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| 1 | 严重颅脑创伤患儿入院72h内开始营养支持与良好预后有关:二次分析一项治疗性低体温随机对照试验显示文摘目的了解严重颅脑损伤(severe traumatic brain injury,TBI)患儿营养支持开始时机与预后的关系。设计二次分析一项关于治疗性低体温的随机对照研究(Pediatric Traumatic Brain Injury Consortium: Hypothermia, also known as the Cool Kids Trial(NCT 00222742)。 | Meinert E Bell MJ Buttram S 方伯梁(译) 钱素云(校) | 2018 | 中国小儿急救医学2018，25，6： | 12 |
| 2 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 3 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 4 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 5 | The vitellogenin of the honey bee, Apis mellifera : structural analysis of the cDNA and expression studies显示文摘 | M.D. Piulachs K.R. Guidugli A.R. Barchuk J. Cruz Z.L.P. Sim?es X. Bellés | 2003 | Insect Biochemistry and Molecular Biology2003，，4： | 2 |
| 6 | Adefovir nephrotoxicity: Possible role of mitochondrial DNA depletion显示文摘 | Nozomu Tanji Kurenai Tanji Neeraja Kambham Glen S Markowitz Alvin Bell Vivette D D’Agati | 2001 | Human Pathology2001，，7： | 2 |
| 7 | Early prediction of endocrine therapy effect in advanced breast cancer patients using ^99mTc-depreotide scintigraphy 显示文摘 | VAN DEN BOSSCHE B VAN BELLE S DE WINTER F | 2006 | J Nucl Med2006，47，11： | 1 |
| 8 | Patterns of expression of Bax, Bcl-2 and Bcl-x(L) in the implantation site in rat during pregnancy 显示文摘 | CORREIA-DA-SILV BELL S C PRINGLE J H | 2005 | Placenta2005，26，10： | 1 |
| 9 | Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis:a randomized trial 显示文摘 | Woher J Seeney S Bell S | 2002 | Thorax2002，57，： | 1 |
| 10 | An analysis of the in vitro and in vivo phenotypes of mutants of herpes simplex virus type 1 lacking glycoproteins gG, gE, gIor the putative gJ显示文摘 | Balan P Davis-Poynter N Bell S | 1994 | J Gen Virol1994，75，6： | 1 |
| 11 | Effect β-glucan from oat and yeast on serum lipids显示文摘 | Bell S Coldmanm V M Bistrian B R | 1999 | Critical reviews in food science and nutrition1999，39，： | 1 |
| 12 | The resources for enhancing Alzheimerl s caregiver health (REACH): project design and baseline characteristics 显示文摘 | Wisniewski S R Belle S H Coon D W | 2003 | Psychol Aging2003，18，3： | 1 |
| 13 | Independent component analysis of electroencephalographic data 显示文摘 | Makeig S Bell A J Sejnowski T J | 1996 | Advances in Neural Information Processing Systems1996，8，： | 1 |
| 14 | Interleukin 12p40 is required for dendritic cell migration and T cell priming af- ter Mycobacterium tuberculosis infection 显示文摘 | Khader S Partida Sanchez S Bell G | 2006 | J Exp Med2006，203，7： | 1 |
| 15 | Involvenrent of NF-kappa B signalling in skin physiology and disease显示文摘 | Bell S Degitz K Quirling M | 2003 | Cell Signal2003，15，1： | 1 |
| 16 | Synthesis and characterization of polypyrrole-magnetite-silica particles显示文摘 | Btterworth M D Bell S A Armes S P Simpson A W | 1996 | J Colloid Interf Sci1996，183，： | 1 |
| 17 | Analysis of fMRI data by blind separation into independent spatial components 显示文摘 | Mckeown M J Makelg S Brown G G Jung T P Kinderman S S Bell A J and Sejnowski T J | 1998 | Human Brain Mapping1998，6，： | 1 |
| 18 | A high-order projection method for tracking fluid interface in variable density incompressible flows显示文摘 | Puckett E G Almgren A S Bell J B | 1997 | Compute Phys1997，130，： | 1 |
| 19 | Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins显示文摘 | Jantzen H M Admon A Bell S P | 1990 | Nature1990，344，： | 1 |
| 20 | Novel integrating adeno viral Pretroviral hybrid vector for gene therapy显示文摘 | Murphy S J Chong H Bell S | 2002 | Hum Gene Ther2002，13，6： | 1 |
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