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| 1 | Fast and sensitive LC–MS/MS method for the simultaneous determination of lisinopril and hydrochlorothiazide in human plasma显示文摘A sensitive and rapid liquid chromatography-tandem mass spectrometry(LC–MS/MS) method has been developed for the simultaneous determination of lisinopril(LIS) and hydrochlorothiazide(HCTZ) in human plasma using their labeled internal standards(ISs). Sample pre-treatment involved solid phase extraction on Waters Oasis HLB cartridges using 100 μL of plasma, followed by liquid chromatography on Hypersil Gold C_(18)(50 mm×3.0 mm, 5 μm) column. The analytes were eluted within 2.0 min using acetonitrile-5.0 m M ammonium formate, p H 4.5(85:15, v/v) as the mobile phase. The analytes and ISs were analyzed in the negative ionization mode and quantified using multiple reaction monitoring. The method showed excellent linearity over the concentration range of 0.50–250.0 ng/m L for both the analytes. The intra-batch and inter-batch precision(% CV) was ≤5.26% and their extraction recoveries were in the range of 96.6%–103.1%. Matrix effect evaluated in terms of IS-normalized matrix factors ranged from 0.97 to 1.03 for both the analytes. The validated method was successfully applied to determine the plasma concentration of the drugs using 10 mg lisinopril and 12.5 mg hydrochlorothiazide fixed dose formulation in 18 healthy Indian volunteers. | Jaivik V.Shah Priyanka A.Shah Priya V.Shah Mallika Sanyal Pranav S.Shrivastav | 2017 | Journal of Pharmaceutical Analysis2017，7，3： | 5 |
| 2 | Application of an LC–MS/MS method for the analysis of amlodipine,valsartan and hydrochlorothiazide in polypill for a bioequivalence study显示文摘A sensitive and selective method has been proposed for the simultaneous determination of amlodipine(AML),valsartan(VAL) and hydrochlorothiazide(HCTZ) in human plasma by liquid chromatography–tandem mass spectrometry(LC–MS/MS). The analytes and their deuterated analogs were quantitatively extracted from100 μL human plasma by solid phase extraction on Oasis HLB cartridges. The chromatographic separation of the analytes was achieved on a Chromolith RP18 e(100 mm × 4.6 mm) analytical column within 2.5 min. The resolution factor between AML and VAL, AML and HCTZ, and VAL and HCTZ was 2.9, 1.5 and 1.4, respectively,under isocratic conditions. The method was validated over a dynamic concentration range of 0.02–20.0 ng/m L for AML, 5.00–10,000 ng/m L for VAL and 0.20–200 ng/m L for HCTZ. Ion-suppression/enhancement effects were investigated by post-column infusion technique. The mean IS-normalized matrix factors for AML, VAL and HCTZ were 0.992, 0.994 and 0.998, respectively. The intra-batch and inter-batch precision(% CV) across quality control levels was ≤ 5.56% and the recovery was in the range of 93.4%–99.6% for all the analytes. The method was successfully applied to a bioequivalence study of 5 mg AML + 160 mg VAL + 12.5 mg HCTZ tablet formulation(test and reference) in 18 healthy Indian males under fasting. The mean log-transformed ratios of C max, AUC0–120 h and AUC0-inf and their 90% CIs were within 90.2%–102.1%. The assay reproducibility was demonstrated by reanalysis of 90 incurred samples. | Jaivik V.Shah Jignesh M.Parekh Priyanka A.Shah Priya V.Shah Mallika Sanyal Pranav S.Shrivastav | 2017 | Journal of Pharmaceutical Analysis2017，7，5： | 3 |
| 3 | Determination of lercanidipine in human plasma by an improved UPLC–MS/MS method for a bioequivalence study显示文摘An improved and reliable ultra-performance liquid chromatography/tandem mass spectrometry(UPLC–MS/MS) method has been developed and validated for the determination of lercanidipine in human plasma. Plasma samples with lercanidipine-d3 as an internal standard(IS) were prepared by solid phase extraction on Phenomenex Strata-X cartridges using 100 μL of human plasma. Chromatographic analysis was performed on UPLC BEH C_(18)(50 mm*2.1 mm, 1.7μm) column under isocratic conditions. Linear calibration curves were obtained over a wide dynamic concentration range of 0.010–20.0 ng/mL. Matrix effect was assessed by post-column infusion, post-extraction spiking and standard-line slope methods.The mean extraction recovery was >94% for the analyte and IS. Inter-batch and intra-batch precision(%CV) across five quality controls was <5.8%. Bioequivalence study was performed with 36 healthy subjects after oral administration of 10 mg of lercanidipine and the assay reproducibility was evaluated by reanalysis of 133 incurred samples. | Darshan V.Chaudhary Daxesh P.Patel Priyanka A.Shah Jaivik V.Shah Mallika Sanyal Pranav S.Shrivastav | 2016 | Journal of Pharmaceutical Analysis2016，6，2： | 2 |
| 4 | ' Connecting' and ' Disconnecting' With Civic Life:Patterns of Internet Use and the Production of Social Capital显示文摘 | Dhavan V.Shah Nojin Kwak R.Lance Holbert | | 0，，02： | 1 |
| 5 | The Internet and Anti-War Activism:A Case Study of Information,Expression,and Action显示文摘 | Seungahn Nab Aaron S.Veenstra Dbavan V.Shah | | 0，，01： | 1 |
| 6 | Epidemiology of HPV infection among Mexican women with normal cervical cytology显示文摘 | EduardoLazcano‐Ponce RolandoHerrero NubiaMu?oz AurelioCruz Keerti V.Shah PatriciaAlonso PilarHernández JorgeSalmerón MauricioHernández | 2001 | Int J Cancer2001，，3： | 1 |
| 7 | Human papillomavirus is a necessary cause of invasive cervical cancer worldwide显示文摘 | Jan M. M.Walboomers Marcel V.Jacobs M. MicheleManos F. XavierBosch J. AlainKummer Keerti V.Shah Peter J. F.Snijders JulianPeto Chris J. L. M.Meijer NubiaMu?oz | 1999 | J Pathol1999，，1： | 1 |
| 8 | Human papillomavirus is a necessary cause of invasive cervical cancer worldwide显示文摘 | Jan M. M.Walboomers Marcel V.Jacobs M. MicheleManos F. XavierBosch J. AlainKummer Keerti V.Shah Peter J. F.Snijders JulianPeto Chris J. L. M.Meijer NubiaMu?oz | 1999 | J Pathol1999，，1： | 1 |
| 9 | Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects gene expression pathways beyond cholesterol metabolism in liver cells显示文摘 | HongLan LingPang Marsha M.Smith DianeLevitan WeiDing LiLiu LixinShan Vidhi V.Shah MaureenLaverty GladysArreaza QingZhang Nicholas J.Murgolo MarcoHernandez Jonathan R.Greene Eric L.Gustafson Marvin L.Bayne Harry R.Davis Joseph A.Hedrick | 2010 | J. Cell. Physiol2010，，1： | 1 |
| 10 | Simultaneous quantification of amiloride and hydrochlorothiazide in human plasma by liquid chromatography–tandem mass spectrometry显示文摘A selective, sensitive and precise assay based on solid phase extraction and liquid chromatography–tandem mass spectrometry(LC–MS/MS) was developed for the simultaneous determination of amiloride(AMI) and hydrochlorothiazide(HCTZ) in human plasma. Sample clean-up with 250 μL of plasma was done on Phenomenex Strata^(?)-X extraction cartridges using their labeled internal standards(AMI-15 N3 and HCTZ-13 C,d2). Chromatography was performed on Hypersil Gold C18(50 mm×3.0 mm, 5 μm) column using acetonitrile with 4.0 m M ammonium formate(p H 4.0, adjusted with 0.1% formic acid)(80:20, v/v) as the mobile phase. Detection was carried out on a triple quadrupole API 5500 mass spectrometer utilizing an electrospray ionization interface and operating in the positive ionization mode for AMI and negative ionization mode for HCTZ. Multiple reaction monitoring was used following the transitions at m/z 230.6/116.0, m/z233.6/116.0, m/z 296.0/204.9 and m/z 299.0/205.9 for AMI, AMI-15 N3, HCTZ and HCTZ-13 C,d2,respectively. Calibration curves were linear(r2≥0.9997) over the concentration range of 0.050–50.0 and0.50–500 ng/m L for AMI and HCTZ, respectively, with acceptable accuracy and precision. The signal-to-noise ratio at the limit of quantitation was ≥14 for both the analytes. The mean recovery of AMI and HCTZ from plasma was 89.0% and 98.7%, respectively. The IS-normalized matrix factors determined for matrix effect ranged from 0.971 to 1.024 for both the analytes. The validated LC–MS/MS method was successfully applied to a bioequivalence study using 5 mg AMI and 50 mg HCTZ fixed dose tablet formulation in 18 healthy Indian volunteers with good reproducibility. | Jaivik V.Shah Priyanka A.Shah Mallika Sanyal Pranav S.Shrivastav | 2017 | Journal of Pharmaceutical Analysis2017，7，5： | 1 |
| 11 | The Correspon-dent,the Comic,and the Combatant:The Consequence of Host Style in Political Talk Shows显示文摘 | Emily K. V Stephanie E L Bode D.Jasun C Mitchell B C.N.Johnson Y.M Kim and Dhavan V.Shah | | 0，，： | 1 |
| 12 | SPE-UPLC-MS/MS assay for determination of letrozole in human plasma and its application to bioequivalence study in healthy postmenopausal Indian women显示文摘A rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) method is described for determination of letrozole in human plasma.Following solid phase extraction(SPE) of letrozole and letrozole-d4 on Orochem DVB-LP cartridges,chromatography was performed on Acquity UPLC BEH C_(18)(50 mm × 2.1 mm.1.7 μm) column using methanol-0.1%formic acid in water(85:15,v/v) as the mobile phase.Detection was carried out on a triple quadrupole mass spectrometer with an electrospray source,operated under positive ionization mode.Quantitation of letrozole and letrozole-d4 was done using multiple reaction monitoring(MRM) following the transitions at m/z286.2→217.0 and m/z 290.2→221.0,respectively.The calibration plots were linear through the concentration range of 0.10-100 ng/mL(r^2 ≥ 0.9990) using 100 μL human plasma.The extraction recovery of letrozole ranged from 94.3%to 96.2%and the intra-batch and inter-batch precision was ≤ 5.2%.The method was successfully applied to a bioequivalence study of letrozole after oral administration of2.5 mg tablet formulation to 16 healthy postmenopausal Indian women.The assay reproducibility was also established through incurred sample reanalysis(ISR) of 74 subject samples. | Pravin G.Vanol Puran Singhal Priyanka A.Shah Jaivik V.Shah Pranav S.Shrivastav Mallika Sanyal | 2016 | Journal of Pharmaceutical Analysis2016，6，4： | 1 |
| 13 | 第三个世界肾脏日:回顾和前瞻显示文摘“从来不要怀疑一小群富于思想的、有责任心的公民能够改变这个世界。事实上,历史从来都是这样的。”——Margaret | Sudhir V.Shah John Feehally 李耀荣(译) 余学清(校) | 2008 | 中华肾脏病杂志2008，24，3： | 0 |
| 14 | Recursive dynamics simulator(ReDySim):A multibody dynamics solver显示文摘Recursive formulations have significantly helped in achieving real-time computations and model-based control laws.The recursive dynamics simulator(ReDySim) is a MATLAB-based recursive solver for dynamic analysis of multibody systems.ReDySim delves upon the decoupled natural orthogonal complement approach originally developed for serial-chain manipulators.In comparison to the commercially available software,dynamic analyses in ReDySim can be performed without creating solid model.The input parameters are specified in MATLAB environment.ReDySim has capability to incorporate any control algorithm with utmost ease.In this work,the capabilities of ReDySim for solving open-loop and closed-loop systems are shown by examples of robotic gripper,KUKA KR5 industrial manipulator and four-bar mechanism.ReDySim can be downloaded for free from http://gffzz2bc0f34722c648dchuuxw0w6ckxob66vn.ffgz.tsg.suse.edu.cn and can be used almost instantly. | Suril V.Shah Paramanand V.Nandihal Subir K.Saha | 2012 | Theoretical & Applied Mechanics Letters2012，2，6： | 0 |
| 15 | Intelligent Subtle Forces and Fields Decide Human Performance:Jain Perspective–I显示文摘In this article,emphasis is laid on the manifesting powers of the soul.The powers of the soul manifest as working intelligent force called here as faculties.Eight faculties are defined corresponding to eight types of karma.A schematic model of human system based on Jain principles and scientific findings is presented.The role of DNA and its inadequacies as physical force is discussed.It is stated that genes are only coding devices and the biological intelligence of the soul provides the information for design and structure of the body.The role of biophotons in regulating the biochemistry and biology of life is discussed.Scientific evidence suggests that biophotons originate from the coherent field in DNA.It is argued that the karman body exists as coherent field and the karmanvarganas shedding off the karman body form the biophotons.These biophotons have the information for the reactions to take place in cells.In this model,biophoton provides a link between the karman body and the gross physical body. | Narayan Lal Kachhara Sudhir V.Shah | 2020 | Journal of Philosophy Study2020，10，10： | 0 |
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