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| 1 | Antidiabetic therapy and increased risk of hepatocellular carcinoma in chronic liver disease显示文摘AIM:To explore the association between hepatocellular carcinoma(HCC) and type 2 diabetes mellitus, describe the temporal relations between the onset of diabetes and the development of HCC and evaluate the possible effects of antidiabetic therapy on HCC risk.METHODS:We recruited 465 HCC patients, 618 with cirrhosis and 490 control subjects.We evaluated the odds ratio(OR) for HCC by univariate and multivariate analysis.Moreover, OR for HCC in diabetic subjects treated with insulin or sulphanylureas and with metformin were calculated.RESULTS:The prevalence of diabetes mellitus was 31.2% in HCC, 23.3% in cirrhotic patients and 12.7% in the Control group.By univariate and multivariate analysis, the OR for HCC in diabetic patients were respectively 3.12(CI 2.2-4.4, P < 0.001) and 2.2(CI 1.2-4.4, P = 0.01).In 84.9% of cases, type 2 diabetes mellitus was present before the diagnosis of HCC.Moreover, we report an OR for HCC of 2.99(CI 1.34-6.65, P = 0.007) in diabetic patients treated with insulin or sulphanylureas, and an OR of 0.33(CI 0.1-0.7, P = 0.006) in diabetic patients treated with metformin.CONCLUSION:Our study confi rms that type 2 diabetes mellitus is an independent risk factor for HCC and pre-exists in the majority of HCC patients.Moreover, in male patients with type 2 diabetes mellitus, our data shows a direct association of HCC with insulin and sulphanylureas treatment and an inverse relationship with metformin therapy. | Valter Donadon Massimiliano Balbi Michela Ghersetti Silvia Grazioli Antonio Perciaccante Giovanni Della Valentina Rita Gardenal Maria Dal Mas Pietro Casarin Giorgio Zanette Cesare Miranda | 2009 | World Journal of Gastroenterology2009，15，20： | 23 |
| 2 | Glycated hemoglobin and antidiabetic strategies as risk factors for hepatocellular carcinoma显示文摘AIM: To evaluate the relationship between glycemic control [assessed by glycated hemoglobin (HbA1c)], antidiabetic therapies and the risk of hepatocellular carcinoma (HCC).METHODS: We recruited 465 patients with HCC, 618 cases with liver cirrhosis and 490 controls with no liver disease. Among subjects with type 2 diabetes mellitus (DM2), the associations between the antidiabetic strategies and HbA1c level with HCC were determined through 2 series of multivariate logistic regression models using cirrhotic patients and controls as comparison groups. RESULTS: DM2 prevalence was 31.2% in patients with HCC, 23.2% in cirrhotic patients and 12.6% in controls (P < 0.0001). In 86% of study subjects, DM2 had been diagnosed for more than 1 year before the HCC diagnosis. HCC patients with DM2 had a 1.52.5fold increased risk of liver cancer. The HbA1c mean levels were signif icantly higher in DM2 patients with HCC than in cirrhoticand control DM2 patients. Antidiabetic treatment with metformin was more common among cirrhotic and control DM2 subjects than among cases with HCC. In both series of multivariate analyses, treatment with metformin signif icantly reduced the risk of HCC by more than 80% compared with sulphonylureas and insulin therapy. No signif icant differences were seen between sulphonylureas and insulin treatment. Elevated HbA1c levels were positively related to the risk for HCC in diabetic patients, with a 26%50% increase in risk for each 1% increase in HbA1c values.CONCLUSION: In patients with preexisting DM2, the risk of HCC is positively associated with poor chronic glycemic control and significantly decreased by metformin therapy. | Valter Donadon Massimiliano Balbi Francesca Valent Angelo Avogaro | 2010 | World Journal of Gastroenterology2010，16，24： | 15 |
| 3 | Association between hepatocellular carcinoma and type 2 diabetes mellitus in Italy:Potential role of insulin显示文摘AIM: To investigate the relationships between Type 2 diabetes mellitus (DM2) and the risk of hepatocellular carcinoma (HCC). METHODS: We studied the association between DM2 and HCC in a large case-control study that enrolled 465 consecutive Caucasian patients with HCC (78.3% males, mean age 68.5 ± 8.9 years) compared with an age and sex matched control group of 490 subjects. RESULTS: Prevalence of DM2 was significantly higher in HCC patients (31.2% vs 12.7%; OR = 3.12, 95% CI: 2.22-4.43) and in HCC cases with alcohol abuse. DM2 has been diagnosed before the appearance of HCC in 84.1% of diabetic HCC subjects with mean duration of 141.5 mo, higher in cases treated with insulin than in those with oral antidiabetic agents (171.5 vs 118.7 mo). Compared to controls, males DM2 with HCC were more frequently treated with insulin (38.1% vs 17.6%, P = 0.009) and with sulfonylurea with or without metformin than with diet with or without metformin (84% vs 68.3%, P = 0.049). CONCLUSION: DM2 in our patients is associated with a 3-fold increase risk of HCC. In most of our cases DM2 pre-existed to HCC. Patients with DM2 and chronic liver disease, particularly insulin treated males, should be considered for HCC close surveillance programs. | Valter Donadon Massimiliano Balbi Pietro Casarin Alessandro Vario Alfredo Alberti | 2008 | World Journal of Gastroenterology2008，14，37： | 11 |
| 4 | Left atrial thrombosis in an anticoagulated patient after bioprosthetic valve replacement:Report of a case显示文摘We present the case of a 74 year old woman suffering from severe mitral valve incompetence and rapid atrial fibrillation. After an appropriate vitamin K antagonist(VKA) therapy, the patient underwent mitral valve replacement by bioprosthesis. Then, the patient was rehospitalized for jaundice. Suspecting hepatotoxicity, VKA was discontinued and fondaparinux was started. During this treatment, the patient developed a symptomatic atrial thrombus. After exclusion of a hepatic disease, VKA was re-established with hemodynamic and liver enzymes normalization and atrial thrombus resolution. Caution has to be used when considering fondaparinux as an alternative strategy to VKA in patients with multiple thrombotic risk factors. | Gian Marco Rosa Antonello Parodi Ulrico Dorighi Federico Carbone Franois Mach Alessandra Quercioli Fabrizio Montecucco Nicolas Vuilleumier Manrico Balbi Claudio Brunelli | 2014 | World Journal of Clinical Cases2014，2，1： | 2 |
| 5 | Synthesis and complimentary complex formation properties of oligonucleotides covalently linked to new stabilizing agents显示文摘 | Sottofattori E Grandi T | 1994 | Tetrahedron1994，50，： | 1 |
| 6 | limitations and potential clinical application on contrast echocardiography显示文摘 | Modonesi E Balbi M Bezante G P | 2010 | Curr Cardiol Rev2010，6，1： | 1 |
| 7 | Living Donor Liver Transplantation for Acute Liver Failure: A Single Center Experience显示文摘 | L.P. Cariús L.F. Pacheco-Moreira E. Balbi C.R.G. Leal A.C. Gonzalez L.V. Agoglia C. Araújo M. Enne J.M. Martinho | 2009 | Transplantation Proceedings2009，，3： | 1 |
| 8 | Increased bronchoalveolar granulocytes and granulocyte/macro-phage colony-stimulating factor during exacerbations of chronic bronchitis 显示文摘 | Balbi B | 1997 | Eur Respir J1997，10，4： | 1 |
| 9 | Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease显示文摘 | Pesci A Balbi B Majori M | 1998 | Eur Respir J1998，12，2： | 1 |
| 10 | Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease显示文摘 | Pesci A Balbi B Majori M | 1998 | Eur Respir J1998，12，： | 1 |
| 11 | COPD: is chenaotaxis the key? 显示文摘 | BALBI B | 2003 | Chest2003，123，4： | 1 |
| 12 | Nineteen-years of pneumococcal invasive disease surveillance in a children's hospital in Mendoza, Argentina 显示文摘 | Abate H J Falaschi A Balbi L | 2014 | Archivos Argentinos de Oediatria2014，112，4： | 1 |
| 13 | River flow indexing using British benthic macro-inverbrates: a framework for setting hydro-ecological objectives显示文摘 | Extence C Balbi D M Chadd R P | 1999 | Regulated Rivers research and management1999，15，： | 1 |
| 14 | Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease显示文摘 | Pesei A Balbi B Majori M | 1998 | Eur Respir J1998，12，： | 1 |
| 15 | Comparative evaluation of standard criteria and CA-125 in ovarian cancers treated with platinum or paclitaxel 显示文摘 | Balbi GC Cardone A Passaro M | 2005 | Eur J Gynaecol Oncol2005，26，3： | 1 |
| 16 | Influence of menstrual factors and dietary habits on menstrual pain in adolescence age显示文摘 | Balbi C Musone R Menditto A | 2000 | European J of Obstet & Gynecol and Reproductive Biology2000，91，： | 1 |
| 17 | Doppler indices in the umbilical arteries:influence of vessel curvature induced by bladder filling显示文摘 | Balbis S Gaglioti P Todros T | | 0，，12： | 1 |
| 18 | Making maps of the cosmic microwave background: The MAXI- MA example显示文摘 | Radek Stompor Amedeo Balbi Julian D Borrill ct al | 2002 | Plays Rev ''2002 D 652002，，02： | 1 |
| 19 | Validation study of a two dimensional model of fire spread across a fuel bed显示文摘 | MORANDINI F SANTONI P A BALBI J H | 2000 | Combustion Science and Technology2000，157，1： | 1 |
| 20 | Influence of men- strual factors and dietary habits on menstrual pain in ad- olescence age 显示文摘 | Balbi C Mosone R Menditto A | 2009 | European J of Obstet & Gynecol and Reproductive Biology2009，91，： | 1 |
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