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| 1 | Skeletal myoblast based delivery of angiogenic growth factors:a comparison between angiopoietin-1 and VEGF gene delivery for therapeutic angiogenesis in the heart显示文摘Objectives This study investigated the efficacy of human skeletal myoblasts (SkM) mediated either human vascular endothelial growth factor-165 (hVEGF165) or angiopoietin-1 (Ang-1) on vascular development and myocardial regional perfusion. Methods A porcine heart model of chronic infarction was created in 28 female swine by coronary artery ligation. The animals were randomized into: (1) group-1, DMEM injected (n=6), (2) group-2, Ad-null transduced SkM transplanted (n=6), (3) group-3, Ad-hVEGF165 transduced SkM transplanted (n=8), and (4) group-4, Ad-Ang-1 transduced SkM (n=8). Three weeks later, 5 ml DMEM containing 3×108 SkM carrying exogenous genes were intramyocardially injected into 20 sites in left ventricle in groups-2, -3 and -4. Animals in group-1 were injected 5 ml DMEM without cells. Animals were kept on 5 mg/kg cyclosporine per day for 6 weeks. Regional blood flow was measured using fluorescent microspheres. The heart was explanted at 2, 6 and 12 weeks after transplantation for histological studies. Results Histological examination showed survival of lac-z expressing myoblasts in host tissue. Capillary density based on Von Willebrand factor-VIII (vWF-VIII) at low power field (×100) was 57.13±11.85 in group-3 at 6 weeks and declined to 32.1±5.21 at 12 weeks, while it was 39.9±10.26 at 6 weeks and increased to 45.14±6.54 at 12 weeks in group-4. The mature blood vessel index was highest in group- 4 at 6 and 12 weeks after transplantation. The regional blood flow in the center and peri-infarct area was significantly increased in animals of groups-3 and -4. Conclusions SkM carrying either hVEGF165 or Ang-1 induced neovascularization with increased blood flow. Ang-1 overexpression resulted in mature and stable blood vessel formation and may be a more potent arteriogenic inducer for neovascularization. | Husnain Kh Haider In-Chin Song Peter K Law Eugene KW Sim | 2006 | Journal of Geriatric Cardiology2006，3，3： | 3 |
| 2 | Phase formation in YAG powder synthesized by chemical methods 显示文摘 | SIM S M KELLER K A | 2000 | J Mater Sci2000，35，： | 2 |
| 3 | A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer 显示文摘 | Sim B K L O'Reilly M S Liang H | 1997 | Cancer Research1997，57，： | 2 |
| 4 | A market driven model for designing negotiation Agents computational inteligence显示文摘 | SIM K M | 2002 | Agent Technology for E-commerce2002，18，4： | 1 |
| 5 | Six-beam piezoresistive accelerometer with self-cancelling cross-axis sensitivity显示文摘 | Kim D K Bae Y H | 1998 | Electron Lett1998，34，5： | 1 |
| 6 | Parosteal osteosarcoma:a clinicopathological study显示文摘 | Okada K Frassica FJ sim FH Sim FH | 1994 | J Bone Joint Surg(Am)1994，76，： | 1 |
| 7 | Angiostatin and endostatin:endothelial cellspecific endogenous inhibitors of angiogenesis and tumor growth显示文摘 | SIM B K | 1998 | Angiogenesis1998，2，1： | 1 |
| 8 | White matter abnormalities in bipolar disorder: insights from diffusion tensor imaging studies显示文摘 | Heng S Song AW Sim K | 2010 | Neural Transm2010，117，： | 1 |
| 9 | Inhibition of biofihn formation and swarming of Bacillus subtilis by ( 5 Z ) -4 -bromo-5- ( bromomethylmm ) - 3-butyl-2(5n)-furanone显示文摘 | Ren D Sims J J Wood T K | 2002 | Lett Appl Microbiol2002，34，4： | 1 |
| 10 | Nonmehing-flesh trait in peaches is not related to low ethylene production rates显示文摘 | Brovelli E A Brecht J K Sherman W B Sims C A | 1999 | HortScience1999，34，： | 1 |
| 11 | Hypertension is associated with serologically active disease in patients with systemic lupus erythematosus:role of increased Th1/Th2ratio and oxidative stress显示文摘 | Lozovoy M A Simo A N Morimoto H K | 2014 | Scand J Rheumatol2014，43，1： | 1 |
| 12 | Parosteal osteosarcoma:a clinicopathological study显示文摘 | Okada K Frassica F J Sim F H | 1994 | J Bone Joint Surg (Am)1994，76，3： | 1 |
| 13 | Cubic AgPbmSbTem+2 bulk thermoelectric materials with high figure of merit显示文摘 | Hsu K F Sim L Fu G | 2004 | Science2004，303，： | 1 |
| 14 | Microscale determination of inorganic nitrogen in water and soil extracts显示文摘 | SIMS G K ELLSWORTH T R MULVANEY R L | 1995 | Commun Soil Sci Plant Anal1995，26，： | 1 |
| 15 | Investigation on the thermalbehavior of HTS power cable under fault current显示文摘 | Kim S Cho J Sim K D | 2006 | IEEE Transactions on Applied Superconductivity2006，16，2： | 1 |
| 16 | Changes in cell wall composition during ripening of grape berries显示文摘 | NUNAN K J SIMS IM BACIC A ROBINSON S P F1NCHER G B | 1998 | Plant Physiology1998，118，3： | 1 |
| 17 | CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney显示文摘 | Soos T J Sims T N Barisoni L Lin K Littman D R Dustin M L | 2006 | Kidney lnt2006，70，： | 1 |
| 18 | Repair of complet acromioclavicular separations using acromioclavicular hook plate 显示文摘 | Sim E Schwarz N Hocher K | 1995 | Clin Orthop1995，，314： | 1 |
| 19 | Isolation and chemical characterization of the heavy metal-binding protein metallothionein from marine invertebrates显示文摘 | OLAFSON R W SIM R G BOTO K G | 1979 | Comp Biochem Physiol1979，62，： | 1 |
| 20 | m-Bop,a repressor protein essential for cardiogenesis,interacts with skNAC,a heart-and muscle-specific transcription factor显示文摘 | Sims R J 3rd Weihe E K Zhu L | 2002 | J Biol Chem2002，277，26： | 1 |
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