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| 1 | AMPK promotes the survival of colorectal cancer stem cells显示文摘Background: Colorectal cancer(CRC) is the third most commonly diagnosed cancer in males and the second in females worldwide in 2012. In the past 20 years, strong evidence suggests that cancer stem cells are the main culprit of cancer metastasis,chemotherapy resistance, and relapse.Methods: To further understand the unique biological properties of cancer stem cells and uncover novel molecular targets to eradicate them, we first established a panel of patient-derived xenograft(PDX) tumor models using tumors surgically removed from human colorectal cancer patients. We then isolated CRC cancer stem cells based on their ALDH activity using fluorescent-activated cell sorting(FACS)and characterized their metabolic properties.Results: Interestingly, we found that the CRC cancer stem cells(ie, CRC cells with higher ALDH activity, or ALDH+) express higher level of antioxidant genes and have lower level of reactive oxygen species(ROS) than non-CRC cancer stem cells(ie, CRC cells with lower ALDH activity, or ALDHà). The CRC cancer stem cells also possess more mitochondria mass and show higher mitochondrial activity. More intriguingly,we observed higher AMP-activated protein kinase(AMPK) activities in these CRC cancer stem cells. Inhibition of the AMPK activity using 2 AMPK inhibitors, Compound C and Iodotubercidin, preferentially induces cell death in CRC cancer stem cells.Conclusion: We propose that AMPK inhibitors may help to eradicate the CRC cancer stem cells and prevent the relapse of CRCs. | Bing Guo Xin Han Diane Tkach Shu-Guang Huang Dong Zhang | 2018 | Animal Models and Experimental Medicine2018，1，2： | 3 |
| 2 | Performance of low temperature Microbial Fuel Cells(MFCs)catalyzed by mixed bacterial consortia显示文摘Microbial Fuel Cells(MFCs) are a promising technology for treating wastewater in a sustainable manner. In potential applications, low temperatures substantially reduce MFC performance. To better understand the effect of temperature and particularly how bioanodes respond to changes in temperature, we investigated the current generation of mixed-culture and pure-culture MFCs at two low temperatures, 10°C and 5°C. The results implied that the mixed-culture MFC sustainably performed better than the pure-culture(Shewanella) MFC at 10°C, but the electrogenic activity of anodic bacteria was substantially reduced at the lower temperature of 5°C. At 10°C, the maximum output voltage generated with the mixed-culture was 540–560 m V, which was 10%–15% higher than that of Shewanella MFCs. The maximum power density reached 465.3 ± 5.8 m W/m^2 for the mixed-culture at10°C, while only 68.7 ± 3.7 m W/m^2 was achieved with the pure-culture. It was shown that the anodic biofilm of the mixed-culture MFC had a lower overpotential and resistance than the pure-culture MFC. Phylogenetic analysis disclosed the prevalence of Geobacter and Pseudomonas rather than Shewanella in the mixed-culture anodic biofilm, which mitigated the increase of resistance or overpotential at low temperatures. | Olga Tkach Thangavel Sangeetha Spiridonova Maria Aijie Wang | 2017 | Journal of Environmental Sciences2017，29，2： | 2 |
| 3 | The ability of Fos family members to produce phenotypic changes in epitheloid cells is not directly linked to their transactivation potentials显示文摘 | Andersen H Mahmood S Tkach V | | 0，，31： | 1 |
| 4 | Expression of a naturallyoccurring constitutively active variant of the epidermal growth factorreceptor in mouse fibroblasts increases motility 显示文摘 | Pedersen MW Tkach V Pedersen N | 2004 | Int J Cancer2004，108，5： | 1 |
| 5 | Four-photon mixing and high-speed WDM systems显示文摘 | Chralyvy A R Forghieri F | 1995 | IEEE J Lightwave Technol1995，13，5： | 1 |
| 6 | Electron-Phonon Interaction In Semiconductor Spherical Quan- tum Dot Embedded in a Semiconductor Medium (HgS/CdS)显示文摘 | Tkach M Holovatsky V Voitsekhivska O | 2001 | Phys Stat Sol (b)2001，225，2： | 1 |
| 7 | Permanent neurological deficit related to magnetic resonance imaging in a patient with implanted deep brain stimulation electrodes tbr Parkinson's disease: case report显示文摘 | Henderson JM Tkach J Phillips M | 2005 | Neurosurgery2005，57，5： | 1 |
| 8 | p42/p44 MAPK- mediated Stat3Ser727 phosphorylation is required for progestin- induced full activation of Stat3 and breast cancer growth 显示文摘 | Tkach My Rosemblit C Rivas M A | 2013 | Endocr Related Cancer2013，20，2： | 1 |
| 9 | Improving the Nonlinear Tolerance of Polarization- Division- Multiplexed CO OFDM in Long-Haul Fiber Transmission显示文摘 | X. Liu F. Buchali R. W. Tkach | | 0，，16： | 1 |
| 10 | Intraspecific variability among NADH dehydrogenase subunit I sequences of Taenia hydatigena显示文摘 | Kedra A H Tkach V V Swiderski Z | | 0，，02： | 1 |
| 11 | Issues For Routing In The Optical Layer显示文摘 | STRAND J CHIU A L TKACH R | 2001 | IEEE Communications Magazine2001，39，2： | 1 |
| 12 | Improvement of spiral MRI with the measured k-space trajectory显示文摘 | Ding X P Tkach J Ruggieri P | 1997 | JMRI-J Magn Reson Imaging1997，7，5： | 1 |
| 13 | Neurostimulation System Used for Deep Brain Stimulation (DBS): MR Safety Issues and Implications of Failing to Follow Safety Recommendations显示文摘 | Ali R. Rezai Michael Phillips Kenneth B. Baker Ashwini D. Sharan John Nyenhuis Jean Tkach Jaimie Henderson Frank G. Shellock | 2004 | Investigative Radiology2004，，5： | 1 |
| 14 | Real-timeand offline performance of pattern recognitionmyoelectric control using a generic electrodegrid with targeted muscle reinnervation patients显示文摘 | Tkach DC Young AJ Smith LH | 2014 | IEEE Transactions on Neural Systems andRehabilitation Engineering2014，22，4： | 1 |
| 15 | Fading in Lightwave Systems due to Polarization-Mode Dispersion显示文摘 | POOLE C D TKACH R W CHRAPLYVY A R | 1991 | Photonics Technol Lett1991，3，： | 1 |
| 16 | High-capacity optical transmission systems显示文摘 | GNAUCK A H TKACH R W CHRAPLYVY A R | 2008 | Journal of Lightwave Technology2008，26，9： | 1 |
| 17 | Implant ruptures after augmentation mammoplasty显示文摘 | Pinchuk V Tymofii O Tkach O | 2013 | Aesthetic Plast Surg2013，37，1： | 1 |
| 18 | Reduction of four-wave mixing erosstalk in WDM systems using unequally spaced channels 显示文摘 | Forghieri Tkach R W | 1994 | IEEE Photonics Technology Letters1994，6，6： | 1 |
| 19 | Patellar component medialization in total knee arthroplasty显示文摘 | Hofmann AA Tkach TK Evanich CJ | 1997 | J Arthroplasty1997，12，2： | 1 |
| 20 | Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos显示文摘 | Murray AR Kisin ER Tkach AJ | 2012 | Part Fibre Toxicol2012，9，： | 1 |
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