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| 1 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 2 | Performance and limitations of the Hilbert-Huang transformation (HHT) with an application to irregular water waves显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering2004，31，9： | 1 |
| 3 | Performance and limitations of the Hilbert-Huang transformation (HHT) with an application to irregular water显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering2004，31，： | 1 |
| 4 | Performance and limitations of the Hilbert-Huang Transformation(HHT) with an application to irregular water waves显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering2004，31，1415： | 1 |
| 5 | Performance and lim- itations of the Hilbert-Huang transformation (HHT) with an application to irregular water waves 显示文摘 | MARCUS D TORSTEN S | 2004 | Ocean Engineering2004，31，1415： | 1 |
| 6 | IGF-I has a direct proliferative effect in adult hippocampal progenitor cells显示文摘 | Maria A.I ?berg N.David ?berg Theo D Palmer Ann-Marie Alborn Christine Carlsson-Skwirut Peter Bang Lars E Rosengren Torsten Olsson Fred H Gage Peter S Eriksson | 2003 | Molecular and Cellular Neuroscience2003，，1： | 1 |
| 7 | Reversal of Multidrug Resistance in Chinese Hamster Ovary Cells by the Immunosuppressive Agent Rapamycin显示文摘 | Torsten H Annette D Uwe C | 1993 | Eur J Pharmacology1993，246，： | 1 |
| 8 | Thiol-disulfide oxidoreductases are essential for the production of the lantibiotic sublancin 168显示文摘 | RONALD D TORSTEN S JORRIT K | 2002 | The Journal of Biological Chemistry2002，277，16： | 1 |
| 9 | Performance and limitations of the Hilbert-Huang transformation (HHT) with an application to irregular water waves 显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering (S0029-8018)2004，31，1415： | 1 |
| 10 | Performance and limitations of the Hilbert-Huang transformation (HHT) with an application to irregular water waves显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering2004，，1415： | 1 |
| 11 | Diagnostic accuracy of noninvasive coronary imaging using 16-detector alice spiral computed tomography with 188 ms temporal resolution显示文摘 | Axel K Torsten B Tanja D | 2005 | J Am Caudiol2005，1，： | 1 |
| 12 | Subtilosin production by two Bacillus subtilis subspecies and variance of the sbo-alb cluster显示文摘 | Torsten S Stefanie D Anke S | 2004 | Applied and Environmental Microbiology2004，70，4： | 1 |
| 13 | The spindle: a dynamis assembly of microtubules and motors显示文摘 | Torsten W Anthony H Arshad D | 2001 | Nature Cell Biology2001，3，： | 1 |
| 14 | Reactions involved in the sulfonation of heat treated abietic acid 显示文摘 | TORSTEN D | 1938 | J Am Chem Soc1938，60，： | 1 |
| 15 | Performance and limitations of the Hilbert-Huang transformation (HHT) with an application to irregular water waves显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering2004，31，1415： | 1 |
| 16 | Performance and limitations of the Hilbert- Huang transformation(HHT) with an application to irregular water waves显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering2004，31，1415： | 1 |
| 17 | Markerless real-time 3-D target region racking by motion backprojection from projection images显示文摘 | TORSTEN R JOACHIM D | 2005 | IEEE Transactions on Medical Imaging2005，24，11： | 1 |
| 18 | Performance and limitations of the Hilbert-Huang transformation (HHT) with an application to irregular water waves显示文摘 | Marcus D Torsten S | 2004 | Ocean Engineering2004，31，1415： | 1 |
| 19 | Markerless real-time 3-D target region tracking by motion backprojection from projection images显示文摘 | Torsten R Joachim D | 2005 | IEEE Transactions on Medical Imaging2005，24，11： | 1 |
| 20 | Performance and limitations of the Hilbert-Huang transform (HHT) with an application to irregular water waves显示文摘 | Marcus D Torsten S | | 0，，： | 1 |
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