporin-4expression.CONCLUSION:Intrathecal administration of ciclosporin does not attenuate intracranial hypertension or brain oedema in rats with portacaval anastomosis and 4 h of ammonia infusion. | Rikke Hebo Larsen Mette S Kjr Martin Eefsen Fin Stolze Larsen Peter Nissen Bjerring | 2013 | World Journal of Hepatology2013，5，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员