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| 1 | 重症患者继发硬化性胆管炎研究现状与进展显示文摘硬化性胆管炎(sclerosing cholangitis,SC)是一种慢性胆汁淤积性疾病,以胆管慢性炎症和闭塞性纤维化为特点,根据病因不同,临床可将SC分为原发性硬化性胆管炎(primary sclerosing cholangitis,PSC)与继发性硬化性胆管炎(secondary sclerosing cholangitis,SSC)两类。PSC的病因尚不明确,一般认为可能与自身免疫性损伤相关,而SSC的病因明确, | 田孝东 杨尹默 | 2018 | 中华肝脏外科手术学电子杂志2018，7，1： | 1 |
| 2 | Cholestatic liver injury:A rare but fatal complication during and after COVID-19 infection显示文摘The 2019 coronavirus disease(COVID-19),resulting from the severe acute respiratory syndrome 2 virus,has transformed our globe and provided a new perspective on respiratory tract infections.However,COVID-19 would not be recognized as a condition restricted to only pneumonia.This narrative review was conducted by searching manuscripts in several databases,including PubMed/MEDLINE,Web of Science,and Reference Citation Analysis,from December 2019 to July 2022.Many studies have revealed a broad spectrum of potential systemic symptoms,including biliary complications.Although biliary injury has been observed in a very low proportion of COVID-19 patients,it is associated with increased mortalities and long-term morbidities.We identify a cholangiopathy condition in individuals during infection and after recovering from severe COVID-19,defined by a significant increase in serum alkaline phosphatase and signs of bile duct injury.Understanding the pathogeneses behind this condition would help us develop new techniques to prevent these complications.This review thoroughly discusses and summarizes the current information regarding COVID-19-associated cholangiopathy.In addition,the possible explanations for COVID-19-associated cholangiopathy are presented.Since the exact pathogenesis may not be concluded,this review could provide relevant information to encourage additional investigations shortly. | Wachira Wongtanasarasin | 2022 | World Journal of Virology2022，11，6： | 0 |
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