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| 1 | Systemic treatment of hepatocellular carcinoma:Past,present and future显示文摘Hepatocellular carcinoma(HCC) is a common neoplasia which represents the second leading cause of cancer related death. Most cases occur in developing countries, but its incidence is rising in Western countries due to hepatitis C. Although hepatitis therapies have evolved and the HCC screening has increased in several areas, 40% present with advanced disease which is only amenable for palliative systemic treatment. HCC continues posing a challenge, in part due to the inherent chemoresistance of this neoplasia, the pharmacologic challenges due to an ill liver, difficulty in assessing radiological responses accurately, etc. Traditional chemotherapy have shown some responses without clear survival benefit, however, sorafenib demonstrated advantages in survival in advanced HCC when liver function is kept and recently immunotherapy seems to be a promising approach for some patients. This article will briefly expose the most relevant systemic treatment modalities to offer a general view from the past to the future. | Esther Una Cidon | 2017 | World Journal of Hepatology2017，9，18： | 11 |
| 2 | Digitally determining forest inventory units with an ecological classification system显示文摘Management-level forest resource data in China were obtained with a combination of two forest inventories. However, inconsistencies in the spatial attributes of forest data vary between the two inventory types and between two inventories of the same type. The inconsistencies make it inconvenient for long-term forest management planning with digital technologies. Ecological Land Types (ELTs) and Ecological Land Type Phases (ELTPs) have been mapped in selected forestry regions in northeast China, where important forest industries are located. The boundaries of ELTs are determined by geomorphic conditions, which are quantified by Digital Elevation Models (DEM); ELTPs are classified by overlaying ELTs with forest vegetation data layers that are obtained with both remotely sensed and ground data. The ELTPs represent the divisions of land in terms of both natural and human-induced forest conditions, and therefore they are reliable units for forest inventories and management. This paper introduces a case study for digitally determining forest inventory units in Benxi City, Liaoning Province, northeast China. The general objective of the study was to explain how a compatible forest inventory system should be designed and why the compatible forest inventory system was significant to digital forestry in China. | TANG Una, WANG Qingli, Guofan Shao, DAI Limin, WANG Shunzhong, LI Xiufen & XU Dong Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Graduate University of Chinese Academy of Sciences, Beijing 100101, China Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN 47907, USA | 2006 | Science China(Technological Sciences)2006，49，z1： | 6 |
| 3 | New therapeutic approaches to metastatic gastroenteropancreatic neuroendocrine tumors:A glimpse into the future显示文摘Neuroendocrine(NE) gastroenteropancreatic tumors are a heterogeneous group of neoplasias arising from neuroendocrine cells of the embryological gut. Their incidence have increased significantly over the past 3 decades probably due to the improvements in imaging and diagnosis. The recent advances in molecular biology have translated into an expansion of therapeutic approaches to these patients. Somatostatin analogs, which initially were approved for control of hormonal syndromes, have recently been proven to inhibit tumor growth. Several new drugs such as antiangiogenics and others targeting mammalian target of rapamycin pathways have been approved to treat progressive pancreatic neuroendocrine tumors(NETs) although their role in nonpancreatic is still controversial. The treatment of NETs requires a coordinated multidisciplinary approach. The management of localized NETs primarily involves surgical resection followed by surveillance. However, the treatment of unresectable and/or metastatic disease may involve a combination of surgical resection, systemic therapy, and liver-directed therapies with the goal of alleviating symptoms of peptide release and controlling tumor growth. This article will review the current therapeutic strategies for metastatic gastroenteropancreatic NETs and will take a glimpse into the future approaches. | Esther Una Cidon | 2017 | World Journal of Gastrointestinal Oncology2017，9，1： | 4 |
| 4 | Quantifying soil erosion with GIS-based RUSLE under different forest management options in Jianchang Forest Farm显示文摘Quantitatively estimating soil erosion with an integration of geographic information system (GIS) and the revised universal soil loss equation (RUSLE) under four different exposed soil proportion scenarios caused by forest management practices was studied at Jianchang Forest Farm. The GIS provided means of input data generation required by RUSLE model and allowed a spatial assessment of the erosion hazard over the study area. Four exposed soil proportion scenarios of 5%, 10%, 20% and 30% were tested with the GIS-based RUSLE model to evaluate soil erosion hazard. The predicted soil erosion potentials were classified into five categories in order to provide valuable aids for management planning. | ZHANG Hengming, WANG Qingli, DAI Limin, Guofan Shao, TANG Una, WANG Shunzhong & GU Huiyan Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Graduate University of Chinese Academy of Sciences, Beijing 100101, China Department of Forestry and Natural Resources, Purdue University, Lafayette IN47901, USA Northeast Forestry University, Harbin 150040, China | 2006 | Science China(Technological Sciences)2006，49，z1： | 3 |
| 5 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 6 | Epidemiology of Cryptosporidium : transmission, detection and identification显示文摘 | Ronald Fayer Una Morgan Steve J Upton | 2000 | International Journal for Parasitology2000，，12： | 3 |
| 7 | Digital forestry research in China显示文摘Digital Forestry as a concept was developed after the Digital Earth program. The Chinese scientists were not only among the pioneers who first proposed the concept of Digital Forestry, but also contributed a lot to the development of Digital Forestry. Digital Forestry is a digital framework to maintain forest planting, management, using, and protect. The synergetic use of computationally-intensive quantitative methods together with information technologies is the most important foundation for the development of Digital Forestry. Under this situation, the experience of Digital Forestry development in China is relatively rich. A number of academicians, scholars, and professional administrators were involved in discussing the Digital Forestry Construction Scheme. The Project of Digital Forestry Practicability approved by the State Forestry Administration is a major instance in developing Digital Forestry standard and key techniques. By introducing a case study of Digital Forestry, this paper reviews the concept of Digital Forestry, the way turning traditional forestry into Digital Forestry, and the future development of Digital Forestry. | TANG Shouzheng, TANG Una, Guofan Shao & DAI Limin Research Institute of Resource Information Techniques, Chinese Academy of Forestry, Beijing 100091, China Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Departmet of Forestry and Natural Resources, Purdue University, West Lafayette, IN 47907, USA Graduate University, Chinese Academy of Sciences, Beijing 100101, China | 2006 | Science China(Technological Sciences)2006，49，z1： | 2 |
| 8 | Application of Superresolution Techniques to Radar Imaging显示文摘ApplicationofSuperresolutionTechniquestoRadarImagingA.Fanrina,F.Prodi&F.Vinelli(Alenia.UnaAziendaFinmeccanica.Radar&C2Divisio... | A. Fanrina, F.Prodi & F. Vinelli(Alenia. Una Azienda Finmeccanica. Radar & C2 DivisionVia Tiburtina km. 12.400. 00131 Roma, Italy) | 1994 | Journal of Systems Engineering and Electronics1994，5，1： | 2 |
| 9 | Epidemiology of Cryptosporidium : transmission, detection and identification显示文摘 | Ronald Fayer Una Morgan Steve J Upton | 2000 | International Journal for Parasitology2000，，12： | 2 |
| 10 | Cryptosporidium andersoni n. sp. (Apicomplexa: Cryptosporiidae) from Cattle, Bos taurus显示文摘 | DAVID S.LINDSAY STEVE J.UPTON DOUGLAS S.OWENS UNA M.MORGAN JAN R.MEAD BYRON L.BLAGBURN | 2005 | Journal of Eukaryotic Microbiology2005，，1： | 2 |
| 11 | Determination of formic-acid and acetic acid concentrations formed during hydrothermal of birch wood and its relation to colour, strength and hardness显示文摘 | Bror Sundqvist Olov Karlsson Una Westermark | 2006 | Wood Sci Technol2006，40，： | 1 |
| 12 | User acceptance model of open source software 显示文摘 | M DOLORES GALLEGO PAULA I UNA SALVADOR BLJENO | 2008 | Computers in Human Behavior2008，24，5： | 1 |
| 13 | Cryptosporidium fayeri n. sp. (Apicomplexa: Cryptosporidiidae) from the Red Kangaroo (Macropus rufus)显示文摘 | UNA M.RYAN MICHELLEPOWER LIHUAXIAO | 2007 | Journal of Eukaryotic Microbiology2007，，1： | 1 |
| 14 | Advances in the development of bacterial vector technology显示文摘 | Sims K Kevin P Una S | 2003 | Exp Rev Vaccines2003，2，1： | 1 |
| 15 | Cryptosporidium varanii takes precedence over C. saurophilum显示文摘 | Ivan Pavlasek Una Ryan | 2007 | Experimental Parasitology2007，，3： | 1 |
| 16 | The first finding of a natural infection of Cryptosporidium muris in a cat显示文摘 | Ivan Pavlasek Una Ryan | 2006 | Veterinary Parasitology2006，，3： | 1 |
| 17 | Resident perceptions of tourism development in Riga, Latvia显示文摘 | Upchurch Randall Teivane Una | 2000 | Tourism Management2000，21，： | 1 |
| 18 | Cryptosporidium hominis n. sp. (Apicomplexa: Cryptosporidiidae) from Homo sapiens显示文摘 | UNA M.MORGAN‐RYAN ABBIEFALL LUCY A.WARD NAWALHIJJAWI IRSHADSULAIMAN RONALDPAYER R. C. ANDREWTHOMPSON M.OLSON ALTAFLAL LIHUAXIAO | 2005 | Journal of Eukaryotic Microbiology2005，，6： | 1 |
| 19 | Molecular epidemiology of giar- diasis显示文摘 | Simone M Caccio Una Ryan | 2008 | Mol Biochem Parasitol2008，160，2： | 1 |
| 20 | Drug discovery from natural sources 显示文摘 | Chin Y Ba|unas M J Chai HB | 2006 | AAPSJ2006，8，2： | 1 |
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