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| 1 | Double-composite rectangular truss bridge and its joint analysis显示文摘This paper describes a novel composite tubular truss bridge with concrete slab and concrete-filled rectangular chords. With concrete slab plus truss system and joints reinforced with concrete and Perfobond Leiste rib, double composite truss bridge proved to be a fairly suitable solution in negative moment area. Perfobond Leiste shear connector(PBL) is widely implemented in the composite structure for its outstanding fatigue resistance. In this pilot bridge, Perfobond Leister ribs(PBR) were installed in the truss girder's joints,which played double roles as shear connector and stiffener. An erection method and overall bridge structural analysis were then presented. Typical joints in the pilot bridge were selected to analyze the effect of PBR. Investigation of the effect of PBR in concretefilled tubular joints was elaborated. Comparison has revealed that concrete-filled tubular joints with PBR have much higher constraint capability than joints without PBR. For rectangular tubular truss, the punching shear force of the concrete filled joint with PBR is approximately 43% larger than that of the joint without PBR. Fatigue performance of the joint installed with PBR was improved, which was found through analysis of the stress concentration factor of joint. The PBR installed in the joints mitigated the stress concentration factor in the chord face. Therefore, the advantages of this new type of bridge are demonstrated, including the convenience of construction using rectangular truss, innovative concept of structural design and better global and local performances. | Yongjian Liu Zhihua Xiong Yalin Luo Gao Cheng Ge Liu Jian Yang | 2015 | Journal of Traffic and Transportation Engineering(English Edition)2015，2，4： | 8 |
| 2 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 3 | Tectonic Units Division of Crystalline Basement in the Tarim Basin, NW China显示文摘By the geological investigation for crystalline basement outcrops in Northeast and northwest margins of Tarim Basin,we provide essential constrains interpreting the structure,petrology and age of the pre-Sinian basement.On the basis of interpretation for aeromagnetic anomalies, | ZHOU Xiaobei LI Jianghai LI Wenshan CHENG Yalin WANG Honghao | 2015 | Acta Geologica Sinica(English Edition)2015，89，A02： | 1 |
| 4 | A High Selective Chemiluminescent Probe Derived from Iso-luminol Enabling High Sensitive Determination of Ferrous Ions in the Environmental Waters显示文摘A new chemiluminescence(CL)reagent named 4-amino-5-thiocyanato-phthalyl-hydrazine(iso-luminol-SCN)is synthesized by the bromide-mediated substitution reaction of iso-luminol with sodium thiocyanate in dimethyl formamide(DMF)at room temperature.Strong CL is observed for iso-luminol-SCN oxidized by hydrogen peroxide(H2O2)in the presence of Fe^(2+),with the CL intensity strongly depending on the concentration of Fe^(2+)and being hardly interferred by other common metal ions.Based on this fact,a flow injection CL method is established for the high sensitive and selective determination of Fe^(2+).The CL intensity was linearly correlated with the concentration of Fe^(2+)in the range of 1.0×10^(–8) mol·L^(-1) to 1.0×10^(–5) mol·L^(-1) following the equation CLnet=166.3c+57.7(c,×10^(–6) mol·L^(-1);n=7;R2=0.9988).The detection limit is calculated to be 3.2×10–9 mol·L^(-1) Fe^(2+)based on the 3S0/K principle.The relative standard deviation(RSD)was 3.7%for 1.0×10^(–6) mol·L^(-1) Fe^(2+)(n=11),a support for the precision of Fe^(2+)measurement.The recoveries of Fe^(2+)were obtained in the range of 98.8%—101.6%in three real water samples,showing the applicability and reliability by the proposed method.The possible CL mechanism is proposed based on the kinetic characteristic of the CL reaction and the CL spectrum. | Shenghai Zhang Yalin Shi Jiawang Deng Jidong Zhang Mengqi Cheng Geting Yu | 2021 | Chinese Journal of Chemistry2021，39，11： | 0 |
| 5 | Comparative transcriptomic and metabolomic analysis reveals pectoralis highland adaptation across altitudinal songbirds显示文摘Pectoralis phenotypic variation plays a fundamental role in locomotion and thermogenesis in highland birds.How-ever,its regulatory and metabolic mechanisms remain enigmatic to date.Here,we integrated phenomic,tran-scriptomic,and metabolomic approaches to determine muscle variation and its underpinning mechanisms across altitudinal songbirds.Phenomics confirmed that all highland birds had considerable increases in muscle oxidative capacity,capillarity,and mitochondrial abundance in our study.Correspondingly,transcriptomic analyses found that differentially expressed genes in phenotype-associated modules enriched for blood vessel,muscle structure development,and mitochondrial organization.Despite similar traits and functional enrichments across highland birds,different mechanisms drove their occurrence in high-altitude tree sparrow and 2 snowfinches.Importantly,a metabolic feature shared by all the 3 highland birds is the improvement in insulin sensitivity and glucose utilization through activating insulin signaling pathway,which is vital to increase muscle oxidative capacity and maintain metabolic homeostasis.Nevertheless,fatty acid biosynthesis and oxidation are enhanced in only 2 snowfinches which had a long evolutionary history on the high plateau,also differing from ketone body metabolism in recently introduced colonizer of the tree sparrow of the high plateau.Our study represents a vital contribution to reveal the regulatory and metabolic basis of pectoralis variation across altitudinal songbirds. | Ying XIONG Yan HAO Yalin CHENG Liqing FAN Gang SONG Dongming LI Yanhua QU Fumin LEI | 2022 | Integrative Zoology2022，17，6： | 0 |
| 6 | BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes显示文摘Brain-specific serine/threonine-protein kinase 2(BRSK2)plays critical roles in insulin secretion andβ-cell biology.However,whether BRSK2 is associated with human type 2 diabetes mellitus(T2DM)has not been determined.Here,we report that BRSK2 genetic variants are closely related to worsening glucose metabolism due to hyperinsulinemia and insulin resistance in the Chinese population.BRSK2 protein levels are significantly elevated inβcells from T2DM patients and high-fat diet(HFD)-fed mice due to enhanced protein stability.Mice with inducibleβ-cell-specific Brsk2 knockout(βKO)exhibit normal metabolism with a high potential for insulin secretion under chow-diet conditions.Moreover,βKO mice are protected from HFD-induced hyperinsulinemia,obesity,insulin resistance,and glucose intolerance.Conversely,gain-of-function BRSK2 in matureβcells reversibly triggers hyperglycemia due toβ-cell hypersecretion-coupled insulin resistance.Mechanistically,BRSK2 senses lipid signals and induces basal insulin secretion in a kinase-dependent manner.The enhanced basal insulin secretion drives insulin resistance andβ-cell exhaustion and thus the onset of T2DM in mice fed an HFD or with gain-of-function BRSK2 inβcells.These findings reveal that BRSK2 links hyperinsulinemia to systematic insulin resistance via interplay betweenβcells and insulin-sensitive tissues in the populations carrying human genetic variants or under nutrient-overload conditions. | Rufeng Xu Kaiyuan Wang Zhengjian Yao Yan Zhang Li Jin Jing Pang Yuncai Zhou Kai Wang Dechen Liu Yaqin Zhang Peng Sun Fuqiang Wang Xiaoai Chang Tengli Liu Shusen Wang Yalin Zhang Shuyong Lin Cheng Hu Yunxia Zhu Xiao Han | 2023 | Journal of Molecular Cell Biology2023，15，5： | 0 |
| 7 | Anti-inflammatory sesquiterpene polyol esters from the stem and branch of Tripterygium wilfordii显示文摘The stem and branch extract of Tripterygium wilfordii(Celastraceae)afforded seven new dihydroagarofuran sesquiterpene polyesters[tripterysines A‒G(1‒7)]and eight known ones(8‒15).The chemical structures of these new compounds were established based on combinational analysis of HR-ESI-MS and NMR techniques.The absolute configurations of tripterysines A‒C(1‒3)and E‒G(5‒7)were determined by X-ray crystallographic analysis and circular dichroism spectra.All the compounds were screened for their inhibitory effect on inflammation through determining their inhibitory effect on nitric oxide production in LPS-induced RAW 264.7 cells and the secretion of inflammatory cytokines TNF-αand IL-6 in LPS-induced BV2 macrophages.Compound 9 exhibited significant inhibitory activity on NO production with an IC50 value of 8.77μmol·L−1.Moreover,compound 7 showed the strongest inhibitory effect with the secretion of IL-6 at 27.36%. | HU Yalin XU Tianqi YIN Wenjing CHENG Huaiyu ZHANG Xia LIU Ying ZHANG Yubo ZHOU Guangxiong | 2023 | Chinese Journal of Natural Medicines2023，21，3： | 0 |
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