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| 1 | Current status of laparoscopic and robotic ventral mesh rectopexy for external and internal rectal prolapse显示文摘External and internal rectal prolapse with their affiliated rectocele and enterocele, are associated with debilitating symptoms such as obstructed defecation, pelvic pain and faecal incontinence. Since perineal procedures are associated with a higher recurrence rate, an abdominal approach is commonly preferred. Despite the description of greater than three hundred different procedures, thus far no clear superiority of one surgical technique has been demonstrated. Ventral mesh rectopexy(VMR) is a relatively new and promising technique to correct rectal prolapse. In contrast to the abdominal procedures of past decades, VMR avoids posterolateral rectal mobilisation and thereby minimizes the risk of postoperative constipation. Because of a perceived acceptable recurrence rate, good functional results and low mesh-related morbidity in the short to medium term, VMR has been popularized in the past decade. Laparoscopic or robotic-assisted VMR is now being progressively performed internationally and several articles and guidelines propose the procedure as the treatment of choice for rectal prolapse. In this article, an outline of the current status of laparoscopic and robotic ventral mesh rectopexy for the treatment of internal and external rectal prolapse is presented. | Jan J van Iersel Tim JC Paulides Paul M Verheijen John W Lumley Ivo AMJ Broeders Esther CJ Consten | 2016 | World Journal of Gastroenterology2016，22，21： | 20 |
| 2 | Sex differences in cognitive impairment in Alzheimer's disease显示文摘Sex differences in neurocognitive abilities have been extensively explored both in the healthy population andin many disorders. Until recently, however, little work has examined such differences in people with Alzheimer's disease(AD). This is despite clear evidence that AD is more prevalent in women, and converging lines of evidence from brain imaging, post-mortem analyses, hormone therapy and genetics suggesting that AD affects men and women differently. We provide an overview of evidence attesting to the poorer cognitive profiles in women than in men at the same stage of AD. Indeed, men significantly outperform women in several cognitive domains, including: Language and semantic abilities, visuospatial abilities and episodic memory. These differences do not appear to be attributable to any differences in age, education, or dementia severity. Reasons posited for this female disadvantage include a reduction of estrogen in postmenopausal women, greater cognitive reserve in men, and the influence of the apolipoprotein E ε4 allele. Assessment of cognitive abilities contributes to the diagnosis of the condition and thus, it is crucial to identify the role of sex differences if potentially more accurate diagnoses and treatments are to emerge. | Keith R Laws Karen Irvine Tim M Gale | 2016 | World Journal of Psychiatry2016，6，1： | 18 |
| 3 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 4 | Biochar and the Nitrogen Cycle: Introduction显示文摘 | Clough Tim J Condron Leo M | 2010 | Journal of Environmental Quality2010，，4： | 2 |
| 5 | Rainfall estimation from a combination of TRMM precipitation radar and GOES multispectral satellite imagery through the use of an artificial neural network显示文摘 | Bellerby Tim M Todd D Kniveton | 2000 | J Appl Meteor2000，39，： | 2 |
| 6 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 7 | Evolution of volatile aldehydes in Iberian ham matured under different processing conditions显示文摘 | Martín L Timón M L Petrón M J | | 0，，04： | 1 |
| 8 | Understanding innovation in small and medium-sized enterprises: A process manifest 显示文摘 | Tim E Rick D Max M | 2005 | Technovation2005，25，10： | 1 |
| 9 | Biochar and the nitrogen cycle:Introduction显示文摘 | Tim J C Leo M C | 2010 | Journal of Environmental Quality2010，39，4： | 1 |
| 10 | Intraday periodicity, long memory volatility, and macroeconomic announcement effects in the US Treasury bond market显示文摘 | Jun Cai Frank M Song | 2000 | Journal of Empirical Finance2000，，7： | 1 |
| 11 | T-Snakes: topology, adaptive snakes 显示文摘 | TIM M DEMETRI T | 2000 | Medical Image Analysis2000，4，2： | 1 |
| 12 | Do Long-Term Shareholders Benefit from Corporate Acquisitions? 显示文摘 | Tim L Vijh A M | 1997 | Journal of Finance1997，52，5： | 1 |
| 13 | Generation of activated and antigen-specific T cells with cytotoxic activity after co-culture with dendritic cells显示文摘 | Angela M Tim G Carsten Z | 2002 | Cancer immunol immunother2002，51，： | 1 |
| 14 | Assessment of sediment and porewater after one year of sub aqueous capping of contaminated sediments in Hamilton Harbour, Canada显示文摘 | Azcue J M Zeman A J Alena Mudroch Fernando Rosa Tim Patterson | 1998 | Wat Sci Tech1998，37，67： | 1 |
| 15 | Extracellular superoxide dismutase in biology and medicine 显示文摘 | Cheryl L Fattman Lisa M Schaefer Tim D Oury | 2003 | Free Radical Biology & Medicine2003，35，3： | 1 |
| 16 | Biochar Incorporation into Pasture Soil Suppresses in situ Nitrous Oxide Emissions from Ruminant Urine Patches显示文摘 | Taghizadeh-Toosi Arezoo Clough Tim J Condron Leo M Sherlock Robert R Anderson Craig R Craigie Robin A | 2011 | EN2011，，2： | 1 |
| 17 | Brain natriuretic peptide and acute hypobaric in humans显示文摘 | David W Tim H Adrian M | 2011 | Physiol Sci2011，61，： | 1 |
| 18 | Coherent interaction of atoms with a beam of light confined in a light cage显示文摘Controlling coherent interaction between optical fields and quantum systems in scalable,integrated platforms is essential for quantum technologies.Miniaturised,warm alkali-vapour cells integrated with on-chip photonic devices represent an attractive system,in particular for delay or storage of a single-photon quantum state.Hollow-core fibres or planar waveguides are widely used to confine light over long distances enhancing light-matter interaction in atomic-vapour cells.However,they suffer from inefficient filling times,enhanced dephasing for atoms near the surfaces,and limited light-matter overlap.We report here on the observation of modified electromagnetically induced transparency for a non-diffractive beam of light in an on-chip,laterally-accessible hollow-core light cage.Atomic layer deposition of an alumina nanofilm onto the light-cage structure was utilised to precisely tune the high-transmission spectral region of the light-cage mode to the operation wavelength of the atomic transition,while additionally protecting the polymer against the corrosive alkali vapour.The experiments show strong,coherent light-matter coupling over lengths substantially exceeding the Rayleigh range.Additionally,the stable non-degrading performance and extreme versatility of the light cage provide an excellent basis for a manifold of quantum-storage and quantumnonlinear applications,highlighting it as a compelling candidate for all-on-chip,integrable,low-cost,vapour-based photon delay. | Flavie Davidson-Marquis Julian Gargiulo Esteban Gómez-López Bumjoon Jang Tim Kroh Chris Müller Mario Ziegler Stefan A.Maier Harald Kübler Markus A.Schmidt Oliver Benson | 2021 | Light(Science & Applications)2021，10，7： | 1 |
| 19 | Label-free imaging of trabecular meshwork cells using Coherent Anti-Stokes Raman Scattering (CARS) microscopy显示文摘 | Tim C L David A A Omid M | 2011 | Mol Vis2011，17，： | 1 |
| 20 | Morphological differences in BMP-2-induced ectopic bone between solid and crushed hyaluronan hydrogel templates显示文摘 | Gry Hulsart-Billstr?m Sonya Piskounova Lars Gedda Britt-Marie Andersson Kristoffer Bergman J?ns Hilborn Sune Larsson Tim Bowden | 2013 | Journal of Materials Science: Materials in Medicine2013，，5： | 1 |
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