|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Synthesis, characterization and biological applications of novel Schiff bases of 2-(trifluoromethoxy) aniline显示文摘A series of five new Schiff bases(1–5) were synthesized by reacting 2-(trifluoromethoxy) aniline with different aromatic aldehydes. The Schiff base compounds were characterized by spectroscopic and analytical methods. Crystal structure of one new compound was also reported. The pharmacological properties, including antibacterial(14 bacterial species), antifungal(7 strains), antimalarial, anti-trypanosomal and anti-HIV activities of the compounds, were investigated. Cytotoxicity of the tested compounds was evaluated against human cervix adernocarcinoma cells(He La). Bacterial minimum inhibitory concentration(MIC) results by broth microdilution method showed that Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Proteus vulgaris, Klebsiella oxytoc and Klebsiella pneumonia were more sensitive in the presence of tested compounds with an MIC value of 15.6 μg/m L. All the tested compounds showed good to moderate activity against fungi. The sensitivity of Aspergillus fumigatus was higher than other strains with a minimum cell death concentration(MFC) of 15.6 μg/m L. Compound 1 showed greater antimalarial and anti-trypanosomal properties with very low to no cytotoxic effects against He La cells as compared with compound 5, while other compounds exhibited poor activity. Compounds 1–5 demonstrated good activity against HIV type-1. These Schiff base compounds could be used as good antimicrobial agents. | Thierry Youmbi Fonkui Monisola Itohan Ikhile Freddy Munyololo Muganza Marthe Carine Djuidje Fotsing Charmaine Arderne Xavier Siwe-Noundou Rui Werner Macedo Krause Derek Tantoh Ndinteh Patrick Berka Njobeh | 2018 | Journal of Chinese Pharmaceutical Sciences2018，27，5： | 2 |
| 2 | Deter- mination of six water-soluble vitamins in a pharmaceu-tical formulation by capillary electrophoresis显示文摘 | FOTSING L FILLET M BECHET I | 1997 | Jour- nal of Pharmaceutical and Biomedical Analysis1997，15，8： | 1 |
| 3 | ABCB4/MDR3 gene mutations and cholangiocarcinomas显示文摘 | Tougeron D Fotsing G Barbu V | | 0，，02： | 1 |
| 4 | Crystallization kinetics of amorphous SiC films:Influence of substrate显示文摘 | SCHMIDT H FOTSING E R BORCHARDT G CHASSAGNON R CHEVALIER S BRUNS U | 2005 | Applied Surface Science2005，252，： | 1 |
| 5 | Determination of six water- soluble vitamins in a pharmaceutical formulation by eapillary eleetrophoresis显示文摘 | Fotsing L Fillet M Hubert P | 1997 | J Pharmae Biomed Anal1997，15，8： | 1 |
| 6 | Determination of six water-soluble vitamins in a pharmaceutical formulation by capillary electrophoresis 显示文摘 | Fotsing L Fillet M Hubert P | 1997 | Journal of Pharmaceutical and Biomedical Analysis1997，15，8： | 1 |
| 7 | Griffonianone D, an isoflavone with anti-inflammatory activity from the root bark of Millettia griffoniana 显示文摘 | Yankep E Njamen D Fotsing M T | 2003 | J Nat Prod2003，66，9： | 1 |
| 8 | Determination of six water-soluble vitamins in a pharmaceutical formulation by capillary electrophoresis显示文摘 | L. Fotsing M. Fillet I. Bechet Ph. Hubert J. Crommen | 1997 | Journal of Pharmaceutical and Biomedical Analysis1997，，8： | 1 |
| 9 | Determination of six water-soluble vitamins in a pharmaceutical formulation by capillaryelectrophoresis 显示文摘 | Fotsing L Fillet M Hubert P | 1997 | Journal of Pharmaceutical and Biomedical Analysis1997，15，8： | 1 |
| 10 | Deter-mination of six water-soluble vitamina in a pharmaceu-tical formulation by capillary electrophoresis显示文摘 | FOTSING L FILLET M HUBERT P | 1997 | J Pharmac Biomed Anal1997，15，8： | 1 |
| 11 | 显示文摘 | FILLETM FOTSING L CROMMEN J | 1998 | J Chromatogr A1998，817，12： | 1 |
| 12 | Determination of six water-soluble vitamina in a pharmaceutical formulation by capillary electrophoresis显示文摘 | FOTSING L FILLET M HUBERT P | 1997 | J Pharmac Biomed Anal1997，15，8： | 1 |
| 13 | Determination of Six Water-Soluble Vitamins in a Pharmaceutical Formulation by Capillary Electrophoresis 显示文摘 | Fotsing L Fillet M Hubert P | 1997 | J Pharmac Biomed Anal1997，15，8： | 1 |
| 14 | Bonding analysis of carbon/epoxy composites with viscoelastic acrylic adhe sive显示文摘 | Fotsing E R Miron F Eury Y | 2012 | Composites Part B Eng2012，43，5： | 1 |
| 15 | modulated optical reflectance of thin semiconductor films on glass显示文摘 | Fotsing J L N Hoffmeyer M Chotikaprakhan S | 2003 | Rev Sci Instrum2003，74，1： | 1 |
| 16 | 显示文摘 | Bein B K Fotsing J L Gibkes | 2003 | American Institu- te of Physics2003，74，1： | 1 |
| 17 | Determination of six water-soluble vitamins in a pharmaceutical formulation by capillary electrophoresis显示文摘 | Fotsing L Fillet M Bechet I | 1997 | J Pharm Biomed Anal1997，15，8： | 1 |
| 18 | Crystallization kinetics of amorphous SiC films:Influence of substrate显示文摘 | Schmidt H Fotsing E R Borchardt G | 2005 | Applied Surface Science2005，252，： | 1 |
| 19 | Griffo nianone D: An isoflavone with anti inflammatory ac tivity from the root bark of Millettia griffoniana 显示文摘 | Yankep E Njamen D Fotsing M T | 2003 | Journal of Natural Products2003，66，9： | 1 |
| 20 | Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde显示文摘Four novel Schiff bases were synthesized by the condensation reaction of 2-hydroxyl-3-nitrobenzaldehyde with either benzothiazoles or benzimidazolamines. The compounds 1–4 were characterized by spectroscopic and analytical methods. The crystal structures of 6-methoxy-1,3-benzothiazol-2-amine and compound 2 are reported only. The 6-methoxy-1,3-benzothiazol-2-amine was found to crystallize in the orthorhombic crystal system in the space group Pbca, having eight molecules in the unit cell, while compound 2 was found to crystallize in the monoclinic crystal system in the space group P2_1/c. The biological activities of these compounds were investigated by evaluating their antibacterial, antifungal, antimalarial, anti-HIV and anti-trypanosomiasis activities. These compounds displayed very interesting antibacterial, antifungal, antimalarial, anti-trypanosomiasis, anti-HIV and low cytotoxicity activity against HeLa cells. | Monisola Itohan Ikhile Marthe Carine Djuidje Fotsing Charmaine Ardeme Jane Catherine Ngila Derek Tantoh Ndinteh | 2017 | Journal of Chinese Pharmaceutical Sciences2017，26，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员