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| 1 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 2 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 3 | Communication skills training in heahhcare: A review of the literature 显示文摘 | Simon C Tim J Jacqueline R l | 2002 | Nurs Edu Today2002，22，3： | 1 |
| 4 | Label-free imaging of trabecular meshwork cells using Coherent Anti-Stokes Raman Scattering (CARS) microscopy显示文摘 | Tim C L David A A Omid M | 2011 | Mol Vis2011，17，： | 1 |
| 5 | Organic compounds trapped in aqueous fluid inclusions 显示文摘 | Tim E R Simon C G Mark L Robinson A Q | 1998 | Organic Geochemistry1998，29，13： | 1 |
| 6 | Prevalence of maternal smoking and environmental tobacco smoke exposure during pregnancy and impact on birth weight : retrospective study using Millennium Cohort 显示文摘 | Corinne W Sarah L Tim C | 2007 | BMC Public Health2007，7，： | 1 |
| 7 | Bioanalytics and Biolabeling with Semiconductor Nanoparticles(Quantum Dots)显示文摘 | Lin C J Tim L Ralph A S | 2007 | Journal of Matery Chemistry2007，17，： | 1 |
| 8 | Discovery of genes associated with fruit ripening in Carica popaya using expreased sequence tags显示文摘 | Devitt L C Tim S Timothy A H | 2006 | Plant Science2006，170，： | 1 |
| 9 | Discovery of genes associated with fruit ripening in Carica papaya using expressed sequence tags 显示文摘 | Devitt L C Tim S Timothy A H | 2006 | Plant Sci2006，170，： | 1 |
| 10 | Microbial production and modification of gases in , sedimentary basins : A geochemical case study from a Devonian shale gas play, Michiganbasin 显示文摘 | Martini A M Walter L Y Tim C W Ku | 2003 | AAPGBulletin2003，87，8： | 1 |
| 11 | Co-digestion to support low temperature anaerobic pretreatment of municipal sewage in a UASB-digester显示文摘 | Lei Zhang Tim L G Hendrickx C K | 2013 | Bioresource Technology2013，148，： | 1 |
| 12 | Enabling information sharing between E-commerce systems for construction material procurement显示文摘 | Stephen C W Kong Heng Lia Tim P L Hunga | 2004 | Automation in Construction2004，，13： | 1 |
| 13 | Engineered fusion hybrid vaccine of IL-4 gene-modified myeloma and relative mature dendritic cell,Senhances antitumor immunity显示文摘 | Yongqing L Weidong Z Tim C | 2000 | Leukemia Res2000，26，8： | 1 |
| 14 | The Extreme Cold Anomaly over Southeast Asia in February 2008: Roles of ISO and ENSO显示文摘 | HONG C C TIM L | 2008 | J Climate2008，22，15： | 1 |
| 15 | Microbial populations and volatile compounds in the 'bone taint' spoilage of dry cured ham显示文摘 | García C Martín A Timón M L | 2000 | Lett Appl Microbiol2000，30，： | 1 |
| 16 | Discovery of genes associated with fruit ripening in carica papaya using expressed sequence tags显示文摘 | Devitt L C Tim S Timothy A H | 2006 | Plant Sci2006，170，： | 1 |
| 17 | CDCP1 is a novel marker for hematopoietic stem cells显示文摘 | Tim C Reiner L Selim K | 2003 | Ann N Y Acad Sei2003，996，： | 1 |
| 18 | Impact of Dnmtl deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice显示文摘 | Trasler J Deng L Melnyk S Pogribny I Hiou - Tim F Sibani S Oakes C Li E James SJ Rozen R | 2003 | Carcinogenesis2003，24，： | 1 |
| 19 | Response of cassava leaf area expansion to water deficit:cell proliferation,cell expansion and delayed development显示文摘 | Alves Alfredo A C Setter Tim L | 2004 | Annals of Botany2004，94，： | 1 |
| 20 | Detecting Taxus poisoning inhorses using liquid chromatography/mass spectrometry显示文摘 | Geoffrey C K Tim J L Elizabeth A D | 2000 | Vet HumToxico2000，42，3： | 1 |
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