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| 1 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 2 | Predicting Protein Subcellular Localization: Past, Present, and Future显示文摘Functional characterization of every single protein is a major challenge of the postgenomic era. The large-scale analysis of a cell's proteins, proteomics, seeks to provide these proteins with reliable annotations regarding their interaction partners and functions in the cellular machinery. An important step on this way is to determine the subcellular localization of each protein. Eukaryotic cells are divided into subcellular compartments, or organelles. Transport across the membrane into the organelles is a highly regulated and complex cellular process. Predicting the subcellular localization by computational means has been an area of vivid activity during recent years. The publicly available prediction methods differ mainly in four aspects: the underlying biological motivation, the computational method used, localization coverage, and reliability, which are of importance to the user.This review provides a short description of the main events in the protein sorting process and an overview of the most commonly used methods in this field. | Pierre Dnnes Annette Hglund | 2004 | Genomics, Proteomics & Bioinformatics2004，2，4： | 4 |
| 3 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 4 | Micro-Raman studies on DLC coatings 显示文摘 | Irmer G Annett D R | 2005 | Advanced Engineering Materials2005，8，： | 1 |
| 5 | Xp-duplications with and without sex reversal显示文摘 | Gottold B Mahmoud D | 1996 | Hum Genet1996，97，： | 1 |
| 6 | Ethylene tetramerization a new route to produce 1-octenc in exceptionally high selectivities显示文摘 | ANNETTE B KEVIN B JOHN T D | 2004 | J Am Chem Soc2004，126，45： | 1 |
| 7 | Production of hepatic outflow block and ascites with an ameroid constrictor 显示文摘 | Sweat E R Musieant M E Annetts D L | 1966 | Surg Forum1966，17，： | 1 |
| 8 | A study on reducing substrates of manganese-oxidizing peroxidases from Pleurotus eryngii and Bjerkandera adusta 显示文摘 | Annette H Francisco J R D Maria J M | 1998 | FEBS Lett1998，428，3： | 1 |
| 9 | The effects of vapreotide, a somatostatin analogue, on gastric acidity, gallbladder emptying and hormone release after 1 week of continuous subcutaneous infusion in normal subjects显示文摘 | MARC A R JURGEN D ANNETTE Z | 1999 | Brit J Clin Pharmacol1999，47，： | 1 |
| 10 | Position of horse- shoe crabs in estuarine food webs: N and C stable isotopic study of foraging ranges and diet composition 显示文摘 | Carmichael R H Rutecki D Annett B | 2004 | Journal of Experimental Marine Biology and Ecology2004，299，2： | 1 |
| 11 | Nigrostriatal alpha- synueleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson' s disease显示文摘 | Kirik D Annett LE Burger C | 2003 | Proc Natl Aead Sci U S A2003，100，5： | 1 |
| 12 | Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein:a new primate model of Parkinson's disease显示文摘 | Kirik D Annett LE Burger C | 2003 | Proc Natl Acad Sci USA2003，100，5： | 1 |
| 13 | Endophytic and ectophytic potato associated bacterial communities differ in structure and antagonistic function against plant pathogenic fungi 显示文摘 | GABRIELE B ANNETTE K MICHAELA D | 2005 | FEMS2005，51，： | 1 |
| 14 | Dynamic cardiocirculatory control during propofol anesthesia in mechanically ventilated patients显示文摘 | Cornelius K Annette S Martin D | 2000 | Anesth Analg2000，91，5： | 1 |
| 15 | Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats显示文摘 | Shaw D Annett J M Doherty B | 2007 | Phytomedicine2007，14，9： | 1 |
| 16 | Reversal of Multidrug Resistance in Chinese Hamster Ovary Cells by the Immunosuppressive Agent Rapamycin显示文摘 | Torsten H Annette D Uwe C | 1993 | Eur J Pharmacology1993，246，： | 1 |
| 17 | Integrating Point-to-Point Videoconfer- encing into Professional Development of Rural Elementary School Science Teachers 显示文摘 | L Annette D Dickerson | 2006 | Contemporary Issues in Technology and Teacher Education2006，，4： | 1 |
| 18 | Nigrostriatal alpha - synucleinopathy induced by viral vector - mediated overexpression of human alpha - synuclein : a new primate model of Parkinson 's disease 显示文摘 | Kirik D Annett LE Burger C | 2003 | Proe Natl Acad Sci USA2003，100，5： | 1 |
| 19 | Acquiring new knowledge: The role of retaining human capital in acquisitions of high teeh firms 显示文摘 | Annette L L Michael D | 2000 | Journal of High Technology Management Research2000，11，2： | 1 |
| 20 | Carbon Sequestration in the Agriculture Soils of Eu- rope显示文摘 | Freibauer Annette Rounsevell Mark D A Smith etc | 2004 | Geoderma2004，122，1： | 1 |
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