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| 1 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 2 | Quantification of artemisinin in human plasma using liquid chromatography coupled to tandem mass spectrometry 显示文摘 | N Lindegardh J Taming P V Toi | 2009 | J Pharm Biomed Anal2009，49，3： | 1 |
| 3 | Phase Ⅲ,randomized,double-blind,placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant,advanced breast cancer (BOLERO-3)显示文摘 | O' Regan R Ozguroglu M Andre F Toi M Jerusalem G Wilks S Isaacs C Xu B Masuda N Arena FP Yardley D Yap YS Mukhopadhyay P Douma S El-Hashimy M Taran T Sahmoud T Lebwohl D Gianni L | | 0，，15： | 1 |
| 4 | MONARCH 3 : a randomizedphase HI study of anastrozole or letrozole plus abemaciclib, a CDK4/6inhibitor, or placebo in first-line treatment of women with HR+, HER2-locoregionally recurrent or metastatic breast cancer (MBC)显示文摘 | 1Goetz M P Toi M Klise S | 2015 | ASCOMeeting Abstracts2015，33，15： | 1 |
| 5 | Exencephaly : a first-trimester diagnosis 显示文摘 | Johnson S Toi A Glanc P | 2012 | Ultrasound Q2012，28，3： | 1 |
| 6 | Quantification of arte- misinin in human plasma using liquid chromatography coupled to tandem mass spectrometry 显示文摘 | Lindegardh N Taming J Toi P V | 2009 | J Pharm Biomed Anal2009，49，3： | 1 |
| 7 | Studies of octameric vinylsilasesquioxane by carbon-13 and silicon-29 cross polarization magic angle spinning and inversion recovery cross polarization nuclear mag- netic resonance spectroscopy 显示文摘 | BONHOMME C TOI~DANO P MAQUET J | 1997 | J Chem Soc Dalton Trans1997，，9： | 1 |
| 8 | Bacteria contribute to Artemia nutrition in algae-limited conditions:A laboratory study显示文摘 | Toi H T Boeckx P Sorgeloos P | 2013 | Aquaculture2013，，： | 1 |
| 9 | Mutans streptococci and lactobacilli in cariousdentine before and afteratraumatic restorative treatment 显示文摘 | Bonecker M Toi C CleatomJones P | 2003 | J Dent2003，31，6： | 1 |
| 10 | Serum human glandular kallikrein-2 protease levels predict the presence of pros tate cancer among men with elevated prostate-specific antigen 显示文摘 | Nam R K Diancondis E P Toi A | 2000 | J Clin Oncol2000，18，： | 1 |
| 11 | The effect of traditional African food mixtures on growth, pH and extracellular poly saccharide production by mutans streptococci in vitro显示文摘 | TOI C S CLEATON-JONES P | 2006 | Anaer- obe2006，12，9： | 1 |
| 12 | Mutans streptococci and lactobacilli in carious dentine before and after atraumatic restorative treatment显示文摘 | Bonecker M Toi C Cleaton -Jones P | 2003 | J Dent2003，31，6： | 1 |
| 13 | Comparative evaluation of simul- taneous bone marrow aspiration and bone marrow biopsv: an institutional experience显示文摘 | Toi P C h Varghese R G Rai R | 2010 | Indian J Hematol Blood Transfus2010，26，2： | 1 |
| 14 | Bacteria contribute to Artemia nutrition in algae-limited conditions: A laboratory study显示文摘 | TOI H T BOECKX P S SORGELOOS P | 2013 | Aquaculture2013，，： | 1 |
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