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| 1 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 2 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 3 | A comparative evaluation of microalgae for the degradation of piggery wastewater under photosynthetic oxygenation显示文摘 | Ignacio de Godos Virginia A. Vargas Saúl Blanco María C. García González Roberto Soto Pedro A. García-Encina Eloy Becares Raúl Mu?oz | 2010 | Bioresource Technology2010，，14： | 2 |
| 4 | Spatial knowledge spillover and university research : evidence from austria 显示文摘 | Fischer M M Varga A | 2003 | The Annals of Regional Science2003，，37： | 1 |
| 5 | CD70^+ anti gen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa显示文摘 | Laouar A Haridas V Vargas D | 2005 | Nat Immunol2005，6，： | 1 |
| 6 | Geographic spillovers and university Research:a spatial econometric perspective 显示文摘 | ANSELIN L VARGA A ACS Z | 2000 | Growth and Change2000，31，： | 1 |
| 7 | Reduced epidermal growth factor expression in hypohidrotic ectodermal dysplasia and tabby mice 显示文摘 | Emanuelle Fantino Carlos George-Nascimento | 1996 | J Clin Lavest1996，97，： | 1 |
| 8 | An antitumor promoter from Moringa oleifera Lam显示文摘 | Guevara A P Vargas C Sakurai H | 1999 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis1999，440，2： | 1 |
| 9 | Controlof superficial scald on‘d′Anjou’pears byethoxyquin:Effect of ethoxyquin concentration,timeand method of application,and a combined effect withcontrolled atmosphere storage显示文摘 | Chen P M Varga D M Mielke E A | 1990 | Journal of FoodScience1990，55，1： | 1 |
| 10 | Lack of evidence for an increase in interleukin-6 expression in adult murine bone,bone marrow,and marrow stromal cell cultures after ovariectomy显示文摘 | VARGAS SJ NAPRETA A LEE SK | 1996 | J Bone Miner Res1996，11，12： | 1 |
| 11 | Computation of general inner-out-er and spectral factorization problems显示文摘 | Oara C Varga A | 2000 | IEEE Trans on Automatic Control2000，45，： | 1 |
| 12 | A weighted inequality for the Kakeya maximal operator显示文摘 | VARGAS A M | 1994 | Proc Amer Math Soc1994，120，： | 1 |
| 13 | Diet and nutrient factors in colorectal cancer risk 显示文摘 | Vargas A J Thompson P A | 2012 | Nutr Clin Pract2012，27，5： | 1 |
| 14 | Co-occurrence of aflatoxins B1, B2,G1,G2,zearalenone and fumonisin B1 in Brazilian corn显示文摘 | Vargas E A Preis R A Castro L | 2001 | Food Addit Con- tam2001，18，11： | 1 |
| 15 | CFD study of a variable area ratio ejector using R600a and R152a refrigerants显示文摘 | Varga S Lebre P M S Oliveira A C | 2013 | International Journal of Refrigeration2013，36，1： | 1 |
| 16 | Pretreatment of corn stover u- sing wet oxidation to enhance enzymatic digestibility显示文摘 | Varga E Schmidt A S Rczey K | 2003 | Applied Bi- ochemistry and Biotechnotogy2003，104，1： | 1 |
| 17 | Electrochemical instability of LiVzOs as an electrode material for aqueous rechargeable lithium batteries显示文摘 | Caballero A Morales J Vargas O A | 2010 | Journal of Power Sources2010，195，13： | 1 |
| 18 | Effect of solubility and nucleatingduality of N, N ' -dicyclohexyl-2 ,6-naphthalenedicarboxamide on thesupermolecular structure of isotactic polypropylene 显示文摘 | VARGA J MENYHARD A | 2007 | Macromolecules2007，40，7： | 1 |
| 19 | Chordoma of the sacrum:'en bloc' total sacrectomy and lumbopelvic reconstraction显示文摘 | Varga PP Lazary A | 2010 | Eur Spine J2010，19，6： | 1 |
| 20 | Signaling via the NF-kB system 显示文摘 | Mitchell S Vargas J Hoffmann A | 2016 | Wiley Interdiscip Rev Syst Biol Med2016，8，3： | 1 |
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