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| 1 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 2 | Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer显示文摘 | Parker C Milosevic M Toi A | 2004 | Int J Radiat Oncol Biol Phys2004，58，3： | 1 |
| 3 | Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs显示文摘 | Nakanishi C Toi M | 2005 | Nat Rev Cancer2005，5，4： | 1 |
| 4 | Phase Ⅲ,randomized,double-blind,placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant,advanced breast cancer (BOLERO-3)显示文摘 | O' Regan R Ozguroglu M Andre F Toi M Jerusalem G Wilks S Isaacs C Xu B Masuda N Arena FP Yardley D Yap YS Mukhopadhyay P Douma S El-Hashimy M Taran T Sahmoud T Lebwohl D Gianni L | | 0，，15： | 1 |
| 5 | Circulating levels of endostatin in cancer patients显示文摘 | Kuroi K Tanaka C Toi M | 2001 | Oncol Rep2001，8，2： | 1 |
| 6 | Circulating levels of endostatin in cancer patients显示文摘 | Kuroi K Tanaka C Toi M | 2001 | Oncol Rep2001，8，2： | 1 |
| 7 | Circulating levels of endostatin in cancer patients显示文摘 | Kuroi K Tanaka C Toi M | 2001 | Oncol Rep2001，8，2： | 1 |
| 8 | Circulating levels of endostatin in cancer patients显示文摘 | Kuroi K Tanaka C Toi M | 2001 | Oncol Reports2001，8，2： | 1 |
| 9 | Paxillin: Application of immunohistochemistry to the diagnosis of chromophobe renal cell carcinoma and oncocytoma 显示文摘 | Guo L Toi M Naruse K Miyazaki E Hayashi Y Yoshikawa C Ashida S Shuin T Enzan H | 2001 | Appl Immunohistochem Mol Morphol2001，9，4： | 1 |
| 10 | Polarographic elec- trode study of tumor oxygenation in clinically localized pros- tate cancer 显示文摘 | Parker C Milosevic M Toi A | 2004 | Int J Radiat Oncol Biol Plays2004，58，3： | 1 |
| 11 | Studies of octameric vinylsilasesquioxane by carbon-13 and silicon-29 cross polarization magic angle spinning and inversion recovery cross polarization nuclear mag- netic resonance spectroscopy 显示文摘 | BONHOMME C TOI~DANO P MAQUET J | 1997 | J Chem Soc Dalton Trans1997，，9： | 1 |
| 12 | Mutans streptococci and lactobacilli in cariousdentine before and afteratraumatic restorative treatment 显示文摘 | Bonecker M Toi C CleatomJones P | 2003 | J Dent2003，31，6： | 1 |
| 13 | Nuclear factor-kappaB inhibitors as sensitizers to anticaneer drugs 显示文摘 | Nakanishi C Toi M | 2005 | Nat Rev Cancer2005，5，4： | 1 |
| 14 | Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer显示文摘 | Parker C Milosevic M Toi A | 2004 | Int J Radiat Oncol Biol Phys2004，58，3： | 1 |
| 15 | Nuclear factor-κB inhibitors as sensitizers to anticancer drugs显示文摘 | Nakanishi C Toi M | 2005 | Nature Review Cancer2005，5，： | 1 |
| 16 | Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs 显示文摘 | Nakanishi C Toi M | 2005 | Nat Rev Cancer2005，5，4： | 1 |
| 17 | Nuclear factor kappaB inhibitors as sensitizers to anticancer drugs显示文摘 | Nakanishi C Toi M | 2005 | Nat Rev Canc2005，5，： | 1 |
| 18 | Circulating levels of endostatin in cancer patients显示文摘 | Kuroi K Tanaka C Toi M | 2001 | Oncol Rep2001，8，2： | 1 |
| 19 | Circulating levels of endostatin in cancer patients 显示文摘 | Kuroi K Tanaka C Toi M | 2001 | Oncol Reports2001，8，2： | 1 |
| 20 | Nuclear factor - kappaB inhibitors assensitizers to anticancer drugs显示文摘 | NAKANISHI C TOI M | 2005 | Nat Rev Cancer2005，5，4： | 1 |
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