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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Ampullary cancer of intestinal origin and duodenal cancer-A logical clinical and therapeutic subgroup in periampullary cancer显示文摘Periampullary cancers include pancreatic, ampullary, biliary and duodenal cancers. At presentation, the majority of periampullary tumours have grown to involve the pancreas, bile duct, ampulla and duodenum. This can result in difficulty in defining the primary site of origin in all but the smallest tumors due to anatomical proximity and architectural distortion. This has led to variation in the reported proportions of resected periampullary cancers. Pancreatic cancer is the most common cancer resected with a pancreaticoduodenectomy followed by ampullary(16%-50%), bile duct(5%-39%), and duodenal cancer(3%-17%). Patients with resected duodenal and ampullary cancers have a better reported median survival(29-47 mo and 22-54 mo) compared to pancreatic cancer(13-19 mo). The poorer survival with pancreatic cancer relates to differences in tumour characteristics such as a higher incidence of nodal, neural and vascular invasion. While small ampullary cancers can present early with biliary obstruction, pancreatic cancers need to reach a certain size before biliary obstruction ensues. This larger size at presentation contributes to a higher incidence of resection margin involvement in pancreatic cancer. Ampullary cancers can be subdivided into intestinal or pancreatobiliary subtype cancers with histomolecular staining. This avoids relying on histomorphology alone, as even some poorly differentiated cancers preserve the histomolecular profile of their mucosa of origin. Histomolecular profiling is superior to anatomic location in prognosticating survival. Ampullary cancers of intestinal subtype and duodenal cancers are similar in their intestinal origin and form a logical clinical and therapeutic subgroup of periampullary cancers. They respond to 5-FU based chemotherapeutic regimens such as capecitabine-oxaliplatin. Unlike pancreatic cancers, KRAS mutation occurs in only approximately a third of ampullary and duodenal cancers. Future clinical trials should group ampullary cancers of intestinal origin and duodenal cancers together given their similarities and their response to fluoropyrimidine therapy in combination with oxaliplatin. The addition of anti-epidermal growth factor receptor therapy in this group warrants study. | Manju D Chandrasegaram Anthony J Gill Jas Samra Tim Price John Chen Jonathan Fawcett Neil D Merrett | 2017 | World Journal of Gastrointestinal Oncology2017，9，10： | 4 |
| 3 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 4 | Rainfall estimation from a combination of TRMM precipitation radar and GOES multispectral satellite imagery through the use of an artificial neural network显示文摘 | Bellerby Tim M Todd D Kniveton | 2000 | J Appl Meteor2000，39，： | 2 |
| 5 | CsBi4Te6: A high-performance thermoelectric material for low-temperature applications 显示文摘 | Chung D Y Hogan Tim Brazis Paul | 2000 | Science2000，1，1287： | 2 |
| 6 | Grading system modification and management of blunt aortic injury显示文摘 | Kaavya N Reddy Tim Matatov Linda D Doucet Maureen Heldmann Cynthia X Zhao Wayne W Zhang | 2013 | Chinese Medical Journal2013，，3： | 2 |
| 7 | Ritual-enema-induced colitis显示文摘 | Segal I Tim L O Hamilton D G | 1979 | Dis Colon Rectum1979，22，3： | 1 |
| 8 | A Parallel Architecture for the Discrete Wavelet Transform with Integer Lifting Scheme显示文摘 | Ferret tiM R izzo D | 2001 | Journal of VLSI Signal Processing2001，28，： | 1 |
| 9 | U-series chronology of lacustrine deposits in Death Valley, California显示文摘 | Ku T L Luo S D Tim K L | 1998 | Quaternary research1998，50，： | 1 |
| 10 | The coronary delivery of marrow stromal cells for myocardial regeneration: pathophysiologic and therapeutic implications显示文摘 | Wang JS Shum Tim D Chedrawy E | | 0，，： | 1 |
| 11 | Creation of viable pulmonary artery autografts through tissue engineering显示文摘 | Shinoka T Shum Tim D Ma PX | 1998 | Thorac Cardiovasc Surg1998，115，3： | 1 |
| 12 | Primary Repair Minimizing the Use of Conduits in Neonates and Infants with Tetralogy or Double-outlet Right Ventricle and Anomalous Coronary Arteries显示文摘 | Tchervenkov CL Pelletier MP Shum Tim D | 2000 | J Thorac Cardiovasc Surg2000，119，2： | 1 |
| 13 | Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise显示文摘 | Hu BH Henderson D Nicotera TiM | 2002 | Hear Res2002，166，12： | 1 |
| 14 | Understanding innovation in small and medium-sized enterprises: A process manifest 显示文摘 | Tim E Rick D Max M | 2005 | Technovation2005，25，10： | 1 |
| 15 | The competent novice:life long learn- ing at work显示文摘 | Teunissen PW Tim D | 2008 | BMJ2008，336，7645： | 1 |
| 16 | Tissue engineering of autologous aorta using a new biodegradable polymer显示文摘 | Shum Tim D Stock U Hrkach J | 1999 | Ann Thorac Surg1999，68，6： | 1 |
| 17 | Mobilization and homing of bone marrow stromal cells in myocardial infarction显示文摘 | Bittira B Shum - Tim D Al - Khaldi A | 2003 | Eur J Cardiothorac Surg2003，24，3： | 1 |
| 18 | Marrow stromal cells for cellular cardiomyoplasty: Feasibility and potential clinical advantages显示文摘 | Shum - Tim D Galipeau J | 2000 | J Thorac Cardiovasc Surg2000，120，5： | 1 |
| 19 | Creation of viable pulmonary artery autografts through tissue engineering显示文摘 | Shinoka T Tim A D Ma P X | 1998 | J Thorac Cardiovas Surg1998，115，： | 1 |
| 20 | The coronary delivery of marrow stromal cells for myocardial regeneration: pathophysiologic and therapeutic implications 显示文摘 | Wang J S Shum Tim D Chedrawy E | 2001 | J Thorac Caridovasc Surg2001，122，4： | 1 |
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