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| 1 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 2 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 3 | Floor stress evolution laws and its effect on stability of floor roadway显示文摘According to the distribution of abutment stress in a stope,this research established the mechanical model of mining abutment pressure transmission in floor base on the theory of semi-infnite plate body in elasticity.This study takes the 762 working face of Haizi Coal Mine as a case in point,and analyzed the dynamic evolution law of seam floor stress during the mining process.With an organic combination of the mining floor stress and surrounding rock stress,the study obtained the change laws of the maximum principle stress and the minimum one for the floor roadway surrounding rock when mining the upper working face.Considering the non-constant pressure force state and the cracks revolution mechanisms of floor roadway surrounding rock,the research built the mechanical model of roadway stress.Simulation results verify the reliability of the above conclusions.Moreover,this model could provide the theoretical basis and technical support for controlling floor roadway surrounding rock. | Zhang Hualei Cao Jianjun Tu Min | 2013 | International Journal of Mining Science and Technology2013，23，5： | 20 |
| 4 | Diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy显示文摘With improvements in care of at-risk neonates, more and more children survive. This makes it increasingly important to assess, soon after birth, the prognosis of children with hypoxic-ischemic encephalopathy. Computed tomography, ultrasound, and conventional magnetic resonance imaging are helpful to diagnose brain injury, but cannot quantify white matter damage. In this study, ten full-term infants without brain injury and twenty-two full-term neonates with hypoxic-ischemic encephalopathy(14 moderate cases and 8 severe cases) underwent diffusion tensor imaging to assess its feasibility in evaluating white matter damage in this condition. Results demonstrated that fractional anisotropy, voxel volume, and number of fiber bundles were different in some brain areas between infants with brain injury and those without brain injury. The correlation between fractional anisotropy values and neonatal behavioral neurological assessment scores was closest in the posterior limbs of the internal capsule. We conclude that diffusion tensor imaging can quantify white matter injury in neonates with hypoxic-ischemic encephalopathy. | Hong-xin Li Xing Feng Qian Wang Xuan Dong Min Yu Wen-juan Tu | 2017 | Neural Regeneration Research2017，12，4： | 19 |
| 5 | Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction显示文摘 | Mei Hua Jiang Bing Cai Ying Tuo Jiancheng Wang Zhi Jun Zang Xiang'an Tu Yong Gao Zhijian Su Weiqiang Li Guilan Li Min Zhang Jianwei Jiao Zi Wan Chunhua Deng Bruce T Lahn Andy Peng Xiang | 2014 | Cell Research2014，24，12： | 14 |
| 6 | A double-blind,randomized,placebo-and positive-controlled phase III trial of 1% benvitimod cream in mild-to-moderate plaque psoriasis显示文摘Background:Benvitimod cream,a novel synthetic small molecule,was effective in treating mild-to-moderate plaque psoriasis.We conducted a phase III clinical trial to assess the efficacy and safety of benvitimod cream in patients with mild-to-moderate plaque psoriasis.Methods:We randomly assigned 686 patients(2:1:1)to receive 1%benvitimod cream,0.005%calcipotriol ointment or placebo twice a day for 12 weeks.The primary efficacy end points were the percentage of patients with a 75%or greater reduction from baseline in the psoriasis area and severity index(PASI 75)score and with a score of 0 or 1 in static physician’s global assessment(sPGA)at week 12.Results:The results showed that 50.4%of patients in the benvitimod group achieved PASI 75,which was significantly higher than that in the calcipotriol(38.5%,P<0.05)and placebo(13.9%,P<0.05)groups.The proportion of patients achieving an sPGA score 0 or 1 was 66.3%in the benvitimod group and 63.9%in the calcipotriol group,which were both significantly higher than that in the placebo group(34%,P<0.05).In the long-term follow-up study,50.8%of patients experienced recurrence.After retreatment with 1%benvitimod,73.3%of patients achieved an sPGA score of 0 or 1 again at week 52.Adverse events included application site irritation,follicular papules,and contact dermatitis.No systemic adverse reactions were reported.Conclusion:During this 12-week study,benvitimod cream was demonstrated with high effectiveness and safety in patients with mild-to-moderate plaque psoriasis. | Lin Cai Gen-Hui Chen Qian-Jin Lu Min Zheng Yu-Zhen Li Jin Chen Jie Zheng Fu-Ren Zhang Jian-Bin Yu Sen Yang Fu-Qiu Li Sheng-Xiang Xiao Qiu-Ning Sun Jin-Hua Xu Xing-Hua Gao Hong Fang Tian-Wen Gao Fei Hao Quan-Zhong Liu Ya-Ting Tu Ruo-Yu Li Bao-Xi Wang Dan-Qi Deng Qing-Shan Zheng Hong-Xia Liu Jian-Zhong Zhang | 2020 | Chinese Medical Journal2020，，24： | 11 |
| 7 | A Fault Diagnosis Method of Power Systems Based on an Improved Adaptive Fuzzy Spiking Neural P Systems and PSO Algorithms显示文摘A new fault diagnosis method based on improved Adaptive fuzzy spiking neural P systems(in short,AFSN P systems) and Particle swarm optimization(PSO)algorithm is presented to improve the efficiency and accuracy of diagnosis for power systems in this paper. AFSN P systems are a novel kind of computing models with parallel computing and learning ability. Based on our previous works, this paper focuses on AFSN P systems inference algorithms and learning algorithms and builds the fault diagnosis model using improved AFSN P systems for diagnosing effectively. The process of diagnosis based on AFSN P systems is expressed by matrix successfully to improve the rate of diagnosis eminently. Furthermore, particle swarm optimization algorithm is introduced into the learning algorithm of AFSN P systems, thus the convergence speed of diagnosis has a big progress. An example of 4-node system is given to verify the effectiveness of this method. Compared with the existing methods, this method has faster diagnosis speed, higher accuracy and strong ability to adapt to the grid topology changes. | WANG Jun PENG Hong TU Min Perez-Jimenez J. Mario SHI Peng | 2016 | Chinese Journal of Electronics2016，25，2： | 10 |
| 8 | Decreased Average Albumin-to-Globulin Ratio During Radiotherapy Worsens the Prognosis of Esophageal Squamous Cell Carcinoma:Implications for Nutritional Management显示文摘Objective Malnutrition and cachexia are common in esophageal squamous cell carcinoma(ESCC)patients undergoing radiotherapy.This study evaluated how malnutrition-and cachexia-related indicators,including the albumin-to-globulin ratio(AGR),and their changes during radiotherapy predict the treatment outcomes.Methods We reviewed a total of 172 ESCC patients receiving radiotherapy(as a primary cohort)and performed a Cox regression analysis on potential prognostic factors,including the AGR,as well as the TNM stage and concomitant chemotherapy.A subsequent receiver operating characteristics(ROC)curve and Kaplan Meier survival analysis was performed for ESCC patients stratified by the average AGR cut-off point.Results In addition to the well-documented factors(i.e.TNM stage and concomitant chemotherapy),the average AGR was a significant prognostic factor for ESCC patients receiving radiotherapy.By plotting the ROC curve of the average AGR with regard to the ESCC prognosis,we obtained cut-off points for the overall patients(cut-off point:1.5,AUC:0.636),for patients with stageⅡ/Ⅲdisease(cut-off point:1.5,AUC:0.611),and for patients with stageⅣdisease(cut-off point:1.84,AUC:0.900).The ESCC patients with higher average AGR had a significantly more favorable OS compared with those with a lower average AGR.Notably,ESCC patients who had an increasingΔAGR during radiotherapy had a considerably more favorable OS compared with those with a decreasingΔAGR.All of these findings were reproducible in the validation cohort.Conclusion A lower average AGR is indicative of a poorer prognosis for ESCC patients following radiotherapy.Improving the nutritional status and preventing or ameliorating cachexia might contribute to improving the prognosis of ESCC patients. | Fen Cai Xiu Lian Zhang Xiao Ling Wu Ting Ting Zhuang Lei Huang Yi Fei Tu Yuan Yuan Lu Min Xia Jiang Qing Ying Zhang Yan Lin Chang Chun Ma | 2021 | Journal of Nutritional Oncology2021，6，2： | 8 |
| 9 | Epidemiological survey of primary palmar hyperhidrosis in adolescents显示文摘尽管有在主要手掌的剧汗( PPH )的识别和治疗的最近的进展的背景,流行病学的调查几乎没是学习到过 i.lvestigate 的这的 conducted.The 目的流行和在东南 China.Methods 成层簇的采样的三个城市里的青少年之中的主要 PPH 的流行病学的特征被执行,由问询表的代表性的流行病学的调查在 33 000 学院和高 schooJ students.Results | LI Xu CHEN Rong TU Yuan-rong LIN Min LAI Fan-cai LI Yue-ping CHEN Jian-feng YE Jian-gang | 2007 | Chinese Medical Journal2007，，24： | 8 |
| 10 | Internal fixation with headless compression screws and back buttress plate for treatment of old Hoffa fracture显示文摘Hoffa 破裂的早临床、 X 光线照相术的结果用无头的压缩螺丝钉由开的减小和内部固定的一个标准协议对待的 ObjectiveTo 分析在 8 中国 patients.MethodsOpen 减小的一个连续系列与背撑墙板结合了,内部固定在所有病人上被执行。破裂被 K 电线解剖地暂时减少并且成立。如果破裂的结束是衰退的,从 ipsilateral 的自体同源的骨头接枝肠骨的冠在结束之间被包装。然后,破裂碎片与 AO 6.5 被修理;公里无头的压缩 cannulated 螺丝钉。至少二个螺丝钉被用来提供旋转稳定性。一个轮廓 pre 的重建盘子作为背撑墙 plate.ResultsAll posteromedially 或 posterolaterally 被放在 nonarticular 表面上病人被跟随在上面为至少 12 个月(范围 12-25 月) 。所有破裂完成了解剖减小并且临床上并且 X 光线照相术地愈合了。在最近的后续,吝啬的屈曲学位是 120.6 °
( 范围 110 °-135°) ,吝啬的延期学位是 2.5 °
( 范围 0 °-5°) 。平均视觉类似物规模分数是 1.6 个点(范围 0-3 ) 。六个病人作为优秀被估计并且 2 作为根据为特殊外科膝 20 系统的医院好。没有表面或深的感染,或硬件破裂。没有病人让了膝让路或锁住,尽管一些有断断续续的疼痛并且在奋发的锻练以后胀大。损害机制在功能的结果上有重要影响(P = 0.046 ) 与背撑墙板或自体同源的骨头 grafting 相结合对待旧 Hoffa 的 .ConclusionHeadless 压缩螺丝钉断裂是有效措施之一。它将对不仅骨折愈合而且早锻练和功能的恢复导致。 | Min Li Tu Chongqi Wang Guanglin Fang Yue Duan Hong Liu Lei Zhang Hui | 2014 | Chinese Journal of Traumatology2014，17，2： | 7 |
| 11 | Growth of ZnO self-converted 2D nanosheet zeolitic imidazolate framework membranes by an ammoniaassisted strategy显示文摘塑造象金属那样的水晶的多孔的材料器官的框架(MOF ) 和沸石进二维(2D ) nanosheet 形成为开发高效的分子的 sieving 膜是高度合乎需要的。然而,常规脱落免职为 nanosheet MOF 管状的膜的大规模制造复杂、挑战性。第一次,这里,我们由 ZnO 自我变换和氨帮助报导一种直接生长技术制作 zeolitic imidazolate 框架(ZIF ) 膜在多孔的空纤维底层上由 2D nanosheets 组成;膜对大规模工业煤气的分离过程合适。为 ZIF nanosheet 膜的建议制造过程在作为一个调节的人包含铵氢氧化物的一个 ligand 答案基于 ZnO 的预先扔的薄层的局部性的自我变换。产生 ZIF 2D nanosheet 管状的膜是高度面向的并且仅仅在厚度的 50 nm。它展出优秀分子的 sieving 性能,与为 H 2/CO2 分离的高 H 2 渗入和选择。这种技术为大规模分子的 sieving 应用在 MOF nanosheet 膜制造显示出大诺言。 | Yujia Li Lu Lin Min Tu Pei Nian Ashlee J. Howarth Omar K. Farha Jieshan Qiu Xiongfu Zhang | 2018 | Nano Research2018，11，4： | 6 |
| 12 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 13 | Imaging diagnosis of two unusual forms of gallstone ileus显示文摘Ileus from an impacted gallstone in the duodenum orany other part of intestine is a rare complication ofcholelithiasis.When a gallstone impacted in the distalstomach or in the duodenum,it is called Bouveret'ssyndrome,a rare form of gallstone ileus.~1 Small bowelileus caused by gallstone has become more and morecommon recently due to popular usage of computedtomography(CT)and magnetic resonance imaging(MRI).In the past,imaging diagnosis relied primarily onconventional radiography and contrast-enhancedfluoroscopy.~1 CT has subsequently been shown to bequite useful for this diagnosis.^(2,3)Recently,MRcholangiopancreatography(MRCP)has emerged as avaluable noninvasive technique for evaluation of biliarydisease.Here we described the CT,MRCP andgastroenterography findings in two patients with unusualform of gallstone ileus(GI),one is Bouveret's syndromeand the other is negative gallstone-induced ileus.Fewreports about GI with angiografin and MRCP findings ofBouveret's syndrome has been published.^(3-8) | JI Jian-song ZHANG Si-zheng SHAO Chu-xiao ZHAO Zhong-wei WANG Zu-fei LV Gui-jian XU Min TU Jian-fei LU Chen-ying | 2007 | Chinese Medical Journal2007，，10： | 6 |
| 14 | Management of limb fractures in a teaching hospital: comparison between Wenchuan and Yushu earthquakes显示文摘 | MIN Li TU Chong-qi LIU Lei ZHANG Wen-li YI Min SONG Yue-ming HUANG Fu-guo YANG Tian-fu PEI Fu-xing | 2013 | Chinese Journal of Traumatology2013，16，1： | 5 |
| 15 | Seam Tracking and Visual Control for Robotic Arc Welding Based on Structured Light Stereovision显示文摘A real-time arc welding robot visual control system based on a local network with a multi-level hierarchy is developed in this paper. It consists of an intelligence and human-machine interface level, a motion planning level, a motion control level and a servo control level. The last three levels form a local real-time open robot controller, which realizes motion planning and motion control of a robot. A camera calibration method based on the relative movement of the end-effector connected to a robot is proposed and a method for tracking weld seam based on the structured light stereovision is provided. Combining the parameters of the cameras and laser plane, three groups of position values in Cartesian space are obtained for each feature point in a stripe projected on the weld seam. The accurate three-dimensional position of the edge points in the weld seam can be calculated from the obtained parameters with an information fusion algorithm. By calculating the weld seam parameter from position and image data, the movement parameters of the robot used for tracking can be determined. A swing welding experiment of type Ⅴgroove weld is successfully conducted, the results of which show that the system has high resolution seam tracking in real-time, and works stably and efficiently. | De Xu, Min Tan, Xiaoguang Zhao, Zhiguo Tu Laboratory of Complex Systems and Intelligence Science, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, PRC | 2004 | International Journal of Automation and computing2004，1，1： | 5 |
| 16 | Application of Adaptive Fuzzy Spiking Neural P Systems in Fault Diagnosis of Power Systems显示文摘Adaptive fuzzy spiking neural P systems(AFSN P systems) are a novel kind of computing models with parallel computing and learning ability. Based on our existing works, AFSN P systems are applied to deal with the fault diagnosis problems of power systems and the uncertainty of action messages about protective relays and breakers, and a new fault diagnosis model of power systems is proposed with simple reasoning process and fast speed with parallel processing capabilities. The effectiveness of the fault diagnosis model is verified by some examples of fault diagnosis. Furthermore, the learning ability of AFSN P systems can be applied to adjust the weights in the fault diagnosis model automatically. | TU Min WANG Jun PENG Hong SHI Peng | 2014 | Chinese Journal of Electronics2014，23，1： | 4 |
| 17 | Failure Mechanism and Stability Analysis of an Active Landslide in the Xiangjiaba Reservoir Area,Southwest China显示文摘Dam construction for hydropower development is a very important subject all around the world, especially in developing countries due to energy crises. Filling of reservoir lakes may trigger or reactivate landslides in reservoir area. Active landslides in populated districts in the Xiangjiaba Reservoir area have become a striking problem for residents, local government and construction engineers. The key objective of this study is to analyze the role of reservoir filling and fluctuation in the activation/reactivation of the landslide as well as the mechanism of landslide from microstructures of pre-sheared slip surface. A large active landslide with a total volume of 1.25 Mm^3 at the left margin of Jinsha River in Pingshan County of Sichuan Province, Southwest China, was selected as a case study. Field investigation, field monitoring and laboratory tests were carried out to find out the failure mechanism and the stability of the active landslide. The shear strength test and stability analysis confirm that the water level fluctuations have an adverse effect on slope stability. It is obvious from microstructure analysis that the clay minerals contribute to down-slope movement at micro-scale as well as presence of expansive minerals(e.g., montmorillonite) decreases the strength of soil due to water level rise. | Javed Iqbal Fuchu Dai Min Hong Xinbin Tu Qizhi Xie | 2018 | Journal of Earth Science2018，29，3： | 4 |
| 18 | Breaking mechanism and control technology of sandstone straight roof in thin bedrock stope显示文摘The key problem to be solved urgently is how to avoid the occurrence of support break-off and water inrush in the stoping of sandstone straight roof under the action of load transfer in unconsolidated aquifer.For this reason,taking the thin bedrock 1602(3)working face of Huainan(the middle part of Anhui Province)Panyi Coal Mine as the engineering background,this study establishes the stope mining model by using the discrete element UDEC software and the mathematics mechanical model of the support load,and analyzes the reason of support crushing and decides to re-mining the working face by using the compulsive roof caving method.It is concluded that when the working face of sandstone straight roof is broken,the'voussoir beam'structure cannot be formed and acts on the support in the form of cantilever beam,but only when it falls to the high key stratum can the'voussoir beam'structure be formed and at this point,at this time,the bracket bears the weight of the rock layer in the range from the fractured sandstone layer to the lower critical layer.The working resistance of the support increases with the increase of the thickness and the breaking length of straight sandstone roof.When the breaking length of the roof reaches a certain extreme value,the support crushing accidents will occur.Managing roof with compulsive roof caving method can reduce the intensity of rock pressure in the stope,and the working face can be safely stoped,which provides a certain reference for similar conditions. | Hualei Zhang Min Tu Hua Cheng Yongzhi Tang | 2020 | International Journal of Mining Science and Technology2020，30，2： | 4 |
| 19 | Resting-state network complexity and magnitude changes in neonates with severe hypoxic ischemic encephalopathy显示文摘Resting-state functional magnetic resonance imaging has revealed disrupted brain network connectivity in adults and teenagers with cerebral palsy. However, the specific brain networks implicated in neonatal cases remain poorly understood. In this study, we recruited 14 termborn infants with mild hypoxic ischemic encephalopathy and 14 term-born infants with severe hypoxic ischemic encephalopathy from Changzhou Children's Hospital, China. Resting-state functional magnetic resonance imaging data showed efficient small-world organization in whole-brain networks in both the mild and severe hypoxic ischemic encephalopathy groups. However, compared with the mild hypoxic ischemic encephalopathy group, the severe hypoxic ischemic encephalopathy group exhibited decreased local efficiency and a low clustering coefficient. The distribution of hub regions in the functional networks had fewer nodes in the severe hypoxic ischemic encephalopathy group compared with the mild hypoxic ischemic encephalopathy group. Moreover, nodal efficiency was reduced in the left rolandic operculum, left supramarginal gyrus, bilateral superior temporal gyrus, and right middle temporal gyrus. These results suggest that the topological structure of the resting state functional network in children with severe hypoxic ischemic encephalopathy is clearly distinct from that in children with mild hypoxic ischemic encephalopathy, and may be associated with impaired language, motion, and cognition. These data indicate that it may be possible to make early predictions regarding brain development in children with severe hypoxic ischemic encephalopathy, enabling early interventions targeting brain function. This study was approved by the Regional Ethics Review Boards of the Changzhou Children's Hospital(approval No. 2013-001) on January 31, 2013. Informed consent was obtained from the family members of the children. The trial was registered with the Chinese Clinical Trial Registry(registration number: ChiCTR1800016409) and the protocol version is 1.0. | Hong-Xin Li Min Yu Ai-Bin Zheng Qin-Fen Zhang Guo-Wei Hua Wen-Juan Tu Li-Chi Zhang | 2019 | Neural Regeneration Research2019，14，4： | 4 |
| 20 | Metabolic and molecular analysis of nonuniform anthocyanin pigmentation in tomato fruit under high light显示文摘Pigment intensity and patterns are important factors that determine the nutritional and market values of tomato fruits.The acropetal manner of light-dependent anthocyanin accumulation with the highest levels at the stem end of the fruit makes Pro35S:BrTT8 tomato plants an ideal system for investigating the effects of light intensity on anthocyanin biosynthesis.Extensive transcript analyses indicate that anthocyanin pigmentation in Pro35S:BrTT8 plants under high light might be coordinately regulated by the exogenous protein BrTT8 and endogenous proteins SlAN2 and SlMYBL2.Furthermore,yeast two-hybrid assays showed that BrTT8 could interact efficiently with SlAN2,SlMYBL2,and SlAN11.Moreover,the physical interaction between BrTT8 and SlAN2 was validated by FRET.Simultaneous overexpression of SlAN2 and BrTT8 activated significant anthocyanin biosynthesis in infiltrated tobacco leaves.In addition,the ability of SlMYBL2 to suppress anthocyanin accumulation was also demonstrated in infiltrated tobacco leaves.Altogether,these results prove that tissue-specific assemblage of the heterogeneous MYB-bHLH-WD40 complex consisting of SlAN2,BrTT8 and SlAN11 triggers nonuniform anthocyanin accumulation in tomato fruit under high light.Additionally,it is proposed that a negative-feedback loop fulfilled by SlMYBL2 also participates in the regulation of anthocyanin production. | Yanjie Zhang Yan Li Wanping Li Zongli Hu Xiaohui Yu Yun Tu Min Zhang Jinyong Huang Guoping Chen | 2019 | Horticulture Research2019，6，1： | 4 |
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