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您的检索式：作者名="Laurian VLASE"
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| 1 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 2 | Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes显示文摘Genistein, the main isoflavone from soy, and bisphenol A(BPA), a food contaminant, are considered ubiquitous xenoestrogens. Here we investigated the influence of genistein and BPA on estrone(E1) metabolism in rat liver microsomes. Both substances inhibited the 2-hydroxylation and 16α-hydroxylation of E1, but in different degrees, thereby reducing the 2-OH-E1/16α-OH-E1 ratio, a biomarker for the risk of breast cancer. Although the 2-OH-E1/16α-OH-E1 ratio was lower under BPA treatment than under the control condition, the difference was not statistically significant. The 2-OH-E1/16α-OH-E1 ratio was significantly reduced by genistein treatment(P<0.05), and this effect was more pronounced when using a combination of BPA and genistein(P<0.01). Our findings suggest that a synergistic inhibition effect of genistein and BPA on E1 metabolism is associated with an increased risk of breast cancer. | GHELDIU Ana-Maria POPA Daniela-Saveta LOGHIN Felicia VLASE Laurian | 2015 | Biomedical and Environmental Sciences2015，28，11： | 1 |
| 3 | Antioxidative, anti-inflammatory potentials and phytochemical profile of Commiphora africana(A. Rich.) Engl.(Burseraceae) and Loeseneriella africana(Willd.)(Celastraceae) stem leaves extracts显示文摘Objective: To assess the antioxidant and anti-inflammatory activities as well as to determine the flavonoids and phenolic acids content of active fractions.Methods: Two medicinal plant samples were extracted successively in Soxhlet apparatus with n-hexane, dichloromethane, acetonitrile, ethyl acetate, methanol and n-butanol. Five methods were used to evaluate the antioxidant activity. Anti-inflammatory activity was done through the inhibition of the cyclooxygenase enzymes(COX-1 and COX-2).Polyphenolic compounds were analyzed by using a spectrophotometrical and high performance liquid chromatography-mass spectrometry(HPLC-MS) methods.Results: The data showed that the stem leaves extracts of Commiphora africana and Loeseneriella africana possessed significant in vitro antioxidant and anti-inflammatory activities. Polar extracts had radical scavenging effects and they reduced iron(III). The prostaglandin production was significantly stopped by acetonitrile and methanol extracts.These biological activities were supported by some bioactive compounds quantified by using the HPLC-MS. p-Coumaric acid, ferulic acid, isoquercitrin, quercitrin, quercetin,rutin, kaempferol and apigenin were the most metabolites quantified.Conclusions: The present study may explain the effectiveness of plants in traditional medicine of Burkina Faso, singularly Commiphora africana and Loeseneriella africana.The next investigation was to sub-fractionate the methanol fraction in order to isolate new antioxidant and/or anti-inflammatory compounds. | Moussa Compaore Roland Nag-Tiero Meda Sahabi Bakasso Laurian Vlase Martin Kiendrebeogo | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，8： | 0 |
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