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25篇 您的检索式：作者名="Tougeron"

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	题名	作者	年代	出处	被引量
1	Anti program death-1/anti program death-ligand 1 in digestive cancers显示文摘Human tumors tend to activate the immune system regulatory checkpoints as a means of escaping immunosurveillance. For instance, interaction between program death-1(PD-1) and program death-ligand 1(PD-L1) will lead the activated T cell to a state of anergy. PD-L1 is upregulated on a wide range of cancer cells. Anti-PD-1 and anti-PD-L1 monoclonal antibodies(m Abs), called immune checkpoint inhibitors(ICIs), have consequently been designed to restore T cell activity. Accumulating data are in favor of an association between PD-L1 expression in tumors and response to treatment. A PD-L1 expression is present in 30% to 50% of digestive cancers. Multiple anti-PD-1(nivolumab, pembrolizumab) and anti-PD-L1 m Abs(MPDL3280A, Medi4736) are under evaluation in digestive cancers. Preliminary results in metastatic gastric cancer with pembrolizumab are highly promising and phase Ⅱ will start soon. In metastatic colorectal cancer(CRC), a phase Ⅲ trial of MPDL3280 A as maintenance therapy will shortly be initiated. Trials are also ongoing in metastatic CRC with high immune T cell infiltration(i.e., microsatellite instability). Major challenges are ahead in order to determine how, when and for which patients we should use these ICIs. New radiologic criteria to evaluate tumor response to ICIs are awaiting prospective validation. The optimal therapeutic sequence and association with cytotoxic chemotherapy needs to be established. Finally, biomarker identification will be crucial to selection ofpatients likely to benefit from ICIs.	Eléonore de Guillebon Pauline Roussille Eric Frouin David Tougeron	2015	World Journal of Gastrointestinal Oncology2015，7，8：	12
2	ABCB4/MDR3 gene mutations and cholangiocarcinomas显示文摘	Tougeron D Fotsing G Barbu V		0，，02：	1
3	Immune response and colorectal cancer显示文摘	Tougeron D Fauquembergue E Latouche JB		0，，03：	1
4	Esophageal cancer in the elderly: an analysis of the factors associat- ed with treatment decisions and outcomes显示文摘	Tougeron D Hamidou H Scotte M	2010	BMC Can- cer2010，10，：	1
5	Association of beclin 1 expression with response to neoadjuvant chemoradiation therapy in patients with locally advanced rectal carcinoma显示文摘	Aziz Zaanan Jae Myung Park David Tougeron Shengbing Huang Tsung‐Teh Wu Nathan R. Foster Frank A. Sinicrope	2015	Cancer2015，，6：	1
6	MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibi- tor in human colon carcinoma cells 显示文摘	Park J M Huang S Tougeron D	2013	PLoS One2013，8，65：	1
7	Safety and outcome of definitive chemoradiotherapy in elderly patients with oe- sophageal cancer显示文摘	Tougeron D Di Fiore F Thureau S	2008	Br J Cancer2008，99，10：	1
8	Esophageal cancer in the elderly: an analysis of the factors associated with treatment decisions and outcomes 显示文摘	Tougeron D Hamidou H Scotte M	2010	BMC Cancer2010，10，：	1
9	Esophageal cancer in the elderly : an analysis of the factors associated with treatment de- cisions and outcomes显示文摘	Tougeron D Hamidou H Scott6 M	2010	BMC Cancer2010，10，：	1
10	Esophageal cancer in the elderly: an analysis of the factors associated with treat- ment decisions and outcomes显示文摘	TOUGERON D HAMIDOU H SCOTT6 M	2010	BMC Cancer2010，10，：	1
11	Esophageal cancer in the elderly:an analysis of the factors associated with treatment decisions and outcomes显示文摘	Tougeron D Hamidou H ScottéM		0，，：	1
12	Safety and outcome of definitive chemoradiotherapy in elderly patients with oe- sophageal cancer显示文摘	TOUGERON D FIORE F D THUREAU S	2008	Br J Cancer2008，99，10：	1
13	A rare case of mantle cell lymphoma as lymphomatous polyposis with widespread involvement of the digestive tract显示文摘	C. Chung Kim Yuen C. Tomowiak M. Yacoub T. Barrioz C. Silvain D. Tougeron	2010	Gastroenterologie Clinique et Biologique2010，，1：	1
14	Epidermal growth factor receptor ( EGFR ) and KRAS mutations during chemotherapy plus anti-EGFR monoclonal antibody treatment in metastatic colorectal cancer显示文摘	David Tougeron Ulrich Cortes Aurélie Ferru Claire Villalva Christine Silvain Jean Marc Tourani Pierre Levillain Lucie Karayan-Tapon	2013	Cancer Chemotherapy and Pharmacology2013，，2：	1
15	Mutation‐specific antibody detects mutant BRAF^V600E protein expression in human colon carcinomas显示文摘	Frank A. Sinicrope Thomas C. Smyrk David Tougeron Stephen N. Thibodeau Shalini Singh Andrea Muranyi Kandavel Shanmugam Thomas M. Grogan Steven R. Alberts Qian Shi	2013	Cancer2013，，15：	1
16	Safety and outcome of definitive chemoradiotherapy in elderly patients with oesophageal cancer显示文摘	Tougeron D Di Fiore F Thureau S	2008	Br J Cancer2008，99，10：	1
17	Safety and outcome of definitive chemoradiotherapy in elderly patients with oesophageal cancer显示文摘	Tougeron D Di Fiore F Thureau S	2008	Br J Cancer2008，99，10：	1
18	Immune response and colorectal cancer 显示文摘	Tougeron 0 Fauquembergue E Latouche JB	2013	Bull Cancer2013，100，3：	1
19	Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and main- tain centrosome stability in colorectal cancer cells 显示文摘	Park JM Tougeron D Huang S	2014	PLoS One2014，9，10：	1
20	Esophageal cancer in the elderly:an analysis of the factors associated with treatment decisions and outcomes显示文摘	Tougeron D Hamidou H Scotté M		0，，：	1

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