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	题名	作者	年代	出处	被引量
1	Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy显示文摘AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen.METHODS: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading system.RESULTS: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor regression.CONCLUSION: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes.	Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker Gustavo B Baretton Daniela E Aust	2008	World Journal of Gastroenterology2008，14，7：	29
2	Maternal characteristics and twin gestation outcomes over 10 years: impact of conception methods显示文摘	Christian Bamberg Christina Fotopoulou Philipp Neissner Torsten Slowinski Joachim W. Dudenhausen Hans Proquitte Christoph Bührer Wolfgang Henrich	2012	Fertility and Sterility2012，，1：	1
3	Carbon-carbon: A summary of resend developments and applications 显示文摘	TORSTEN W GORDON B	1997	Materials & Design1997，18，1：	1
4	Integrated dynamic aquaculture and wastewater treatment modelling for recirculating aquaculture systems显示文摘	Torsten E I Wik B T Linden P I	2009	Aquaculture2009，287，34：	1
5	Cytoprotection does not preserve brain functionality in rats during the acute post -stroke phase despite evidence of non - infarction provided by MR显示文摘	Torsten R Robert P Diana B	2000	NMR Biomed2000，6，3：	1
6	Nonstructural proteins NS2-3 and NS4A of classical swine fever virus: Essential features for infectious particle formation 显示文摘	Herve R Torsten S Oliver B	2007	Journal of Virology2007，365，：	1
7	Biological control of undesirable cyanobacteria in culturally eutrophic lakes显示文摘	Age B Bjorn A F Torsten K	1983	Oecologia1983，60，：	1
8	How to establish international limits for myco toxins in food and feed显示文摘	Torsten B	2003	Food Control2003，14，：	1
9	Tabebuia avellanedae extracts inhibit IL-2-independent T-lymphocyte activation and proliferation 显示文摘	Torsten B Jochen N Purevtseren G	2008	Transpl immunol2008，18，4：	1
10	Diagnostic accuracy of noninvasive coronary imaging using 16-detector alice spiral computed tomography with 188 ms temporal resolution显示文摘	Axel K Torsten B Tanja D	2005	J Am Caudiol2005，1，：	1
11	Total phenolics, flavonoids, an-thocyanins and antioxidant activity following simulated gastro-intestinal digestion and dialysis of apple varieties: Bioaccessibility and potential uptake显示文摘	JAOUAD B LUCIEN H TORSTEN B	2011	Food Chem2011，128，1：	1
12	Energy storage by the eleetroehemieal reduetion of CO2 to CO at a porous Au film 显示文摘	Gregory B S Torsten R Burkhard R	2002	Journal of Electroanalytical Chemistry2002，526，：	1
13	PCR-ELISA for the CaMV-35S promoter as a screening method for genetically modified Roundup Ready soybeans显示文摘	Hans-Josef B Friedrich S Torsten B	2001	Eur Food Res Technol2001，213，：	1
14	Continuous synthesis and excretion of the compatible solute ectoine by a transgenic, nonhalophilic bacterium显示文摘	Torsten S Thomas M Dirk B	2007	Applied and Environmental Microbiology2007，73，10：	1
15	Low model order approximations of continuously stirred biofilm reactors with Monod kinetics 显示文摘	Torsten W Elin G Claes B	2006	Biochemical Engineering Journal2006，30，1：	1
16	Apical tissue tracking echocardiography for characterization of regional left ventricular function:comparison with magnetic resonance imaging in patients after myocardial infarction 显示文摘	Adrian B Dietmar K Torsten W	2003	J Am Soc Echocardiogr2003，16，：	1
17	A microscopic model for packet transport in the lntemet显示文摘	TORSTEN H ROBERT B WOLFGANG K	2001	Physica A2001，294，1：	1
18	Is Kidney Function Altered by the Duration of Cardiopulmonary Bypass显示文摘	Joachim B Torsten B Andreas L	2003	Ann Thorac Surg2003，75，3：	1
19	Modeling framework and validation of a smart grid and demand response system for wind power integration显示文摘	TORSTEN B JASON F FRANCIS T	2014	Applied Energy2014，113，：	1
20	High force measurement sensitivity with fiber Bragg gratings fabricated in uniform-waist fiber tapers显示文摘	TORSTEN W SVEN B HARTMUT B	2011	Measurement Science and Technology2011，22，07：	1

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