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| 1 | 吐哈盆地煤成烃研究新进展显示文摘运用生物标记物及碳同位素等地化参数对吐鲁番 -哈密盆地的原油及其源岩进行了油源对比 ,结果将该区原油分为三类 :第一类原油 ,根据生标特征分析其具有显著的淡水环境、藻含量低、细菌影响大、C2 9甾烷含量高、C3 04α 甲基甾烷低、C2 4 四环烷和C19三环烷含量高和碳同位素偏重 (δ13 C为 - 2 5‰~ - 2 7‰ )的特点 ,初步对比结果 ,本区西山窑组的煤是该类原油的主要源岩 ;第二类原油 ,富含藻类物质 (C2 7甾烷与C3 0 4α 甲基甾烷含量较高 ) ,该类原油可能来自侏罗系的富藻湖相泥岩 ;第三类原油 ,全油碳同位素δ13 C为 - 30‰~ - 32‰ ,这类原油的生标反映出其源岩相的特征为缺氧、咸水、中等含藻的湖相沉积 (高含量的伽玛蜡烷和 β 胡萝卜烷 ,C3 5/C3 4藿烷比值大等 )。 | 程克明 熊英 J M Moldowan J Greene Todd | 2002 | 沉积学报2002，20，3： | 10 |
| 2 | ERCP for the treatment of bile leak after partial hepatectomy and fenestration for symptomatic polycystic liver disease显示文摘AIM: To describe endoscopic treatment of bile leaks in these patients and to identify risk factors in these patients which can predict the development of bile leaks. METHODS: Retrospective case-control study examining consecutive patients who underwent partial hepatectomy for polycystic liver disease (PLD) and developed a postoperative bile leak managed endoscopically over a ten year period. Each case was matched with two controls with PLD who did not develop a postoperative bile leak. RESULTS: Ten cases underwent partial hepatectomy with fenestration for symptoms including abdominal distention, pain and nausea. Endoscopic retrograde cholangiopancreatography (ERCP) showed anatomic abnormalities in 1 case. A biliary sphincterotomy was performed in 4 cases. A plastic biliary stent was placed with the proximal end at the site of the leak in 9 cases; in 1 case two stents were placed. The overall success rate of ERCP to manage the leak was 90%. There were no significant differences in age, gender, comorbidities, duration of symptoms, history of previous surgery or type of surgery performed between cases and controls. CONCLUSION: ERCP with stent placement is safe and effective for management of post-hepatectomy bile leak in patients with PLD. | Nayantara Coelho-Prabhu David M Nagorney Todd H Baron | 2012 | World Journal of Gastroenterology2012，18，28： | 6 |
| 3 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 4 | 含高钙和维生素D的强化奶能有效提高健康的绝经后的中国女性体内的维生素D水平并减少骨吸收显示文摘目的钙摄入水平低以及体内维生素D不足是导致亚洲女性罹患骨质疏松的危险因素。此项研究的目的是评估高钙维生素D强化牛奶(HCM)对健康的中国绝经后妇女的体内维生素D状态和骨吸收标志物进行干预的影响。方法本试验对象为55岁以上,绝经至少5年的女性。共有124名女性进行了总体健康状况和骨密度检查筛选。63名女性被随机分为对照组和试验组,试验组在12w内每日饮用两次高钙/维生素D强化奶(含900 mg钙、96 mg镁、2.4 mg锌和6.4μg维生素D)。2组分别在试验开始、试验2 w、8 w和12 w时测量血矿物质、25(OH)维生素D3和Ⅰ型胶原C端肽(CTX)水平。结果对照组女性平均年龄为63±4.6岁,高钙强化奶(HCM)组女性平均年龄为62±3.8岁。所测得的每日钙摄入量的基线值为HCM组260~482 mg,对照组为252~692 mg。12 w后HCM组的平均身体质量指数(BMI)显著降低(P<0.05)。HCM组的血25(OH)维生素D3水平显著提高(33.13~39.49 nmol/L),而对照组则维持不变(29.27~28.21 nmol/L)。HCM组的血CTX水平在0 w和2 w之间下降了25%,并保持不变直至第12w。从第2w开始HCM组和对照组相比血CTX水平就出现了显著差异(P<0.001)。结论通过饮用含高钙和维生素D的强化奶(HCM),在2至4w内能显著提高中国绝经妇女体内维生素D水平,并减少骨吸收破坏。如果长期持续地饮用含高钙和维生素D的强化奶(HCM),能减少骨吸收和骨量丢失的风险,从而减少患骨质疏松和由此引起骨折的风险。 | Marlena C Kruger PengCheng Ha Joanne M Todd Barbara Kuhn-Sherlock Linda M Schollum Jiliang Ma George Qin Edith Lau | 2013 | 中国骨质疏松杂志2013，19，2： | 2 |
| 5 | Satellite identification of rain days over the upper Nile river basin using an optimum infrared rain/no-rain threshold temperature model显示文摘 | Todd M E C Barrett M J Beaumont | 1995 | J Appl Meteor1995，34，： | 2 |
| 6 | A simple method to retrieve 3 hourly estimates of global tropical and subtropical precipitation from International Satellite Cloud Climatology Program (ISCCP) D1 data显示文摘 | Todd M R Washington | 1999 | J Atmos Ocean Technol1999，16，： | 2 |
| 7 | Rainfall estimation from a combination of TRMM precipitation radar and GOES multispectral satellite imagery through the use of an artificial neural network显示文摘 | Bellerby Tim M Todd D Kniveton | 2000 | J Appl Meteor2000，39，： | 2 |
| 8 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3hxfckkvpownpb6cfu.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 9 | Monolithic microfabricated valves and pumps by multilayer soft lithography 显示文摘 | M A Unger H P Choi Todd Thorsen | 2000 | Science2000，288，： | 1 |
| 10 | Captopril: An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure显示文摘 | Brogden Rex N Todd Peter A Sorkin Eugene M | 1988 | Drugs1988，36，5： | 1 |
| 11 | Dust-storm source areas determined by the total ozone monitoring spectrometer and surface observations显示文摘 | Washington R Todd M Middleton N J | 2003 | Annals of the Association of American Geographers2003，93，2： | 1 |
| 12 | Characterization of novel circovirus DNAs associated with wasting syndromes in pigs显示文摘 | Meehan B M McNeilly F Todd D | 1998 | J Gen Virol1998，79，9： | 1 |
| 13 | Microsatllites for linkage analysis of genetic traits显示文摘 | Hearne C M Ghosh S Todd J A | 1992 | Trends in Genetic1992，8，： | 1 |
| 14 | Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis显示文摘 | Riedner G Rusizoka M Todd J | 2005 | N Engl J Med2005，353，12： | 1 |
| 15 | A study of chemical aging effects on HDD Fe-zeolite SCR catalyst显示文摘 | Silver R G Stefanick M O Todd B I | 2008 | Catalysis Today2008，72，： | 1 |
| 16 | A single chicken anemia virus protein induces apoptosis显示文摘 | Noteborn M H Todd D Verschueren C h | 1994 | J Viro11994，68，1： | 1 |
| 17 | Unrave- ling the Chronic Toxicity of Lead:an Essential Pri- ority for Environmental Health 显示文摘 | Todd A C Wetmur J G Moline J M | 1996 | Environ Health Perspect1996，104，4： | 1 |
| 18 | A mathematical model of human semicircular canal geometry:a new basis for interpreting vestibular physiology显示文摘 | BRADSHAW A P CURTHOYS I S TODD M J | 2010 | J Assoc Res Otolaryngol2010，11，： | 1 |
| 19 | A single Chicken anemia virus protein induces apoptosis显示文摘 | NOTEBORN M H TODD D VERSCHUEREN C V | 1994 | Virol1994，68，1： | 1 |
| 20 | Molecular basis for the herbicide resistance of roundup ready crops显示文摘 | Todd F Han H J Healy-Fried M L Fischer M Schnbrunn E | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，，13： | 1 |
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