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| 1 | Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis显示文摘Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Given that the burden of chronic liver disease is expected to rise owing to increasing rates of alcoholism, hepatitis B and C prevalence and obesity-related fatty liver disease, it is expected that the incidence of HCC will also increase in the foreseeable future. This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance. | Asmaa Ibrahim Gomaa Shahid A Khan Mireille B Toledano Imam Waked Simon D Taylor- Robinson | 2008 | World Journal of Gastroenterology2008，14，27： | 78 |
| 2 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 3 | Reactive hemophagocytic syndrome presenting as a component of multiple organ dysfunction syndrome显示文摘 | Gauvin F Toledano B Champagne J | 2000 | Crit Care Med2000，28，9： | 1 |
| 4 | Regulation of bacterial gene expression in response to oxidative stress显示文摘 | Storz G Toledano M B | 1994 | Methods Enzymol1994，236，： | 1 |
| 5 | P53 mutations in human cholangiocnoma:a review显示文摘 | Khan S A Thomas H C Toledano M B | 2005 | Livei Int2005，25，4： | 1 |
| 6 | Precipitable water vapor characterization in the Gulf of Cadiz region (soutbwestem Spain) based on Sun photometer, GPS, and radiosonde data 显示文摘 | TORRES B CACHORRO V E TOLEDANO C | 2010 | Journal of Geophysical Research2010，115，18： | 1 |
| 7 | ROS as signalling molecules:Mechanisms that generate specificity in ROS homeostasis显示文摘 | D'Autr aux B Toledano M B | | 0，，10： | 1 |
| 8 | Antidotal treatment of cyanide poisoning 显示文摘 | Megarbane B Delahaye A Goldgran Toledano D | 2003 | Chin Med Assoc2003，66，4： | 1 |
| 9 | ROS as signalling molecules:mechanisms that generate specificity in ROS homeostasis显示文摘 | D'Autré aux B Toledano MB | | 0，，10： | 1 |
| 10 | Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review 显示文摘 | Nieuwenhuijsen M J Toledano M B Eaton N E | 2000 | Occupational and Environmental Medicine2000，57，2： | 1 |
| 11 | 显示文摘 | Mazer BD Toledano B Saririan M | 1998 | J Allergy Clin Immunol1998，102，2： | 1 |
| 12 | Dose-dependent agonist and antagonist effects of the platelet-activating factor analogue 1- palmitoyl-2-acetoyl-Sn- glycero-3-phosphocholine on B lymphocytes显示文摘 | Toledano B Saririan M | 1998 | J Allergy Clin Immunol1998，102，2： | 1 |
| 13 | The let-7-imp axis legulates ageing of the Drosophila testis stem-cell niche显示文摘 | Toledano H D'Alterio C Czech B | 2012 | Nature2012，485，7400： | 1 |
| 14 | ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis 显示文摘 | D'Autr6aux B Toledano MB | 2007 | Nat Rev Mol Cell Biol2007，8，10： | 1 |
| 15 | Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review显示文摘 | Nieuwenhuijsen M J Toledano M B Eaton N E | 2000 | Occup Environ Med2000，57，2： | 1 |
| 16 | Changing international trends in mortality rates for liver, biliary and pancreatic tumours显示文摘 | Khan S A Taylor Robinson S D Toledano M B | 2002 | J Hepatol2002，37，6： | 1 |
| 17 | A genetic investigation of the essential role of glutathione 显示文摘 | SPECTOR D LABARRE J TOLEDANO M B | 2001 | J Biol Chem2001，276，10： | 1 |
| 18 | Chlorination disinfection by-products and risk of con- genital anomalies in England and Wales显示文摘 | Nieuwenhuijsen M J Toledano M B Bennett J | 2008 | Environ-mental Health Perspectives2008，116，2： | 1 |
| 19 | p53 Mutations in human cholangiocarcinoma: a review 显示文摘 | Khan S A Thomas H C Toledano M B | 2005 | Liver Int2005，25，4： | 1 |
| 20 | ROS as signalling molecules:mechanisms that generate specificity in ROS homeostasis显示文摘 | D'Autreaux B Toledano M B | | 0，，： | 1 |
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