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| 1 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 2 | Composites of small Ag clusters confined in the channels of well-ordered mesoporous anatase TiO2 and their excellent solar-light-driven photocatalytic performance显示文摘 | Wei Zhou Ting Li Jianqiang Wang Yang Qu Kai Pan Ying Xie Guohui Tian Lei Wang Zhiyu Ren Baojiang Jiang Honggang Fu | 2014 | Nano Research2014，7，5： | 17 |
| 3 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 4 | Simultaneous removal of Cd(II)and As(III)from co-contaminated aqueous solution byα-FeOOH modified biochar显示文摘A novelα-FeOOH modified wheat straw biochar(α-FeOOH@BC)was developed and the findings of the current study showed thatα-FeOOH@BC is an efficient material for the simultaneous removal of cations(Cd(II))and anions(As(III))from aqueous solutions.The SEM,FTIR,and XRD analysis proved thatα-FeOOH@BC was covered byα-FeOOH.In the single adsorption system,the maximum adsorption capacities ofα-FeOOH@BC for Cd(II)and As(III)were 62.9 and 78.3 mg/g,respectively.In the dual adsorption system,the maximum adsorption capacities ofα-FeOOH@BC for Cd(II)and As(III)dropped to 39.3 and 67.2 mg/g,respectively.The adsorption capacities of Cd(II)and As(III)byα-FeOOH@BC were much higher by BC andα-FeOOH both in single and dual adsorbate system.The adsorption results were well fitted by the Langmuir and pseudo-second-order kinetics models.The Cd(II)and As(III)co-adsorption onα-FeOOH@BC had a competitive effect,and the dominant adsorption mechanisms were co-precipitation and ion exchange.Our study showed thatα-FeOOH@BC could be an effective remediation material for Cd(II)and As(III)co-adsorption from aqueous environment. | Sihang Zhu Ting Qu Muhammad Kashif Irshad Jianying Shang | 2020 | Biochar2020，2，1： | 7 |
| 5 | Multicenter prospective study of magnetic resonance imaging prior to breast-conserving surgery for breast cancer显示文摘 | Liu Qian Liu Yinhua Xu Ling Duan Xuening Li Ting Qin Naishan Kang Hua Jiang Hongchuan Yang Deqi Qu Xiang Jiang Zefei Yu Chengze | 2014 | Chinese Medical Journal2014，，13： | 6 |
| 6 | Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma显示文摘BACKGROUND Cellular senescence is a recognized barrier for progression of chronic liver diseases to hepatocellular carcinoma(HCC). The expression of a cluster of genes is altered in response to environmental factors during senescence. However, it is questionable whether these genes could serve as biomarkers for HCC patients.AIM To develop a signature of senescence-associated genes(SAGs) that predicts patients' overall survival(OS) to improve prognosis prediction of HCC.METHODS SAGs were identified using two senescent cell models. Univariate COX regression analysis was performed to screen the candidate genes significantly associated with OS of HCC in a discovery cohort(GSE14520) for the least absolute shrinkage and selection operator modelling. Prognostic value of this seven-gene signature was evaluated using two independent cohorts retrieved from the GEO(GSE14520) and the Cancer Genome Atlas datasets, respectively.Time-dependent receiver operating characteristic(ROC) curve analysis was conducted to compare the predictive accuracy of the seven-SAG signature and serum α-fetoprotein(AFP).RESULTS A total of 42 SAGs were screened and seven of them, including KIF18 B, CEP55,CIT, MCM7, CDC45, EZH2, and MCM5, were used to construct a prognostic formula. All seven genes were significantly downregulated in senescent cells andupregulated in HCC tissues. Survival analysis indicated that our seven-SAG signature was strongly associated with OS, especially in Asian populations, both in discovery and validation cohorts. Moreover, time-dependent ROC curve analysis suggested the seven-gene signature had a better predictive accuracy than serum AFP in predicting HCC patients' 1-, 3-, and 5-year OS.CONCLUSION We developed a seven-SAG signature, which could predict OS of Asian HCC patients. This risk model provides new clinical evidence for the accurate diagnosis and targeted treatment of HCC. | Xiao-Hong Xiang Li Yang Xing Zhang Xiao-Hua Ma Run-Chen Miao Jing-Xian Gu Yu-Nong Fu Qing Yao Jing-Yao Zhang Chang Liu Ting Lin Kai Qu | 2019 | World Journal of Gastroenterology2019，25，14： | 4 |
| 7 | Expression of Innate Immunity Genes in Epithelial Cells of Hypertrophic Adenoids with and without Pediatric Chronic Rhinosinusitis: A Preliminary Report显示文摘 | Xiao-Peng Qu Zhen-Xiao Huang Yan Sun Ting Ye Shun-Jiu Cui Qian Huang Li-Jing Ma Qing-Wen Yang Hong Wang Er-Zhong Fan Ying Li Liang Zhang Bing Zhou | 2015 | Chinese Medical Journal2015，，21： | 4 |
| 8 | Evaluation of the fishbone model in simulating the seismic response of multistory reinforced concrete moment-resisting frames显示文摘The fishbone model is a simplified numerical model for moment-resisting frames that is capable of modelling the effects of column-beam strength and stiffness ratios. The applicability of the fishbone model in simulating the seismic responses of reinforced concrete moment-resisting frames of different sets of column-beam strength and stiffness ratios are evaluated through nonlinear static, dynamic and incremental dynamic analysis on six prototype buildings of 4-, 8-and 12-stories. The results show that the fishbone model is practically accurate enough for reinforced concrete frames, although the assumption of equal joint rotation does not hold in all cases. In addition to the ground motion characteristics and the number of stories in the structures, the accuracy of the model also varies with the column-beam stiffness and strength ratios. The model performs better for strong column-weak beam frames, in which the lateral drift patterns are better controlled by the continuous stiffness provided by the strong columns. When the inelastic deformation is large, the accuracy of the model may be subjected to large record-to-record variability. This is especially the case for frames of weak columns. | Qu Zhe Gong Ting Li Qiqi Wang Tao | 2019 | Earthquake Engineering and Engineering Vibration2019，18，2： | 3 |
| 9 | Effect of Alemtuzumab on Intestinal Intraepithelial Lymphocytes and Intestinal Barrier Function in Cynomolgus Model显示文摘 | Lin-Lin Qu Ya-Qing Lyu Hai-Tao Jiang Ting Shan Jing-Bin Zhang Qiu-Rong Li Jie-Shou Li | 2015 | Chinese Medical Journal2015，，5： | 3 |
| 10 | Detection of tris-(2, 3-dibromopropyl) isocyanurate as a neuronal toxicant in environmental samples using neuronal toxicity-directed analysis显示文摘Neuronal toxic pollutants in environment possess hazards to human health. It is essential to determine the causative neuronal toxicants in environmental samples. In the present study, viability of primary cultured cerebellar granule neurons (CGNs), combined with sample extraction, chemical fractionation and identification, was applied for screening acid-resistant neuronal toxic substances in environmental samples. River sediments and agricultural soils along the river near a brominated flame retardant (BFR) manufacturing plant in South China were collected to screen the key neuronal toxicants. The results indicated that the manufacturing plant was a source of neuronal toxicity risks. In the sediment and soil near the plant, one of the causative toxicants was identified as tris-(2,3-dibromopropyl) isocyanurate (TBC) using HPLC-MS/MS. In addition, an unknown chemical possibly causing significant neuronal toxicity was isolated from all the soil samples in the region. | QU GuangBo SHI JianBo LI ZhuoNa RUAN Ting FU JianJie WANG Pu WANG Thanh JIANG GuiBin | 2011 | Science China Chemistry2011，54，10： | 3 |
| 11 | dentification of DW532 as a novel anti-tumor agent targeting both kinases and tubulin显示文摘 | Ting PENG Jian-rui WU Lin-jiang TONG Meng-yuan LI Fang CHEN Yi-xin LENG Rong QU Kun HAN Yi SU Yi CHEN Wen-hu DUAN Hua XIE Jian DING | 2014 | Acta Pharmacologica Sinica2014，35，7： | 3 |
| 12 | Comparison of measurements of anterior chamber angle via anterior segment optical coherence tomography and ultrasound biomicroscopy显示文摘BACKGROUND Glaucoma is an irreversible optic neuropathy with the loss of visual field and decrease of vision.The variable clinical manifestations may result in differential diagnostic difficulties.The early screening and diagnosis of glaucoma are currently experiencing a demand for anterior segment analysis tools that can gather more information with one short measurement.Therefore,we analyzed the agreement,difference,and correlation of chamber angle parameters such as angel opening distance at 500μm(AOD500)and trabeculo-iris space area at 500μm^2(TISA500)measured by anterior segment optical coherence tomography(ASOCT)and ultrasound biomicroscopy(UBM).AIM To compare the differences,correlation,and agreement in measuring AOD500 and TISA500 by AS-OCT and UBM.METHODS Both AS-OCT and UBM were performed to measure AOD500 and TISA500 in 45 subjects(72 eyes).All subjects without glaucoma were collected from October 2015 to August 2016 at the Ophthalmology Department of the Fourth Affiliated Hospital of China Medical University.Data of the two groups(AOD500 and TISA500)were compared by nonparametric tests.Pearson correlative analysis and Bland-Altman analysis were used to compare the correlation and agreement.RESULTS There were no significant differences between AS-OCT and UBM in measuring AOD500(P1=0.110,P2=0.633,P3=0.078,and P4=0.474)and TISA500(P1=0.584,P2=0.889,P3=0.297,and P4=0.550)of the four quadrants of the anterior chamber angle.There was a high correlation in measuring AOD500(r1=0.562,r2=0.671,r3=0.635,and r4=0.720;P<0.001)and TISA500(r1=0.584,r2=0.889,r3=0.297,and r4=0.550;P<0.001).There was a good agreement in measuring AOD500 and TISA500 by the two modalities.CONCLUSION There is a high correlation and agreement between AOD500 and TISA500 measurements by AS-OCT and UBM.They are interchangeable under some circumstances.AS-OCT proves to be a better early screening tool for glaucoma. | Zi-Yan Yu Ting Huang Lu Lu Bo Qu | 2020 | World Journal of Clinical Cases2020，8，15： | 2 |
| 13 | Thrombocytopenia for prediction of hepatocellular carcinoma recurrence: Systematic review and meta-analysis显示文摘AIM: To investigate the association between thrombocytopenia and relapse after treatment for hepatocellular carcinoma(HCC).METHODS: We searched the Pub Med, EMBASE, and Web of Science databases to obtain eligible studies. The hazard ratios(HRs) values and 95% confidence intervals(CIs) were pooled by random effects model. Subsequently, we estimated the heterogeneity, performed a sensitivity analysis, determined the publication bias, and performed subgroup and meta-regression analyses. Study quality was assessed by using the Oxford Center for Evidence Based Medicine tool.RESULTS: We identified 18 eligible studies by retrieval(published during 2000-2014). Out of the 4163 patients with HCC who were recruited, 2746(66.0%) experienced recurrence. In general, our meta-analysis suggested that low platelet count(PLT) before therapy significantly increased the probability of postoperative recurrence(HR = 1.53, 95%CI: 1.29-1.81). PLT was also valuable in the prediction of intrahepatic distant recurrence(HR = 1.49, 95%CI: 1.25-1.77). Subgroupand meta-regression analyses identified various therapeutic modalities as the source of a high degree of heterogeneity. The pooled HR values showed no obvious change when a single study was removed, but otherwise, an opposite-effects model was used. In addition, no significant publication bias was detected.CONCLUSION: Thrombocytopenia before treatment might be an inexpensive and useful predictor of postoperative recurrence in patients with HCC. | Qing Pang Kai Qu Jian-Bin Bi Su-Shun Liu Jing-Yao Zhang Si-Dong Song Ting Lin Xin-Sen Xu Yong Wan Ming-Hui Tai Hao-Chen Liu Ya-Feng Dong Chang Liu | 2015 | World Journal of Gastroenterology2015，21，25： | 2 |
| 14 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 15 | Sclerosing cholangitis in critically ill patients: an important and easily ignored problem based on a German experience显示文摘(ICU ) 特别护理联合起来在极其有病的病人的康复是重要的。在过去的十年,在 ICU 接受了好攻击的治疗的许多病人在多重中心开发了 sclerosing 胆管炎。在极其有病的病人(SC-CIP ) 的 Sclerosing 胆管炎是一个相对新的问题。调查 SC-CIP 的原因,临床的表明,治疗,和预后,我们从 2001 ~ 2012 在 PubMed,高空绳索,和 Elsevier 的数据库寻找了出版案例。数据用一种标准形式被提取并且回顾地分析了。与 64 个男人和 24 个女人一起,盖住 88 个病人的 12 合格研究在这分析被注册。吝啬的年龄是 49.8 年。所有从重病病人恢复了,例如损伤,感染,灼伤,和主要手术。高迫使积极结束吐气的压力(偷看,在 12.8 厘米 H2O 的山峰水平) 为所有病人被利用,与 36.3 d 的平均持续时间。另外, vasopressor 代理人在近似 60%of SC-CIP 被管理。cholestasis 的快速的增加和在 intrahepatic 胆汁管的不规则的苛评在下列月内被观察。与 17.9 个月的平均后续经期,差的结果在 54 个病人被观察,包括 34 死亡。在结论,胆汁的树的 ischemic 损害,可以被偷看或 vasopressor 管理影响,影响 cholangiopathic 过程。作为第二等的 sclerosing 胆管炎的一种最新发现的类型, SC-CIP 是在 ICU 的病人的严重进步复杂并发症并且应该被临床医生小心地监视。 | Ting Lin Kai Qu Xinsen Xu Min Tian Jie Gao Chun Zhang Ying Di Yuelang Zhang Chang Liu | 2014 | Frontiers of Medicine2014，8，1： | 2 |
| 16 | Genetic Analysis of Streaked and Abnormal Floret Mutant st-fon显示文摘A double mutant with streaked leaf and abnormal floret was found and temporarily named streaked leaf and floral organ number mutant (st-fon).For this mutant,besides white streak appeared on culm,leaves and panicles,the number of floral organs increased and florets cracked.The extreme phenotype was that several small florets grew from one floret or branch rachis in small florets extended and developed into panicles.By using transmission electron microscope to observe the ultrastructure of white histocytes of leaves at the seedling stage,the white tissues which showed abnormal plastids,lamellas and thylakoids could not develop into normal chloroplast,and the development of chloroplast was blocked at the early growth stage of plastid.Scanning electron microscope and paraffin section were also used to observe the development of floral organs,and the results indicated that the development of floral meristem was out of order and unlimited,whereas in the twisty leaves,vascular bundle sheath cells grew excessively,or some bubbly cells increased.Genetic analyses carried out by means of cross and backcross with four normal-leaf-color materials revealed that the mutant is of cytoplasm inheritance. | CHEN De-xi LI Ting QU Guang-lin HUANG Wen-juan HE Zhong-quan LI Shi-gui | 2013 | Rice science2013，20，4： | 2 |
| 17 | Epidural Labor Analgesia Is Associated with a Decreased Risk of Postpartum Depression: A Prospective Cohort Study显示文摘 | Ting Ding Dong-Xin Wang Yuan Qu Qian Chen Sai-Nan Zhu | 2014 | Anesthesia & Analgesia2014，，2： | 2 |
| 18 | Reactive oxygen species generation is essential for cisplatininduced accelerated senescence in hepatocellular carcinoma显示文摘因为这个过程涉及肿瘤抑制并且被许多化学疗法的代理人导致了,加速的老朽是重要的。基于铂的化学疗法的代理人 cisplatin 显示大量 antitumor 活动。然而,在 hepatocellular 癌(HCC ) 的导致 cisplatin 的加速的老朽的分子的机制仍然保持不清楚。在现在的学习,生长 HepG2 和 SMMC-7721 细胞上的 cisplatin 的禁止的效果被 3-(4,5-dimethylthiazol-2-yl ) 检测 -2,5-diphenyltetrazolium 溴化物试金。细胞的老朽然后被牛乳糖试金估计。包括 p53, p21,和 p16,老朽相关的因素被量的反向的抄写聚合酶链反应评估。反应的氧种类(ROS ) 被流动 cytometry 分析。我们的结果表明 cisplatin 在一个剂量依赖者和时间依赖者举止减少了 HepG2 和 SMMC-7721 房间的增长。在 cisplatintreated hepatoma 房间观察的衰老的显型依赖于 p53 和 p21 激活然而并非在 p16 激活上。而且, cisplatininduced 加速了取决于的老朽细胞内部的 ROS 产生。ROS scavenger N-acetyl-L-cysteine 显著地也压制了 HepG2 和 SMMC-7721 房间的导致 cisplatin 的老朽。在结论,我们的结果揭示了在细胞内部的 ROS 产生和导致 cisplatin 的加速的老朽之间的一个功能的连接,并且这个连接可以被用作 HCC 的一个潜在的目标。 | Kai Qu Ting Lin Zhixin Wang Sinan Liu Hulin Chang Xinsen Xu Fandi Meng Lei Zhou Jichao Wei Minghui Tai Yafeng Dong Chang Liu | 2014 | Frontiers of Medicine2014，8，2： | 2 |
| 19 | Industrial-Scale Polypropylene–Polyethylene Physical Alloying Toward Recycling显示文摘Polypropylene(PP)and polyethylene(PE)play central roles in our daily life.However,their immiscibility presents a major hurdle in both industry and academia when recycling them into alloys with favorable mechanical properties.Moreover,typical compatibilizer-enabled approaches are limited due to increased environmental concerns.Herein,inspired by a traditional Chinese technique,we report a facile,industry-scale methodology that produces a PP/PE binary blend with a highly ordered honeycomb nanostructure without any additives.Due to its nanostructure,the blend exhibits enhanced tensile properties in com-parison with the parent components or with a sample prepared using an internal mixer.This approach has potential for applications not only in immiscible polymer blending,but also in non-sorting,compatibilizer-free waste plastics recycling.Through this technique,we expect that an environmentally friendly and sustainable plastic wastes recycling avenue can be found,and great economic benefits can be gained. | Jinping Qu Zhaoxia Huang Zhitao Yang Guizhen Zhang Xiaochun Yin Yanhong Feng Hezhi He Gang Jin Ting Wu Guangjian He Xianwu Cao | 2022 | Engineering2022，8，2： | 2 |
| 20 | Development of pot-cover effect apparatus with freezing-thawing cycles显示文摘‘Pot-cover effect’ refers to the phenomenon of moisture accumulation beneath the pavement under condensation or desublimation because the vapor transfer in the soil is blocked by the pavement. To study this phenomenon in the laboratory, we have developed the pot-cover effect apparatus with freezing-thawing cycles(PEAFC), which consists of three parts, namely, the vapor transfer system, the temperature control system, and the temperature and water content monitoring system. The major functions of this apparatus include: simulation of both vapor transfer and freezing-thawing cycling in the soil, real-time monitoring of the temperature and the water content in soil samples, and one-dimensional heat and moisture transfer in the samples. The FDR(frequency domain reflectometry) sensors of the apparatus are calibrated and a calibration formula is proposed to eliminate the water content measurement errors induced by temperature changes. Constant temperature difference tests and a freezing-thawing cycling test are conducted with the apparatus. Results indicate that the apparatus can control the water replenishment in the soil samples, monitor the vapor transfer in the samples in real time, and simulate the vapor transfer process under the condition of the freezing-thawing cycling in the soil. These tests verify the effectiveness and reliability of the apparatus, which indicates that the development purpose is achieved. | LUO Ting CHEN Han YAO YangPing WANG NaiDong QU Xiao | 2019 | Science China(Technological Sciences)2019，62，9： | 2 |
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