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| 1 | 用荧光原位杂交技术研究人类未受精卵细胞的染色体非整倍体显示文摘目的 探讨人类未受精卵细胞非整倍体的产生机制。方法 取未受精卵细胞固定后行多色荧光原位杂交 ,分析卵细胞中 13、16、18、2 1和 2 2号染色体的核型情况。结果 4 7%的卵细胞核型正常 ,5 3%的卵细胞为异常核型 ,其中 18%为同源染色体不分离 ,12 %为姐妹染色单体非平衡性过早分离 ,36 %为姐妹染色单体平衡性过早分离 ;在体外培养 >2 4小时的卵细胞中 ,姐妹染色单体平衡性过早分离的发生率明显高于体外培养≤ 2 4小时的卵细胞 ( P<0 .0 1)。结论 同源染色体不分离和姐妹染色单体平衡性及非平衡性过早分离这三种机制均参与了卵细胞非整倍体的产生。 | 陈雯 Liselotte Mettlter | 2004 | 中华医学遗传学杂志2004，21，3： | 4 |
| 2 | 光谱核型分析检测人未受精卵细胞非整倍体显示文摘目的建立光谱核型分析检测人未受精卵细胞非整倍体的方法。方法取试管婴儿术后成熟未受精卵细胞,固定后行光谱核型分析,检测卵细胞各染色体的核型情况。结果64%的卵细胞核型正常,36%的卵细胞为非整倍体,其中22%为同源染色体不分离,14%为姐妹染色单体非平衡性过早分离。结论光谱核型分析可用于检测卵细胞各条染色体的异常。同源染色体不分离和姐妹染色单体非平衡性过早分离均参与了卵细胞非整倍体的产生。 | 陈雯 朱桂金 Liselotte Mettler | 2005 | 中华医学遗传学杂志2005，22，4： | 2 |
| 3 | Adhesion formation after intracapsular myomectomy with or without adhesion barrier显示文摘 | Andrea Tinelli Antonio Malvasi Marcello Guido Daniel Alberto Tsin Gernot Hudelist Brad Hurst Michael Stark Liselotte Mettler | 2011 | Fertility and Sterility2011，，5： | 2 |
| 4 | 母本对雌激素暴露和PCB对斑马鱼(Danio rerio)不同生活阶段的影响显示文摘人类已发现多氯联苯(PCBs)影响着鱼的繁殖和发育。我们研究了:2,3,3’,4,4’,5,6-HpCB(PCB-190);2,3,4,4’-TeCB(PCB-60);和2,2’,4,6,6’-PeCB(PCB-104)三种PCB同系化合物以及雌激素17β-雌二醇对斑马鱼(Danio rerio)的繁殖力、早期生活阶段死亡率、总体形态学和组织学的影响。虽然没有一种被研究物质会降低鱼的繁殖力,但它们却增加了胚胎和幼体的死亡率。我们发现用17β-雌二醇或弱雌激素性的PCB-104处理时对生育力有最严重的影响。鱼暴露于17β-雌二醇或PCB-104后,在卵黄囊吸收期内持续有死亡发生。另一方面,PCB-60只在30%原肠期到75%原肠期之间能导致死亡。当胚胎开始死亡的同时,胚胎的发育和孵化被延缓。PCB-190仅对早期生理阶段的死亡率有轻微的影响。鱼被养殖到性成熟后才用来进行总体形态学和组织学的分析。用PCB-104和PCB-190处理过的鱼可观察到形态的变化。这两种物质都产生颅面畸形,而且PCB-104还对雌性鱼产生脊柱前凸,对两种性别的鱼都产生脊柱侧凸。根据组织学分析,我们发现PCB-104和17β-雌二醇在肾脏中引起了细胞核破裂和核溶解。用17β-雌二醇和PCB-190处理的鱼,可以观察到可能是胆汁郁积症状。在用17β-雌二醇、PCB-104和PCB-60处理的鱼中,可观察到对性腺的一些影响,包括在卵巢中显示闭锁区域和精巢在一定程度上不产生精子。虽然所有被研究的物质都对后代产生影响,但雌激素性物质具有很高的胚胎毒性,这个观察结果提出了对污染地区导致内分泌紊乱的物质可能严重减少鱼的种群的注意。 | Per-ErikOlsson Liselotte Westerlund SweeJ.Teh Karin Billsson A.H■kanBerg Mats Tysklind Jan Nilsson Lars-OveEriksson David.E.Hinton 孙学飞 | 1999 | 人类环境杂志1999，28，1： | 2 |
| 5 | Update of Meat Standards Australia and the cuts based grading scheme for beef and sheepmeat显示文摘Changing markets and evolving consumer demand present new challenges for the beef and sheep industries. In response, the industry has been investing in innovations to deliver new products and management systems to consumers. One such innovation is the Meat Standards Australia(MSA) system. This system is a Total Quality Management System, aimed at delivering an eating quality guarantee to consumers, and through this adding value to the entire supply chain. At present, it is well developed for beef and still evolving for sheepmeat. MSA has identified Critical Control Points(CCPs) in the production, pre-slaughter, processing and value-adding aspects of the supply chain that impact on consumer palatability through the large-scale taste testing of meat by untrained consumers. These CCPs are used as either(1) mandatory criteria determining eligibility for grading, and(2) inputs in a model predicting the palatability of individual combinations of muscle and different cooking methods. Through the prediction of palatability, MSA increases consumer satisfaction and is used to provide assurance for branded products and new marketing innovations in Australia and internationally. This has added significant value to the Australian beef industry, with several retail examples demonstrating consumer willingness to pay more for premium quality beef and sheepmeat products based on the MSA grading scores. This price differential at retail allows the value of the carcass to be calculated based on the eating quality as well as the volume produced, thereby delivering a financial reward for farmers producing high quality carcasses. The continuous quality scale of MSA allows producers to realise the financial gain of incremental improvements in quality, as well as the precise economic weights associated with traits such as marbling, ossification score, or breed. The use of MSA in this fashion has underpinned a new and innovative supply chain where the pricing is transparent and allows producers to make informed decisions to modify both quality and yield traits. To date, the MSA system for beef has proved to be effective in predicting beef palatability not only in Australia but also in many other countries(France, Poland, Ireland, Northern Ireland, Japan, South Korea, New-Zealand, the USA and South Africa). In Europe, results of the Pro Safe Beef and Pro Opti Beef projects as well as other national projects demonstrate the potential to develop an MSA-like international grading system for the supply chain in the EU, despite thediverse cultures and complex beef production systems within the member states. International testing in lamb has only just begun and preliminary results are discussed here. | Sarah P.F.Bonny Rachel A.O'Reilly David W.Pethick Graham E.Gardner Jean-Francois Hocquette Liselotte Pannier | 2018 | Journal of Integrative Agriculture2018，17，7： | 2 |
| 6 | 巨噬细胞集落刺激因子在卵泡黄素化颗粒细胞中的表达显示文摘目的 了解巨噬细胞集落刺激因子 (M CSF)在人卵泡黄素化颗粒细胞中的表达 ,探讨促卵泡激素 (FSH)在体外对人卵泡黄素化颗粒细胞合成分泌M CSF的调节作用。方法 取接受卵母细胞单精子显微注射治疗的 2 0例妇女的卵泡黄素化颗粒细胞 ,采用免疫细胞化学染色法测定黄素化颗粒细胞中M CSF的表达 ,并将黄素化颗粒细胞单独培养及在不同浓度的FSH(2、5、15、2 5IU/ml)作用下培养 72h ,采用酶联免疫吸附法测定黄素化颗粒细胞培养液中的M CSF含量。结果 约 80 %的黄素化颗粒细胞胞浆有M CSF表达 ;黄素化颗粒细胞在培养 72h后 ,基础状态下M CSF分泌量为(5 9± 13)ng/L ,浓度为 2、5、15、2 5IU/ml的FSH作用下M CSF分泌量分别为 (16 5± 32 )、(2 10± 5 8)、(2 99± 6 6 )、(390± 78)ng/L ,在不同浓度的FSH作用下黄素化颗粒细胞培养液中M CSF的含量与基础状态下相比 ,差异均有极显著性 (P <0 0 1)。结论 卵泡黄素化颗粒细胞能合成分泌M CSF ;FSH能促进黄素化颗粒细胞M CSF的分泌 ,FSH对卵泡发育和成熟的调节 ,可能部分通过M | 张治芬 Ali Salmassi Liselotte Mettler | 2002 | 中华妇产科杂志2002，37，8： | 2 |
| 7 | Localized Benign and Malignant Fibrous Tumors of the Pleura: A Clinicopathologic Review of 223 Cases显示文摘 | Douglas M. England Liselotte Hochholzer Michael J. McCarthy | 1989 | The American Journal of Surgical Pathology1989，，8： | 2 |
| 8 | Decreased serum testosterone levels in rats exposed intraperitoneally to bismuth subnitrate显示文摘 | Meredin S Allen F Liselotte G S Jorgen R | 2002 | Journal of Applied Toxicology2002，22，2： | 1 |
| 9 | Man- nan-Binding Lectin (MBL) Serum Concentration in Relation to Propagation of Infectious Bronchitis Virus (IBV) in Chickens显示文摘 | Helle R Juul-Madsen Liselotte R Norup Kurt J | 2007 | Viral Immunology2007，20，4： | 1 |
| 10 | “The South China Sea:ASEAN’s Security Concerns About China”显示文摘 | Liselotte Odgaard | | 0，，01： | 1 |
| 11 | Combined Surgical and Hormone Therapy for Endometriosis is the Most Effective Treatment: Prospective, Randomized, Controlled Trial显示文摘 | Ibrahim Alkatout Liselotte Mettler Carmen Beteta Jürgen Hedderich Walter Jonat Thoralf Schollmeyer Ali Salmassi | 2013 | The Journal of Minimally Invasive Gynecology2013，，4： | 1 |
| 12 | The potential of metabolic fingerprints as a tool for the modernization of TCM preparations显示文摘 | Helen Sheridan Liselotte Krenn Renwang J | | 0，，140： | 1 |
| 13 | Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease显示文摘 | Silvia Melgar Lisa Karlsson Erika Rehnstr?m Agneta Karlsson Helena Utkovic Liselotte Jansson Erik Micha?lsson | 2008 | International Immunopharmacology2008，，6： | 1 |
| 14 | Crosstalk between Innate and Adaptive Immune Responses to Infectious Bronchitis Virus after Vaccination and Challenge of Chickens varying in Serum Mannose-binding Lectin Concentra- tions显示文摘 | Helle R Juul-Madsen Liselotte R Norup Poul H | 2011 | Vaccine2011，29，： | 1 |
| 15 | A critical overview on Thymus daenensis Celak.: phytochemical and pharmacological investigations显示文摘Thymus daenensis Celak. is an herb endemic to Iran belonging to the Lamiaceae family. Growing in many parts of Iran, the plant is extensively used in folk medicine. This review was performed to compile phytochemical and pharmacological data of T. daenensis. Databases such as Pub Med, Scopus, Web of Science, Science Direct, Scientific Information Database, Embase, Iran Medex and Google Scholar were searched for the terms 'Thymus daenensis' and 'Avishan-e-denaii' up to 1st January 2014. Following reported ethnopharmacological uses, various T. daenensis preparations have been investigated for antimicrobial, antioxidant, insecticidal and immunomodulatory effects in recent studies. Moreover, numerous studies have been published on the composition of the herb's essential oil, focusing either on environmental parameters or preparation methods. Due to its high concentration of thymol, the plant's essential oil possesses high antimicrobial activities on human pathogenic strains. However, comprehensive studies on the toxicity and teratogenicity as well as clinical efficacy of Thymus daenensis are missing. | Mohammad M.Zarshenas Liselotte Krenn | 2015 | Journal of Integrative Medicine2015，13，2： | 1 |
| 16 | Efficient Cell-free Production of Olfactory Receptors: Detergent Optimization, Structure, and Ligand Binding Analyses 显示文摘 | Liselotte Kaiser Johanna Graveland-Bikker Dirk Steuerwald etc | 2008 | PNAS2008，105，15： | 1 |
| 17 | Functional variability of the Lr34 durable re sistance gene in transgenic wheat显示文摘 | Joanna MRisk Liselotte L Selter Simon G Kratting er | 2012 | Plant Biotech nology Journal2012，10，1111： | 1 |
| 18 | A functional methylome map of ulcerative colitis显示文摘 | Robert Hsler Zhe Feng Liselotte Bckdahl | 2012 | Genome Research2012，22，： | 1 |
| 19 | Real-time nucleic acid sequence-based amplification is more convenient than real-time PCR for quantification of plasmodium falciparum显示文摘 | Petra S Liselotte W Gerard S | 2005 | Journal of clinical microbiology2005，43，1： | 1 |
| 20 | Paleoproductivity increase at the Eocene-Oligocene climatic transition: ODP/DSDP sites 763 and 592 显示文摘 | Liselotte Diest er-Haass Rainer Zahn | 2001 | Paleoproductivity Palaeoclimatology Palaeoecology2001，172，： | 1 |
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