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| 1 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Mesenchymal stem cells in the treatment of spinal cord injuries:A review显示文摘With technological advances in basic research,the intricate mechanism of secondary delayed spinal cord injury(SCI)continues to unravel at a rapid pace.However,despite our deeper understanding of the molecular changes occurring after initial insult to the spinal cord,the cure for paralysis remains elusive.Current treatment of SCI is limited to early administration of high dose steroids to mitigate the harmful effect of cord edema that occurs after SCI and to reduce the cascade of secondary delayed SCI.R ecent evident-based clinical studies have cast doubt on the clinical benefit of steroids in SCI and intense focus on stem cell-based therapy has yielded some encouraging results.An array of mesenchymal stem cells(MSCs)from various sources with novel and promising strategies are being developed to improve function after SCI.In this review,we briefly discuss the pathophysiology of spinal cord injuries and characteristics and the potential sources of MSCs that can be used in the treatment of SCI.We will discuss the progress of MSCs application in research,focusing on the neuroprotective properties of MSCs.Finally,we will discuss the results from preclinical and clinical trials involving stem cell-based therapy in SCI. | Venkata Ramesh Dasari Krishna Kumar Veeravalli Dzung H Dinh | 2014 | World Journal of Stem Cells2014，6，2： | 32 |
| 2 | Risk of New-Onset Atrial Fibrillation in Elderly Patients with the Overlap Syndrome: A Retrospective Cohort Study显示文摘Background Co-existence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) is referred to as overlap syndrome. Overlap patients have greater degree of hypoxia and pulmonary hypertension than patients with OSA or COPD alone. Studies showed that elderly patients with OSA alone do not have increased risk of atrial fibrillation (AF) but it is not known if overlap patients have higher risk of AF. Objective To determine whether elderly patients with overlap syndrome have an increased risk of AF. Methods In this single center, community-based retrospective cohort analysis, data were collected on 2,873 patients > 65 years of age without AF, presenting in the year 2006. Patients were divided into OSA group (n = 60), COPD group (n = 416), overlap syndrome group (n = 28) and group with no OSA or COPD(n = 2369). The primary endpoint was incidence of new-onset AF over the following two years. Logistic regression was performed to adjust for heart failure (HF), coronary artery disease, hypertension (HTN), cerebrovascular disease, cardiac valve disorders, diabetes mellitus, hyperlipidemia, chronic kidney disease (CKD) and obesity. Results The incidence of AF was 10% in COPD group, 6% in OSA group and 21% in overlap syndrome group (P < 0.05). After adjusting for age, sex, HF, CKD, and HTN, patientswith overlap syndrome demonstrated a significant association with new-onset AF (OR = 3.66, P = 0.007). HF, CKD and HTNwere also significantly associated with new-onset AF (P < 0.05). Conclusion Among elderly patients, the presence of overlap syndrome is associatedwith a marked increase in risk of new-onset AF as compared to the presence of OSA or COPDalone. | Harsha V. Ganga Sanjeev U. Nair Venkata K. Puppala Wayne L. Miller | 2013 | Journal of Geriatric Cardiology2013，10，2： | 9 |
| 3 | FBG Based High Sensitive Pressure Sensor and Its Low-Cost Interrogation System With Enhanced Resolution显示文摘有高敏感和分辨率的一个纤维布拉格栅栏(FBG ) 压力传感器被设计了并且示威。传感器被坚定地与金属修理 FBG 设置吼叫结构。传感器借助于关于压力变化测量 FBG 的布拉格波长移动工作。从试验性的结果,传感器的压力敏感被发现是 90.6 下午 / 希腊语的第二十三个字母,它作为一个赤裸的纤维布拉格栅栏的是约 4000 次。99.86% 的很好的线性在 FBG 的布拉格波长之间被观察并且使用了压力。设计传感器与一个可以忽略的磁滞现象错误显示出好重覆性 ???? 吗?? | Vengal Rao PACHAVA Srimannarayana KAMINENI Sai Shankar MADHUVARASU Kishore PUTHA Venkata Reddy MAMIDI | 2015 | Photonic Sensors2015，5，4： | 7 |
| 4 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 5 | Statistical design and evaluation of a propranolol HCl gastric floating tablet显示文摘The purpose of this research was to apply statistical design for the preparation of a gastric floating tablet(GFT)of propranolol HCl and to investigate the effect of formulation variables on drug release and the buoyancy properties of the delivery system.The contents of polyethylene oxide(PEO)WSR coagulant and sodium bicarbonate were used as independent variables in central composite design of the best formulation.Main effects and interaction terms of the formulation variables were evaluated quantitatively using a mathematical model approach showing that both independent variables have significant effects on floating lag time,%drug release at 1 h(D_(1h))and time required to release 90%of the drug(t_(90)).The desired function was used to optimize the response variables,each with a different target,and the observed responses were in good agreement with the experimental values.FTIR and DSC studies of the statistically optimized formulation revealed there was no chemical interaction between drug and polymer.The statistically optimized formulation released drug according to first order kinetics with a non-Fickian diffusion mechanism.Evaluation of the optimized formulation in vivo in human volunteers showed that the GFT was buoyant in gastric fluid and that its gastric residence time was enhanced in the fed but not the fasted state. | Meka Venkata Srikanth Nali Sreenivasa Rao Songa Ambedkar Sunil Battu Janaki Ram Venkata Ramana Murthy Kolapalli | 2012 | Acta Pharmaceutica Sinica B2012，2，1： | 6 |
| 6 | Quantification of sibutramine and its two metabolites in human plasma by LC-ESI-MS/MS and its application in a bioequivalence study显示文摘Obesity can be considered as a chronic illness of epidemic proportion and its incidents have increased exponentially in recent years. The use of anti-obesity drugs such as sibutramine is somewhat helpful. There is a need to quantify such drugs in biological samples, which is generally quite difficult. In this report, we developed and validated a simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of sibutramine (SB) and its two metabolites N-des methyl sibutramine (DSB) and N-di desmethyl sibutramine (DDSB) in human plasma. Zorbax SBC18 (4.6 mm 75 mm, 3.5 mm, 80 A) analytical column and 5 mM ammonium formate:acetonitrile (10:90, v/v) mobile phase were used for chromatographic separation of SB, DSB and DDSB. Multiple reaction monitoring (MRM) in the positive mode was used to detect SB, DSB and DDSB at m/z 280.3/124.9, 266.3/ 125.3 and 252.2/124.9, respectively. Liquid-liquid extraction was used for the extraction of analytes and internal standard from human plasma. This method was validated over a linear concentration range of 10.0-10,000.0 pg/mL for SB, DSB and DDSB with correlation coefficients (r) of Z0.9997. The drug and the two metabolites were stable in plasma samples. The validated method was successfully applied in a bioequivalence and pharmacokinetic study with human volunteers under fasting condition. | Venkata Suresh Ponnuru B.R.Challa RamaRao Nadendla | 2012 | Journal of Pharmaceutical Analysis2012，2，4： | 6 |
| 7 | Pooled genetic analysis in ultrasound measured non-alcoholic fatty liver disease in Indian subjects:A pilot study显示文摘AIM: To investigate genetic susceptibility in Indian subjects with non-alcoholic fatty liver disease(NAFLD) by performing a pooled genetic study.METHODS: Study subjects(n = 306) were recruited and categorized into NAFLD and control groups based on ultrasound findings of fatty infiltration. Of the 306 individuals, 156 individuals had fatty infiltration and thus comprised the NAFLD group. One hundred and fifty(n = 150) individuals were normal, without fatty infiltration of the liver, comprising the control group. Blood samples, demographic and anthropometric data from the individuals were collected after obtaining informed consent. Anthropometric data, blood glucose, lipids and liver function tests were estimated using standard methods. Genome wide association stud-ies done to date on NAFLD were identified, 19 single nucleotide polymorphisms(SNPs) were selected from these studies that were reported to be significantly associated with NAFLD and genotyping was performed on the Sequenom platform. Student's t test for continuous variables and χ2 test was applied to variant carriers from both groups. Required corrections were applied as multiple testing was done.RESULTS The mean age of the control group was 39.78 ± 10.83 and the NAFLD group was 36.63 ± 8.20 years. The waist circumference of males and females in the control and NAFLD groups were 80.13 ± 10.35; 81.77 ± 13.65 and 94.09 ± 10.53; 92.53 ± 8.27 respectively. The mean triglyceride and alanine transaminase(ALT) levels in the control and NAFLD groups were 135.18 ± 7.77; 25.39 ± 14.73 and 184.40 ± 84.31; 110.20 ± 67.05 respectively. When χ2 test was applied to the number of individuals carrying the variant risk alleles between the control and NAFLD group, a significant association was seen between rs738409 of the patatin-like phospholipase domain containing 3(PNPLA3) gene(P = 0.001), rs2073080 of the PARVB gene(P = 0.02), rs2143571 of SAMM50 gene(P = 0.05) and rs6487679 of the pregnancy zone protein(PZP) gene(P = 0.01) with the disease. Variant single nucleotide polymorphisms(SNPs) in NCAN and PNPLA3 gene were associated with higher levels of ALT, whereas variant SNPs in APOC3, PNPLA3, EFCAB4 B and COL13A1 were associated with high triglyceride levels. Apart from the above associations, rs2073080, rs343062 and rs6591182 were significantly associated with high BMI; rs2854117 and rs738409 with high triglyceride levels; and rs2073080, rs2143571, rs2228603, rs6487679 and rs738409 with high ALT levels.CONCLUSION: Pooled genetic analysis revealed an association of SNPs in PNPLA3, PARVB, SAMM50 and PZP genes with NAFLD. SNPs in NCAN and PNPLA3gene were associated with higher levels of ALT,whereas variant SNPs in APOC3, PNPLA3, EFCAB4 B and COL13A1 were associated with high triglyceride levels. | Vishnubhotla Venkata Ravi Kanth Mitnala Sasikala Padaki Nagaraja Rao Urmila Steffie Avanthi Kalashikam Rajender Rao Duvvuru Nageshwar Reddy | 2014 | World Journal of Hepatology2014，6，6： | 6 |
| 8 | Role of Positive Selection Pressure on the Evolution of H5N1 Hemagglutinin显示文摘The surface glycoprotein hemagglutinin (HA) helps the influenza A virus to evade the host immune system by antigenic variation and is a major driving force for viral evolution. In this study, the selection pressure on HA of H5N1 influenza A virus was analyzed using bioinformatics algorithms. Most of the identified positive selection (PS) sites were found to be within or adjacent to epitope sites. Some of the identified PS sites are consistent with previous experimental studies, providing further support to the biological significance of our findings. The highest frequency of PS sites was observed in recent strains isolated during 2005–2007. Phylogenetic analysis was also conducted on HA sequences from various hosts. Viral drift is almost similar in both avian and human species with a progressive trend over the years. Our study reports new mutations in functional regions of HA that might provide markers for vaccine design or can be used to predict isolates of pandemic potential. | Venkata R.S.K. Duvvuri Bhargavi Duvvuri Wilfred R. Cuff Gillian E. Wu Jianhong Wu | 2009 | Genomics, Proteomics & Bioinformatics2009，7，1： | 6 |
| 9 | Quantification of desloratadine in human plasma by LC-ESI-MS/MS and application to a pharmacokinetic study显示文摘A simple, sensitive, and specific liquid chromatography tandem mass spectrometry (LC-MS/ MS) method was developed for the quantification of desloratadine (DL) in human plasma using desloratadine-d5 (DLD5) as an internal standard (IS). Chromatographic separation was performed using an Xbridge C18 column (50 mm 4.6 mm, 5 mm) with an isocratic mobile phase composed of 10 mM ammonium formate: methanol (20:80, v/v), at a flow rate of 0.7 mL/min. DL and DLD5 were detected with proton adducts at m/z 311.2-259.2 and 316.2-264.3 in multiple reaction monitoring (MRM) positive modes, respectively. Liquid-liquid extraction (LLE) method was used to extract the drug and the IS. The method was validated over a linear concentration range of 5.0-5000.0 pg/mL with a correlation coefficient of (r2)Z0.9994. This method demonstrated intra- and inter-day precision within 0.7-2.0% and 0.7-2.7%, and an accuracy within 101.4-102.4%, and 99.5-104.8%. DL was found to be stable throughout the freeze-thaw cycles, bench-top, and postoperative stability studies. This method was successfully applied in the analysis of plasma samples following oral administration of DL (5 mg) in 35 healthy Indian male human volunteers under fasting conditions. | Venkata Suresh Ponnuru B.R. Challa Ramarao Nadendla | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 5 |
| 10 | In-vitro antimicrobial activity of marine actinobacteria against multidrug resistance Staphylococcus aureus显示文摘Objective:To investigate the antibacterial aclivily of marine actinobacteria against multidrug resistance Staphylococcus aureus(MDRSA).Methods:Fifty one actinobacterial strains were isolated from salt pans soil,costal area in Kothapattanam,Ongole,Andhra Pradesh.Primary screening was done using cross-streak method against MDRSA.The bioaclive compounds are extracted from efficient actinobacteria using solvent extraction.The antimicrobial activity of crude and solvent extracts was perfomied using Kirby-Bauer method.MIC for ethyl acetate extract was determined by modified agar well diffusion method.The potent actinobacteria are identified using Nonomura key,Shirling and Gottlieb 1966 with Bergey's manual of determinative bacteriology.Results:Among the fifty one isolates screened for antibacterial activity,SRB25were found efficient against MDRSA.The ethyl acetate extracts showed high inhibition against test organism.MIC test was performed with the ethyl acetate extract against MDRSA and found to be 1 000μg/mL.The isolaled actinobacteria are identified as Streptomyces sp with the help of Nonomura key.Conclusions:The current investigation reveals that the marine actinobacteria from salt pan environment can be able to produce new drug molecules against drug resistant microorganisms. | Sathish Kumar SR Kokati Venkata Bhaskara Rao | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，10： | 5 |
| 11 | Silica gel catalyzed α-bromination of ketones using N-bromosuccinimide: An easy and rapid method显示文摘An easy and rapid method for the a-bromination of ketones using N-bromosuccinimide(NBS) catalyzed by silica gel in methanol under reflux conditions was developed. The expected products were formed in excellent isolated yields within a short period of time(5–20 min). Major advantages of the present procedure include use of inexpensive and readily available catalyst, exclusion of pre- and post-chemical treatment of catalyst and use of methanol as solvent instead of ethers and chlorinated solvents. | Bodireddy Mohan Reddy Velpula Venkata Ramana Kumar Nallagondu Chinna Gangi Reddy Siripragada Mahender Raob | 2014 | Chinese Chemical Letters2014，25，1： | 5 |
| 12 | Microstructure and pitting corrosion resistance of AA2219 Ale Cu alloy friction stir welds e Effect of tool profile显示文摘AA2219 Ale Cu alloy is widely used in defence and aerospace applications due to required combination of high strength-to-weight ratio and toughness.Fabrication of components used for defence always involves welding.Even though the mechanical properties of the base metal are better,but the alloy suffers from poor mechanical and corrosion properties during fusion welding.To overcome the problems of fusion welding,friction stir welding(FSW) is recognized as an alternative solid state joining method aimed to improve the mechanical and corrosion properties.Tool profile is one of the important variables which affect the performance of the friction stir weld.In the present work the effect of tool profile on the microstructure and pitting corrosion of AA2219 aluminiumecopper alloy was studied.Electron backscattered diffraction results established that the grain size and orientation of weld nugget of triangle profile is finer than that of conical profile.Differential scanning calorimetric results show the evidence of precipitate dissolution during FSW.It was found that the microstructure changes,such as grain size and its orientation precipitate dissolution during FSW influence the hardness and corrosion behaviour.Pitting corrosion resistance of friction stir welds of AA2219 was found to be better for triangle profile tool compared to conical profile which is attributed to material flow and strengthening precipitate morphology in various zones.Higher amount of heat generation during FSW made using triangle profile tool may be the reason for greater dissolution of strengthening precipitates in nugget zone and coarsening in thermo mechanically affected zone(TMAZ) and heat affected zone(HAZ). | Ch VENKATA RAO G.MADHUSUDHAN REDDY K.SRINIVASA RAO | 2015 | Defence Technology(防务技术)2015，11，2： | 5 |
| 13 | Factors That Predict Response of Patients With Hepatitis C Virus Infection to Boceprevir显示文摘 | Fred Poordad Jean–Pierre Bronowicki Stuart C. Gordon Stefan Zeuzem Ira M. Jacobson Mark S. Sulkowski Thierry Poynard Timothy R. Morgan Cliona Molony Lisa D. Pedicone Heather L. Sings Margaret H. Burroughs Vilma Sniukiene Navdeep Boparai Venkata S. Goteti | 2012 | Gastroenterology2012，，3： | 5 |
| 14 | Separation and estimation of nanofiltration membrane transport parameters for cerium and neodymium显示文摘Lanthanides are widely used in various commercial applications, which results in public exposure to them, and it is a matter of concern. Many methods were used to remove lanthanides from wastewaters generated from their commercial use. In the present work, nanofiltration membrane process was used to remove the cerium and neodymium from their respective feed solutions. The feed and permeates were analyzed for solute concentration by inductively coupled plasma-atomic emission spectroscopy. Irreversible thermodynamics Spiegler-Kedem model, in combination with the film theory, was used to estimate the membrane transport parameters, viz., reflection coefficient of membrane and solute permeability, and mass transfer coefficient to study their dependence on feed solute concentration. | Zagabathuni Venkata Panchakshari MURTHY Anshul CHOUDHARY | 2012 | Rare Metals2012，31，5： | 4 |
| 15 | Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients显示文摘AIM To investigate the role of genetic variants of angiotensin converting enzyme(ACE) and angiotensinogen(AGT) genes in the antiproteinuric efficacy of ACE inhibitor therapy in diabetic nephropathy(DN) patients.METHODS In the present study, 270 type 2 diabetes mellitus patients with nephropathy were enrolled and treated with ACE inhibitor(ramipril) and followed at 6 mo for renal function and albumin excretion by estimating serum creatinine, end stage renal disease, and albumin/creatinine ratio(ACR) in urine. Genotyping of ACE I/D and AGT M235 T polymorphisms were performed by using primer specific polymerase chain reaction(PCR) and PCR-RFLP techniques, respectively. RESULTS Forty-eight percent of DN patients(responders) benefited with respect to proteinuria from ACE inhibitor therapy at 6 mo follow-up. A significant reduction in ACR was observed after 6 mo treatment with ACE inhibitor irrespective of whether DN patients were micro-albuminuric(≥ 30 and < 300 mg/g creatinine) or macro-albuminuric(≥ 300 mg/g creatinine) at the time of enrollment. However, macro-albuminuric patients(55%) showed better response to therapy. A reduction in urinary ACR was found independent of genotypes of ACE I/D and AGT M235 T polymorphisms although macro-albuminuric patients having TT genotype showed statistically insignificant increased response(72%). CONCLUSION ACE inhibitor therapy reduced urinary ACR by ≥ 30% in 50% of DN patients and the response is independent of ACE I/D and AGT M235 T polymorphisms. | Neerja Aggarwal Pawan Kumar Kare Parul Varshney Om Prakash Kalra Sri Venkata Madhu Basu Dev Banerjee Anil Yadav Alpana Raizada Ashok Kumar Tripathi | 2017 | World Journal of Diabetes2017，8，3： | 4 |
| 16 | Evaluation of atmospheric corrections on hyperspectral data with special reference to mineral mapping显示文摘Hyperspectral images have wide applications in the fields of geology,mineral exploration,agriculture,forestry and environmental studies etc.due to their narrow band width with numerous channels.However,these images commonly suffer from atmospheric effects,thereby limiting their use.In such a situation,atmospheric correction becomes a necessary pre-requisite for any further processing and accurate interpretation of spectra of different surface materials/objects.In the present study,two very advance atmospheric approaches i.e.QUAC and FLAASH have been applied on the hyperspectral remote sensing imagery.The spectra of vegetation,man-made structure and different minerals from the Gadag area of Karnataka,were extracted from the raw image and also from the QUAC and FLAASH corrected images.These spectra were compared among themselves and also with the existing USGS and JHU spectral library.FLAASH is rigorous atmospheric algorithm and requires various parameters to perform but it has capability to compensate the effects of atmospheric absorption.These absorption curves in any spectra play an important role in identification of the compositions.Therefore,the presence of unwanted absorption features can lead to wrong interpretation and identification of mineral composition.FLAASH also has an advantage of spectral polishing which provides smooth spectral curves which helps in accurate identification of composition of minerals.Therefore,this study recommends that FLAASH is better than QUAC for atmospheric correction and correct interpretation and identification of composition of any object or minerals. | Nisha Rani Venkata Ravibabu Mandla Tejpal Singh | 2017 | Geoscience Frontiers2017，8，4： | 3 |
| 17 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 18 | Antioxidant activity of newly discovered lineage of marine actinobacteria显示文摘Objective:To investigate the antioxidant activity of marine actinobacteria.Methods:The content of total phenolics,the level of antioxidant potential by DPPH radical scavenging activity,metal chelating activity,FRAP method,βcarotene assay and NO scavenging activity in extract were determined.Results:In all the methods the extract exhibited good scavenging activity except NO scavenging activity.The IC50 values of marine actinobacteria extract on DPPH radical were found to be 41.09μg/mL.The zone of color retention was 12 mm inβ-carotene bleaching assay. DNA protective efficiency of the extracts was also studied using UV- photolysed H2O2-driven oxidative damage to pBR322.HPLC analysis identified some of the major phenolic compounds in extracts,which might he responsible for the antioxidant potential and cyto-protection.It showed a 100%cytotoxic effect in brine shrimp lethality assay within 10 mins.The novel actinobacteria was identified as Streptomyces LK-3(JF710608) through I6S rDNA Sequencing.Conclusions:The results obtained suggest that the extracts bear anti-cancer metabolites and could be considered as a potential source for anti-cancer drug development. | Loganathan Karthik Gaurav Kumar Kokati Venkata Bhaskara Rao | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，4： | 3 |
| 19 | Effect of grain size on dielectric and ferroelectric properties of nanostructured Ba_0.8)Sr_(0.2)TiO_(3) ceramics显示文摘Barium strontium titanate( Ba_0.8)Sr_(0.2)TiO_(3),BST)nanocrystalline ceramics have been synthesized by high energy ball milling.As the sintering temperature increases from 1200℃to 1350℃,the average grain size of BST ceramics increases from 86 nm to 123 nm.The X-ray diffraction(XRD)studies show that these ceramics are tetragonal.The phase and grain size of the sintered pellets have been estimated from the XRD patterns,scanning electron microscopy(SEM)and transmission electron microscopy(TEM)images.The effect of grain size on dielectric and ferroelectric properties is studied.The dielectric and piezoelectric parameters are greatly improved at room temperature with increase in grain size.The Curie transition temperature is found to shift slightly towards higher temperatures as the grain increases from 86 nm to 123 nm.The coercive field decreases and the remnant polarization and spontaneous polarization increase as the grain size of BST nano ceramics increases.These ceramics are promising materials for tunable capacitor device applications. | Venkata Ramana MUDINEPALLI Leng FENG Wen-Chin LIN B.S.MURTY | 2015 | Journal of Advanced Ceramics2015，4，1： | 3 |
| 20 | 一期与分期修复双侧膝关节骨关节炎的临床效果比较(英文)显示文摘背景:当患者双侧膝关节发生退变性骨性关节炎时,是一期双侧同时全膝关节置换还是分期置换,目前仍存在争论。目的:比较一期与分期全膝关节置换修复双侧膝关节骨性关节炎的效果。方法:收集于2005年1月至2008年12月在在苏州大学附属第一医院进行治疗的双侧膝关节骨性关节炎患者,按照患者手术方法分为一期组(n=68)和分期组(n=71),采用Gemini MK II全膝关节系统分别进行一期全膝关节置换和分期全膝关节置换治疗。结果与结论:与分期组相比,一期组患者手术时间、住院时间较短,平均术后输血量较大,医疗费用较低,但两组患者的术后膝关节功能、并发症、患者满意度情况差异无显著性意义,且至末次随访均未发现假体周围骨溶解。提示尽管一期双侧全膝关节置换增加患者的输血量,但是能够节约医疗费用、减少住院天数,因此是一种安全有效的治疗双侧膝关节骨关节炎的方法,值得推广应用。 | Maddali Taraka Venkata Pavan 孙俊英 查国春 | 2015 | 中国组织工程研究2015，19，9： | 3 |
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