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| 1 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | 以CT图像为基础构建人狭窄颈动脉的血流动力学模型显示文摘目的探索以CT图像为基础构建动脉血流动力学模型的技术方法,对颈动脉狭窄局部进行计算血流动力学(computationalfluid dynamics,CFD)数值模拟。方法以CT图像为基础进行颈动脉三维几何建模,依据MRI测量的模型出入口血流速度确定数值模拟的边界条件。结果数值模拟结果包括狭窄颈动脉内的速度场和壁面剪应力(wall shear stress,WSS)分布,可见狭窄段血管WSS增高,且在狭窄邻近区域出现新的血液逆流区(对应低或振荡的WSS)。结论以CT图像为基础的CFD技术是在体评价人狭窄颈动脉内血流动力学状况与颈动脉斑块之间关系的有效方法。 | 金龙 Augsburger L Vargas MI Rufenacht DA | 2007 | 中国医学影像技术2007，23，8： | 4 |
| 3 | A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease显示文摘 | C. Fernández-Miranda M. Pérez-Carreras F. Colina G. López-Alonso C. Vargas J.A. Solís-Herruzo | 2007 | Digestive and Liver Disease2007，，3： | 2 |
| 4 | A comparative evaluation of microalgae for the degradation of piggery wastewater under photosynthetic oxygenation显示文摘 | Ignacio de Godos Virginia A. Vargas Saúl Blanco María C. García González Roberto Soto Pedro A. García-Encina Eloy Becares Raúl Mu?oz | 2010 | Bioresource Technology2010，，14： | 2 |
| 5 | Autonomic and sensory nerve dysfunction in primary biliary cirrhosis显示文摘AIM: Cardiovascular autonomic and peripheral sensory neuropathy is a known complication of chronic alcoholic and non-alcoholic liver diseases. We aimed to assess the prevalence and risk factors for peripheral sensory nerve and autonomic dysfunction using sensitive methods in patients with primary biliary cirrhosis (PBC). METHODS: Twenty-four AMA M2 positive female patients with clinical, biochemical and histological evidence of PBC and 20 age matched healthy female subjects were studied. Five standard cardiovascular reflex tests and 24-h heart rate variability (HRV) analysis were performed to define autonomic function. Peripheral sensory nerve function on median and peroneal nerves was characterized by current perception threshold (CPT), measured by a neuroselective diagnostic stimulator (Neurotron, Baltimore, MD). RESULTS: Fourteen of 24 patients (58%) had at least one abnormal cardiovascular reflex test and thirteen (54%) had peripheral sensory neuropathy. Lower heart rate response to deep breathing (P=0.001), standing (P=0.03) and Valsalva manoeuvre (P=0.01), and more profound decrease of blood pressure after standing (P=0.03) was found in PBC patients than in controls. As a novel finding we proved that both time domain and frequency domain parameters of 24-h HRV were significantly reduced in PBC patients compared to controls. Each patient had at least one abnormal parameter of HRV. Lower CPT values indicated hyperaesthesia as a characteristic feature at peroneal nerve testing at three frequencies (2000 Hz: P=0.005; 250 Hz: P=0.002; 5 Hz: P=0.004) in PBC compared to controls. Correlation of autonomic dysfunction with the severity and duration of the disease was observed. Lower total power of HRV correlated with lower CPT values at median nerve testing at 250 Hz (P = 0.0001) and at 5 Hz (P=0.002), as well as with those at peroneal nerve testing at 2000 Hz (P=0.01). CONCLUSION: Autonomic and sensory nerve dysfunctions are frequent in PBC. Twenty-four-hour HRV analysis is more sensitive than standard cardiovascular tests for detecting of both parasympathetic and sympathetic impairments. Our novel data suggest that hyperaesthesia is a characteristic feature of peripheral sensory neuropathy and might contribute to itching in PBC. Autonomic dysfunction is related to the duration and severity of PBC. | Katalin Keresztes lldikó Istenes Aniko Folhoffer Peter L Lakatos Andrea Horvath Timea Csak Peter Varga Peter Kempler Ferenc Szalay | 2004 | World Journal of Gastroenterology2004，10，20： | 2 |
| 6 | Effect of acaia honey on the characteristic microflora of yogurt during refrigerated storage显示文摘 | VARGA L | 2006 | International Journal of Food Microbiology2006，108，： | 1 |
| 7 | Geographic spillovers and university Research:a spatial econometric perspective 显示文摘 | ANSELIN L VARGA A ACS Z | 2000 | Growth and Change2000，31，： | 1 |
| 8 | Uncertainty and Rank Order in the Analytic Hierarchy Process显示文摘 | Satty T L Vargas LG | 1987 | European Journal of Operational Research1987，，： | 1 |
| 9 | Co-occurrence of aflatoxins B1, B2,G1,G2,zearalenone and fumonisin B1 in Brazilian corn显示文摘 | Vargas E A Preis R A Castro L | 2001 | Food Addit Con- tam2001，18，11： | 1 |
| 10 | Study of humic-like substances in fog and interstitial aerosol by size-exclusion chromatography and capillary electrophoresis显示文摘 | Z Krivácsy Gy Kiss B Varga I Galambos Zs Sárvári A Gelencsér á Molnár S Fuzzi M.C Facchini S Zappoli A Andracchio T Alsberg H.C Hansson L Persson | 2000 | Atmospheric Environment2000，，25： | 1 |
| 11 | Refractive surgery survey 2001 显示文摘 | Solomon KD Holzer MP Sandoval HP Vargas LG Werner L Vroman DT et ol | 2002 | J Cataract Refract Surg2002，28，2： | 1 |
| 12 | Chemical Composition and Biodegradability of Crop Residues Colonized by White-rot Fungi 显示文摘 | Karunanandaa K Fales S L Varga G A | 1992 | J Sci Food Agric1992，60，： | 1 |
| 13 | Magnetization processes in thin magnetic wires 显示文摘 | Varga R Garcia K L Zhukov A | 2006 | Journal of Magnetism & Magnetic Materials2006，300，1： | 1 |
| 14 | Transient elastography to rule out esophageal varices and portal hypertensive gastropathy in HIV-infected individuals with liver cirrhosis显示文摘 | Maria L. Montes Ramirez Jose F. Pascual-Pareja Matilde Sánchez-Conde Jose I. Bernardino De la Serna Francisco X. Zamora Vargas Pilar Miralles Juan M. Castro Margarita Ramírez Isabel Gutierrez Juan Gonzalez-García Juan Berenguer Jose R. Arribas López | 2012 | AIDS2012，，14： | 1 |
| 15 | Patents and innovation counts as measures of regional production of new knowledge 显示文摘 | Acs Z J Anselin L Varga A | 2002 | Research Policy2002，31，7： | 1 |
| 16 | Improved capacitive properties of layered manganese dioxide grown as nanowires 显示文摘 | Vargas O A Caballero A Hem6n L | 2011 | Journal of Power Sources2011，196，： | 1 |
| 17 | Clinical and laboratory parameters in the differential diagnosis of pleural effusion secondary to tuberculosis or cancer显示文摘 | Antonangelo L Vargas FS Seiscento M | 2007 | Clinics2007，62，5： | 1 |
| 18 | Role of complement in the pathomechanism of atherosclerotic vascular diseases显示文摘 | Szeplaki G Varga L Fast G | 2009 | Mol Immunol2009，46，14： | 1 |
| 19 | Effects of rolipram and diazepam on the adaptive changes induced by morphine withdrawal in the hypothalamic paraventricular nucleus 显示文摘 | Nunez C Gonzalez'Cuello A Sanchez L Vargas ML Milan6s MV Laorden ML | 2009 | Eur J Pharmacol2009，620，13： | 1 |
| 20 | Oxidative stress in distant ornans and the effects of allopurinol during experimental acute pancreatitis显示文摘 | Czako L Takacs T Varga IS | 2000 | Int J Pancreatol2000，27，3： | 1 |
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